Individualized Chinese medicine for the treatment of diabetic patients with dry eye disease

Objective: To determine the prevalence of dry eye disease in type 2 diabetic patients and its correlation with retinopathy Materials and Methods: A cross-sectional study was conducted in the Department of Ophthalmology, Chandka Medical College & Shaheed Mohtarma Benazir Bhutto Medical University Larkana, from 1st April 2021 to 30th September 2021. Consecutive 100 patients with type 2 diabetes mellitus (DM) who attended outpatient department were included as per inclusion-exclusion criteria. Results: The patients were mostly female (58%) with a female-to-male ratio of 1.38:1. Most patients (43%) were under 50, followed by 51–60. (34 %). The overall mean age was 54.26 10.06. More than half (63%) of patients had diabetes for up to 5 years. The patients had a 42 percent frequency of DES. Mild, moderate, and severe dry eye were diagnosed in 21%, 16%, and 5% of individuals. Longevity and poor diabetes control exacerbated the disease. Conclusions: Type 2 DM patients' age, but not their gender, was found to be a significant predictor of DES. Dry eye was found to be more common among diabetics with poor control of their condition. In patients with type 2 diabetes, the age, but not the gender, was substantially linked to DES. Keywords: Type 2 diabetes, Dry eye disease, Diabetic retinopathy, Meibomian gland dysfunction.

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Determination of Risk Factors and Treatment of Dry Eye Disease in Type 1 Diabetes Before Corneal Complications at Sindh Institute of Ophthalmology And Visual Sciences

The Open Ophthalmology Journal ◽

10.2174/1874364101711010355 ◽

2017 ◽

Vol 11 (1) ◽

pp. 355-361 ◽

Cited By ~ 3

Author(s):

Shehnilla Shujaat ◽

Muhammad Jawed ◽

Shahzad Memon ◽

Khalid Iqbal Talpur

Keyword(s):

Risk Factors ◽

Type 1 Diabetes ◽

Dry Eye ◽

Tear Film ◽

Dry Eye Disease ◽

Eye Disease ◽

Diabetic Patients ◽

Dry Eyes ◽

Department Of Ophthalmology

Objective: The objective of this study was to assess and determine the risk factors and treatment of dry eye disease in type 1 diabetes before any ocular surface or corneal complication occurs. This study was conducted at Sindh Institute of Ophthalmology And Visual Sciences, Hyderabad, Pakistan. Methodology: Subjects and methods for observational study were undertaken at the Department of Ophthalmology Sindh Institute Of Ophthalmology And Visual Sciences, Hyderabad, Pakistan. Hundred confirmed cases of type 1 diabetes were included in the study by non probability convenience sampling. Tear film breakup time and schrimer test were carried out to determine dry eye disease. Data was collected by self-prepared questionnaire and entered and analyzed by using Statistical Program for Social Sciences (SPSS, version 20.0). The frequencies and percentage were recorded and any associations with predisposing factors were statistically analyzed by t test. Results: Out of hundred patients, 71 (71%) were found to have dry eyes (P<0.001). The mean age of the subject in this study was 50.97 years (range 30-70 years). Old age was related to high risk of dry eye disease (P<0.001). There was no big difference in the incidence of dry eyes in males and females. Long duration was found to be related with increased occurrence of dry eyes (P<0.001). We found higher values for abnormal tear film break up time than schirmer test values leading to increased occurrence of evaporative dry eyes. Conclusion: There is marked increase in frequency/ risk of developing dry eye disease in type 1 diabetes patients. Therefore, it is recommended to have periodic ophthalmic examination for type 1 diabetic patients.

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Retrospective evaluation of the curative effect of traditional Chinese medicine on dry eye disease

Tzu Chi Medical Journal ◽

10.4103/tcmj.tcmj_281_20 ◽

2021 ◽

Vol 0 (0) ◽

pp. 0

Author(s):

Cheng-Chan Yang ◽

San-Hua Su ◽

Tsung-Jung Ho

Keyword(s):

Chinese Medicine ◽

Traditional Chinese Medicine ◽

Dry Eye ◽

Dry Eye Disease ◽

Eye Disease ◽

Retrospective Evaluation ◽

Curative Effect

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Prevalence and clinical characteristics of dry eye disease in community-based type 2 diabetic patients: the Beixinjing eye study

BMC Ophthalmology ◽

10.1186/s12886-018-0781-7 ◽

2018 ◽

Vol 18 (1) ◽

Cited By ~ 17

Author(s):

Xinrong Zou ◽

Lina Lu ◽

Yi Xu ◽

Jianfeng Zhu ◽

Jiangnan He ◽

...

Keyword(s):

Dry Eye ◽

Clinical Characteristics ◽

Dry Eye Disease ◽

Eye Disease ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Community Based ◽

Type 2 Diabetic

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Ocular Surface Microbiota in Diabetic Patients With Dry Eye Disease

Investigative Opthalmology & Visual Science ◽

10.1167/iovs.62.12.13 ◽

2021 ◽

Vol 62 (12) ◽

pp. 13

Author(s):

Zhang Zhang ◽

Xinrong Zou ◽

Wenwen Xue ◽

Pei Zhang ◽

Shanshan Wang ◽

...

Keyword(s):

Dry Eye ◽

Ocular Surface ◽

Dry Eye Disease ◽

Eye Disease ◽

Diabetic Patients

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Current Advances in Mechanisms and Treatment of Dry Eye Disease: Toward Anti-inflammatory and Immunomodulatory Therapy and Traditional Chinese Medicine

Frontiers in Medicine ◽

10.3389/fmed.2021.815075 ◽

2022 ◽

Vol 8 ◽

Author(s):

Jiawei Ling ◽

Ben Chung-Lap Chan ◽

Miranda Sin-Man Tsang ◽

Xun Gao ◽

Ping Chung Leung ◽

...

Keyword(s):

Chinese Medicine ◽

Dry Eye ◽

Ocular Surface ◽

Dry Eye Disease ◽

Research Progress ◽

Inflammatory Factors ◽

Eye Disease ◽

Research Fields ◽

Ocular Discomfort ◽

Anti Inflammatory

Dry eye is currently one of the most common ocular surface disease. It can lead to ocular discomfort and even cause visual impairment, which greatly affects the work and quality of life of patients. With the increasing incidence of dry eye disease (DED) in recent years, the disease is receiving more and more attention, and has become one of the hot research fields in ophthalmology research. Recently, with the in-depth research on the etiology, pathogenesis and treatment of DED, it has been shown that defects in immune regulation is one of the main pathological mechanisms of DED. Since the non-specific and specific immune response of the ocular surface are jointly regulated, a variety of immune cells and inflammatory factors are involved in the development of DED. The conventional treatment of DED is the application of artificial tears for lubricating the ocular surface. However, for moderate-to-severe DED, treatment with anti-inflammatory drugs is necessary. In this review, the immunomodulatory mechanisms of DED and the latest research progress of its related treatments including Chinese medicine will be discussed.

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