scholarly journals Cloning, sequencing, characterisation and implications for vaccine design of the novel dihydrolipoyl acetyltransferase of Neisseria meningitidis

1996 ◽  
Vol 45 (6) ◽  
pp. 419-432 ◽  
Author(s):  
D. A. A. Ala'Aldeen ◽  
A. H. Westphal ◽  
A. De Kok ◽  
V. Weston ◽  
M. S. Atta ◽  
...  
Keyword(s):  
Neisseria Meningitidis ◽  
Vaccine Design ◽  
The Novel ◽  
Dihydrolipoyl Acetyltransferase

scholarly journals Increase in meningococcal disease associated with the emergence of a novel ST-11 variant of serogroup C Neisseria meningitidis in Victoria, Australia, 1999–2000

2002 ◽  
Vol 128 (1) ◽  
pp. 7-14 ◽  
Author(s):  
D. E. TRIBE ◽  
A. M. ZAIA ◽  
J. M. GRIFFITH ◽  
P. M. ROBINSON ◽  
H. Y. LI ◽  
...  
Keyword(s):  
Czech Republic ◽  
Dna Sequencing ◽  
Neisseria Meningitidis ◽  
Meningococcal Disease ◽  
Age Distribution ◽  
Housekeeping Gene ◽  
Restriction Pattern ◽  
The Novel ◽  
Age Group ◽  
The Czech Republic

In the years 1999–2000, there was an increase in the incidence of meningococcal disease in Victoria, largely caused by Neisseria meningitidis serogroup C. This change was associated with a shift in age distribution of cases, with relatively more disease appearing in the 15–29 year age group, and with 40/58 serogroup C isolates in 2000 exhibiting a new macrorestriction pattern (pattern A). Thirty-four of 52 pattern A isolates tested displayed the novel phenotype C:2a:P1.4, and were consistently porA VR type P1.7-2,4 by DNA sequencing. Nine of 10 representative pattern A isolates analysed displayed a housekeeping gene allele profile (ST-11) that is characteristic of the electrophoretic type (ET)-15 variant that has caused outbreaks in Canada, the Czech Republic and Greece. Meningococci belonging to the ST-11 complex that were isolated in Victoria prior to 1999 did not display either restriction pattern A or PorA VR type P1.7-2,4.

The novel NhaE-type Na+/H+ antiporter of the pathogenic bacterium Neisseria meningitidis

2012 ◽  
Vol 195 (3) ◽  
pp. 211-217 ◽  
Author(s):  
Pedro M. F. Sousa ◽  
Marco A. M. Videira ◽  
Thomas Vorburger ◽  
Sara T. N. Silva ◽  
James W. Moir ◽  
...  
Keyword(s):  
Neisseria Meningitidis ◽  
Pathogenic Bacterium ◽  
The Novel

scholarly journals Whole-Genome Sequencing of Emerging Invasive Neisseria meningitidis Serogroup W in Sweden

2018 ◽  
Vol 56 (4) ◽  
Author(s):  
Lorraine Eriksson ◽  
Sara Thulin Hedberg ◽  
Susanne Jacobsson ◽  
Hans Fredlund ◽  
Paula Mölling ◽  
...  
Keyword(s):  
Neisseria Meningitidis ◽  
Whole Genome Sequencing ◽  
Genome Sequencing ◽  
Clonal Complex ◽  
Invasive Disease ◽  
South American ◽  
Whole Genome ◽  
The Novel ◽  
Content Type ◽  
Low Incidence

ABSTRACT Invasive disease caused by Neisseria meningitidis serogroup W (MenW) has historically had a low incidence in Sweden, with an average incidence of 0.03 case/100,000 population from 1995 to 2014. In recent years, a significant increase in the incidence of MenW has been noted in Sweden, to an average incidence of 0.15 case/100,000 population in 2015 to 2016. In 2017 (1 January to 30 June), 33% of invasive meningococcal disease cases (7/21 cases) were caused by MenW. In the present study, all invasive MenW isolates from Sweden collected in 1995 to June 2017 ( n = 86) were subjected to whole-genome sequencing to determine the population structure and to compare isolates from Sweden with historical and international cases. The increase of MenW in Sweden was determined to be due to isolates belonging to the South American sublineage of MenW clonal complex 11, namely, the novel U.K. 2013 lineage. This lineage was introduced in Sweden in 2013 and has since been the dominant lineage of MenW.

scholarly journals PorA typing of Neisseria meningitidis isolates from Iranian children for vaccine design

2018 ◽  
Vol 5 (1) ◽  
pp. 4-6
Author(s):  
P Afrough ◽  
M Vosogh ◽  
MR Asadi Karam ◽  
A Behrouzi ◽  
G Mardani ◽  
...  
Keyword(s):  
Neisseria Meningitidis ◽  
Vaccine Design ◽  
Iranian Children

scholarly journals Vaccination against Neisseria meningitidis Using Three Variants of the Lipoprotein GNA1870

2003 ◽  
Vol 197 (6) ◽  
pp. 789-799 ◽  
Author(s):  
Vega Masignani ◽  
Maurizio Comanducci ◽  
Marzia Monica Giuliani ◽  
Stefania Bambini ◽  
Jeannette Adu-Bobie ◽  
...  
Keyword(s):  
Young Adults ◽  
Neisseria Meningitidis ◽  
Rat Model ◽  
Genome Mining ◽  
Recombinant Form ◽  
The Novel ◽  
Passive Protection ◽  
Infant Rat ◽  
Geographic Diversity ◽  
High Yields

Sepsis and meningitis caused by serogroup B meningococcus are devastating diseases of infants and young adults, which cannot yet be prevented by vaccination. By genome mining, we discovered GNA1870, a new surface-exposed lipoprotein of Neisseria meningitidis that induces high levels of bactericidal antibodies. The antigen is expressed by all strains of N. meningitidis tested. Sequencing of the gene in 71 strains representative of the genetic and geographic diversity of the N. meningitidis population, showed that the protein can be divided into three variants. Conservation within each variant ranges between 91.6 to 100%, while between the variants the conservation can be as low as 62.8%. The level of expression varies between strains, which can be classified as high, intermediate, and low expressors. Antibodies against a recombinant form of the protein elicit complement-mediated killing of the strains that carry the same variant and induce passive protection in the infant rat model. Bactericidal titers are highest against those strains expressing high yields of the protein; however, even the very low expressors are efficiently killed. The novel antigen is a top candidate for the development of a new vaccine against meningococcus.

scholarly journals Population coverage analysis of T-Cell epitopes of Neisseria meningitidis serogroup B from Iron acquisition proteins for vaccine design

2011 ◽  
Vol 6 (7) ◽  
pp. 255-261 ◽  
Author(s):  
Namrata Misra ◽  
Prasanna Kumar Panda ◽  
Kavita Shah ◽  
Lala Bihari Sukla ◽  
Priyanka Chaubey
Keyword(s):  
T Cell ◽  
Neisseria Meningitidis ◽  
Iron Acquisition ◽  
Vaccine Design ◽  
T Cell Epitopes ◽  
Population Coverage ◽  
Coverage Analysis
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