Is it Possible to Prefabricate a Vascularized Peripheral Nerve Graft?

2010 ◽  
Vol 64 (3) ◽  
pp. 323-326 ◽  
Author(s):  
Savaş Serel ◽  
Burak Kaya ◽  
Yldrm Sara ◽  
Rüştü Onur ◽  
Aylin Okçu Heper
Keyword(s):  
Peripheral Nerve ◽  
Nerve Graft ◽  
Peripheral Nerve Graft

The use of the cutaneous saphenous nerve as a source of nerve graft material in the dog (the use of the CSN as a graft)

2001 ◽  
Vol 14 (02) ◽  
pp. 84-89 ◽  
Author(s):  
O. Vigneron ◽  
Y. Duchossoy ◽  
P. Moissonnier
Keyword(s):  
Peripheral Nerve ◽  
Cross Section ◽  
Surgical Approach ◽  
Nerve Graft ◽  
Saphenous Nerve ◽  
Graft Material ◽  
Femoral Length ◽  
Average Cross Section ◽  
Peripheral Nerve Graft ◽  
Multiple Levels

This paper analyses the feasibility of using the cutaneous saphenous nerve (CSN) as a source of peripheral nerve graft (PNG). In 34 fresh dog cadavers, the PNG length (PNGL) was measured, pattern of collateralization was studied, fascicles diameter and number were assessed at multiple levels along the length of the CSN (levels of section A, B, C and D) and surgical approach was described. The PNGL was correlated to femoral length. The pattern of CSN collateralization was consistent for all but 2 of the dogs. The average cross section diameter and fascicle number of the CSN was 2.0 to 0.1 mm (1 to 7 fascicles). CSN provides a large-sized, easily accessible nerve graft that could be used to bridge nerve gaps in the dog.

scholarly journals Implantation of autologous peripheral nerve grafts into the substantia nigra of subjects with idiopathic Parkinson's disease treated with bilateral STN DBS: a report of safety and feasibility

2017 ◽  
Vol 126 (4) ◽  
pp. 1140-1147 ◽  
Author(s):  
Craig G. van Horne ◽  
Jorge E. Quintero ◽  
Julie A. Gurwell ◽  
Renee P. Wagner ◽  
John T. Slevin ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Substantia Nigra ◽  
Peripheral Nerve ◽  
Neurotrophic Factors ◽  
Sural Nerve ◽  
Cell Function ◽  
Nerve Graft ◽  
Clinical Trial Registration ◽  
Peripheral Nerve Graft

OBJECTIVE One avenue of intense efforts to treat Parkinson's disease (PD) involves the delivery of neurotrophic factors to restore dopaminergic cell function. A source of neurotrophic factors that could be used is the Schwann cell from the peripheral nervous system. The authors have begun an open-label safety study to examine the safety and feasibility of implanting an autologous peripheral nerve graft into the substantia nigra of PD patients undergoing deep brain stimulation (DBS) surgery. METHODS Multistage DBS surgery targeting the subthalamic nucleus was performed using standard procedures in 8 study participants. After the DBS leads were implanted, a section of sural nerve containing Schwann cells was excised and unilaterally delivered into the area of the substantia nigra. Adverse events were continuously monitored. RESULTS Eight of 8 participants were implanted with DBS systems and grafts. Adverse event profiles were comparable to those of standard DBS surgery. Postoperative MR images did not reveal edema, hemorrhage, or significant signal changes in the graft target region. Three participants reported a patch of numbness on the outside of the foot below the sural nerve harvest site. CONCLUSIONS Based on the safety outcome of the procedure, targeted peripheral nerve graft delivery to the substantia nigra at the time of DBS surgery is feasible and may provide a means to deliver neurorestorative therapy. Clinical trial registration no.: NCT01833364 (clinicaltrials.gov)

scholarly journals Muscle graft as a substitute for peripheral nerve graft in rats

2009 ◽  
Vol 24 (3) ◽  
pp. 221-225 ◽  
Author(s):  
Aristides Palhares ◽  
Fausto Viterbo ◽  
Ricardo Galesso Cardoso
Keyword(s):  
Peripheral Nerve ◽  
Nerve Injury ◽  
Nerve Fibers ◽  
Nerve Graft ◽  
Muscle Graft ◽  
Nerve Grafts ◽  
Peripheral Nerve Graft ◽  
Histological Appearance ◽  
Almost All

PURPOSE: To evaluate the applicability of the use of autogenous muscle treated in various ways, as a substitute of the nerve grafts. METHODS: Rats were divided into seven groups that received, as a treatment for a standard nerve injury, the following types of grafts: fresh muscle, muscle fixed with 10% formaldehyde, muscle frozen in a freezer, muscle frozen in refrigerator, nerveless muscle, peripheral nerve and a group was without any treatment. It assessed the histological appearance of the nerve fibers in the segment repaired. RESULTS: The evaluation of the segment nervous repaired showed nerve fibers through the graft in almost all groups, but the methodology employed has not adequately characterized the differences between the groups. CONCLUSION: This study showed the migration of nerves fibers through all grafts used.

428 TRANSPLANTATION OF PERIPHERAL NERVE GRAFT FOLLOWING CONTUSION INJURY TO THE ADULT SPINAL CORD.

2004 ◽  
Vol 52 (Suppl 1) ◽  
pp. S154.3-S154
Author(s):  
A. G. Hadden ◽  
O. Steward ◽  
N. S. Pham ◽  
R. Gupta ◽  
A. R. Colohan
Keyword(s):  
Spinal Cord ◽  
Peripheral Nerve ◽  
Nerve Graft ◽  
Peripheral Nerve Graft ◽  
Contusion Injury ◽  
Adult Spinal Cord

Survival of adult rat retinal ganglion cells with regrown axons in peripheral nerve grafts: a comparison of graft attachment with suture or fibrin glue

2000 ◽  
Vol 93 (2) ◽  
pp. 275-278 ◽  
Author(s):  
Grant A. Robinson ◽  
Roger D. Madison
Keyword(s):  
Nervous System ◽  
Peripheral Nerve ◽  
Fibrin Glue ◽  
Ganglion Cells ◽  
Nerve Graft ◽  
Retinal Ganglion ◽  
Content Type ◽  
Adult Rat ◽  
Peripheral Nerve Graft ◽  
Fine Print

Object. The goal of this study was to examine whether the method of attachment of a peripheral nerve graft would have an effect on retinal ganglion cell (RGC) regeneration.Methods. The number of adult rat RGCs with regrown axons in a peripheral nerve graft was compared under two grafting conditions: 1) attachment of the graft to the optic nerve stump made using a suture; and 2) attachment made using fibrin glue. Counts of RGCs retrogradely labeled with FluoroGold from the grafts 1 month after attachment revealed approximately seven times the number of RGCs in the fibrin-glue group compared with the suture group.Conclusions. The use of fibrin glue may be a useful tool for enhancing the regrowth of central nervous system neuron axons into peripheral nervous system grafts.

scholarly journals In vivo application of poly-3-hydroxyoctanoate as peripheral nerve graft

2013 ◽  
Vol 14 (11) ◽  
pp. 993-1003 ◽  
Author(s):  
D. Burcu Hazer ◽  
Ercan Bal ◽  
Gülay Nurlu ◽  
Kemal Benli ◽  
Serdar Balci ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Nerve Graft ◽  
Peripheral Nerve Graft
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