The Role of CT Scan in Reversible Airflow Obstruction

2007 ◽  
Vol 100 (5) ◽  
pp. 459-460
Author(s):  
Anthony O’Regan
Keyword(s):  
Ct Scan ◽  
Airflow Obstruction ◽  
Reversible Airflow Obstruction

scholarly journals Essential Role of Pharmacists in Asthma Care and Management

2020 ◽  
pp. 089719002092727
Author(s):  
Mary B. Bridgeman ◽  
Lori A. Wilken
Keyword(s):  
Airflow Obstruction ◽  
Bronchial Hyperresponsiveness ◽  
The United States ◽  
Chronic Respiratory Disease ◽  
Inhalation Technique ◽  
Clinical Expertise ◽  
Asthma Care ◽  
Related Factors ◽  
Reversible Airflow Obstruction

Asthma, a chronic respiratory disease characterized by chronic airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, poses a substantial economic burden on patients and caregivers alike. Moreover, the heterogeneous nature of the disease and the presence of various phenotypes make the treatment of asthma challenging and nuanced. Despite the availability of several approved pharmacological treatments, approximately half of patients with asthma in the United States experienced exacerbations in 2016, highlighting the need for effective add-on treatments. Furthermore, asthma control remains suboptimal due to low adherence to medications, poor inhaler technique, and several patient-related factors. Importantly, the primary care setting, in which pharmacists play an integral role, represents a critical environment for providing long-term follow-up care for the effective management of chronic diseases, such as asthma. Pharmacists are uniquely positioned to ensure optimal clinical outcomes in patients with asthma since they have the clinical expertise to educate patients on their disease state and the role of asthma medications, provide training on inhalation technique, address patients’ concerns about potential side effects of medications, and improve adherence to therapy. Therefore, in this review article, we discuss the overall role of pharmacists in effective asthma care and management.

The Potential Role of The Long non-coding RNA MEG3 in Bronchial Asthma in children

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Basma Tarek Rezk ◽  
Fayda Ibrahim Abdel Motaleb ◽  
Terez Boshra Kamel ◽  
Enas Samir Nabih ◽  
Marwa Ali Abd El-Khalek
Keyword(s):  
Bronchial Asthma ◽  
Airflow Obstruction ◽  
Response To Therapy ◽  
Control Group ◽  
Healthy Children ◽  
Asthmatic Children ◽  
Clinical Biomarkers ◽  
Asthma In Children ◽  
Reversible Airflow Obstruction

Abstract Aim and Background Asthma is an inflammatory disease affecting the airways of the lungs being characterized by reversible airflow obstruction and bronchospasm. Environmental and genetic factors play a role in the pathogenesis of the disease; these factors are controlled by epigenetic mechanisms. There is a demand of clinical biomarkers for diagnosis of asthma and monitoring the response to therapy. In this study, we aimed to evaluate the role of lnc-MEG3 expression and its downstream effector in the pathogenesis of bronchial asthma disease. Methods Based on bioinformatics analysis using online databases, the current work has been designed to study the expression status of lnc-MEG3 and GDF15 mRNA in serum and sputum of asthmatic children aiming to find its clinical significance. This study was conducted on 30 children, 15 children newly diagnosed with bronchial asthma as patient group (A) and 15 age and sex matched healthy children as control group (B). Quantitative PCR was carried out to evaluate the expression pattern of selected biomarkers in serum and sputum of asthmatic children. Results The expression of circulating lnc-MEG3 was highly significantly up-regulated in asthmatic children than in control group (p ≤ 0.01), while the expression of circulating GDF15 mRNA was highly significantly down-regulated in asthmatic children than in control group (p ≤ 0.01). The findings showed a negative significant correlation between both investigated biomarkers. Conclusion This study supports the role of lnc-MEG3 and GDF15 protein as potential biomarkers in diagnosis of bronchial asthma in children.

scholarly journals Regulation of Eosinophilia in Asthma—New Therapeutic Approaches for Asthma Treatment

Cells ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 817
Author(s):  
Ruth P. Cusack ◽  
Christiane E. Whetstone ◽  
Yanqing Xie ◽  
Maral Ranjbar ◽  
Gail M. Gauvreau
Keyword(s):  
Drug Targets ◽  
Airflow Obstruction ◽  
Chronic Inflammatory Disease ◽  
Therapeutic Approaches ◽  
Eosinophilic Asthma ◽  
Airway Eosinophilia ◽  
Gm Csf ◽  
New Therapeutic Approaches ◽  
Cellular Apoptosis ◽  
Reversible Airflow Obstruction

Asthma is a complex and chronic inflammatory disease of the airways, characterized by variable and recurring symptoms, reversible airflow obstruction, bronchospasm, and airway eosinophilia. As the pathophysiology of asthma is becoming clearer, the identification of new valuable drug targets is emerging. IL-5 is one of these such targets because it is the major cytokine supporting eosinophilia and is responsible for terminal differentiation of human eosinophils, regulating eosinophil proliferation, differentiation, maturation, migration, and prevention of cellular apoptosis. Blockade of the IL-5 pathway has been shown to be efficacious for the treatment of eosinophilic asthma. However, several other inflammatory pathways have been shown to support eosinophilia, including IL-13, the alarmin cytokines TSLP and IL-33, and the IL-3/5/GM-CSF axis. These and other alternate pathways leading to airway eosinophilia will be described, and the efficacy of therapeutics that have been developed to block these pathways will be evaluated.

scholarly journals Role of Integrated Functional Assessment Pathway Using 99m Tc -Mebrofinate SPECT-CT Scan, ICG, Elastography and HVPG in Patients at Risk of Post Hepatectomy Liver Failure

HPB ◽  
2021 ◽  
Vol 23 ◽  
pp. S38
Author(s):  
B.V. Dasari ◽  
P. Kadam ◽  
K.J. Roberts ◽  
R.P. Sutcliffe ◽  
N. Chatzizacharias ◽  
...  
Keyword(s):  
At Risk ◽  
Liver Failure ◽  
Ct Scan ◽  
Functional Assessment ◽  
Patients At Risk

Incidence of silent hemorrhage and delayed deterioration after stereotactic brain biopsy

1998 ◽  
Vol 89 (1) ◽  
pp. 31-35 ◽  
Author(s):  
Abhaya V. Kulkarni ◽  
Abhijit Guha ◽  
Andres Lozano ◽  
Mark Bernstein
Keyword(s):  
Ct Scan ◽  
Neurological Deficit ◽  
Stereotactic Biopsy ◽  
Brain Biopsy ◽  
Ct Scanning ◽  
Ct Scans ◽  
Stereotactic Brain Biopsy ◽  
Content Type ◽  
Fine Print

Object. Many neurosurgeons routinely obtain computerized tomography (CT) scans to rule out hemorrhage in patients after stereotactic procedures. In the present prospective study, the authors investigated the rate of silent hemorrhage and delayed deterioration after stereotactic biopsy sampling and the role of postbiopsy CT scanning. Methods. A subset of patients (the last 102 of approximately 800 patients) who underwent stereotactic brain biopsies at the Toronto Hospital prospectively underwent routine postoperative CT scanning within hours of the biopsy procedure. Their medical charts and CT scans were then reviewed. A postoperative CT scan was obtained in 102 patients (aged 17–87 years) who underwent stereotactic biopsy between June 1994 and September 1996. Sixty-one patients (59.8%) exhibited hemorrhages, mostly intracerebral (54.9%), on the immediate postoperative scan. Only six of these patients were clinically suspected to have suffered a hemorrhage based on immediate postoperative neurological deficit; in the remaining 55 (53.9%) of 102 patients, the hemorrhage was clinically silent and unsuspected. Among the clinically silent intracerebral hemorrhages, 22 measured less than 5 mm, 20 between 5 and 10 mm, five between 10 and 30 mm, and four between 30 and 40 mm. Of the 55 patients with clinically silent hemorrhages, only three demonstrated a delayed neurological deficit (one case of seizure and two cases of progressive loss of consciousness) and these all occurred within the first 2 postoperative days. Of the neurologically well patients in whom no hemorrhage was demonstrated on initial postoperative CT scan, none experienced delayed deterioration. Conclusions. Clinically silent hemorrhage after stereotactic biopsy is very common. However, the authors did not find that knowledge of its existence ultimately affected individual patient management or outcome. The authors, therefore, suggest that the most important role of postoperative CT scanning is to screen for those neurologically well patients with no hemorrhage. These patients could safely be discharged on the same day they underwent biopsy.

Mo1406 Functional Role of 18F-FDG PET/CT Scan in Diabetic Patients With Pancreatic Ductal Adenocarcinomas

2013 ◽  
Vol 144 (5) ◽  
pp. S-658
Author(s):  
Kwang Hyun Chung ◽  
Yoon Suk Lee ◽  
Joo Kyung Park ◽  
Sang Hyub Lee ◽  
Jin-Hyeok Hwang
Keyword(s):  
Ct Scan ◽  
Fdg Pet ◽  
Functional Role ◽  
Diabetic Patients ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct ◽  
Pet Ct Scan

Infections of the Aorta: Case Report and Review of Treatment

Vascular ◽  
2005 ◽  
Vol 13 (4) ◽  
pp. 252-256 ◽  
Author(s):  
Shannon Lehner ◽  
Catherine Wittgen
Keyword(s):  
Back Pain ◽  
Case Report ◽  
Ct Scan ◽  
Rapid Development ◽  
Compression Fracture ◽  
Lower Lobe ◽  
Computed Tomographic ◽  
Emergent Operation ◽  
Surgical Options

Radiographic documentation of the rapid development of an aortic infection has not previously been reported. We report the case of a 68-year-old woman who presented with back pain. A computed tomographic(CT) scan documented a nondisplaced L1 compression fracture as well as an atherosclerotic but nonaneurysmal aorta. Two weeks after discharge, she developed left lower lobe pneumonia and was readmitted. A second CT scan was obtained because of continuous complaints of back pain. A contained rupture of the visceral aorta was now clearly visible. Emergent operation successfully repaired her aorta. The microorganisms responsible for aortic infection have changed since the widespread use of antibiotics. Patterns of aortic involvement have also evolved. The difficulty in making these diagnoses, the role of current antibiotic therapy, and the surgical options for these infections will be discussed.

CT scan and 3D reconstructions of Pre-Dynastic child mummy 527 B* (Museum of Anthropology and Ethnography of Turin)

1970 ◽  
Vol 80 (1) ◽  
Author(s):  
Raffaella Bianucci ◽  
Rosa Boano ◽  
Gino Carnazza ◽  
Rudy Lallo ◽  
Grazia Mattutino ◽  
...  
Keyword(s):  
Ct Scan ◽  
Spiral Ct ◽  
Whole Body ◽  
Age At Death ◽  
Non Invasive ◽  
Thin Slices ◽  
Invasive Techniques ◽  
The University ◽  
Reconstruction Interval

Mummy 527 B* belongs to the “Giovanni Marro” Egyptian Collection of the Museum of Anthropology and Ethnography of the University of Turin. This mummy of a oneyear- old pre-dynastic child was found in Gebelein in 1935 in a small necropolis discovered during excavations of the “Missione Archeologica Italiana” led by G. Farina, the new Director of the Egyptian Museum of Turin, with the participation of Prof. G. Marro as anthropologist. A whole body spiral CT scan with thin slices (1,00 mm thickness, 0,5 mm reconstruction interval) was followed by multiplanar and 3D reconstruction. The aim was to evaluate the child’s age at death and the presence of lethal pathologies. This study confirms the fundamental role of non-invasive techniques in the study of such rare pre-dynastic specimens.

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