scholarly journals Physico-chemical characterization of caesium and strontium using fluorescent intensity of bacteria in a microfluidic platform

2019 ◽  
Vol 6 (5) ◽  
pp. 182069
Author(s):  
Changhyun Roh ◽  
Thi Toan Nguyen ◽  
Jae-Jin Shim ◽  
Chankyu Kang
Keyword(s):  
Shear Stress ◽  
Wall Shear Stress ◽  
Pore Space ◽  
Fluid Velocity ◽  
Microfluidic Devices ◽  
Strontium Chloride ◽  
Fluorescent Intensity ◽  
Caesium Chloride ◽  
Wall Shear ◽  
The Impact

Recently, the impact of radioactive caesium (Cs) and strontium (Sr) on human health and the ecosystem has been a major concern due to the use of nuclear energy. However, this study observed changes in green-fluorescent (GFP)-tagged Pseudomonas aeruginosa PAO1 biofilms by injecting non-radioactive caesium chloride (CsCl) and strontium chloride (SrCl 2 ) into microstructures embedded in polydimethylsiloxane microfluidic devices, which were used due to their strong toxicity limitations. Four types of microstructures with two different diameters were used in the study. The change of biofilm thickness from fluid velocity and wall shear stress was estimated using computational fluid dynamics and observed throughout the experiment. The effect of pore space became a significant physical factor when the fluid was flowing through the microfluidic devices. As the pore space increased, the biofilm growth increased; therefore, triangular microstructures with the largest pore space showed the best growth of biofilm. Caesium chloride (CsCl) and strontium chloride (SrCl 2 ), less toxic than radioactive caesium (Cs) and strontium (Sr), completely eradicated the P. aeruginosa PAO1 biofilm with low concentrations. The combined effect of toxicity, fluid velocity, wall shear stress and microstructures increased the efficiency of biofilm eradication. These findings on microfluidic chips can help to indirectly predict the impact on human public health and ecosystems without using radioactive chemicals.

scholarly journals The Effect of Wall Shear Stress on Two Phase Fluctuating Flow of Dusty Fluids by Using Light Hill Technique

Water ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1587
Author(s):  
Dolat Khan ◽  
Ata ur Rahman ◽  
Gohar Ali ◽  
Poom Kumam ◽  
Attapol Kaewkhao ◽  
...  
Keyword(s):  
Shear Stress ◽  
Wall Shear Stress ◽  
Base Fluid ◽  
Perturbation Technique ◽  
Fluid Velocity ◽  
Dust Particles ◽  
Stress Effect ◽  
Parallel Plates ◽  
Dusty Fluid ◽  
Wall Shear

Due to the importance of wall shear stress effect and dust fluid in daily life fluid problems. This paper aims to discover the influence of wall shear stress on dust fluids of fluctuating flow. The flow is considered between two parallel plates that are non-conducting. Due to the transformation of heat, the fluid flow is generated. We consider every dust particle having spherical uniformly disperse in the base fluid. The perturb solution is obtained by applying the Poincare-Lighthill perturbation technique (PLPT). The fluid velocity and shear stress are discussed for the different parameters like Grashof number, magnetic parameter, radiation parameter, and dusty fluid parameter. Graphical results for fluid and dust particles are plotted through Mathcad-15. The behavior of base fluid and dusty fluid is matching for different embedded parameters.

P3588The synergistic effect of NIRS-detected lipid-rich plaque and 5 different multidirectional wall shear stress metrics on human coronary plaque growth

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
E M J Hartman ◽  
A M Kok ◽  
A Hoogendoorn ◽  
F J H Gijsen ◽  
A F W Steen ◽  
...  
Keyword(s):  
Shear Stress ◽  
Wall Shear Stress ◽  
Synergistic Effect ◽  
Coronary Arteries ◽  
Wall Thickness ◽  
Plaque Progression ◽  
Lipid Rich Plaque ◽  
Plaque Growth ◽  
Wall Shear ◽  
The Impact

Abstract Introduction Local wall shear stress (WSS) metrics, high local lipid levels (as detected by near-infrared spectroscopy (NIRS)), as well as systemic lipid levels, have been individually associated with atherosclerotic disease progression. However, a possible synergistic effect remains to be elucidated. This study is the first study to combine WSS metrics with NIRS-detected local lipid content to investigate a potential synergistic effect on plaque progression in human coronary arteries. Methods The IMPACT study is a prospective, single centre study investigating the relation between atherosclerotic plaque progression and WSS in human coronary arteries. Patients with ACS treated with PCI were included. At baseline and after 1-year follow-up, patients underwent near-infrared spectroscopy intravascular ultrasound (NIRS-IVUS) imaging and intravascular doppler flow measurements of at least one non-culprit coronary artery. After one month, a CT angiography was made. CT derived centreline combined with IVUS lumen contours resulted in a 3D reconstruction of the vessel. The following WSS metrics were computed using computational fluid dynamics applying the vessel specific invasive flow measurements: time-average wall shear stress (TAWSS), relative residence time (RRT), cross-flow index, oscillatory shear index and transverse wall shear stress. Low TAWSS is known as pro atherogenic, in contrast to all the other shear stress metrics, at which a high magnitude is pro-atherogenic. The arteries were divided into 1.5mm/45° sectors. Based on NIRS-IVUS, wall thickness change over time was determined and NIRS positive sectors detected. Furthermore, per vessel the shear stress was divided into tertiles (low, intermediate, high). To investigate the synergistic effect of local lipids on shear stress related plaque growth, wall thickness change over time was related to the different shear stress metrics comparing the NIRS-positive with the NIRS-negative sectors. Results 15 non-culprit coronary arteries from the first 14 patients were analyzed (age 62±10 years old and 92.9% male). A total of 2219 sectors were studied (5.2%, N=130, NIRS-positive) for wall thickness changes. After studying all five shear stress metrics, we found for TAWSS and RRT that presence of lipids, as detected by NIRS, amplified the effect of shear stress on plaque progression (see figure). Sectors presenting with lipid-rich plaque, compared to NIRS-negative sectors, showed more progression when they were exposed to low TAWSS (p=0.07) or high RRT (p=0.012) and more regression in sectors exposed to high TAWSS (p=0.10) or low RRT (p=0.06). Delta wall thickness vs shear stress Conclusion We presented the first preliminary results of the IMPACT study, showing the synergistic effect of lipid rich plaque and shear stress on plaque progression. Therefore, intravascular lipid-rich plaque (NIRS) assessment has added value to shear stress profiling for the prediction of plaque growth, leading to improved risk stratification. Acknowledgement/Funding ERC starting grant 310457

Analysis of Flow and Wall Shear Stress in Curvature Induced Dorsal Aneurysms: Effect of Arterial Curvature

2009 ◽  
Author(s):  
Arun Ramu ◽  
Guo-Xiang Wang
Keyword(s):  
Shear Stress ◽  
Wall Shear Stress ◽  
Fluid Dynamic ◽  
Cerebral Arteries ◽  
Cerebral Aneurysms ◽  
Morbidity Rate ◽  
Mortality And Morbidity ◽  
Wall Shear ◽  
Primary Velocity ◽  
The Impact

Intracranial aneurysms are abnormal enlargement in the walls of cerebral arteries. The rupture of aneurysms is the leading cause of subarachnoid hemorrhage (SAH), with a high mortality and morbidity rate. A majority of saccular cerebral aneurysms occur at sites of arterial bifurcations. However, a good percentage of aneurysms are curvature induced and are found along the cavernous arterial segment. The occurrence of such non branching aneurysms, clinically called dorsal aneurysms, can be related to the increased wall shear stress at the curved arteries. The rupture of aneurysms usually occurs at the dome region, which is subjected to reduced wall shear stress (wss) owing to low re-circulating flow. Hence it is important to understand the impact of arterial curvature on the WSS distribution along the dome of aneurysms. Previously, studies have not taken into account the aspect of low WSS along the dome region. In the present 3-d computational fluid dynamic approach, we investigate the impact of varying arterial curvature on spherical dorsal aneurysms. The primary velocity patterns, the WSS distribution along the dome of the aneurysm and the area of increased WSS have been quantified for steady flow conditions.

scholarly journals Impact of blood rheology on wall shear stress in a model of the middle cerebral artery

2013 ◽  
Vol 3 (2) ◽  
pp. 20120094 ◽  
Author(s):  
Miguel O. Bernabeu ◽  
Rupert W. Nash ◽  
Derek Groen ◽  
Hywel B. Carver ◽  
James Hetherington ◽  
...  
Keyword(s):  
Shear Stress ◽  
Wall Shear Stress ◽  
Middle Cerebral Artery ◽  
Cerebral Artery ◽  
Decomposition Analysis ◽  
Blood Rheology ◽  
Vascular Pathology ◽  
Newtonian Model ◽  
Wall Shear ◽  
The Impact

Perturbations to the homeostatic distribution of mechanical forces exerted by blood on the endothelial layer have been correlated with vascular pathologies, including intracranial aneurysms and atherosclerosis. Recent computational work suggests that, in order to correctly characterize such forces, the shear-thinning properties of blood must be taken into account. To the best of our knowledge, these findings have never been compared against experimentally observed pathological thresholds. In this work, we apply the three-band diagram (TBD) analysis due to Gizzi et al. (Gizzi et al. 2011 Three-band decomposition analysis of wall shear stress in pulsatile flows. Phys. Rev. E 83 , 031902. ( doi:10.1103/PhysRevE.83.031902 )) to assess the impact of the choice of blood rheology model on a computational model of the right middle cerebral artery. Our results show that, in the model under study, the differences between the wall shear stress predicted by a Newtonian model and the well-known Carreau–Yasuda generalized Newtonian model are only significant if the vascular pathology under study is associated with a pathological threshold in the range 0.94–1.56 Pa, where the results of the TBD analysis of the rheology models considered differs. Otherwise, we observe no significant differences.

Negative Correlation of Wall Thickness With Wall Blood Pressure in a Patient-Specific Atherosclerotic Coronary Artery: A Case Report

2012 ◽  
Author(s):  
Biyue Liu ◽  
Jie Zheng ◽  
Richard Bach ◽  
Dalin Tang
Keyword(s):  
Blood Pressure ◽  
Shear Stress ◽  
Wall Shear Stress ◽  
Wall Thickness ◽  
Patient Specific ◽  
Artery Wall ◽  
Atherosclerosis Progression ◽  
Wall Shear ◽  
Intensive Investigation ◽  
The Impact

There are two major hemodynamic stresses imposed at the blood-arterial wall interface by flowing blood: the wall shear stress (WSS) acting tangentially to the wall, and the wall pressure (WP) acting vertically to the wall. These forces influence the artery wall metabolism and correspond to the local modifications of artery wall thickness, composition, microarchitecture, and compliance [2]. The role of flow wall shear stress in atherosclerosis progression has been under intensive investigation [4], while the impact of local blood pressure on plaque progression has been under-studied.

scholarly journals Studying the Impact of Wall Shear Stress on the Development and Performance of Electrochemically Active Biofilms

ChemPlusChem ◽  
2020 ◽  
Vol 85 (10) ◽  
pp. 2298-2307
Author(s):  
Christopher Moß ◽  
Niklas Jarmatz ◽  
Dave Hartig ◽  
Lukas Schnöing ◽  
Stephan Scholl ◽  
...  
Keyword(s):  
Shear Stress ◽  
Wall Shear Stress ◽  
Electrochemically Active ◽  
Wall Shear ◽  
And Performance ◽  
The Impact

The Impact of Hemorheology on Wall Shear Stress in a Separated and Reattached Flow Region

2013 ◽  
Author(s):  
Khaled J. Hammad
Keyword(s):  
Shear Stress ◽  
Wall Shear Stress ◽  
Yield Stress ◽  
Flow Region ◽  
Shear Thinning ◽  
Progression Rate ◽  
Vortex Center ◽  
Wall Shear ◽  
Separated And Reattached Flow ◽  
The Impact

Wall-bounded separating and reattaching flows are encountered in biological applications dealing with blood flows through arteries and prosthetic devices. Separated and reattached flow regions have been associated in the past with the most common arterial disease, atherosclerosis. Previous studies suggest that local wall shear stress (WSS) patterns affect the location and progression rate of atherosclerotic lesions. A parametric study is performed to investigate the influence of hemorheology on the wall shear stress distribution in a separated and reattached flow region. Recent hemorheological studies quantified and emphasized the yield stress and shear-thinning non-Newtonian characteristics of unadulterated human blood. Numerical solutions to the governing equations that account for yield stress and shear-thinning rheological effects are obtained. A low WSS region is observed around the flow reattachment point while a peak WSS always exists close to the vortex center. The yield shear-thinning hemorheological model always results in the highest observed peak WSS. The yield stress impact on WSS distribution is most pronounced in the case of severe restrictions to the flow.

scholarly journals THE IMPACT OF SPATIAL GRADIENT OF ENDOTHELIAL WALL SHEAR STRESS ON PLAQUE COMPOSITION AND DESTABILIZATION IN ADVANCED PLAQUES

2011 ◽  
Vol 57 (14) ◽  
pp. E1867
Author(s):  
Wang-Soo Lee ◽  
Sang-Wook Kim ◽  
Young-Mi Jo ◽  
Seung-Wook Kim ◽  
Keung-Chul Rho ◽  
...  
Keyword(s):  
Shear Stress ◽  
Wall Shear Stress ◽  
Spatial Gradient ◽  
Plaque Composition ◽  
Wall Shear ◽  
The Impact

The Use of Active Ionic Polymers in Dynamic Skin Friction Measurements

Volume 1 ◽  
2004 ◽  
Author(s):  
Ali Etebari ◽  
Barbar Akle ◽  
Kevin Farinholt ◽  
Matthew Bennet ◽  
Donald J. Leo ◽  
...  
Keyword(s):  
Shear Stress ◽  
Wall Shear Stress ◽  
Skin Friction ◽  
Fluid Velocity ◽  
Mechanical Strain ◽  
Plate Boundary ◽  
High Sensitivity ◽  
Ionic Polymers ◽  
Ionic Polymer ◽  
Wall Shear

A class of wall shear stress sensors has been developed. The potential of ionic polymer membrane transducers for measuring skin friction in liquid flows is demonstrated. Ionic polymer transducers are thin polymer membranes that exhibit high sensitivity to mechanical strain, and have been shown to demonstrate sensitivities two orders of magnitude higher in charge-sensing mode than piezoelectric polymers such as PVDF. Thus, they are as sensitive to mechanical strain as piezoelectric ceramics (i.e. PZT) but have the high compliance and durability of a polymer. The application of active ionic polymers in delivering easy to implement, accurate, dynamic measurements of skin friction in harsh environments promises significant advantages over current technologies. In particular, a robust technique for measuring wall shear stress is needed to assess the effectiveness of new friction-reducing techniques, including the use of lubricants and micro-bubble injection within the viscous sublayer. Conventional technologies have been unable to provide sufficiently accurate measurements over a large range of fluid velocity fluctuation scales. Moreover, their implementation can be complicated in the case of non-flush mounting sensors, and their applicability is often limited to forgiving environments. An initial feasibility test was designed with the objective of replicating classic theoretical and experimental skin friction coefficient results for a sharp edge flat plate boundary layer. An ionic polymer and a piezoelectric film (PVDF) were evaluated for Reynolds numbers ranging from the laminar flow regime to fully turbulent flow. The PVDF sensor displayed no discernable response to wall shear. The ionic polymer sensor, however, showed significant response to wall shear and strong correlation with the Reynolds number. In addition, a Stokes oscillating plate apparatus was designed for calibration and testing of the ionic polymer sensor.

Effects of Nasal Cavity and Pharyngeal Regions on Airflow Simulation and Particle Depositions in Lower Generations of the Airways

2016 ◽  
Author(s):  
Shahab Taherian ◽  
Hamid Rahai ◽  
Diego Aguilar
Keyword(s):  
Shear Stress ◽  
Wall Shear Stress ◽  
Nasal Cavity ◽  
High Velocity ◽  
Secondary Flows ◽  
Lower Airways ◽  
Wall Shear ◽  
Type 3 ◽  
The Impact

This study evaluates the impact of excluding various regions of the upper respiratory system on particle depositions in lower airways. Three types of models were investigated, Type 1 includes nasal cavity, pharyngeal regions, trachea, and lower generations, Type 2 includes pharyngeal regions, trachea and lower generations, and finally Type 3 includes just the trachea and lower generations. Results indicate increased mean velocity, turbulent kinetic energy, and wall shear stress in hypopharynx and trachea regions for Types 1 and 2 models. There are strong secondary flows within the trachea just before the lower generations in these models, moving high velocity toward the wall regions, resulting in large velocity gradients and thus increased wall shear stress. For Type 3 model, only a small region experiences high velocity secondary flow and its distribution is significantly different than those of Type 1 and 2. Although total particle depositions differ between models, results show that for fine particles, the deposition ratios in lower airways are nearly the same.

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