A Population-Based Observational Study of Restrictive Guidelines for Antibiotic Therapy in Early-Onset Neonatal Infections

2007 ◽  
Vol 26 (7) ◽  
pp. 593-599 ◽  
Author(s):  
Marc Labenne ◽  
Francis Michaut ◽  
B??atrice Gouyon ◽  
Cyril Ferdynus ◽  
Jean-Bernard Gouyon
Keyword(s):  
Observational Study ◽  
Antibiotic Therapy ◽  
Early Onset ◽  
Population Based ◽  
Neonatal Infections

scholarly journals Reduction of Duration of Antibiotic Therapy for Suspected Early-Onset Sepsis in Late-Preterm and Term Newborns After Implementation of a Procalcitonin-Guided Algorithm: A Population-Based Study in Central Switzerland

2021 ◽  
Vol 9 ◽  
Author(s):  
Jennifer Zihlmann-Ji ◽  
Christian Braun ◽  
Michael Buettcher ◽  
Markus Hodel ◽  
Dirk Lehnick ◽  
...  
Keyword(s):  
Antibiotic Therapy ◽  
Gestational Age ◽  
Early Onset ◽  
Population Based ◽  
Unintended Consequences ◽  
Late Preterm ◽  
Population Based Study ◽  
Early Onset Sepsis ◽  
Central Switzerland ◽  
Guided Therapy

Background: Suspected early-onset sepsis (EOS) is the main reason for antibiotic therapy at the start of life. Prolonged antibiotic therapy for culture-negative sepsis is often reported. Antibiotic stewardship is mandatory due to the potential negative effects of unnecessary antibiotics. Procalcitonin (PCT)-guided therapy is one possible strategy with published evidence to shorten antibiotic therapy. The aim of this study is to analyze the feasibility and the performance of the published PCT-algorithm in the clinical setting without study support.Methods: This is a retrospective, population-based study regarding duration of antibiotic therapy for suspected EOS in Central Switzerland between 2014 and 2018. All neonates >34 0/7 weeks of gestational age started on antibiotic therapy for suspected EOS within the first 3 calendar days of life were included. The Procalcitonin-guided algorithm according to the NeoPInS study was used as strategy to determine duration of antibiotic therapy.Results: In a population-based cohort of 35,642 life born neonates, the duration of antibiotic therapy of 879 neonates (2.5% of the cohort) treated for suspected EOS was 4 calendar days (median, IQR 2–5). We observed a statistically significant reduction from 4 (median, IQR 3–6) to 3 calendar days (median, IQR 2–4) from 2014 to 2018. Duration of antibiotic therapy was independent of gestational age (late-preterm vs. term neonates), of the presence of risk factors or clinical signs, but dependent on the presence of abnormal laboratory measurements (C-reactive protein > 10 mg/l or leukocytopenia <5 Giga/l) before start of antibiotic therapy (p < 0.01).Conclusions: PCT-guided therapy using the NeoPInS algorithm is feasible and may lead to reduced duration of antibiotic therapy for suspected EOS as reported in the original study. We observed a learning curve to the new algorithm which may be explained as change process. The use of biomarker to guide duration of antibiotic therapy for suspected EOS may have unintended consequences with prolongation of antibiotic therapy in some cases.

The influence of intrapartum antibiotic therapy on the diagnosis of early-onset neonatal sepsis

1997 ◽  
Vol 73 (3) ◽  
pp. 171-175 ◽  
Author(s):  
Rita de Cássia S. Vieira ◽  
Renato S. Procianoy ◽  
Lisiane Dalle Mulle ◽  
Cristina H. A. Prado
Keyword(s):  
Antibiotic Therapy ◽  
Neonatal Sepsis ◽  
Early Onset ◽  
Intrapartum Antibiotic

scholarly journals Survival in patients diagnosed with castration-resistant prostate cancer: a population-based observational study in Sweden

2020 ◽  
Vol 54 (2) ◽  
pp. 115-121 ◽  
Author(s):  
Markus Aly ◽  
Amy Leval ◽  
Frida Schain ◽  
Johan Liwing ◽  
Joe Lawson ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Observational Study ◽  
Population Based ◽  
Castration Resistant Prostate Cancer ◽  
Castration Resistant

Neonatal Early-Onset Sepsis Calculator and Antibiotic Therapy—Reply

2020 ◽  
Vol 174 (5) ◽  
pp. 508
Author(s):  
Niek B. Achten ◽  
Claus Klingenberg ◽  
Frans B. Plötz
Keyword(s):  
Antibiotic Therapy ◽  
Early Onset ◽  
Early Onset Sepsis ◽  
Sepsis Calculator

scholarly journals Clinical and functional differences between early-onset and late-onset adult asthma: a population-based Tasmanian Longitudinal Health Study

Thorax ◽  
2016 ◽  
Vol 71 (11) ◽  
pp. 981-987 ◽  
Author(s):  
Daniel J Tan ◽  
E Haydn Walters ◽  
Jennifer L Perret ◽  
John A Burgess ◽  
David P Johns ◽  
...  
Keyword(s):  
Early Onset ◽  
Late Onset ◽  
Population Based ◽  
Health Study ◽  
Adult Asthma ◽  
Functional Differences
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