scholarly journals Intravenous administration of mesenchymal stromal cells leads to a dose dependent coagulopathy and is unable to attenuate acute traumatic coagulopathy in rats

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Xiaowu Wu ◽  
Daniel N. Darlington ◽  
Barbara A. Christy ◽  
Bin Liu ◽  
Jeffrey D. Keesee ◽  
...  
Keyword(s):  
Mesenchymal Stromal Cells ◽  
Intravenous Administration ◽  
Stromal Cells ◽  
Acute Traumatic Coagulopathy ◽  
Dose Dependent ◽  
Traumatic Coagulopathy

scholarly journals hTERT-Immortalized Bone Mesenchymal Stromal Cells Expressing Rat Galanin via a Single Tetracycline-Inducible Lentivirus System

2017 ◽  
Vol 2017 ◽  
pp. 1-11 ◽  
Author(s):  
Ke An ◽  
Hui-ping Liu ◽  
Xiao-long Zhong ◽  
David Y. B. Deng ◽  
Jing-jun Zhang ◽  
...  
Keyword(s):  
Cell Line ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Pain Processing ◽  
Dependent Manner ◽  
Human Telomerase Reverse Transcriptase ◽  
Therapy Strategy ◽  
Research Platform ◽  
Human Telomerase ◽  
Dose Dependent

The use of human telomerase reverse transcriptase-immortalized bone marrow mesenchymal stromal cells (hTERT-BMSCs) as vehicles to deliver antinociceptive galanin (GAL) molecules into pain-processing centers represents a novel cell therapy strategy for pain management. Here, an hTERT-BMSCs/Tet-on/GAL cell line was constructed using a single Tet-on-inducible lentivirus system, and subsequent experiments demonstrated that the secretion of rat GAL from hTERT-BMSCs/Tet-on/GAL was switched on and off under the control of an inducer in a dose-dependent manner. The construction of this cell line is the first promising step in the regulation of GAL secretion from hTERT-immortalized BMSCs, and the potential application of this system may provide a stem cell-based research platform for pain.

Bone marrow-derived mesenchymal stromal cells improve vascular regeneration and reduce leukocyte-endothelium activation in critical ischemic murine skin in a dose-dependent manner

Cytotherapy ◽  
2014 ◽  
Vol 16 (10) ◽  
pp. 1345-1360 ◽  
Author(s):  
Riccardo Schweizer ◽  
Pranitha Kamat ◽  
Dennis Schweizer ◽  
Cyrill Dennler ◽  
Shengye Zhang ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Dependent Manner ◽  
Vascular Regeneration ◽  
Dose Dependent

Mesenchymal stromal cells inhibit graft-versus-host disease of mice in a dose-dependent manner

Cytotherapy ◽  
2010 ◽  
Vol 12 (3) ◽  
pp. 361-370 ◽  
Author(s):  
Sun-Young Joo ◽  
Kyung-Ah Cho ◽  
Yun-Jae Jung ◽  
Han-Seong Kim ◽  
Seong-Yeol Park ◽  
...  
Keyword(s):  
Mesenchymal Stromal Cells ◽  
Graft Versus Host Disease ◽  
Stromal Cells ◽  
Dependent Manner ◽  
Host Disease ◽  
Graft Versus Host ◽  
Dose Dependent

Co-culture with cardiomyocytes enhanced the myogenic conversion of mesenchymal stromal cells in a dose-dependent manner

2010 ◽  
Vol 339 (1-2) ◽  
pp. 89-98 ◽  
Author(s):  
Xiao-qing He ◽  
Min-sheng Chen ◽  
Shu-Hong Li ◽  
Shi-ming Liu ◽  
Yun Zhong ◽  
...  
Keyword(s):  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Dependent Manner ◽  
Dose Dependent
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