Maternal exposure to tributyltin during early gestation increases adverse pregnancy outcomes by impairing placental development

2021 ◽  
Author(s):  
Hui Liu ◽  
Wenyu Jiang ◽  
Yafen Ye ◽  
Bei Yang ◽  
Xin Shen ◽  
...  
Keyword(s):  
Pregnancy Outcomes ◽  
Maternal Exposure ◽  
Adverse Pregnancy Outcomes ◽  
Placental Development ◽  
Early Gestation ◽  
Adverse Pregnancy

scholarly journals Association between exposure to drinking water disinfection byproducts and adverse pregnancy outcomes in South Africa

2020 ◽  
Author(s):  
Funanani Mashau ◽  
Esper Jacobeth Ncube ◽  
Kuku Voyi
Keyword(s):  
Drinking Water ◽  
Pregnancy Outcomes ◽  
Premature Birth ◽  
Disinfection Byproducts ◽  
Maternal Exposure ◽  
Adverse Pregnancy Outcomes ◽  
Water Disinfection ◽  
Regulatory Data ◽  
Adverse Pregnancy ◽  
The Individual

Abstract Currently, there is contradictory evidence for the risk of adverse pregnancy outcomes associated with maternal exposure to disinfection byproducts (DBPs). We examine the association between maternal exposure to trihalomethanes (THMs) in drinking water and adverse pregnancy outcomes, including premature birth, low birth weight (LBW) and small for gestational age (SGA). In total, 1,167 women older than 18 years were enrolled at public antenatal venues in two geographical districts. For each district, we measured the levels of residential drinking water DBPs (measured in THMs) through regulatory data and routine water sampling. We estimated the individual uptake of water of each woman by combining individual water use and uptake factors. Increased daily internal dose of total THMs during the third trimester of pregnancy significantly increased the risk of delivering premature infants (AOR 3.13, 95% CI 1.36–7.17). The risk of premature birth was also positiviely associated with exposure to total THMs during the whole pregnancy (AOR 2.89, 95% CI 1.25–6.68). The risk of delivering an SGA and LBW infant was not associated with maternal exposure to THMs. Our findings suggest that exposure to THMs is associated with certain negative pregnancy outcomes. The levels of THMs in water should be routinely monitored.

scholarly journals Maternal exposure to folic acid antagonists and placenta-mediated adverse pregnancy outcomes

2008 ◽  
Vol 179 (12) ◽  
pp. 1263-1268 ◽  
Author(s):  
S. W. Wen ◽  
J. Zhou ◽  
Q. Yang ◽  
W. Fraser ◽  
O. Olatunbosun ◽  
...  
Keyword(s):  
Folic Acid ◽  
Pregnancy Outcomes ◽  
Maternal Exposure ◽  
Adverse Pregnancy Outcomes ◽  
Folic Acid Antagonists ◽  
Adverse Pregnancy

scholarly journals The Shared Pathoetiological Effects of Particulate Air Pollution and the Social Environment on Fetal-Placental Development

2014 ◽  
Vol 2014 ◽  
pp. 1-20 ◽  
Author(s):  
Anders C. Erickson ◽  
Laura Arbour
Keyword(s):  
Risk Factors ◽  
Air Pollution ◽  
Pregnancy Outcomes ◽  
Social Geography ◽  
Potential Effect ◽  
Adverse Pregnancy Outcomes ◽  
Placental Development ◽  
Negative Effects ◽  
Particulate Air Pollution ◽  
Adverse Pregnancy

Exposure to particulate air pollution and socioeconomic risk factors are shown to be independently associated with adverse pregnancy outcomes; however, their confounding relationship is an epidemiological challenge that requires understanding of their shared etiologic pathways affecting fetal-placental development. The purpose of this paper is to explore the etiological mechanisms associated with exposure to particulate air pollution in contributing to adverse pregnancy outcomes and how these mechanisms intersect with those related to socioeconomic status. Here we review the role of oxidative stress, inflammation and endocrine modification in the pathoetiology of deficient deep placentation and detail how the physical and social environments can act alone and collectively to mediate the established pathology linked to a spectrum of adverse pregnancy outcomes. We review the experimental and epidemiological literature showing that diet/nutrition, smoking, and psychosocial stress share similar pathways with that of particulate air pollution exposure to potentially exasperate the negative effects of either insult alone. Therefore, socially patterned risk factors often treated as nuisance parameters should be explored as potential effect modifiers that may operate at multiple levels of social geography. The degree to which deleterious exposures can be ameliorated or exacerbated via community-level social and environmental characteristics needs further exploration.

scholarly journals Maternal exposure to sulfonamides and adverse pregnancy outcomes: A systematic review and meta-analysis

PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0242523
Author(s):  
Peixuan Li ◽  
Xiaoyun Qin ◽  
Fangbiao Tao ◽  
Kun Huang
Keyword(s):  
Systematic Review ◽  
Pregnancy Outcomes ◽  
Congenital Malformations ◽  
Fixed Effects ◽  
Meta Analysis ◽  
Maternal Exposure ◽  
Adverse Pregnancy Outcomes ◽  
Fixed Effects Model ◽  
Increased Risk ◽  
Adverse Pregnancy

Background Sulfonamides are widely used to treat infectious diseases during pregnancy. However, the safety of maternal exposure to sulfonamides is controversial. This study aims to systematically review the available studies and examine the effect of maternal sulfonamides use on adverse pregnancy outcomes. Methods We searched PubMed, Science Direct, Web of Science, ClinicalTrials.gov, CNKI and Wanfang Database (in Chinese). The meta-analysis used random effects model or fixed effects model to obtain the total odds ratio (OR) for each outcome through Stata11.0 software. Study on the relationship between sulfonamide exposure during pregnancy and adverse pregnancy outcomes. The study design covered randomized controlled trials, cohort studies and case-control studies. The study protocol was registered in PROSPERO with protocol number CRD42020178687. Results A total of 10 studies, and 1096350 participants were included for systematic review. Maternal exposure to sulfonamides was found to be possibly associated with increased risk of congenital malformations (OR = 1.21, 95% CI 1.07–1.37). The use of sulfonamides in the first trimester of pregnancy and during the entire pregnancy might be associated with congenital malformations. Conclusions Maternal exposure to sulfonamides may be associated with offspring’ s congenital malformations. Prescription of sulfonamides for pregnant women is suggested to be carefully censored.

scholarly journals Drinking water disinfection by-products exposure and health effects on pregnancy outcomes: a systematic review

2018 ◽  
Vol 16 (2) ◽  
pp. 181-196 ◽  
Author(s):  
Funanani Mashau ◽  
Esper Jacobeth Ncube ◽  
Kuku Voyi
Keyword(s):  
Drinking Water ◽  
Exposure Assessment ◽  
Pregnancy Outcomes ◽  
Assessment Method ◽  
Maternal Exposure ◽  
Adverse Pregnancy Outcomes ◽  
Water Disinfection ◽  
Increased Risk ◽  
Adverse Pregnancy ◽  
By Products

Abstract Epidemiological studies have found that maternal exposure to disinfection by-products (DBPs) may lead to adverse pregnancy outcomes although the findings tend to be inconsistent. The objective of this study was to systematically review the evidence in associated with drinking water DBP exposure in relation to adverse pregnancy outcomes. Peer-reviewed articles were identified using electronic databases searched for studies published in the English language. Studies selected for review were evaluated for exposure assessment, confounders, and analyses risks of bias in the selection, outcomes assessment, and attrition. A comprehensive search and screening yielded a total of 32 studies, of which 12 (38%) reported a statistical association between maternal exposure to DBPs and adverse pregnancy outcomes. A maternal exposure to trihalomethanes (THMs) shows an increased risk of small for gestational age (SGA) and slightly increased risk of pregnancy loss. Risks of bias were low among the studies included in the review. Evidence on association relating to adverse pregnancy outcomes to DBP exposure is still less significant. There is a need for future robust research in this field, with the use of urinary trichloroacetic acid (TCAA) biomarkers as a direct exposure assessment method for this field.

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