Ongoing HIV-1 transmission among men who have sex with men in Amsterdam: a 25-year prospective cohort study

Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) infections are common among men who have sex with men (MSM). Many oropharyngeal and anorectal infections remain asymptomatic. We aimed to evaluate triple-site screening following PrEP introduction. We enrolled a prospective cohort study including 210 asymptomatic MSM during 2019–2020, analyzed by groups: HIV positive (HIV+), HIV−uninfected using PrEP (HIV−/PrEP+), or HIV-uninfected not using PrEP (HIV−/PrEP−). A self-administered questionnaire captured demographic information and sexual risk-taking behaviors. CT/NG testing results were compared between study groups and predictors of infection were evaluated. We included 59 HIV+, 70 HIV−/PrEP+, and 81 HIV−/PrEP− subjects. 30% ( n = 62) of participants tested positive for CT/NG. HIV−/PrEP+ group had highest proportion of infections ( n = 33, 47%) followed by HIV−/PrEP− ( n = 16, 22%) and HIV+ ( n=13, 20%; p < .001). Importantly, 98% (80/82) of pharyngeal/anorectal CT/NG infections were missed in genitourinary tract screening alone. PrEP use and previous syphilis infection were the strongest risk factor for CT/NG. Extra-genital asymptomatic CT/NG infections were prevalent among MSM. These data highlight the importance of routine extra-genital CT/NG testing in asymptomatic sexually active MSM. The study describes the consequences for three-site testing lack of implementation in the PrEP era.

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Comparison of HIV-1 and HIV-2 infectivity from a prospective cohort study in Senegal

Statistics in Medicine ◽

10.1002/sim.1342 ◽

2003 ◽

Vol 22 (4) ◽

pp. 573-593 ◽

Cited By ~ 69

Author(s):

Peter B. Gilbert ◽

Ian W. McKeague ◽

Geoffrey Eisen ◽

Christopher Mullins ◽

Aissatou Guéye-NDiaye ◽

...

Keyword(s):

Cohort Study ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Hiv 1

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Increase in recreational drug use between 2008‐2018: results from a prospective cohort study among HIV‐negative men who have sex with men

Addiction ◽

10.1111/add.15666 ◽

2021 ◽

Author(s):

Liza Coyer ◽

Anders Boyd ◽

Udi Davidovich ◽

Ward P. H. Bilsen ◽

Maria Prins ◽

...

Keyword(s):

Cohort Study ◽

Drug Use ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Recreational Drug ◽

Recreational Drug Use ◽

Sex With Men ◽

Hiv Negative

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Prevalence and Antimicrobial Resistance of Mycoplasma genitalium Infection Among Women Living With Human Immunodeficiency Virus in South Africa: A Prospective Cohort Study

Clinical Infectious Diseases ◽

10.1093/cid/ciz045 ◽

2019 ◽

Vol 69 (5) ◽

pp. 873-876 ◽

Cited By ~ 2

Author(s):

Jason J Ong ◽

Mahlape Precious Magooa ◽

Admire Chikandiwa ◽

Helen Kelly ◽

Marie-Noelle Didelot ◽

...

Keyword(s):

Human Immunodeficiency Virus ◽

Cohort Study ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Odds Ratio ◽

Adjusted Odds Ratio ◽

Mycoplasma Genitalium ◽

Cd4 Counts ◽

Immunodeficiency Virus ◽

Hiv 1

Abstract This prospective cohort study of 622 women living with human immunodeficiency virus (HIV) from Johannesburg (2012) detected Mycoplasma genitalium in 7.4% (95% confidence interval [CI]: 5.5–9.7, 46/622), with detection more likely with lower CD4 counts(adjusted odds ratio [AOR] 1.02 per 10 cells/μL decrease, 95% CI: 1.00–1.03) and higher plasma HIV-1 RNA (AOR 1.15 per log copies/mL increase, 95% CI: 1.03–1.27). No mutations for macrolide/quinolone resistance was detected.

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Incidence and duration of incident oropharyngeal gonorrhoea and chlamydia infections among men who have sex with men: prospective cohort study

Sexually Transmitted Infections ◽

10.1136/sextrans-2020-054764 ◽

2020 ◽

pp. sextrans-2020-054764 ◽

Cited By ~ 1

Author(s):

Eric P F Chow ◽

Lenka A Vodstrcil ◽

Deborah A Williamson ◽

Kate Maddaford ◽

Jane S Hocking ◽

...

Keyword(s):

Risk Factors ◽

Cohort Study ◽

Prospective Cohort Study ◽

Median Duration ◽

Prospective Cohort ◽

Nucleic Acid Amplification ◽

Oropharyngeal Infection ◽

Duration Of Infection ◽

Sex With Men ◽

Exposure Prophylaxis

ObjectivesThis prospective cohort study aimed to determine the natural history and incidence of oropharyngeal gonorrhoea and chlamydia among a cohort of men who have sex with men (MSM) over a 12-week period, and to examine risk factors associated with incident oropharyngeal infections.MethodsMSM either aged ≥18 years and had a diagnosis of oropharyngeal gonorrhoea by nucleic acid amplification test (NAAT) in the past 3 months or aged 18–35 years who were HIV-negative taking pre-exposure prophylaxis (PrEP) were eligible for this study. Enrolled men were followed up for 12 weeks. Oropharyngeal swabs were collected at week 0 (baseline) and week 12 (end of study). Between these time points, weekly saliva specimens and the number of tongue kissing, penile–oral and insertive rimming partners were collected by post. Oropharyngeal swabs and saliva specimens were tested by NAAT for Neisseria gonorrhoeae and Chlamydia trachomatis. Poisson regression was performed to examine the risk factors (weekly number of partners) associated with incident oropharyngeal gonorrhoea.ResultsA total of 100 MSM were recruited. The incidence of oropharyngeal gonorrhoea and chlamydia was 62 (95% CI 37 to 105) and 9 (95% CI 2 to 35)/100 person-years, respectively. The median duration of incident oropharyngeal infection with gonorrhoea was 28 days (IQR=21–36, n=7). The incidence rate ratio (IRR) for oropharyngeal gonorrhoea increased with an increased number of kissing partners (IRR=1.08; 95% CI 1.03 to 1.12) an increased number of penile-oral sex partners (IRR=1.07, 95% CI 1.01 to 1.14) but not with an increased number of insertive rimming partners (IRR=1.11, 95% CI 0.96 to 1.29) or other demographic factors. The IRR and duration of incident oropharyngeal chlamydia were not calculated due to the small number of cases (n=2).ConclusionsMSM have a high incidence of oropharyngeal gonorrhoea and the median duration of infection was less than 3 months.

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