Joint Effect of Depression and Chronic Conditions on Disability: Results From a Population-Based Study

2007 ◽  
Vol 69 (4) ◽  
pp. 332-338 ◽  
Author(s):  
Norbert Schmitz ◽  
JianLi Wang ◽  
Ashok Malla ◽  
Alain Lesage
Author(s):  
Mahdi Nalini ◽  
Masoud Khoshnia ◽  
Farin Kamangar ◽  
Maryam Sharafkhah ◽  
Hossein Poustchi ◽  
...  

Abstract Background Many diabetic individuals use prescription and non-prescription opioids and opiates. We aimed to investigate the joint effect of diabetes and opiate use on all-cause and cause-specific mortality. Methods Golestan Cohort study is a prospective population-based study in Iran. A total of 50 045 people—aged 40–75, 28 811 women, 8487 opiate users, 3548 diabetic patients—were followed during a median of 11.1 years, with over 99% success follow-up. Hazard ratio and 95% confidence intervals (HRs, 95% CIs), and preventable death attributable to each risk factor, were calculated. Results After 533 309 person-years, 7060 deaths occurred: 4178 (10.8%) of non-diabetic non-opiate users, 757 (25.3%) diabetic non-users, 1906 (24.0%) non-diabetic opiate users and 219 (39.8%) diabetic opiate users. Compared with non-diabetic non-users, HRs (95% CIs) for all-cause mortality were 2.17 (2.00–2.35) in diabetic non-opiate users, 1.63 (1.53–1.74) in non-diabetic opiate users and 2.76 (2.40–3.17) in diabetic opiate users. Among those who both had diabetes and used opiates, 63.8% (95% CI: 58.3%–68.5%) of all deaths were attributable to these risk factors, compared with 53.9% (95% CI: 50%–57.4%) in people who only had diabetes and 38.7% (95% CI: 34.6%–42.5%) in non-diabetic opiate users. Diabetes was more strongly associated with cardiovascular than cancer mortality. The risk of early mortality in known cases of diabetes did not depend on whether they started opiate use before or after their diagnosis. Conclusions Using opiates is detrimental to the health of diabetic patients. Public awareness about the health effects of opiates, and improvement of diabetes care especially among individuals with or at risk of opiate use, are necessary.


2020 ◽  
Vol 56 (9) ◽  
pp. 1365-1370
Author(s):  
Jane Bell ◽  
Raghu Lingam ◽  
Claire E Wakefield ◽  
Joanna E Fardell ◽  
Justin Zeltzer ◽  
...  

2009 ◽  
Vol 25 (1) ◽  
pp. 59-67 ◽  
Author(s):  
Fábio Monteiro da Cunha Coelho ◽  
Ricardo Tavares Pinheiro ◽  
Bernardo Lessa Horta ◽  
Pedro Vieira da Silva Magalhães ◽  
Carla Maria Maia Garcias ◽  
...  

A cross-sectional population-based study was conducted to identify the prevalence of common mental disorders and verify the association with chronic non-communicable diseases (NCDs) and the self-reported number of chronic diseases. The Self-Reporting Questionnaire (SRQ-20) was applied in a multi-stage random sample of 1,276 adults aged 40 and older. Socio-demographic, behavioral, and health-related variables were also obtained using a structured questionnaire. Prevalence of common mental disorders was 30.2%. Lower schooling and social class and the 46-55-year age bracket were associated with psychiatric morbidity. Each chronic illness was independently associated with common mental disorders. However, a stronger association was found between common mental disorders and the total number of self-reported chronic conditions, with a prevalence ratio of 4.67 (95%CI: 3.19-6.83) for five or more self-reported NCDs. The current study emphasizes the importance of common mental disorders in chronically ill patients, particularly in those with more total chronic conditions.


2020 ◽  
Vol 9 (5) ◽  
pp. 1563
Author(s):  
Mercedes Clerencia-Sierra ◽  
Ignatios Ioakeim-Skoufa ◽  
Beatriz Poblador-Plou ◽  
Francisca González-Rubio ◽  
Mercedes Aza-Pascual-Salcedo ◽  
...  

This study aims to describe the clinical course, drug use, and health services use characteristics during the last year of life of elders who die being centenarians and to identify key aspects differentiating them from elders who die at an earlier age, with a particular focus on sex differences. We conducted an observational, population-based study in the EpiChron Cohort (Aragón, Spain). The population was stratified by sex and into three age sub-populations (80–89, 90–99, and ≥100 years), and their characteristics were described and compared. Multimorbidity was the rule in our elders, affecting up to 3 in 4 centenarians and 9 in 10 octogenarians and nonagenarians. Polypharmacy was also observed in half of the centenarian population and in most of the younger elders. Risk factors for cardiovascular disease (i.e., hypertension, dyslipidaemia, diabetes), cerebrovascular disease and dementia were amongst the most common chronic conditions in all age groups, whereas the gastroprotective drugs and antithrombotic agents were the most dispensed drugs. Centenarians presented in general lower morbidity and treatment burden and lower use of both primary and hospital healthcare services than octogenarians and nonagenarians, suggesting a better health status. Sex-differences in their clinical characteristics were more striking in octogenarians and tended to decrease with age.


Epilepsia ◽  
2010 ◽  
Vol 51 (5) ◽  
pp. 853-861 ◽  
Author(s):  
Claire Hinnell ◽  
Jeanne Williams ◽  
Amy Metcalfe ◽  
Scott B. Patten ◽  
Robyn Parker ◽  
...  

2010 ◽  
Vol 46 (1) ◽  
pp. 77-82 ◽  
Author(s):  
Muktar H. Aliyu ◽  
Sabrina Luke ◽  
Sibylle Kristensen ◽  
Amina P. Alio ◽  
Hamisu M. Salihu

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Lucia Borsari ◽  
Carlotta Malagoli ◽  
Martha M. Werler ◽  
Kenneth J. Rothman ◽  
Marcella Malavolti ◽  
...  

Smoking and pregestational diabetes (PGD) are recognized risk factors for adverse pregnancy outcomes, but to date, no population-based study has investigated their joint effects. Using hospital discharges, we identified all women with PGD delivering in Emilia-Romagna region during 2007–2010 matched 1 : 5 with parturients without diabetes. Our study endpoints were preterm births and congenital anomalies. We measured interaction between PGD and maternal smoking, by calculating excess prevalence and prevalence ratio due to interaction, relative excess risk due to interaction (RERI), attributable proportion (AP), and the synergy index (S). Analyses were performed in the overall study population and in the subgroup whose PGD was validated through diabetes registers. The study included 992 women with PGD (10.5% smokers) and 4788 comparison women (11.9% smokers). The effects of PGD and maternal tobacco smoking were greater than additive for both preterm birth (excess prevalence due to interaction = 11.7%, excess ratio due to interaction = 1.5, RERI = 2.39, AP = 0.51, S = 2.82) and congenital anomalies (excess prevalence due to interaction = 2.2%, excess ratio due to interaction = 1.3, RERI = 1.33, AP = 0.49, S = 5.03). Joint effect on both endpoints was confirmed in the subgroup whose PGD status was validated. In conclusion, we found that maternal tobacco smoking and PGD intensify each other’s effect on preterm birth and congenital anomalies.


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