The impact of superficial injections of radiocolloids and dynamic lymphoscintigraphy on sentinel node identification in oral cavity cancer: a same-day protocol

Background Operating room slowdowns occur at specific intervals in the year as a cost-saving measure. We aim to investigate the impact of these slowdowns on the care of oral cavity cancer patients at a Canadian tertiary care centre.Methods A total of 585 oral cavity cancer patients seen between 1999 and 2015 at the London Health Science Centre (lhsc) Head and Neck Multidisciplinary Clinic were included in this study. Operating room hours and patient load from 2006 to 2014 were calculated. Our primary endpoint was the wait time from consultation to definitive surgery. Exposure variables were defined according to wait time intervals occurring during time periods with reduced operating room hours.Results Overall case volume rose significantly from 2006 to 2014 (p < 0.001), while operating room hours remained stable (p = 0.555). Patient wait times for surgery increased from 16.3 days prior to 2003 to 25.5 days in 2015 (p = 0.008). Significant variability in operating room hours was observed by month, with lowest reported for July and August (p = 0.002). The greater the exposure to these months, the more likely patients were to wait longer than 28 days for surgery (odds ratio per day [or]: 1.07, 95% confidence interval [ci]: 1.05 to 1.10, p < 0.001). Individuals seen in consultation preceding a month with below average operating room hours had a higher risk of disease recurrence and/or death (hazard ratio [hr]: 1.59, 95% ci: 1.10 to 2.30, p = 0.014).Conclusions Scheduled reductions in available operating room hours contribute to prolonged wait times and higher disease recurrence. Further work is needed to identify strategies maximizing efficient use of health care resources without negatively affecting patient outcomes.

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The impact of trans-arterial embolization on the result of chemoradiotherapy in oral cavity cancer

Ear Nose & Throat Journal ◽

10.1177/01455613211054181 ◽

2021 ◽

pp. 014556132110541

Author(s):

Dang Nguyen Van ◽

Quang Le Van ◽

Nhung Nguyen Thi Thu ◽

Giang Bui Van ◽

To Ta Van

Keyword(s):

Oral Cavity ◽

Concurrent Chemoradiotherapy ◽

Oral Cavity Cancer ◽

Locally Advanced ◽

Arterial Embolization ◽

Progression Free Survival ◽

Bleeding Complications ◽

Selective Embolization ◽

Acute Bleeding ◽

The Impact

Objectives: Evaluation of the hemostatic effect of trans-arterial embolization on patients with advanced oral cavity cancer who had bleeding complications while undergoing definitive concurrent chemoradiotherapy (CCRT). Additionally, assess the effect of trans-arterial embolization on treatment response following concurrent chemoradiotherapy, as well as overall survival (OS) and progression-free survival (PFS) in the group of patients following the intervention. Method: From September 2018–June 2021, a retrospective descriptive study was conducted on 16 patients with inoperable, locally advanced oral cavity cancer who received definitive concurrent chemoradiotherapy, experienced acute bleeding complications, and received selective intravascular intervention with various embolization materials at Vietnam National Cancer Hospital. Results: After selective embolization, 16/16 patients ceased bleeding; 1 patient re-bled for the second time after 3 weeks. The average duration of chemoradiotherapy interruption due to intervention was 6.7 days. After CCRT, 15/16 (93.75%) patients achieved a response, with 9/16 (56.25%) patients achieving a complete response. The median OS was 14 months (range, 3–26 months), and the median PFS was 10 months (range, 3–20 months). There were no significant complications, particularly neurological side effects. ConclusionsTumor bleeding is a common and serious complication of CCRT treatment in patients with locally advanced oral cavity cancer. Embolization is a safe and effective method of controlling acute bleeding that has no adverse effect on the outcome of definitive concurrent chemoradiotherapy.

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Тютюнокуріння: розповсюдженість та вплив на органи і тканини порожнини рота (огляд літератури)

CLINICAL DENTISTRY ◽

10.11603/2311-9624.2016.2.6718 ◽

2016 ◽

Author(s):

V. V. Shcherba ◽

O. Ya. Lavrin

Keyword(s):

Oral Cavity ◽

Oral Cavity Cancer ◽

Age Of Onset ◽

Free Radical Oxidation ◽

Extensive Experience ◽

Major Health ◽

Radical Oxidation ◽

Increased Risk ◽

Smoking Duration ◽

The Impact

<p>Smoking is a global problem of humanity, and its impact on the organs and tissues of the oral cavity is a major health and social problem. Smoking is associated with significantly increased risk of the oral cavity diseases, especially with paradont pathology and cancer. Persons who have extensive experience of smoking, use tobacco products for oral use, except of smoking alcohol abuse belong to risk group of the oral cavity cancer. The severity of periodontal disease depends on the age of onset of smoking, duration of smoking and number of cigaretteswhich are smoked daily. In the literature many papers are devoted to research the impact of smoking on periodontal status. However, a number of aspects, including free radical oxidation state is left without proper attention, which is the aim of our further investigation.</p>

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Feasibility of Real-Time Near-Infrared Fluorescence Tracer Imaging in Sentinel Node Biopsy for Oral Cavity Cancer Patients

Annals of Surgical Oncology ◽

10.1245/s10434-015-4883-7 ◽

2015 ◽

Vol 23 (2) ◽

pp. 565-572 ◽

Cited By ~ 33

Author(s):

Anders Christensen ◽

Karina Juhl ◽

Birgitte Charabi ◽

Jann Mortensen ◽

Katalin Kiss ◽

...

Keyword(s):

Oral Cavity ◽

Sentinel Node ◽

Real Time ◽

Cancer Patients ◽

Sentinel Node Biopsy ◽

Near Infrared ◽

Oral Cavity Cancer ◽

Near Infrared Fluorescence ◽

Node Biopsy ◽

Tracer Imaging

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Locoregionally advanced oral cavity cancer: A propensity-score matched analysis on overall survival with emphasis on the impact of adjuvant radiotherapy

Head & Neck ◽

10.1002/hed.25185 ◽

2018 ◽

Vol 40 (9) ◽

pp. 1934-1946

Author(s):

Jacob Y. Shin ◽

Ja Kyoung Yoon ◽

Aaron K. Shin ◽

Aidnag Z. Diaz

Keyword(s):

Overall Survival ◽

Propensity Score ◽

Oral Cavity ◽

Adjuvant Radiotherapy ◽

Oral Cavity Cancer ◽

The Impact

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The Impact of Hospital Safety-Net Burden on Survival Outcomes in Oral Cavity Cancer Patients

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/j.ijrobp.2020.02.560 ◽

2020 ◽

Vol 108 (2) ◽

pp. E40

Author(s):

Minh T. Truong ◽

Christa Lam ◽

Muhammad Mustafa Qureshi

Keyword(s):

Oral Cavity ◽

Cancer Patients ◽

Oral Cavity Cancer ◽

Safety Net ◽

Survival Outcomes ◽

Hospital Safety ◽

The Impact

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Association between smokeless tobacco use and oral cavity cancer risk in women compared with men: a systematic review and meta-analysis

BMC Cancer ◽

10.1186/s12885-021-08691-x ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Guangyan Mu ◽

Jiayi Wang ◽

Zhiyan Liu ◽

Hanxu Zhang ◽

Shuang Zhou ◽

...

Keyword(s):

Relative Risk ◽

Oral Cavity ◽

Smokeless Tobacco ◽

Oral Cavity Cancer ◽

Meta Analysis ◽

Pooled Analysis ◽

Cochrane Library ◽

Comparison Results ◽

Increased Risk ◽

The Impact

Abstract Background The impact of smokeless tobacco (SLT) use on the risk of oral cavity cancer (OCC) has been confirmed; however, the sex-based difference in this association remains inconclusive. Therefore, this study aimed to estimate the association between SLT use and OCC risk in women and compared it to that in men. Methods PubMed, Embase, and Cochrane Library databases were systematically searched for eligible studies from their inception up to August 2020. Studies reporting the effect estimates of SLT use on OCC risk in men and women, were eligible for inclusion. The relative risk ratio (RRR) was applied to calculate the sex-based difference in the relationship between SLT use and OCC risk, and pooled analysis was conducted using a random-effects model with inverse variance weighting. Results Nineteen studies reporting a total of 6593 OCC cases were included in the final meta-analysis. The pooled relative risk (RR) suggested that SLT use was associated with an increased risk of OCC in both men (RR, 2.94; 95% confidence interval [CI], 2.05–4.20; P < 0.001) and women (RR, 6.39; 95%CI, 3.16–12.93; P < 0.001). Moreover, the SLT-use-related risk of OCC was higher in women than that in men (RRR,1.79; 95%C, 1.21–2.64; P = 0.003). The risk of OCC related to SLT use in women was still significantly higher than that in men (RRR, 1.75; 95%CI, 1.15–2.66; P = 0.008) after excluding indirect comparison results. Finally, a subgroup analysis suggested significant sex-based differences only in individuals who received chewed smokeless products, regardless of the control definition. Pooled analysis of studies with high design quality confirmed the notably higher risk of OCC in women than in men. Conclusions This study found that SLT use was associated with a higher risk of OCC in women than in men. Further large-scale prospective cohort studies should be conducted to verify sex-based differences in the association between use of specific smokeless products and OCC risk.

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