Association of vitamin D deficiency with arterial stiffness in newly diagnosed hypertension

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Sinem Cakal ◽  
Beytullah Çakal ◽  
Oguz Karaca
Keyword(s):  
Vitamin D ◽  
Arterial Stiffness ◽  
Vitamin D Deficiency ◽  
Newly Diagnosed

scholarly journals Serum vitamin D deficiency in children and adolescents is associated with type 1 diabetes mellitus

2018 ◽  
Vol 7 (12) ◽  
pp. 1275-1279 ◽  
Author(s):  
Changwei Liu ◽  
Jingwen Wang ◽  
Yuanyuan Wan ◽  
Xiaona Xia ◽  
Jian Pan ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Vitamin D Deficiency ◽  
Newly Diagnosed ◽  
25Ohd Level ◽  
Serum 25Ohd ◽  
The Mean

Background To investigate the relationship 25-hydroxy vitamin D (25OHD) level among children and in children with type 1 diabetes mellitus (T1DM). Methods A case–control study was conducted to compare the serum 25OHD levels between cases and controls. This study recruited 296 T1DM children (106 newly diagnosed T1DM patients and 190 established T1DM patients), and 295 age- and gender-matched healthy subjects as controls. Results The mean serum 25OHD in T1DM children was 48.69 ± 15.26 nmol/L and in the controls was 57.93 ± 19.03 nmol/L. The mean serum 25OHD in T1DM children was lower than that of controls (P < 0.01). The mean serum 25OHD level (50.42 ± 14.74 nmol/L) in the newly diagnosed T1DM children was higher than that (47.70 ± 15.50 nmol/L) in the established T1DM children but the difference was not statistically significant (P = 0.16). HbA1c values were associated with 25OHD levels in established T1DM children (r = 0.264, P < 0.01), and there was no association between 25OHD and HbA1c in newly diagnosed T1DM children (r = 0.164; P > 0.05). Conclusion Vitamin D deficiency is common in T1DM children, and it should be worthy of attention on the lack of vitamin D in established T1DM children.

Alteration of the Intestinal Microbial Flora and the Serum IL-17 Level in Patients with Graves’ Disease Complicated with Vitamin D Deficiency

2021 ◽  
pp. 1-10
Author(s):  
Mengxue Yang ◽  
Fei Li ◽  
Rui Zhang ◽  
Yueyue Wu ◽  
Qian Yang ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Intestinal Flora ◽  
Graves Disease ◽  
Newly Diagnosed ◽  
Tsh Receptor Antibody ◽  
Differential Species ◽  
Intestinal Microbial Flora ◽  
Deficiency Group ◽  
Case Number

<b><i>Background:</i></b> Intestinal flora is associated with Graves’ disease (GD). This study explored the association of serum 25(OH)D with the diversity of the intestinal flora and serum IL-17 in GD patients. <b><i>Methods:</i></b> Patients newly diagnosed with GD at 2 centers between 2018 and 2021 were consecutively included. According to their 25(OH)D levels, they were divided into the deficiency group, the insufficiency group, and the sufficiency group. Some patients with vitamin D deficiency or insufficiency were randomly selected and were matched with healthy volunteers (normal control [NC]) in terms of sex, age, and case number. The diversity and differential species of the intestinal flora and serum IL-17 levels were compared. <b><i>Results:</i></b> Serum 25(OH)D negatively correlated with serum IL-17, the platelet/lymphocyte ratio, and TSH receptor antibody. The diversity of the intestinal flora decreased in the GD group, with noticeable differences in the composition of the intestinal flora when compared with the NC group. At the phylum level, the GD group exhibited a significantly lower abundance of Firmicutes but a higher abundance of Actinobacteria. At the genus level, the GD group exhibited higher relative abundances of Bifidobacterium, Collinsella, and Pediococcus but lower abundances of Roseburia and Dialister. <b><i>Conclusions:</i></b> The changes in the vitamin D level and the composition of the intestinal flora may partially contribute to the development of GD.

Vitamin D Deficiency and Hypocalcemia in an Infant With Newly Diagnosed AML

2014 ◽  
Vol 36 (2) ◽  
pp. e118-e120
Author(s):  
Cathleen Cook ◽  
Valeria Bernardo ◽  
John Shelso ◽  
Raul C. Ribeiro
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Newly Diagnosed

SUPPLEMENTATION OF VITAMIN D IN HYPERTENSIVE PATIENTS WITH CKD STAGE 3 AND VITAMIN D-DEFICIENCY DOES NOT IMPROVE ARTERIAL STIFFNESS

2018 ◽  
Vol 36 (Supplement 1) ◽  
pp. e197
Author(s):  
E. Rodilla Sala ◽  
D. Gil Alós ◽  
E. Ruiz Pérez ◽  
P. Serrano Torres ◽  
J. Costa Muñoz ◽  
...  
Keyword(s):  
Vitamin D ◽  
Arterial Stiffness ◽  
Vitamin D Deficiency ◽  
Hypertensive Patients ◽  
Ckd Stage

Vitamin D Deficiency in Children With Newly Diagnosed Idiopathic Epilepsy

2015 ◽  
Vol 30 (11) ◽  
pp. 1428-1432 ◽  
Author(s):  
Fatma Mujgan Sonmez ◽  
Ahsen Donmez ◽  
Mehmet Namuslu ◽  
Metin Canbal ◽  
Emel Orun
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Idiopathic Epilepsy ◽  
Newly Diagnosed

scholarly journals High-Dose versus Low-Dose Vitamin D Supplementation and Arterial Stiffness among Individuals with Prehypertension and Vitamin D Deficiency

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Amanda Zaleski ◽  
Gregory Panza ◽  
Heather Swales ◽  
Pankaj Arora ◽  
Christopher Newton-Cheh ◽  
...  
Keyword(s):  
Vitamin D ◽  
Arterial Stiffness ◽  
Pulse Wave Velocity ◽  
Vitamin D Deficiency ◽  
Wave Velocity ◽  
Low Dose ◽  
Pulse Wave ◽  
Vitamin D Supplementation ◽  
High Dose ◽  
High Dose Vitamin

Introduction. Vitamin D deficiency is associated with the onset and progression of hypertension and cardiovascular disease (CVD). However, mechanisms underlying vitamin D deficiency-mediated increased risk of CVD remain unknown. We sought to examine the differential effect of high-dose versus low-dose vitamin D supplementation on markers of arterial stiffness among ~40 vitamin D deficient adults with prehypertension.Methods. Participants were randomized to high-dose (4000 IU/d) versus low-dose (400 IU/d) oral vitamin D3 for 6 months. 24 hr ambulatory blood pressure (BP), carotid-femoral pulse wave velocity, and pulse wave analyses were obtained at baseline and after 6 months of vitamin D supplementation.Results. There were no changes in resting BP or pulse wave velocity over 6 mo regardless of vitamin D dose (allp>0.202). High-dose vitamin D decreased augmentation index and pressure by 12.3 ± 5.3% (p=0.047) and 4.0 ± 1.5 mmHg (p=0.02), respectively. However, these decreases in arterial stiffness were not associated with increases in serum 25-hydroxyvitamin D over 6 mo (p=0.425).Conclusion. High-dose vitamin D supplementation appears to lower surrogate measures of arterial stiffness but not indices of central pulse wave velocity.Clinical Trial Registration. This trial is registered with www.clinicaltrials.gov (Unique Identifier:NCT01240512).

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