Head and Neck Mesenchymal Neoplasms With GLI1 Gene Alterations

ABSTRACT Lipomas can be found anywhere in the body, with the majority being located in the head and neck region, as well as the back and abdomen. Lipomas are one of the most common benign, mesenchymal neoplasms. They may progress in size overtime and they may or may not be painful. They may be superficial or deep. Deep soft-tissue lipomas of the hand are rare. Among them, thenar intramuscular lipomas are very rare. We are reporting case of thenar intramuscular lipoma. Desai AA, Chandrakar BL, Thakkar R, Peswani R. Lipoma in Thenar Region. The Duke Orthop J 2015;5(1):68-69.

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Mesenchymal neoplasms with NTRK and other kinase gene alterations

Histopathology ◽

10.1111/his.14443 ◽

2021 ◽

Vol 80 (1) ◽

pp. 4-18

Author(s):

Jessica L Davis ◽

Alyaa Al‐Ibraheemi ◽

Erin R Rudzinski ◽

Lea F Surrey

Keyword(s):

Kinase Gene ◽

Mesenchymal Neoplasms ◽

Gene Alterations

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p16 gene alterations in locally advanced squamous cell carcinoma of the head and neck

Oncology Reports ◽

10.3892/or.15.3.661 ◽

2006 ◽

Cited By ~ 2

Author(s):

Dian Wang ◽

John Grecula ◽

Reinhard Gahbauer ◽

David Schuller ◽

Kris Jatana ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Head And Neck ◽

Squamous Cell ◽

Locally Advanced ◽

Advanced Squamous Cell Carcinoma ◽

P16 Gene ◽

Gene Alterations

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Mesenchymal neoplasms of the head and neck: a cytopathologic analysis on fine needle aspiration

Journal of the American Society of Cytopathology ◽

10.1016/j.jasc.2017.03.001 ◽

2017 ◽

Vol 6 (3) ◽

pp. 105-113

Author(s):

James Lee ◽

Samia Kazmi ◽

Christopher J. VandenBussche ◽

Syed Z. Ali

Keyword(s):

Head And Neck ◽

Fine Needle Aspiration ◽

Needle Aspiration ◽

Fine Needle ◽

Mesenchymal Neoplasms

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Malignant and Nonmalignant Gene Signatures in Squamous Head and Neck Cancer

Journal of Oncology ◽

10.1155/2012/752860 ◽

2012 ◽

Vol 2012 ◽

pp. 1-8 ◽

Cited By ~ 8

Author(s):

Maria J. Worsham ◽

Mei Lu ◽

Kang Mei Chen ◽

Josena K. Stephen ◽

Shaleta Havard ◽

...

Keyword(s):

Logistic Regression ◽

Head And Neck Cancer ◽

Early Detection ◽

Head And Neck ◽

Neck Cancer ◽

Conditional Logistic Regression ◽

Potential Utility ◽

Multivariable Model ◽

Genetic Events ◽

Gene Alterations

Genetic events specific to the pathogenesis of malignancy can offer clues to the tumorigenesis process. The objective of this study was to identify gene alterations that differentiate tumor and nontumor lesions in squamous head and neck cancer (HNSCC). DNA from 220 primary HNSCC with concurrently present tumor and nontumor lesions from the same patient was interrogated for genomic alterations of loss or gain of copy. Conditional logistic regression dealt with tumor and non-tumor records within a patient. Of 113 genes, 53 had univariate effects (P<0.01), of which 16 genes remained in the multivariable model withP<0.01. The model had a C-index (ROC) of 0.93. Loss ofCDKN2Band gain ofBCL6, FGF3, andPTP4A3predicted tumor. Loss ofBAK1andCCND1and gain ofSTCHpredicted nontumor. This highly powered model assigned alterations in 16 genes specific for malignant versus nonmalignant lesions, supporting their contribution to the pathogenesis of HNSCC as well as their potential utility as relevant targets for further evaluation as markers of early detection and progression.

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Cyclin L1 (CCNL1) gene alterations in human head and neck squamous cell carcinoma

British Journal of Cancer ◽

10.1038/sj.bjc.6603036 ◽

2006 ◽

Vol 94 (7) ◽

pp. 1041-1044 ◽

Cited By ~ 14

Author(s):

D Muller ◽

R Millon ◽

S Théobald ◽

T Hussenet ◽

B Wasylyk ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Head And Neck ◽

Squamous Cell ◽

Human Head ◽

Neck Squamous Cell Carcinoma ◽

Gene Alterations

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Lipoma of Oral Cavity – A Case Report and Review of Literature

Journal of Evolution of Medical and Dental Sciences ◽

10.14260/jemds/2021/580 ◽

2021 ◽

Vol 10 (33) ◽

pp. 2851-2853

Author(s):

Deepali Prakash Mohite ◽

Prakash M. Mohite ◽

Snehal U. Udapure

Keyword(s):

Case Report ◽

Oral Cavity ◽

Head And Neck ◽

Buccal Mucosa ◽

Neck Region ◽

The Body ◽

Review Of Literature ◽

Soft Tissue Tumours ◽

Head And Neck Region ◽

Mesenchymal Neoplasms

Connective tissue neoplasms or soft tissue tumours as they are popularly called are mesenchymal neoplasms that affect any part of the body. They occur frequently in all organs including the head and neck region and the oral cavity is no exception. The frequency of their occurrence contributes to 15 - 20 % of all head and neck neoplasms and neoplasms of oral cavity form 1 - 4 % of the reported lesions,1,2 representing 2.2 % of all lipomas.3 In a study by Moreno SE et al. in 2016 the most frequently affected sites were the buccal mucosa followed by the lips, tongue, palate, and other areas of the oral cavity.4Here we are documenting a case occurring in the buccal mucosa.

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