Cyclotorsion Measurement on Scanning Laser Ophthalmoscopy Imaging Compared With Fundus Photography in Patients With Fourth Nerve Palsy and Healthy Controls

Background/Aims To describe some novel vitreoretinal microstructural findings in patients with mild familial exudative vitreoretinopathy (FEVR) on ultra-wide-field scanning laser ophthalmoscopy (UWF-SLO) and UWF optical coherence tomography (UWF-OCT) and to evaluate their clinical significance.MethodsA total of 32 patients and 32 healthy controls were studied. An additional independent 40 FEVR patients, 44 patients with non-FEVR retinopathies and 40 healthy controls participated in a diagnostic test to validate the abilities of novel findings in FEVR screening.ResultsA novel anatomic change, named Temporal Mid-Peripheral Vitreoretinal Interface Abnormality (TEMPVIA), was found on UWF-SLO in 88.3% of FEVR patients and in none of the healthy controls. The clinical significance of TEMPVIA was further validated by a diagnostic test in new independent cases, with satisfying sensitivity (91.5%) and specificity (98.8%) and Youden Index 0.90. In addition to foveal hypoplasia, some previously unrecognised, novel clinical changes in FEVR, for instance, retinoschisis, focal retinal thickening, sudden thinning of the retina and retinal ridge, were identified using UWF-OCT.ConclusionThe results of this study have led to an update of the clinical spectrum of FEVR and have improved our understanding of its pathogenesis. TEMPVIA is therefore suggested to be a useful biomarker in the screening strategy for mild FEVR.

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Nonmydriatic Ultra-Wide-Field Scanning Laser Ophthalmoscopy (Optomap) versus Two-Field Fundus Photography in Diabetic Retinopathy

Ophthalmologica ◽

10.1159/000355092 ◽

2013 ◽

Vol 231 (1) ◽

pp. 31-36 ◽

Cited By ~ 14

Author(s):

Raffael Liegl ◽

Kristine Liegl ◽

Lala Ceklic ◽

Christos Haritoglou ◽

Anselm Kampik ◽

...

Keyword(s):

Diabetic Retinopathy ◽

Fundus Photography ◽

Scanning Laser ◽

Wide Field ◽

Scanning Laser Ophthalmoscopy

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IDENTIFICATION OF INCREASED BLUE LIGHT REFLECTIVITY IN MACULAR TELANGIECTASIA TYPE 2 USING SCANNING LASER OPHTHALMOSCOPY VERSUS RED-FREE FUNDUS PHOTOGRAPHY

Retinal Cases & Brief Reports ◽

10.1097/icb.0000000000000550 ◽

2019 ◽

Vol 13 (2) ◽

pp. 115-117 ◽

Cited By ~ 1

Author(s):

Talha Soorma ◽

Tjebo Heeren ◽

Daniela Florea ◽

Irene Leung ◽

Tunde Peto

Keyword(s):

Blue Light ◽

Fundus Photography ◽

Scanning Laser ◽

Scanning Laser Ophthalmoscopy ◽

Macular Telangiectasia ◽

Macular Telangiectasia Type 2

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Comparison of multicolor scanning laser ophthalmoscopy and optical coherence tomography angiography for detection of microaneurysms in diabetic retinopathy

Scientific Reports ◽

10.1038/s41598-021-96371-y ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Takato Sakono ◽

Hiroto Terasaki ◽

Shozo Sonoda ◽

Ryoh Funatsu ◽

Hideki Shiihara ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Diabetic Retinopathy ◽

Positive Predictive Value ◽

Predictive Value ◽

Optical Coherence Tomography Angiography ◽

Fundus Photography ◽

Scanning Laser ◽

Scanning Laser Ophthalmoscopy ◽

Optical Coherence ◽

Cross Sectional

AbstractThis study aimed to evaluate the usefulness of multicolor (MC) scanning laser ophthalmoscopy (MC-SLO) in detecting microaneurysm (MA) in eyes with diabetic retinopathy (DR). This was a retrospective cross-sectional study. Eyes with DR underwent fluorescein angiography (FA), MC-SLO, optical coherence tomography angiography (OCTA), and color fundus photography (CFP) were analyzed. The foveal region was cut in an 6 × 6 mm image and the number of MA in each image was counted by retina specialists to determine the sensitivity and positive predictive value. FA results were used as the ground standard. MAs were classified as those with early, late, or no dye leakage based on FA images. Fifty-four eyes of 35 patients with an average age of 64.5 ± 1.24 years were included. The sensitivity of MA detection was 37.3%, 15.3%, and 4.12% in MC-SLO, OCTA, and CFP, respectively (P < 0.01 in each pair).The positive predictive value was 66.4%, 46.4%, and 27.6% in MC, OCTA, and CFP, respectively (P < 0.01 in each pair). Sensitivity for MAs with early leakage was 36.4% in MC-SLO, which was significantly higher than 4.02% in OCTA. MC-SLO was more useful in detecting MA in eyes with DR than OCTA.

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