scholarly journals Incidence, Outcomes, and Long-term Immune Response to Tuberculosis in Organ Transplant Recipients

2019 ◽  
Vol 103 (1) ◽  
pp. 210-215 ◽  
Author(s):  
Yoichiro Natori ◽  
Victor H. Ferreira ◽  
Srinivas Nellimarla ◽  
Shahid Husain ◽  
Coleman Rotstein ◽  
...  
Keyword(s):  
Immune Response ◽  
Organ Transplant ◽  
Transplant Recipients ◽  
Organ Transplant Recipients

scholarly journals The role of sport-based social networks in the management of long-term health conditions: Insights from the World Transplant Games

2020 ◽  
pp. 101269022097920
Author(s):  
Gareth Wiltshire ◽  
Nicola J Clarke ◽  
Cassandra Phoenix ◽  
Carl Bescoby
Keyword(s):  
Social Networks ◽  
Social Engagement ◽  
Sport Participation ◽  
Organ Transplant ◽  
Unintended Consequences ◽  
Health Conditions ◽  
Transplant Recipients ◽  
Organ Transplant Recipients

In the context of an increasing clinical need to better support self-managemt for people living with long-term health conditions an interest in the role of social networks has emerged. Given that sport participation often provides opportunities for social engagement, a space to explore Self-managemt at the intersection of medical sociology and the sociology of sport has opened up. This article presents findings from an exploratory qualitative study with organ transplant recipients who have participated in Transplant Games events – national and international multi-sport competitions for organ transplant recipients. Our findings illustrate how sport-based Social networks serve as resources for health-related knowledge, provide participants with additional affective support and help shape health expectations for the future. Although sport-based Social networks were seen as an overwhelmingly positive resource for our participants, it is plausible that harmful unintended consequences could arise for patients with existing Self-managemt issues. As such, it is recommended that people seeking to use sport as a tool to enhance illness Self-managemt should consider the various and powerful ways that Social networks can be impactful and anticipate the potential consequences accordingly.

scholarly journals 156. Clinical Characteristics and Acute-phase Cytokine Response of Solid-Organ Transplant Recipients with Bloodstream Infections Differs According to Bacterial Type and Transplant Status

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S104-S104
Author(s):  
Emily Eichenberger ◽  
Felicia Ruffin ◽  
Sin-Ho Jung ◽  
Reginald Lerebours ◽  
Batu K Sharma-Kuinkel ◽  
...  
Keyword(s):  
Immune Response ◽  
Acute Phase ◽  
Clinical Characteristics ◽  
Organ Transplant ◽  
Host Immune Response ◽  
Solid Organ Transplant ◽  
Solid Organ ◽  
Transplant Recipients ◽  
Organ Transplant Recipients ◽  
Solid Organ Transplant Recipients

Abstract Background Clinical outcomes and host immune response in solid-organ transplant recipients (Tx) with Staphylococcus aureus bacteremia (SAB) and Gram-negative bacteremia (GNB) are poorly understood. The aims of this study were to describe (1) clinical characteristics and outcomes and (2) acute-phase cytokine response in Tx recipients with SAB and GNB as compared with matched non-transplant subjects (Non-Tx). Methods Thirty-two Tx recipients who were prospectively enrolled in the Blood Stream Infection Biorepository (BSIB) were matched 1:1 with Non-Tx patients on age, race, gender and bacteria using a perfect matching algorithm (Tx-SAB n = 16, Non-Tx SAB n = 16; Tx GNB n = 16, Non-Tx GNB n = 16). GNB included Escherichia coli (n = 16) and Klebsiella pneumoniae (n = 16). Multiplex cytokine testing was performed (Luminex) to evaluate acute-phase serum cytokines levels. Baseline characteristics were summarized using mean with standard deviation (SD), median with interquartile range (IQR), and ranges (min and max), or frequency with %. Differences between the Tx and Non-Tx SAB and GNB were compared using either the equal or unequal variance version of the Student’s t-test or Wilcoxon rank-sum test for continuous variables. Fisher’s exact test was used for categorical variables. Results An endovascular source was more common in Tx SAB vs. Non-Tx SAB (75.0% vs. 0.0%; P = 0.0003) and Tx-GNB (42.9% vs. 18.8%; P = 0.006). Fewer SAB cases were attributed to a skin/soft tissue/osteoarticular in Tx vs. Non-Tx (8.3% vs. 91.7%; P = 0.0001). APACHE II scores were higher in Tx SAB vs. Non-Tx SAB (14.0 [IQR: 11.0, 17.5] vs. 10.0 [IQR: 7.0, 12.5] P = 0.02), but not between Tx GNB vs. Non-Tx GNB (14 [IQR: 12.0, 15.5] vs. 13.5 [12.0, 15.0] P = 0.54). No significant difference length of stay, recurrent bacteremia or mortality were noted among or between groups. Patients with SAB had significantly higher levels of IL-10, CCL5, eotaxin vs. GNB in both Tx and Non-Tx. Conversely, IL-5, IL-13 and IL-17 levels were significantly lower in SAB compared with GNB in both Tx and Non-Tx. Within Tx alone, IL-8 and IL-15 were significantly higher in SAB as compared with GNB. Conclusion Significant differences exist in etiology and host immune response in Tx and Non-Tx with SAB and GNB. Further research is needed to understand the host immune response to BSI in these patients. Disclosures All authors: No reported disclosures.

scholarly journals Organ Transplant Recipients’ Experiences of Physical Activity: Health, Self-Care, and Transliminality

2020 ◽  
Vol 31 (2) ◽  
pp. 385-398 ◽  
Author(s):  
Gareth Wiltshire ◽  
Nicola J. Clarke ◽  
Cassandra Phoenix ◽  
Carl Bescoby
Keyword(s):  
Physical Activity ◽  
Health Management ◽  
Patient Empowerment ◽  
Organ Transplant ◽  
Self Care ◽  
Organ Transplant Recipient ◽  
Transplant Recipients ◽  
Patient Journey ◽  
Organ Transplant Recipients

Physical activity (PA) is an important lifestyle component of long-term health management for organ transplant recipients, yet little is known about recipients’ experiences of PA. The purpose of this study was to shed light on this experience and to investigate the possible implications of PA in the context of what is a complex patient journey. Phenomenological analysis was used to examine interviews with 13 organ transplant recipients who had taken part in sporting opportunities posttransplantation. Findings illuminate how participants’ experiences of PA were commonly shaped by the transliminal nature of being an organ transplant recipient as well as a sense of duty to enact health, self-care, and donor-directed gratitude. This analysis underlines the potential role of PA in supporting organ transplant recipients’ attempts to live well following transplantation and makes novel connections between PA and our existing knowledge about challenges related to identity, survivorship, obligation, and patient empowerment.

419 HISTORICAL CLINICAL EXPERIENCE OF SKIN CANCER DEVELOPMENT IN LONG TERM ORGAN TRANSPLANT RECIPIENTS

2005 ◽  
Vol 53 (1) ◽  
pp. S151.5-S151
Author(s):  
M. Weber ◽  
K. Johnson ◽  
M. Osgood ◽  
J. Trotter ◽  
N. Hartmann ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Clinical Experience ◽  
Organ Transplant ◽  
Cancer Development ◽  
Transplant Recipients ◽  
Organ Transplant Recipients

scholarly journals SARS-CoV-2 serologic immune response in exogenously immunosuppressed patients

2020 ◽  
Author(s):  
Megan L Zilla ◽  
Christian Keetch ◽  
Gretchen Mitchell ◽  
Jeffery McBreen ◽  
Michael R Shurin ◽  
...  
Keyword(s):  
Immune Response ◽  
Antibody Response ◽  
Organ Transplant ◽  
Solid Organ Transplant ◽  
Organ Transplant Recipient ◽  
Solid Organ ◽  
Transplant Recipients ◽  
Organ Transplant Recipients ◽  
Immunosuppressed Patients ◽  
Solid Organ Transplant Recipients

Abstract Background While it is presumed that immunosuppressed patients, such as solid organ transplant recipients on immunosuppression, are at greater risk from SARS-CoV-2 infection than the general population, the antibody response to infection in this patient population has not been studied. Methods In this report, we follow the anti-SARS-CoV-2 antibody levels in patients with COVID-19 who are undergoing exogenous immunosuppression. Specifically, we studied the antibody response of three solid organ transplant recipient patients, three patients who take daily inhaled fluticasone, and a patient on etanercept and daily inhaled fluticasone, and compared them to five patients not on exogenous immunosuppression. Results We found that the solid organ transplant patients on full immunosuppression are at risk of having a delayed antibody response and poor outcome. We did not find evidence that inhaled steroids nor etanercept predispose patients to delayed immune response to SARS-CoV-2. Conclusion The data presented here suggest that solid organ transplant recipients may be good candidates for early targeted intervention against SARS-CoV-2.

scholarly journals Long-Term Persistence of Immunoglobulin A (IgA) and IgM Antibodies against Human Cytomegalovirus in Solid-Organ Transplant Recipients

1999 ◽  
Vol 6 (4) ◽  
pp. 621-623 ◽  
Author(s):  
Bodo R. Eing ◽  
Horst G. Baumeister ◽  
Joachim E. Kuehn ◽  
Guenter May
Keyword(s):  
Human Cytomegalovirus ◽  
Immunoglobulin A ◽  
Organ Transplant ◽  
Solid Organ Transplant ◽  
Solid Organ ◽  
Transplant Recipients ◽  
Organ Transplant Recipients ◽  
Solid Organ Transplant Recipients

ABSTRACT The retrospective analysis of 494 solid-organ transplant recipients revealed that during the follow-up period (mean duration, 3.2 years) 184 (88%) of 209 anti-human cytomegalovirus (HCMV) immunoglobulin A (IgA)-positive patients remained IgA positive, as did 128 (74.85%) of 171 anti-HCMV IgM-positive patients. We conclude that anti-HCMV IgA and IgM testing for management of clinically relevant HCMV infections in solid-organ transplant recipients is dispensable.

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