scholarly journals How might endotyping guide chronic obstructive pulmonary disease treatment? Current understanding, knowledge gaps and future research needs

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Robert M. Burkes ◽  
Ralph J. Panos ◽  
Michael T. Borchers
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Current Understanding ◽  
Future Research ◽  
Chronic Obstructive ◽  
Research Needs ◽  
Knowledge Gaps ◽  
Disease Treatment ◽  
Obstructive Pulmonary Disease

Cost-Effectiveness of Fixed-Dose Combinations Therapies for Chronic Obstructive Pulmonary Disease Treatment

2018 ◽  
Vol 38 (7) ◽  
pp. 611-620 ◽  
Author(s):  
Margarita Capel ◽  
María Mareque ◽  
Carlos José Álvarez ◽  
Leandro Lindner ◽  
Itziar Oyagüez
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Cost Effectiveness ◽  
Pulmonary Disease ◽  
Fixed Dose ◽  
Chronic Obstructive ◽  
Disease Treatment ◽  
Obstructive Pulmonary Disease

Diagnosis and management of COPD in primary care

2021 ◽  
Vol 14 (4) ◽  
pp. 350-355
Author(s):  
Katarzyna Mycroft ◽  
Katarzyna Górska
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Treatment Initiation ◽  
Disease Diagnosis ◽  
Chronic Obstructive ◽  
Disease Treatment ◽  
Obstructive Pulmonary Disease ◽  
Long Acting ◽  
Significant Health

Chronic obstructive pulmonary disease is a significant health problem. However, a large proportion of cases remain undiagnosed. Early diagnosis of chronic obstructive pulmonary disease leads to earlier treatment initiation, and in consequence, to improvement of patients quality of life. The gold standard for chronic obstructive pulmonary disease diagnosis is spirometry and the presence of irreversible obstruction after a bronchodilator. One of the most important interventions in the treatment of chronic obstructive pulmonary disease is anti-smoking education. The main group of drugs used in chronic obstructive pulmonary disease treatment are the long-acting bronchodilators.

Chronic obstructive pulmonary disease

2017 ◽  
Author(s):  
Amina Jaffer ◽  
Anant Patel ◽  
John Hurst
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Phenotypic Variability ◽  
Evidence Base ◽  
Future Research ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Potential Benefits ◽  
Learning Points

This chapter discusses the case of a 70-year-old man with his first presentation of chronic obstructive pulmonary disease. This case is used as a basis to explore and describe the diagnosis, investigation, and management of this condition. The chapter includes the evidence base and relative guidelines that support current practice, as well as highlighting useful learning points and providing expert opinion. The role of lung volume reduction surgery is discussed, and its potential benefits in selected patients highlighted. Phenotypic variability within chronic obstructive pulmonary disease is increasingly recognized, and this is discussed, including the implications on current management and future research.

scholarly journals Mitochondrial Regulation of Inflammasome Activation in Chronic Obstructive Pulmonary Disease

2015 ◽  
Vol 8 (2) ◽  
pp. 121-128 ◽  
Author(s):  
Chang Min Yoon ◽  
Milang Nam ◽  
Yeon-Mok Oh ◽  
Charles S. Dela Cruz ◽  
Min-Jong Kang
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Inflammatory Responses ◽  
Pulmonary Inflammation ◽  
Innate Immune ◽  
Western Society ◽  
Future Research ◽  
Chronic Obstructive ◽  
Inflammasome Activation ◽  
Obstructive Pulmonary Disease

Chronic obstructive pulmonary disease (COPD) is characterized by enhanced chronic airway and lung inflammatory responses to noxious particles or gases. It is a major unmet medical need worldwide, and in Western society is strongly associated with exposure to cigarette smoke (CS). CS-induced inflammation is believed to be a key immune driver in the pathogenesis of COPD. Since the concept of inflammasomes was first introduced nearly a decade ago, these have been increasingly recognized as a central player in innate immune and inflammatory responses. In addition, studies have emerged demonstrating that mitochondrial innate immune signaling plays an important role in CS-induced inflammasome activation, pulmonary inflammation and tissue remodeling responses. Here, recent discoveries about inflammasome activation and mitochondrial biology and their role in COPD pathogenesis are reviewed. In addition, the current limitations of our understanding of this theme and future research directions are discussed.

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