Vitamin D Receptor BsmІ Polymorphism and Ovarian Cancer Risk: A Meta-Analysis

2013 ◽  
Vol 23 (7) ◽  
pp. 1178-1183 ◽  
Author(s):  
Xue Qin ◽  
Yu Lu ◽  
Aiping Qin ◽  
Zhiping Chen ◽  
Qiliu Peng ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Vitamin D ◽  
Vitamin D Receptor ◽  
Meta Analysis ◽  
Asian Population ◽  
European Population ◽  
Ovarian Cancer Risk ◽  
Bsmi Polymorphism ◽  
Inheritance Model ◽  
The Relationship

ObjectiveVitamin D receptor (VDR) FokI polymorphism has been reported to influence ovarian cancer (OC) susceptibility, but the association between VDR BsmI polymorphism and OC risk remains controversial. To clarify the relationship between them, we performed a meta-analysis.MethodsA comprehensive literature search was conducted to examine all the eligible studies of VDR BsmI polymorphism and OC risk. Odds ratios (OR) with 95% confidence intervals (95% CI) were used to assess the strength of this association.ResultsSeven separate comparisons consisting of 1977 OC cases and 2832 healthy controls were included in our meta-analysis. The pooled analyses showed no significant association between VDR BsmI G/A polymorphism and OC in all of the comparisons (AA vs GG: OR, 1.01; P = 0.919; AG vs GG: OR, 1.12; P = 0.087; AG + AA vs GG: OR, 1.10; P = 0.146; AA vs AG + GG: OR, 0.96; P = 0.629). However, subgroup analysis showed a significant contribution of the dominant inheritance model to OC development in the European group: AG + AA vs GG (OR, 1.43; P = 0.029); AG vs GG (OR, 1.46; P = 0.031).ConclusionsVitamin D receptor BsmI G/A gene variant might be a moderate risk factor of OC development in the European population instead of North America or Asian population.

Meta-analysis of the relation between vitamin D receptor gene BsmI polymorphism and susceptibility to ovarian cancer

Tumor Biology ◽  
2013 ◽  
Vol 34 (6) ◽  
pp. 3317-3321 ◽  
Author(s):  
Yan Zhang ◽  
Sheng-Chun Tong ◽  
Li-Hua Guan ◽  
Fei Na ◽  
Wei Zhao ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Vitamin D ◽  
Vitamin D Receptor ◽  
Meta Analysis ◽  
Receptor Gene ◽  
Vitamin D Receptor Gene ◽  
Bsmi Polymorphism

FokI polymorphism of the vitamin D receptor (VDR) gene and susceptibility to tuberculosis: evidence through a meta-analysis

2021 ◽  
Author(s):  
Upendra Yadav ◽  
Pradeep Kumar ◽  
Vandana Rai
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Meta Analysis ◽  
Receptor Gene ◽  
Asian Population ◽  
Recessive Model ◽  
Dominant Model ◽  
Vdr Gene ◽  
Exact Relation ◽  
Significance Level

Abstract Background: Tuberculosis is one of the top ten causes of deaths worldwide. The deficiency of vitamin D was reported to be associated with the increased susceptibility of tuberculosis. Various previous reports were published to check the association of FokI polymorphism of the vitamin D receptor gene with tuberculosis risk. But their results were inconsistent so, we performed a meta-analysis to know the exact relation of the two.Methods: Different databases were screened up to November, 2020 with the keywords “Vitamin D receptor”, “VDR”, and “FokI”, along with “Tuberculosis” and “TB” to find the suitable articles. All the statistical analyses were performed by the Open Meta-Analyst program and all p-values were two-tailed with a significance level of 0.05.Results: No statistically significant association was observed in the allele contrast model (ORfvs.F= 1.11, 95%CI= 0.99-1.24, p= 0.05, I2= 73.46%), in the dominant model (ORff+Ffvs.FF= 1.11, 95%CI= 0.96-1.28, p= 0.14, I2= 71.39%), and in the co-dominant model (ORFfvs.FF= 1.05, 95%CI= 0.92-1.21, p= 0.41, I2= 65.97%). However, a significant association was found in the homozygote model (ORffvs.FF= 1.32, 95%CI= 1.03-1.69, p= 0.02, I2= 67.02%) and in the recessive model (ORFF+Ff vs.ff= 1.26, 95%CI= 1.03-1.54, p= 0.02, I2= 58.01%). Further analysis was performed on the bases of the ethnicity. In Asian population a significant association was found in the homozygote model (ORffvs.FF= 1.57, 95%CI= 1.12-2.21, p= 0.008, I2= 70.37%) and in the recessive model (ORFF+Ff vs.ff= 1.43, 95%CI= 1.08-1.89, p= 0.01, I2= 63.13%).Conclusion: In conclusion, a significant association of FokI with tuberculosis susceptibility was found in the overall analysis and in the Asian population.

scholarly journals Evidence of Differential Effects of Vitamin D Receptor Variants on Epithelial Ovarian Cancer Risk by Predicted Vitamin D Status

2014 ◽  
Vol 4 ◽  
Author(s):  
Jennifer Prescott ◽  
Kimberly A. Bertrand ◽  
Brett M. Reid ◽  
Jennifer Permuth-Wey ◽  
Immaculata De Vivo ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Vitamin D ◽  
Cancer Risk ◽  
Epithelial Ovarian Cancer ◽  
Vitamin D Receptor ◽  
Ovarian Cancer Risk ◽  
Vitamin D Status ◽  
Differential Effects

scholarly journals Vitamin D Receptor Gene BsmI and FokI Polymorphisms in Relation to Ovarian Cancer Risk in the Polish Population

2013 ◽  
Vol 17 (3) ◽  
pp. 183-187 ◽  
Author(s):  
Adrianna Mostowska ◽  
Stefan Sajdak ◽  
Piotr Pawlik ◽  
Margarita Lianeri ◽  
Pawel P. Jagodzinski
Keyword(s):  
Ovarian Cancer ◽  
Vitamin D ◽  
Cancer Risk ◽  
Vitamin D Receptor ◽  
Receptor Gene ◽  
Ovarian Cancer Risk ◽  
Vitamin D Receptor Gene ◽  
Polish Population

Vitamin D Receptor BsmI Polymorphism and Osteoporosis Risk: A Meta-Analysis from 26 Studies

2013 ◽  
Vol 17 (1) ◽  
pp. 30-34 ◽  
Author(s):  
Fu Jia ◽  
Rui-Fen Sun ◽  
Qun-Hui Li ◽  
Da-Xing Wang ◽  
Feng Zhao ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Meta Analysis ◽  
Bsmi Polymorphism ◽  
Osteoporosis Risk

scholarly journals ERCC1 rs11615 polymorphism and chemosensitivity to platinum drugs in patients with ovarian cancer: a systematic review and meta-analysis

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Yuqiang Zhang ◽  
Sufen Cao ◽  
Chunyu Zhuang ◽  
Jiacheng Chen ◽  
Xiaojing Chen ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Web Of Science ◽  
Meta Analysis ◽  
Asian Population ◽  
Caucasian Population ◽  
Cochrane Library ◽  
Platinum Drugs ◽  
China National Knowledge Infrastructure ◽  
Knowledge Infrastructure ◽  
The Relationship

Abstract Objective To explore the relationship between ERCC1 rs11615 polymorphism and chemosensitivity to platinum drugs in ovarian cancer by the method of meta-analysis. Methods Pubmed, Web of Science, EMBASE, Cochrane Library, China National Knowledge Infrastructure (CNKI), and China Wanfang databases were comprehensively searched up to September 2020, to identify the relationship between ERCC1 rs11615 polymorphism and chemosensitivity of ovarian cancer. The data was analyzed by Stata 15.0 statistic software. Results A total of 10 published papers were included, including 1866 patients with ovarian cancer. The results showed that compared allele C at ERCC1 rs11615 locus with allele T, the pooled OR was 0.92 (95%CI:0.68 ~ 1.24, P > 0.05). There were no significant differences in recessive, dominant, homozygous, and heterozygous models. In accordance with a subgroup analysis of Ethnicity, all genotypes were statistically significant in the Asian population. In the allelic, dominant, recessive, homozygous and heterozygous models, the OR was 0.70 (95%CI:0.51 ~ 0.95), 0.20 (95%CI:0.07 ~ 0.56), 0.79 (95%CI:0.63 ~ 1.00), 0.21 (95%CI:0.07 ~ 0.59), 0.19 (95%CI:0.07 ~ 0.54), respectively, while in the Caucasian population, no statistically significant genotype was found. Conclusion The ERCC1 rs11615 polymorphism is associated with chemosensitivity in patients with ovarian cancer, especially in the Asian population, but not in the Caucasian population.

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