scholarly journals Timing of Prenatal Maternal Exposure to Severe Life Events and Adverse Pregnancy Outcomes: A Population Study of 2.6 Million Pregnancies

2011 ◽  
Vol 73 (3) ◽  
pp. 234-241 ◽  
Author(s):  
Quetzal A. Class ◽  
Paul Lichtenstein ◽  
Niklas Långström ◽  
Brian M. DʼOnofrio
Keyword(s):  
Life Events ◽  
Population Study ◽  
Pregnancy Outcomes ◽  
Maternal Exposure ◽  
Adverse Pregnancy Outcomes ◽  
Adverse Pregnancy ◽  
Severe Life Events

scholarly journals Association between exposure to drinking water disinfection byproducts and adverse pregnancy outcomes in South Africa

2020 ◽  
Author(s):  
Funanani Mashau ◽  
Esper Jacobeth Ncube ◽  
Kuku Voyi
Keyword(s):  
Drinking Water ◽  
Pregnancy Outcomes ◽  
Premature Birth ◽  
Disinfection Byproducts ◽  
Maternal Exposure ◽  
Adverse Pregnancy Outcomes ◽  
Water Disinfection ◽  
Regulatory Data ◽  
Adverse Pregnancy ◽  
The Individual

Abstract Currently, there is contradictory evidence for the risk of adverse pregnancy outcomes associated with maternal exposure to disinfection byproducts (DBPs). We examine the association between maternal exposure to trihalomethanes (THMs) in drinking water and adverse pregnancy outcomes, including premature birth, low birth weight (LBW) and small for gestational age (SGA). In total, 1,167 women older than 18 years were enrolled at public antenatal venues in two geographical districts. For each district, we measured the levels of residential drinking water DBPs (measured in THMs) through regulatory data and routine water sampling. We estimated the individual uptake of water of each woman by combining individual water use and uptake factors. Increased daily internal dose of total THMs during the third trimester of pregnancy significantly increased the risk of delivering premature infants (AOR 3.13, 95% CI 1.36–7.17). The risk of premature birth was also positiviely associated with exposure to total THMs during the whole pregnancy (AOR 2.89, 95% CI 1.25–6.68). The risk of delivering an SGA and LBW infant was not associated with maternal exposure to THMs. Our findings suggest that exposure to THMs is associated with certain negative pregnancy outcomes. The levels of THMs in water should be routinely monitored.

scholarly journals Sexual Dimorphism in Adverse Pregnancy Outcomes - A Retrospective Australian Population Study 1981-2011

PLoS ONE ◽  
2016 ◽  
Vol 11 (7) ◽  
pp. e0158807 ◽  
Author(s):  
Petra E. Verburg ◽  
Graeme Tucker ◽  
Wendy Scheil ◽  
Jan Jaap H. M. Erwich ◽  
Gus A. Dekker ◽  
...  
Keyword(s):  
Sexual Dimorphism ◽  
Population Study ◽  
Pregnancy Outcomes ◽  
Adverse Pregnancy Outcomes ◽  
Australian Population ◽  
Adverse Pregnancy

scholarly journals Maternal exposure to folic acid antagonists and placenta-mediated adverse pregnancy outcomes

2008 ◽  
Vol 179 (12) ◽  
pp. 1263-1268 ◽  
Author(s):  
S. W. Wen ◽  
J. Zhou ◽  
Q. Yang ◽  
W. Fraser ◽  
O. Olatunbosun ◽  
...  
Keyword(s):  
Folic Acid ◽  
Pregnancy Outcomes ◽  
Maternal Exposure ◽  
Adverse Pregnancy Outcomes ◽  
Folic Acid Antagonists ◽  
Adverse Pregnancy

scholarly journals Maternal exposure to sulfonamides and adverse pregnancy outcomes: A systematic review and meta-analysis

PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0242523
Author(s):  
Peixuan Li ◽  
Xiaoyun Qin ◽  
Fangbiao Tao ◽  
Kun Huang
Keyword(s):  
Systematic Review ◽  
Pregnancy Outcomes ◽  
Congenital Malformations ◽  
Fixed Effects ◽  
Meta Analysis ◽  
Maternal Exposure ◽  
Adverse Pregnancy Outcomes ◽  
Fixed Effects Model ◽  
Increased Risk ◽  
Adverse Pregnancy

Background Sulfonamides are widely used to treat infectious diseases during pregnancy. However, the safety of maternal exposure to sulfonamides is controversial. This study aims to systematically review the available studies and examine the effect of maternal sulfonamides use on adverse pregnancy outcomes. Methods We searched PubMed, Science Direct, Web of Science, ClinicalTrials.gov, CNKI and Wanfang Database (in Chinese). The meta-analysis used random effects model or fixed effects model to obtain the total odds ratio (OR) for each outcome through Stata11.0 software. Study on the relationship between sulfonamide exposure during pregnancy and adverse pregnancy outcomes. The study design covered randomized controlled trials, cohort studies and case-control studies. The study protocol was registered in PROSPERO with protocol number CRD42020178687. Results A total of 10 studies, and 1096350 participants were included for systematic review. Maternal exposure to sulfonamides was found to be possibly associated with increased risk of congenital malformations (OR = 1.21, 95% CI 1.07–1.37). The use of sulfonamides in the first trimester of pregnancy and during the entire pregnancy might be associated with congenital malformations. Conclusions Maternal exposure to sulfonamides may be associated with offspring’ s congenital malformations. Prescription of sulfonamides for pregnant women is suggested to be carefully censored.

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