scholarly journals The Impact of Preexposure Prophylaxis Among Men Who Have Sex With Men

2017 ◽  
Vol 75 (2) ◽  
pp. 175-183 ◽  
Author(s):  
Parastu Kasaie ◽  
Jeff Pennington ◽  
Maunank S. Shah ◽  
Stephen A. Berry ◽  
Danielle German ◽  
...  
Keyword(s):  
Preexposure Prophylaxis ◽  
Sex With Men ◽  
The Impact

scholarly journals Projected Impact of Concurrently Available Long-Acting Injectable and Daily-Oral Human Immunodeficiency Virus Preexposure Prophylaxis: A Mathematical Model

2020 ◽  
Vol 223 (1) ◽  
pp. 72-82
Author(s):  
Kevin M Maloney ◽  
Adrien Le Guillou ◽  
Robert A Driggers ◽  
Supriya Sarkar ◽  
Emeli J Anderson ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Reference Model ◽  
Reference Scenario ◽  
Substantial Impact ◽  
Population Impact ◽  
Preexposure Prophylaxis ◽  
Immunodeficiency Virus ◽  
Sex With Men ◽  
Long Acting ◽  
The Impact

Abstract Background Long-acting injectable (LAI) human immunodeficiency virus (HIV) preexposure prophylaxis (PrEP) is reportedly efficacious, although full trial results have not been published. We used a dynamic network model of HIV transmission among men who have sex with men to assess the population impact of LAI-PrEP when available concurrently with daily-oral (DO) PrEP. Methods The reference model represents the current HIV epidemiology and DO-PrEP coverage (15% among those with behavioral indications for PrEP) among men who have sex with men in the southeastern United States. Primary analyses investigated varied PrEP uptake and proportion selecting LAI-PrEP. Secondary analyses evaluated uncertainty in pharmacokinetic efficacy and LAI-PrEP persistence relative to DO-PrEP. Results Compared with the reference scenario, if 50% chose LAI-PrEP, 4.3% (95% simulation interval, −7.3% to 14.5%) of infections would be averted over 10 years. The impact of LAI-PrEP is slightly greater than that of the DO-PrEP–only regimen, based on assumptions of higher adherence and partial protection after discontinuation. If the total PrEP initiation rate doubled, 17.1% (95% simulation interval, 6.7%–26.4%) of infections would be averted. The highest population-level impact occurred when LAI-PrEP uptake and persistence improved. Conclusions If LAI-PrEP replaces DO-PrEP, its availability will modestly improve the population impact. LAI-PrEP will make a more substantial impact if its availability drives higher total PrEP coverage, or if persistence is greater for LAI-PrEP.

scholarly journals Projected HIV and Bacterial Sexually Transmitted Infection Incidence Following COVID-19–Related Sexual Distancing and Clinical Service Interruption

2021 ◽  
Author(s):  
Samuel M Jenness ◽  
Adrien Le Guillou ◽  
Christina Chandra ◽  
Laura M Mann ◽  
Travis Sanchez ◽  
...  
Keyword(s):  
Transmitted Infection ◽  
Sexually Transmitted ◽  
Population Impact ◽  
Service Interruption ◽  
Preexposure Prophylaxis ◽  
Relative Extent ◽  
Sex With Men ◽  
Combined Impact ◽  
The Impact ◽  
Prevention Of Hiv

Abstract Background The global COVID-19 pandemic has the potential to indirectly impact transmission dynamics and prevention of HIV and other sexually transmitted infections (STI). It is unknown what combined impact reductions in sexual activity and interruptions in HIV/STI services will have on HIV/STI epidemic trajectories. Methods We adapted a model of HIV, gonorrhea, and chlamydia for a population of approximately 103 000 men who have sex with men (MSM) in the Atlanta area. Model scenarios varied the timing, overlap, and relative extent of COVID-19–related sexual distancing and service interruption within 4 service categories (HIV screening, preexposure prophylaxis, antiretroviral therapy, and STI treatment). Results A 50% relative decrease in sexual partnerships and interruption of all clinical services, both lasting 18 months, would generally offset each other for HIV (total 5-year population impact for Atlanta MSM, −227 cases), but have net protective effect for STIs (−23 800 cases). If distancing lasted only 3 months but service interruption lasted 18 months, the total 5-year population impact would be an additional 890 HIV cases and 57 500 STI cases. Conclusions Immediate action to limit the impact of service interruptions is needed to address the indirect effects of the global COVID-19 pandemic on the HIV/STI epidemic.

scholarly journals The Context of Sexual Risk Behaviour Among Men Who Have Sex with Men Seeking PrEP, and the Impact of PrEP on Sexual Behaviour

2018 ◽  
Vol 23 (7) ◽  
pp. 1708-1720 ◽  
Author(s):  
Mitzy Gafos ◽  
Rob Horne ◽  
Will Nutland ◽  
Gill Bell ◽  
Caroline Rae ◽  
...  
Keyword(s):  
Sexual Risk ◽  
Sexual Behaviour ◽  
Risk Behaviour ◽  
Sexual Risk Behaviour ◽  
Sex With Men ◽  
The Impact

Syphilis epidemiology and public health interventions in Western Australia from 1991 to 2009

Sexual Health ◽  
2012 ◽  
Vol 9 (3) ◽  
pp. 272 ◽  
Author(s):  
Kellie S. H. Kwan ◽  
Carolien M. Giele ◽  
Heath S. Greville ◽  
Carole A. Reeve ◽  
P. Heather Lyttle ◽  
...  
Keyword(s):  
Public Health ◽  
Western Australia ◽  
Aboriginal People ◽  
Congenital Syphilis ◽  
The United States ◽  
Health Interventions ◽  
Public Health Interventions ◽  
Sex With Men ◽  
Notification Data ◽  
The Impact

Objectives To describe the epidemiology of congenital and infectious syphilis during 1991–2009, examine the impact of public health interventions and discuss the feasibility of syphilis elimination among Aboriginal people in Western Australia (WA). Methods: WA congenital and infectious syphilis notification data in 1991–2009 and national infectious syphilis notification data in 2005–2009 were analysed by Aboriginality, region of residence, and demographic and behavioural characteristics. Syphilis public health interventions in WA from 1991–2009 were also reviewed. Results: During 1991–2009, there were six notifications of congenital syphilis (50% Aboriginal) and 1441 infectious syphilis notifications (61% Aboriginal). During 1991–2005, 88% of notifications were Aboriginal, with several outbreaks identified in remote WA. During 2006–2009, 62% of notifications were non-Aboriginal, with an outbreak in metropolitan men who have sex with men. The Aboriginal : non-Aboriginal rate ratio decreased from 173 : 1 (1991–2005) to 15 : 1 (2006–2009). Conclusions: These data demonstrate that although the epidemiology of syphilis in WA has changed over time, the infection has remained endemic among Aboriginal people in non-metropolitan areas. Given the continued public health interventions targeted at this population, the limited success in eliminating syphilis in the United States and the unique geographical and socioeconomic features of WA, the elimination of syphilis seems unlikely in this state.

scholarly journals Impact of the Centers for Disease Control's HIV Preexposure Prophylaxis Guidelines for Men Who Have Sex With Men in the United States

2016 ◽  
Vol 214 (12) ◽  
pp. 1800-1807 ◽  
Author(s):  
Samuel M. Jenness ◽  
Steven M. Goodreau ◽  
Eli Rosenberg ◽  
Emily N. Beylerian ◽  
Karen W. Hoover ◽  
...  
Keyword(s):  
United States ◽  
The United States ◽  
Preexposure Prophylaxis ◽  
Sex With Men

scholarly journals Modeling the Impact of Post-Diagnosis Behavior Change on HIV Prevalence in Southern California Men Who Have Sex with Men (MSM)

2013 ◽  
Vol 18 (8) ◽  
pp. 1523-1531 ◽  
Author(s):  
Aditya S. Khanna ◽  
Steven M. Goodreau ◽  
Pamina M. Gorbach ◽  
Eric Daar ◽  
Susan J. Little
Keyword(s):  
Behavior Change ◽  
Southern California ◽  
Hiv Prevalence ◽  
Sex With Men ◽  
The Impact
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