La protein is required for efficient translation driven by encephalomyocarditis virus internal ribosomal entry site
1999 ◽
Vol 80
(12)
◽
pp. 3159-3166
◽
Keyword(s):
Translation of internal ribosomal entry site (IRES)-dependent mRNAs is mediated by RNA-binding proteins as well as canonical translation factors. In order to elucidate the roles of RNA-binding proteins in IRES-dependent translation, the role of polypyrimidine tract-binding protein (PTB) and La protein in encephalomyocarditis virus (EMCV) IRES-dependent translation was investigated. PTB was required for efficient EMCV IRES-driven translation but, intriguingly, an excess of PTB suppressed it. Such a translational suppression by surplus PTB was relieved by addition of La protein. A possible role for La protein in IRES-dependent translation is discussed.
2002 ◽
Vol 76
(5)
◽
pp. 2529-2542
◽
2007 ◽
Vol 28
(1)
◽
pp. 93-107
◽
1996 ◽
Vol 70
(9)
◽
pp. 6425-6430
◽
Keyword(s):
Keyword(s):
1999 ◽
Vol 10
(11)
◽
pp. 3849-3862
◽
2006 ◽
Vol 27
(1)
◽
pp. 368-383
◽
Keyword(s):
1994 ◽
Vol 68
(5)
◽
pp. 3183-3192
◽