scholarly journals Racial Differences in Oncogene Mutations Detected in Early-Stage Low-Grade Endometrial Cancers

2012 ◽  
Vol 22 (8) ◽  
pp. 1367-1372 ◽  
Author(s):  
Michele L. Cote ◽  
Govindaraja Atikukke ◽  
Julie J. Ruterbusch ◽  
Sara H. Olson ◽  
Shawnita Sealy-Jefferson ◽  
...  
Keyword(s):  
African American ◽  
Endometrial Cancer ◽  
Endometrial Carcinoma ◽  
African American Women ◽  
Racial Differences ◽  
Early Stage ◽  
Fisher Exact Test ◽  
Low Grade ◽  
Urban Hospital ◽  
American Women

ObjectiveTo describe the pattern and frequency of oncogene mutations in white and African American women with endometrial cancer and to determine if racial differences in oncogene mutations exist among women with pathologically similar tumors.MethodsPatients with endometrial cancer from a large urban hospital were identified through medical records, and representative formalin-fixed paraffin-embedded tumor blocks were retrieved. The study sample included 150 patients (84 African Americans) who underwent total abdominal hysterectomy for endometrial cancer. The Sequenom MassARRAY system and the OncoCarta Assay version 1.0 (Sequenom) were used to test for 238 mutations in 19 common oncogenes. The χ2test and the Fisher exact test were used to assess differences in distribution of variables by race and oncogene mutation status.ResultsThere were 20 mutations identified in 2 oncogenes (PIK3CAandKRAS) in tumors from 19 women (12.7%). Most of the mutations were found inPIK3CA(16/20). Thirteen percent of endometrioid tumors harbored mutations (11PIK3CAand 2KRAS) as did 29% of the malignant mixed Mullerian tumors (3PIK3CAand 1KRAS). There were no observed mutations in serous, clear cell, or mucinous tumor types. Among low-grade endometrioid cancers, tumors from African American patients were significantly associated with harboring either aKRASorPIK3CAmutation (P= 0.04), with 7PIK3CAmutations and all 4KRASmutations identified in African American women.ConclusionsThis study provides preliminary evidence that oncogene mutation frequency of some subtypes of histologically similar endometrial carcinoma differ by race. Additional studies are needed to further explore this phenomenon in patients with endometrial carcinoma.

Differences in Treatment and Outcome Between African-American and White Women With Endometrial Cancer

2003 ◽  
Vol 21 (22) ◽  
pp. 4200-4206 ◽  
Author(s):  
Thomas C. Randall ◽  
Katrina Armstrong
Keyword(s):  
African American ◽  
Endometrial Cancer ◽  
African American Women ◽  
Racial Differences ◽  
White Women ◽  
Sociodemographic Characteristics ◽  
Histologic Type ◽  
American Women ◽  
Epithelial Cancers ◽  
Primary Surgery

Purpose: To investigate disparities in treatment and outcomes between African-American and white women with endometrial cancer. Patients and Methods: We analyzed 1992 to 1998 Surveillance, Epidemiology, and End Results data for 21,561 women with epithelial cancers of the endometrium. Sequential Cox proportional hazard models were used to determine the association between tumor characteristics (stage, grade, and histologic type), sociodemographic characteristics (age and marital status), and treatment (surgery and radiation therapy) and the racial difference in mortality. Results: The unadjusted hazard ratio (HR) for death from endometrial cancer for African-American women compared with white women was 2.57. However, African-American women were significantly more likely to present with advanced-stage disease and have poorly differentiated tumors or tumors with an unfavorable histologic type and were significantly less likely to undergo definitive surgery at all stages of disease. Adjusting for tumor and sociodemographic characteristics lowered the HR for African-American women to 1.80. Further adjustment for the use of surgery reduced the HR to 1.51. The association between surgery and survival was stronger among white women (HR, 0.26) than among African-American women (HR, 0.44). Conclusion: African-American women with endometrial cancer are significantly less likely to undergo primary surgery and have significantly shorter survival than white women with endometrial cancer. Racial differences in treatment are associated with racial differences in survival. The association between use of surgery and survival is weaker among African-American than white women, raising questions about potential racial differences in the effectiveness of surgery.

Latina and African American Women: Continuing Disparities in Health

1993 ◽  
Vol 23 (3) ◽  
pp. 555-584 ◽  
Author(s):  
Marsha Lillie-Blanton ◽  
Rose Marie Martinez ◽  
Andrea Kidd Taylor ◽  
Betty Garman Robinson
Keyword(s):  
African American ◽  
Social Class ◽  
Health Services ◽  
African American Women ◽  
Racial Differences ◽  
Family Income ◽  
Work Conditions ◽  
Social Conditions ◽  
Minority Population ◽  
American Women

Women of all races have faced incredible challenges as they sought to realize the promises of America. For women of color, these challenges were compounded by the second-class citizenship of U.S. racial and ethnic minority population groups. In an effort to assess the quality of life experienced by Latina and African American women, this article provides descriptive information on racial/ethnic differences in women's social conditions, health status, exposure to occupational and environmental risks, and use of health services. When possible, indices are stratified by family income to limit the effects of social class on the comparison of racial differences. The authors provide evidence that Latina and African American women are more likely than nonminority women to encounter social environments (e.g., poverty, densely populated neighborhoods, hazardous work conditions) that place them at risk for ill-health and injury. Although persistent racial disparities in health are often attributed to the lifestyle behaviors of racial minority populations, they are undoubtedly a consequence of poorer social conditions as well as barriers in access to quality health services. To achieve further gains, public policies must reduce social inequalities (i.e., by gender, race, and social class) and assure greater equity in access to resources that facilitate healthier environments and lifestyles. Public health initiatives should be community-based, reflecting a shared partnership that actively engages minority women in decision-making about their lives.

Triple-negative early-stage breast cancer in African American women: A fuel to the fire

2008 ◽  
Vol 26 (15_suppl) ◽  
pp. 11039-11039 ◽  
Author(s):  
A. M. Khan ◽  
I. Sabnani ◽  
P. Tsang ◽  
D. A. Baran ◽  
E. Rogers-Phillips ◽  
...  
Keyword(s):  
Breast Cancer ◽  
African American ◽  
African American Women ◽  
Triple Negative ◽  
Early Stage ◽  
Early Stage Breast Cancer ◽  
American Women

Mammography screening and detection of early stage breast cancer in Hispanic and African American women at a Minnesota safety net healthcare system.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e18074-e18074
Author(s):  
Daniel Fellows Pease ◽  
David T. Gilbertson ◽  
Andres Wiernik
Keyword(s):  
Breast Cancer ◽  
African American ◽  
African American Women ◽  
Healthcare System ◽  
Early Stage ◽  
Screening Mammography ◽  
Advanced Stage ◽  
American Women ◽  
Younger Age ◽  
Caucasian Women

e18074 Background: Approximately 12% of breast cancer cases occur in women younger than 50 years, per SEER data from 2012. Hispanic women are known to present at a younger age and African American women with more advanced stage disease. In this study, we describe the impact of age and race on the initial presentation of breast cancer among minority women treated at the Hennepin Healthcare System (HHS) in the state of Minnesota. Methods: A single-institution retrospective analysis of data from our electronic health record of all breast cancer diagnoses from 2010-2015. Cases were compared by age ( < 50 or > 50 years), race (Caucasian, African American, Hispanic, other), stage (AJCC 7th edition), and method of diagnosis (self-reported mass or screening mammography). Results: A total of 315 breast cancer diagnoses occurred at HHS from 2010-2015. In our cohort, 29% of all breast cancer cases were diagnosed in women < 50yrs. Hispanic and African American women had higher rates of diagnosis at < 50yrs compared to Caucasian women (38.9% vs 37.1% vs 18.1 respectively, p < 0.05). Early stage cancer (stage 0 or I) accounted for most diagnoses in those > 50yrs (54.8%), while advanced stage (stage II-IV) was more prevalent in the < 50yrs age group (59.5%) (p < 0.05). Of all women diagnosed with breast cancer, 63% presented with a self-reported mass and 37% were diagnosed by screening mammography. Hispanics and African American women had a higher rate of presentation with a self-reported mass (74% and 66% respectively) compared to Caucasian women (55%). Women with breast cancer < 50yrs were more likely to present with a self-reported mass than women > 50yrs (80% vs 55%, p < 0.05). 92% of Hispanic and 80% of African American women < 50yrs presented with a self-reported mass, compared to 62% of Caucasian women (p = 0.095). Conclusions: At our institution, Hispanic and African American women are diagnosed at a significantly younger age than Caucasian women, and those diagnosed at a younger age have more advanced disease. Presenting with a self-reported mass is very common for young non-Caucasian women. Whether screening mammography can be better utilized to change these trends requires further study.

A Pilot Study of Microsatellite Instability and Endometrial Cancer Survival in White and African American Women

2012 ◽  
Vol 31 (1) ◽  
pp. 66-72 ◽  
Author(s):  
Michele L. Cote ◽  
Audrey Kam ◽  
Cherry Yin-Yi Chang ◽  
Leon Raskin ◽  
Kerryn W. Reding ◽  
...  
Keyword(s):  
African American ◽  
Endometrial Cancer ◽  
Pilot Study ◽  
Microsatellite Instability ◽  
African American Women ◽  
Cancer Survival ◽  
American Women

Cancer-specific and overall survival in African American women with endometrial cancer: a SEER-Medicare study

2021 ◽  
Vol 162 ◽  
pp. S102
Author(s):  
Daniel Saris ◽  
Anna Jo Smith ◽  
Colleen Brensinger ◽  
Sarah Kim ◽  
Ashley Haggerty ◽  
...  
Keyword(s):  
Overall Survival ◽  
African American ◽  
Endometrial Cancer ◽  
African American Women ◽  
American Women

scholarly journals Comparison of the Genomic Landscape Between Primary Breast Cancer in African American Versus White Women and the Association of Racial Differences With Tumor Recurrence

2015 ◽  
Vol 33 (31) ◽  
pp. 3621-3627 ◽  
Author(s):  
Tanya Keenan ◽  
Beverly Moy ◽  
Edmund A. Mroz ◽  
Kenneth Ross ◽  
Andrzej Niemierko ◽  
...  
Keyword(s):  
Breast Cancer ◽  
African American ◽  
African Americans ◽  
African American Women ◽  
Racial Differences ◽  
Genetic Heterogeneity ◽  
Racial Disparity ◽  
Tumor Recurrence ◽  
Triple Negative ◽  
American Women

Purpose African American women are more likely to die as a result of breast cancer than white women. The influence of somatic genomic profiles on this racial disparity is unclear. We aimed to compare the racial distribution of tumor genomic characteristics and breast cancer recurrence. Methods We assessed white and African American women with stage I to III breast cancer diagnosed from 1988 to 2013 and primary tumors submitted to The Cancer Genome Atlas from 2010 to 2014. We used Cox proportional hazards models to evaluate the association of race and genetic traits with tumor recurrence. Results We investigated exome sequencing and gene expression data in 663 and 711 white and 105 and 159 African American women, respectively. African Americans had more TP53 mutations (42.9% v 27.6%; P = .003) and fewer PIK3CA mutations (20.0% v 33.9%; P = .008). Intratumor genetic heterogeneity was greater in African American than white tumors overall by 5.1 units (95% CI, 2.4 to 7.7) and within triple-negative tumors by 4.1 units (95% CI, 1.4 to 6.8). African Americans had more basal tumors by the 50-gene set predictor using the predication analysis of microarray method (PAM50; 39.0% v 18.6%; P < .001) and fewer PAM50 luminal A tumors (17.0% v 34.7%; P < .001). Among triple-negative subtypes, African Americans had more basal-like 1 and mesenchymal stem-like tumors. African Americans had a higher risk of tumor recurrence than whites (hazard ratio, 2.22; 95% CI, 1.05 to 4.67). Racial differences in TP53 mutation, PAM50 basal subtype, and triple-negative tumor prevalence but not intratumor genetic heterogeneity influenced the magnitude and significance of the racial disparity in tumor recurrence. Conclusion African Americans had greater intratumor genetic heterogeneity and more basal gene expression tumors, even within triple-negative breast cancer. This pattern suggests more aggressive tumor biology in African Americans than whites, which could contribute to racial disparity in breast cancer outcome.

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