Diagnosis and treatment of secretory carcinoma arising from the oral minor salivary gland

Mammary analogue secretory carcinoma (MASC) is a recently described salivary gland tumor, with a limited number of published reports. Less than three hundred cases have been reported in the literature and only 18 of these cases have been reported in minor palatal salivary glands, though publication bias is likely a factor. We present a case of a 57-year-old male who was diagnosed with MASC tumor presenting in a minor salivary gland and briefly review the current literature. MASC has a variety of histological features and different range of clinical behaviors. The histopathological diagnosis of MASC can be difficult, and the immunohistochemical profile of MASC is still being updated. The gold standard for MASC diagnosis is cytogenetics, with the majority having a translocation t(12;15)(p133;q25). Presently, there is no conclusive evidence that MASC should be treated differently than any other low-grade malignant salivary gland tumors, though high-grade transformation has been described.

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Difficulty in the Cytodiagnosis of Mammary Analogue Secretory Carcinoma: Survey of 109 Cytologists with a Case Originating from a Minor Salivary Gland

Acta Cytologica ◽

10.1159/000477390 ◽

2017 ◽

Vol 61 (6) ◽

pp. 469-476 ◽

Cited By ~ 7

Author(s):

Keita Kai ◽

Akimichi Minesaki ◽

Kumiko Suzuki ◽

Mikio Monji ◽

Mitsuo Nakamura ◽

...

Keyword(s):

Salivary Gland ◽

Malignant Tumors ◽

Benign Lesion ◽

Minor Salivary Gland ◽

Needle Aspiration ◽

Class Iii ◽

Secretory Carcinoma ◽

Mammary Analogue Secretory Carcinoma ◽

Old Japanese ◽

A Minor

Background: Mammary analogue secretory carcinoma (MASC) of the salivary gland shows morphologic similarities and shares an immunophenotype and characteristic ETV6-NTRK3 translocation with secretory carcinoma of the breast. We present a buccal case of MASC along with a survey-based debate about its cytologic diagnosis by fine-needle aspiration (FNA). Case: FNA of the buccal nodule of a 58-year-old Japanese man was initially performed by 3 cytologists who gave different assessments of the Papanicolaou classification (i.e., class II, III, and V). To investigate the potential for discrepant diagnosis of MASC on a larger scale, we distributed a survey with questions about the cytological diagnosis of the present case to cytologists at other institutions. A total of 109 cytologists completed the survey, providing varying assessments of the Papanicolaou classification: class I/II (14%), class III (53%), and class IV/V (33%). Most of the respondents (72%) could not identify a particular tumor or disease. Even the respondents who identified a particular tumor suggested widely differing diagnoses, from a benign lesion to various malignant tumors. Only 2 respondents correctly identified MASC. Conclusion: Our experience and the results of the survey suggest difficulty in the cytodiagnosis of MASC.

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Diagnosis and Treatment of Secretory Carcinoma of the Oral Cavity: Report of Two Cases and Pooled Analysis of the Recent Literature

10.21203/rs.3.rs-285629/v1 ◽

2021 ◽

Author(s):

Masaru Ogawa ◽

Satoshi Yokoo ◽

Takahiro Yamaguchi ◽

Keisuke Suzuki ◽

Mai Seki ◽

...

Keyword(s):

Salivary Gland ◽

Oral Cavity ◽

Fusion Gene ◽

Minor Salivary Gland ◽

Salivary Gland Tumor ◽

Cervical Lymph Node Metastasis ◽

Japanese Woman ◽

Secretory Carcinoma ◽

Tissue Samples ◽

Old Japanese

Abstract Background: Secretory carcinoma (SC) is a malignancy of the salivary glands, which is similar to SC of the breast in terms of its association with neurotrophic tyrosine receptor kinase (NTRK) fusion-positive gene. SC is a recently described salivary gland tumor, and there are few reports describing oral minor salivary gland-derived SC. We reported two cases of SC in the oral cavity and reviewed the literature.Case presentation: The patients included a 65-year-old Japanese woman presented with a mass of the upper lip and an 84-year-old Japanese man presented with a mass on the buccal mucosa, respectively. Diagnosis was based on histomorphological and immunohistochemical findings and identification of a specific translocation of the ETS variant 6-neurotrophic receptor tyrosine kinase 3 (ETV6-NTRK3) gene fusion. Case 1 was finally diagnosed using reverse transcription-polymerase chain reaction using formalin-fixed paraffin-embedded tissue samples, while case 2 was diagnosed using fluorescence in situ hybridization analysis. Conclusion: It is highly likely for many cases of SC to be initially diagnosed as acinic cell carcinoma (AciCC) owing to their similar histological findings. The treatment strategy for minor salivary gland-originated SC is the same as that for AciCC, but SC is often highly malignant and involves a high risk of cervical lymph node metastasis. Making an accurate diagnosis in cooperation with pathologists and confirming the presence of the ETV6-NTRK3 fusion gene using genetic analysis is important.

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Update molecular diagnosis and treatment on salivary gland tumors - Mammary Analog Secretory Carcinoma

Medical Case Reports ◽

10.21767/2471-8041-c1-001 ◽

2018 ◽

Vol 04 ◽

Author(s):

Beverly Wang

Keyword(s):

Salivary Gland ◽

Molecular Diagnosis ◽

Salivary Gland Tumors ◽

Diagnosis And Treatment ◽

Secretory Carcinoma ◽

Mammary Analog Secretory Carcinoma

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Secretory Carcinoma of Minor Salivary Gland in Buccal Mucosa: A Case Report and Review of the Literature

Case Reports in Pathology ◽

10.1155/2019/2074504 ◽

2019 ◽

Vol 2019 ◽

pp. 1-8 ◽

Cited By ~ 2

Author(s):

Durga Paudel ◽

Michiko Nishimura ◽

Bhoj Raj Adhikari ◽

Daichi Hiraki ◽

Aya Onishi ◽

...

Keyword(s):

Salivary Gland ◽

Salivary Glands ◽

Buccal Mucosa ◽

Benign Lesion ◽

Minor Salivary Gland ◽

World Health ◽

Positive Staining ◽

Minor Salivary Glands ◽

Secretory Carcinoma ◽

Eosinophilic Cytoplasm

Secretory carcinoma (SC) of the salivary gland was recently added to the fourth edition of the World Health Organization classification of head and neck tumors. Some salivary tumors, including acinic cell carcinoma, have been reclassified as SC. Most of these tumors are located on the parotid gland with very few cases reported in the minor salivary glands of the buccal mucosa. Herein, we present a case of SC of buccal mucosa, which appeared clinically as a benign lesion in a 54-year-old Japanese female patient. Histopathologically, the tumor cells presented with an eosinophilic cytoplasm with microcytic structure along with eosinophilic secretory material and hemosiderin deposit. Immunohistochemical staining revealed strongly positive staining for S100, vimentin, and mammaglobin and negative staining for DOG-1. The tumor was finally diagnosed as secretory carcinoma of the buccal mucosa. We present a review of the medical literature of SC arising from minor salivary glands. We found only 15 cases of SC of buccal mucosa out of 63 cases of SC in the minor salivary glands. They showed good prognoses and only one case of SC in the buccal mucosa exhibited local recurrence and lymph node metastases.

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