scholarly journals Long-term impact of HIV wasting on physical function in the Multicenter AIDS Cohort Study

AIDS ◽  
2015 ◽  
pp. 1 ◽  
Author(s):  
Kristine M. Erlandson ◽  
Xiuhong Li ◽  
Alison G. Abraham ◽  
Joseph B. Margolick ◽  
Jordan E. Lake ◽  
...  
Keyword(s):  
Cohort Study ◽  
Physical Function ◽  
Multicenter Aids Cohort Study ◽  
Long Term Impact

Prophylactic Total Gastrectomy: a Prospective Cohort Study of Long-Term Impact on Quality of Life

2016 ◽  
Vol 20 (12) ◽  
pp. 1950-1958 ◽  
Author(s):  
Jennifer Muir ◽  
Melyssa Aronson ◽  
Mary-Jane Esplen ◽  
Aaron Pollett ◽  
Carol J. Swallow
Keyword(s):  
Quality Of Life ◽  
Cohort Study ◽  
Total Gastrectomy ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Long Term Impact ◽  
Prophylactic Total Gastrectomy

scholarly journals Pulmonary and Physical Function Limitations in Aging Men with and without HIV from the Multicenter AIDS Cohort Study

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 612-612
Author(s):  
Mona Abdo ◽  
Ken Kunisaki ◽  
Valentina Stosor ◽  
Gypsyamber D'Souza ◽  
Madiha Abdel-Maksoud ◽  
...  
Keyword(s):  
Cohort Study ◽  
Pulmonary Function ◽  
Physical Function ◽  
Grip Strength ◽  
Gait Speed ◽  
Pulmonary Function Tests ◽  
Forced Expiratory Volume ◽  
Multicenter Aids Cohort Study ◽  
Aging Men ◽  
Hiv Serostatus

Abstract We sought to determine effects of age, HIV serostatus, and smoking on the associations between pulmonary function and physical function impairments using Multicenter AIDS Cohort Study data. Associations between physical function outcomes gait speed (m/sec) and grip strength (kg) with normalized pulmonary function tests (diffusion capacity for carbon monoxide (DLCO, n=1,048) and forced expiratory volume in one second (FEV1, n=1,029)) were examined. Adjusted mixed-effects models included interaction terms to assess effect modification. 574(55%) were HIV+, with median age 57(IQR=48,64) and mean cumulative smoking pack-years 12.2(SD=19.0). 349(33%) had impaired DLCO (<80% of predicted) and 130(13%) had impaired FEV1 (<80% of predicted). Participants with impaired DLCO had weaker grip strength than those with normal DLCO (estimate= -3.5[95% CI=-4.6,-2.4]kg; p<0.001). Participants with impaired DLCO had slower gait speed than those with normal DLCO (estimate= -0.04[95% CI= -0.06,-0.02]m/sec; p=0.002). Age modified the DLCO effect on gait (p-interaction=0.01) but not grip (p-interaction=0.09). The association between decreased DLCO and slower gait was more pronounced in older participants. Smoking or HIV serostatus did not significantly modify the DLCO effect on gait (all p-interaction≥0.14) or grip (p-interaction=0.74, p-interaction=0.058, respectively). As with DLCO, participants with impaired FEV1 had weaker grip strength (estimate=-3.0[95% CI= -4.7,-1.3]kg; p<0.001) than those with normal FEV1. FEV1 was not associated with gait speed(p=0.98). Age, HIV serostatus or smoking did not modify the associations between FEV1 and gait speed or grip strength (all p-interaction>0.05). Associations between lower DLCO/FEV1 and decreased physical function suggest that interventions to improve pulmonary function may also preserve physical function with aging.

scholarly journals Long term impact on lung function of patients with moderate and severe COVID-19. A prospective cohort study

2021 ◽  
Author(s):  
Sonia Qureshi ◽  
Nosheen Nasir ◽  
Naveed Haroon Rashid ◽  
Naveed Ahmed ◽  
Zoya Haq ◽  
...  
Keyword(s):  
Cohort Study ◽  
Lung Function ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
List Type ◽  
Long Term Impact ◽  
Study Participants ◽  
The Impact

AbstractIntroductionA significant number of patients continue to recover from COVID-19; however, little is known about the lung function capacity among survivors. We aim to determine the long-term impact on lung function capacity in patients who have survived moderate or severe COVID-19 disease in a resource-poor setting.Methods and analysisThis prospective cohort study will include patients aged 15 years and above and have reverse transcriptase-polymerase chain reaction (RT-PCR) positive for COVID 19 (nasopharyngeal or oropharyngeal). Patients with a pre-existing diagnosis of obstructive or interstitial lung disease, lung fibrosis and cancers, connective tissue disorders, autoimmune conditions affecting the lungs, underlying heart disease, history of syncope and refuse to participate will be excluded. Pulmonary function will be assessed using spirometry and diffusion lung capacity for carbon monoxide (DLCO) at three- and six-months interval. A chest X-ray at three and six-month follow-up and CT-chest will be performed if clinically indicated after consultation with the study pulmonologist or Infectious Disease (ID) physician. Echocardiogram (ECHO) to look for pulmonary hypertension at the three months visit and repeated at six months if any abnormality is identified initially. Data analysis will be performed using standard statistical software.Ethics and disseminationThe proposal was reviewed and approved by ethics review committee (ERC) of the institution (ERC reference number 2020-4735-11311). Informed consent will be obtained from each study participant. The results will be disseminated among study participants, institutional, provincial and national level through seminars and presentations. Moreover, the scientific findings will be published in high-impact peer-reviewed medical journals.Strengths and Limitations of this study-The study has the potential to develop context-specific evidence on the long-term impact on lung function among COVID-19 survivors-Findings will play key role in understanding the impact of the disease on vital functions and help devise rehabilitative strategies to best overcome the effects of disease-This is a single-center, study recruiting only a limited number of COVID-19 survivors-The study participants may loss-to-follow up due to uncertain conditions and disease reemergence

scholarly journals Long‐term impact of powered toothbrush on oral health: 11‐year cohort study

2019 ◽  
Author(s):  
Vinay Pitchika ◽  
Christiane Pink ◽  
Henry Völzke ◽  
Alexander Welk ◽  
Thomas Kocher ◽  
...  
Keyword(s):  
Cohort Study ◽  
Oral Health ◽  
Long Term Impact ◽  
Powered Toothbrush

AB0805 Long-Term Impact of Apremilast on Physical Function in Patients with Psoriatic Arthritis Using the HAQ-DI Assessment

2015 ◽  
Vol 74 (Suppl 2) ◽  
pp. 1168.3-1168
Author(s):  
F. Zhang ◽  
Z. Clancy ◽  
S. Li ◽  
A. Kavanaugh ◽  
A. Adebajo ◽  
...  
Keyword(s):  
Psoriatic Arthritis ◽  
Physical Function ◽  
Long Term Impact

scholarly journals Evaluating the long-term impact of an antenatal healthy lifestyle service: retrospective cohort study

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
F Fair ◽  
H Soltani
Keyword(s):  
Cohort Study ◽  
Weight Gain ◽  
Antenatal Care ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Healthy Lifestyle ◽  
School Entry ◽  
Gestational Weight ◽  
Long Term Impact

Abstract Introduction Maternal obesity is associated with increased odds of obesity in the offspring. The antenatal period is considered a good opportunity to promote lifestyle improvements. The long-term impact of maternal characteristics and attending a maternal healthy lifestyle service (MHLS) on childhood risk of overweight was evaluated. Methods Women with a body mass index (BMI) ≥35kg/m² referred to one MHLS in England from 2009 were included in a retrospective cohort study. Pseudo-anonymised data from the National Child Measurement Programme were matched to data from women referred to this service. Children were classified as 'overweight' if their weight centile was ≥95th centile at 6-8 weeks or 9-12 months or their BMI was ≥95th centile at school entry (4-5 years). Univariate logistic regression determined the odds ratios (OR) and 95% confidence intervals (CI) of childhood overweight according to uptake of the MHLS, gestational weight gain (GWG) and other characteristics. Results The proportion of infants classified as overweight increased over time [2.8% at 6-8 weeks (20/713), 13.8% at 9-12 months (89/647) and 30.4% at school entry (206/677)]. The odds of overweight increased with each unit increase in birthweight (OR 39.9 95%CI 13.4-119.1 at 6-8 weeks, OR 3.7 95%CI 2.4-5.7 at 9-12 months and OR 1.9 95%CI 1.4-2.5 at school entry). GWG above Institute of Medicine recommendations increased the odds of overweight at 6-8 weeks (OR 2.9 95%CI 1.1-7.4). Women living in the most deprived quartile (OR 1.6 95%CI 1.1-2.2) or who smoked when booking for antenatal care (OR 1.5 95%CI 1.0-2.2) had increased odds of infant with BMI ≥95th centile at school entry. Attendance at a MHLS and maternal BMI did not significantly impact on child overweight at any time; however the sample only included women with a raised BMI. Conclusions Lifestyle during pregnancy, GWG and other wider health determinants such as deprivation have long lasting effects on infant health and childhood obesity. Key messages Overweight at school entry is high (>30%) for women with a raised BMI when booking for antenatal care. Addressing maternal socioeconomic conditions, gestational weight gain and smoking during pregnancy are key priorities for the long-term health of children.

scholarly journals Long-term Impact of Cardiorespiratory Fitness on Type 2 Diabetes Incidence: A Cohort Study of Japanese Men

2018 ◽  
Vol 28 (5) ◽  
pp. 266-273 ◽  
Author(s):  
Ryoko Kawakami ◽  
Susumu S. Sawada ◽  
I-Min Lee ◽  
Yuko Gando ◽  
Haruki Momma ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cohort Study ◽  
Cardiorespiratory Fitness ◽  
Diabetes Incidence ◽  
Japanese Men ◽  
Long Term Impact

QOLP-10. A LONGITUDINAL OBSERVATIONAL STUDY OF EXERCISE BEHAVIOR IN GLIOBLASTOMA PATIENTS TREATED WITH TUMOR-TREATING FIELDS

2021 ◽  
Vol 23 (Supplement_6) ◽  
pp. vi184-vi185
Author(s):  
Katherine Peters ◽  
Mary Affronti ◽  
Jung-Young Kim ◽  
Mallika Patel ◽  
Margaret Johnson ◽  
...  
Keyword(s):  
Physical Function ◽  
Exercise Behavior ◽  
Patient Report Outcome ◽  
Tumor Treating Fields ◽  
Related Quality ◽  
Health Related ◽  
Intensity Category ◽  
Long Term Impact ◽  
Historical Controls

Abstract Glioblastoma (GBM) patients can use tumor-treating fields (TTFs) with adjuvant temozolomide (TMZ) to treat their disease. TTFs involve wearing transfixed transducers to the shaved scalp, and the transducers are wired to a battery pack that is either fixed or carried (weighing 2.7 pounds). EF-14 clinical trial did evaluate health-related quality of life with standardized patient-report outcome measures but did not measure exercise behavior. We sought to evaluate the exercise behavior of GBM patients using TTFs. We consented GBM patients who intended to use TTFs with adjuvant TMZ after completion of chemoradiation. After informed consent and before starting TTFs, patients completed a self-administered questionnaire, Godin Leisure-Time Exercise Questionnaire, to assess exercise behavior/physical function. To calculate our primary outcome of total exercise behavior, the frequency of exercise sessions per week within each intensity category was multiplied by the average reported duration, weighted by an estimate of the MET, summed across all intensities, and expressed as average MET-hr/wk. Prior work has defined that physical function can be compared as < 9 MET-h/wk vs. ≥ 9 MET-h/wk. We evaluated at baseline and up to 24-week exercise behavior in patients with TTFs vs. historical controls not using TTFs. We enrolled 19 total GBM patients, with 14 proceeding to use TTFs. Of the 14 patients on TTFs, seven patients (50%) completed ≥ 9 MET-h/wk of exercise, and this level was maintained 8, 16, and 24 weeks after starting TTFs. Six months after the completion of chemoradiation, mean MET-h/wk was decreased in the TTFs group (n=6) (10.71 sd=7.06) vs. historical controls (n=38) (27.35 sd=46.94). TTFs did not interfere with exercise behavior in our GBM cohort, but when compared to GBM patients not utilizing TTFs, there could be a long-term impact on exercise behavior. More research is needed to evaluate exercise behavior in GBM patients using TTFs.

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