The Role of the Framingham Risk Score to Predict the Presence of Subclinical Coronary Atherosclerosis in Patients with HIV Infection

2009 ◽  
Vol 52 (2) ◽  
pp. 303-304 ◽  
Author(s):  
Rosario Rossi ◽  
Annachiara Nuzzo ◽  
Giovanni Guaraldi ◽  
Gabriella Orlando ◽  
Nicola Squillace ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Risk Score ◽  
Coronary Atherosclerosis ◽  
Framingham Risk Score ◽  
Framingham Risk

scholarly journals Variability of the Plasma Lipidome and Subclinical Coronary Atherosclerosis

2021 ◽  
Author(s):  
Sock Hwee Tan ◽  
Hiromi W.L. Koh ◽  
Jing Yi Chua ◽  
Bo Burla ◽  
Ching Ching Ong ◽  
...  
Keyword(s):  
Risk Score ◽  
Coronary Atherosclerosis ◽  
Framingham Risk Score ◽  
Coronary Plaque ◽  
High Variability ◽  
Plaque Burden ◽  
Plaque Volume ◽  
Framingham Risk ◽  
Coronary Events ◽  
Noncalcified Plaque

Objective: While the risk of acute coronary events has been associated with biological variability of circulating cholesterol, the association with variability of other atherogenic lipids remains less understood. We evaluated the longitudinal variability of 284 lipids and investigated their association with asymptomatic coronary atherosclerosis. Approach and Results: Circulating lipids were extracted from fasting blood samples of 83 community-sampled symptom-free participants (age 41–75 years), collected longitudinally over 6 months. Three types of coronary plaque volume (calcified, lipid-rich, and fibrotic) were quantified using computed tomography coronary angiogram. We first deconvoluted between-subject (CV g ) and within-subject (CV w ) lipid variabilities. We then tested whether the mean lipid abundance was different across groups categorized by Framingham risk score and plaques phenotypes (lipid-rich, fibrotic, and calcified). Last, we investigated whether visit-to-visit variability of each lipid was associated with plaque burden. Most lipids (72.5%) exhibited higher CV g than CV w . Among the lipids (N=145) with 1.2-fold higher CV g than CV w , 26 species including glycerides and ceramides were significantly associated with Framingham risk score and the 3 plaque phenotypes (false discovery rate <0.05). In an exploratory analysis of person-specific visit-to-visit variability without multiple-comparisons testing, high variability of 3 lysophospholipids (lysophosphatidylcholines 16:0, 18:0, and O-18:1) were associated with lipid-rich and fibrotic (noncalcified) plaque volume while high variability of diacylglycerol 18:1_20:0, triacylglycerols 52:2, 52:3, and 52:4, ceramide d18:0/20:0, dihexosylceramide d18:1/16:0, and sphingomyelin 36:3 were associated with calcified plaque volume. Conclusions: High person-specific longitudinal variation of specific nonsterol lipids are associated with the burden of subclinical coronary atherosclerosis. Larger studies are needed to confirm these exploratory findings.

scholarly journals HIV infection does not contribute to increased cardiovascular risk as assessed by Framingham risk score

2012 ◽  
Vol 15 (6(Suppl 4)) ◽  
Author(s):  
I Ramsay ◽  
A Pryce-Roberts ◽  
S Williams ◽  
E Bolton ◽  
E Hannig ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Hiv Infection ◽  
Risk Score ◽  
Framingham Risk Score ◽  
Framingham Risk

scholarly journals Longitudinal Progression of Subclinical Coronary Atherosclerosis in Swiss HIV-Positive Compared With HIV-Negative Persons Undergoing Coronary Calcium Score Scan and CT Angiography

2020 ◽  
Vol 7 (10) ◽  
Author(s):  
Philip E Tarr ◽  
Bruno Ledergerber ◽  
Alexandra Calmy ◽  
Thanh Doco-Lecompte ◽  
Isabella C Schoepf ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Risk Score ◽  
Framingham Risk Score ◽  
Subclinical Atherosclerosis ◽  
The United States ◽  
Related Factors ◽  
Coronary Segment ◽  
Framingham Risk ◽  
Hiv Negative

Abstract Background People with HIV (HIV+) may have increased cardiovascular event rates compared with HIV-negative (HIV-) persons. Cross-sectional data from the United States and Switzerland, based on coronary artery calcium scan (CAC) and coronary computed tomography angiography (CCTA), suggest, respectively, increased and similar prevalence of subclinical atherosclerosis in HIV+ vs HIV- persons. Methods We repeated CAC/CCTA in 340 HIV+ and 90 HIV- study participants &gt;2 years after baseline CAC/CCTA. We assessed the association of HIV infection, Framingham risk score (FRS), and HIV-related factors with the progression of subclinical atherosclerosis. Results HIV+ were younger than HIV- participants (median age, 52 vs 56 years; P &lt; .01) but had similar median 10-year FRS (8.9% vs 9.0%; P = .82); 94% had suppressed HIV viral load. In univariable and multivariable analyses, FRS was associated with the incidence rate ratio (IRR) of new subclinical atherosclerosis at the follow-up CAC/CCTA, but HIV infection was not: any plaque (adjusted IRR for HIV+ vs HIV- participants, 1.21; 95% CI, 0.62–2.35), calcified plaque (adjusted IRR for HIV+ vs HIV- participants, 1.06; 95% CI, 0.56–2), noncalcified/mixed plaque (adjusted IRR for HIV+ vs HIV- participants, 1.24; 95% CI, 0.69–2.21), and high-risk plaque (adjusted IRR for HIV+ vs HIV- participants, 1.46; 95% CI, 0.66–3.20). Progression of CAC score between baseline and follow-up CAC/CCTA was similar in HIV+ (median annualized change [interquartile range {IQR}], 0.41 [0–10.19]) and HIV- participants (median annualized change [IQR], 2.38 [0–16.29]; P = .11), as was progression of coronary segment severity score (HIV+: median annualized change [IQR], 0 [0–0.47]; HIV-: median annualized change [IQR], 0 [0–0.52]; P = .10) and coronary segment involvement score (HIV+: median annualized change [IQR], 0 [0–0.45]; HIV-: median annualized change [IQR], 0 [0–0.41]; P = .25). Conclusions In this longitudinal CAC/CCTA study from Switzerland, Framingham risk score was associated with progression of subclinical atherosclerosis, but HIV infection was not.

Abstract 17128: Pathophysiology of Coronary Artery Disease in Hiv-infected Patients: Dissociation Between Anatomy and Function

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Massimo Mancone ◽  
Alessandra Cinque ◽  
Noemi Bruno ◽  
Alessandra Armato ◽  
Nicolò Salvi ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Risk Score ◽  
Coronary Atherosclerosis ◽  
Framingham Risk Score ◽  
Microvascular Function ◽  
Hiv Patients ◽  
Coronary Syndrome ◽  
Framingham Risk ◽  
Artery Disease

Introduction: Numerous reports suggest, among HIV+ patients (pts), an increased rate of acute coronary syndrome and cardiac death. Several data suggest that endothelial dysfunction is a major mechanisms in the development of coronary atherosclerosis in non-HIV infected patients. Hypothesis: The aim of our study is to assess coronary microvascular function using Doppler-flow wire in HIV+ patients in therapy with HAART. Methods: Thirteen HIV-infected patients were enrolled from the Department of Cardiovascular, Respiratory, Nephrology, Anesthesiology and Geriatric Sciences of the “Sapienza” University of Rome (Italy). The main inclusion criteria were: Framingham risk score <10%, absence of metabolic syndrome (according to the definition of Adult Treatment Panel III e ATPIII12), negative echocardiographic and ECG stress-test and negative for anti-HCV antibodies. Diagnostic coronary angiography was performed via percutaneous radial approach. Microvascular function was assessed by measuring coronary flow velocity reserve (CFR). Intracoronary functional tests were performed to evaluate both endothelium-dependent microvascular function [via intracoronary (IC) infusion of acetylcholine (2.5[[Unable to Display Character: &#8211;]]10 μg)] and non-endothelium-dependent microvascular function [via IC infusion of adenosine (5 μg) ]. Results: All the patients presented a Framingham risk score <10%. The medium age was 53.3±4.1 years. The mean duration of highly active antiretroviral therapy was 12.9±2.4 years. Thirteen patients presented 23 coronary atherosclerotic plaques; while endothelium and non endothelium-dependent microvascular function was quite normal in our population (CFR after adenosine 2.37±0.4; CFR after Achetylcholine 2.43±0.4). Conclusion: Microvascular function is not compromised in HIV + pts who presented coronary atherosclerotic plaque. Microvascular dysfunction, involved in pathophysiology of coronary artery disease in general population, seems to be not implicated in coronary atherosclerosis in HIV + pts. These data suggest a peculiar pathophysiological mechanisms for HIV related atherosclerosis.

Intravascular ultrasound measures of coronary atherosclerosis are associated with the Framingham risk score: an analysis from a global IVUS registry

2009 ◽  
Vol 5 (2) ◽  
pp. 212-218 ◽  
Author(s):  
Steven Marso ◽  
Andrew Frutkin ◽  
Sameer Mehta ◽  
John House ◽  
Justin McCrary ◽  
...  
Keyword(s):  
Intravascular Ultrasound ◽  
Risk Score ◽  
Coronary Atherosclerosis ◽  
Framingham Risk Score ◽  
Framingham Risk
Sign in / Sign up

Export Citation Format

Share Document