scholarly journals Actinomyces turicensis parapharyngeal space infection in an immunocompetent host: first case report and review of literature

2021 ◽  
Vol 3 (7) ◽  
Author(s):  
Ayla Tabaksert ◽  
Ravi Kumar ◽  
Veena Raviprakash ◽  
Rajeev Srinivasan
Keyword(s):  
Parapharyngeal Space ◽  
Invasive Infection ◽  
Review Of Literature ◽  
Immunocompetent Host ◽  
Incision And Drainage ◽  
Content Type ◽  
Link Type ◽  
Oral Amoxicillin ◽  
First Case ◽  
Intravenous Antibiotics

Actinomyces are common commensals of the oral cavity, gastrointestinal tract and urogenital tract. They are anaerobic, Gram-positive, non-acid-fast bacilli, which can cause invasive infection and abscesses. We present the first reported case of supraglottitis and deep neck space abscess formation secondary to Actinomyces turicensis infection. The patient was managed with intravenous antibiotics, incision and drainage of a left parapharyngeal abscess and subsequent mediastinal abscess. After 6 weeks in hospital, the patient was successfully discharged to complete a 6-month course of oral amoxicillin.

scholarly journals Community-acquired infection caused by the uncommon hypervirulent Klebsiella pneumoniae ST66-K2 lineage

2020 ◽  
Vol 6 (8) ◽  
Author(s):  
Carla Rodrigues ◽  
Camille d’Humières ◽  
Grégory Papin ◽  
Virginie Passet ◽  
Etienne Ruppé ◽  
...  
Keyword(s):  
Klebsiella Pneumoniae ◽  
Acute Otitis Media ◽  
Gene Clusters ◽  
Laboratory Model ◽  
Invasive Infection ◽  
Single Strain ◽  
Content Type ◽  
Link Type ◽  
First Case ◽  
Community Acquired Infection

Klebsiella pneumoniae (Kp) reference strain Kp52.145 is widely used in experimental Klebsiella pathophysiology. Since 1935, only one other strain of the same sublineage (sequence type ST66, capsular serotype K2) was isolated (AJ210, Australia). Here, we describe a community-acquired invasive infection caused by a ST66-K2 Kp strain in France. Four hypermucoviscous Kp isolates responsible for acute otitis media, meningitis, bacteraemia and bacteriuria, respectively, were obtained from a patient with a history of chronic alcoholism and diabetes mellitus, and infected with HIV. The isolates were characterized by phenotypic and genomic methods. The four genetically identical ST66-K2 isolates presented a full antimicrobial susceptibility profile, including to ampicillin, corresponding to a single strain (SB5881), which was more closely related to AJ210 (135 SNPs) than to Kp52.145 (388 SNPs). Colibactin and yersiniabactin gene clusters were present on the integrative and conjugative element ICEKp10 in the chromosome. The two plasmids from Kp52.145 were detected in SB5881. In addition to carrying genes for virulence factors RmpA, aerobactin and salmochelin, plasmid II has acquired in SB5881, the conjugation machinery gene cluster from plasmid I. We report the first case of community-acquired infection caused by a hypervirulent ST66-K2 Kp strain in Europe. This demonstrates the long-term persistence of the high-virulence and laboratory model ST66-K2 sublineage. The combination of a conjugative apparatus and major virulence genes on a single plasmid may contribute to the co-occurrence of hypervirulence and multidrug resistance in single Kp strains.

Delivering a shared library management system for Wales

2016 ◽  
Vol 37 (6/7) ◽  
pp. 385-395 ◽  
Author(s):  
Gareth Wyn Owen
Keyword(s):  
Management System ◽  
Review Of Literature ◽  
Content Type ◽  
Implementation Phase ◽  
Library Management ◽  
First Case ◽  
Library Management System ◽  
The Uk ◽  
Practical Implications

Purpose A case study of the Wales Higher Education Libraries Forum (WHELF) project to procure and implement a shared library management system (LMS) for all universities in Wales, together with the National Health Service Libraries in Wales and the National Library of Wales. In particular, the purpose of this paper is to explore the drivers to this collaboration, outline the benefits achieved and the framework to realise further benefits. Design/methodology/approach Case study review of the process, together with a review of literature on consortia and LMSs. Findings WHELF has developed into a more mature consortium through procuring and implementing a shared LMS. The process has delivered tangible benefits and is driving more work to realise further benefits. Research limitations/implications As the WHELF Shared LMS project is only nearing the end of the implementation phase, many of the anticipated operational benefits cannot be reported. Practical implications Useful case study for other consortia or potential consortia. Originality/value WHELF is in vanguard of consortia developments in the UK, and this is the first case study of the project.

Schwannoma of Tonsillolingual Sulcus: First Case Report and Review of Literature

2013 ◽  
Vol 5 (2) ◽  
pp. 8-9
Author(s):  
Hitesh Verma ◽  
RPS Punia
Keyword(s):  
Smooth Surface ◽  
Parapharyngeal Space ◽  
Needle Aspiration ◽  
Rare Entity ◽  
Review Of Literature ◽  
Common Site ◽  
Aspiration Cytology ◽  
First Case ◽  
History Of ◽  
Needle Aspiration Cytology

ABSTRACT Schwannoma is a benign, encapsulated tumor that is derived from schwann's cells. The most common site is parapharyngeal space of the neck; oropharyngeal occurrence is extremely rare. Fourteen year male boy presented with a history of difficulty in swallowing, more for solids for the last 8 months. The patient also had a change of voice for the last 5 months and was muffled in character. Examination showed single lobulated mass having smooth surface, of the size of approximately 5 × 4 cm and was arising from the tonsillolingual sulcus. The fine needle aspiration cytology from the lesion, reported to be schwannoma. The mass was excised completely under general anesthesia with the help of bipolar cautery. We report first case of schwannoma of tonsillolingual sulcus and also review the literature of the rare entity.

scholarly journals Sneathia amnii bacteraemia and chorioamnionitis leading to second trimester abortion: a case report

2021 ◽  
Vol 3 (12) ◽  
Author(s):  
Lien Gruwier ◽  
Aaron Sprenkels ◽  
Sofie Hulsbosch ◽  
Anne Vankeerberghen ◽  
Reinoud Cartuyvels
Keyword(s):  
Type Species ◽  
Culture Broth ◽  
Second Trimester ◽  
Trimester Abortion ◽  
Content Type ◽  
Link Type ◽  
First Case ◽  
Gene Sequence Analysis ◽  
The Usa ◽  
Septic Abortion

Background. Sneathia amnii (formerly designated as Leptotrichia amnionii ) was first described in 2002 in the USA. Members of the genus Sneathia can be part of the normal flora of the genitourinary tract, but have been implicated in invasive (mostly gynaecological) infections. Case presentation. To the best of our knowledge, here we present the first case of S. amnii infection in Belgium, in a young woman presenting with fever leading to second trimester septic abortion. Conclusions. Despite its pathogenicity, S. amnii remains an underrated cause of infections due to inherent difficulties with conventional laboratory methods. By extracting the bacterial DNA directly from the blood culture broth and performing a 16S ribosomal RNA gene sequence analysis we succeeded in identifying S. amnii as the most probable cause of the septic abortion in our patient.

scholarly journals First case report of post-operative infection due to Francisella tularensis after cardiac surgery

2019 ◽  
Vol 1 (8) ◽  
Author(s):  
Arif Maqsood Ali ◽  
Muhammad Noor ul Amin ◽  
Shazia Arif
Keyword(s):  
Cardiac Surgery ◽  
Case Report ◽  
Francisella Tularensis ◽  
Type Species ◽  
Detection Methods ◽  
Culture Bottle ◽  
Content Type ◽  
Chest Infection ◽  
Link Type ◽  
First Case

Background. Francisella tularensis is a rare zoonotic bacterium that spreads sporadically by various routes, including infected arthropod bites, ingestion of contaminated water and inhalation of contaminated dust. However, its occurrence in postoperative chest infection has never been reported. Pathogen isolation, serology and molecular detection methods are commonly used for the diagnosis of tularaemia. Case presentation. We present the first case report of the isolation of F. tularensis from a patient with a chest infection (a boy in his teens) following cardiac surgery for closure of a ventral septal defect. It was isolated on blood and chocolate agar on the third day after the subculture of drain fluid collected in a blood culture bottle incubated in Bact T/Alert 3-D (bioMerieux, France). The organism was identified as F. tularensis by Vitek GN ID Cards (Vitek 2 Compact, bioMerieux, France). The patient made a smooth recovery with antibiotic therapy. Conclusion. F. tularensis can cause post-operative infection, especially in patients with a rural background.

scholarly journals Bilateral peritonsillar abscess: a case series

2019 ◽  
Vol 5 (3) ◽  
pp. 772
Author(s):  
Ng Chun Tau ◽  
Ahmad Nordin Afandi
Keyword(s):  
Medical Therapy ◽  
Complete Resolution ◽  
Case Series ◽  
Needle Aspiration ◽  
Peritonsillar Abscess ◽  
The Other ◽  
Incision And Drainage ◽  
Tomography Imaging ◽  
First Case ◽  
Intravenous Antibiotics

<p class="abstract">Peritonsillar abscess (PTA) is one of the most common deep neck abscesses. Unlike unilateral peritonsillar abscess, bilateral peritonsillar abscess is rather rare. We report 3 cases of bilateral peritonsillar abscess which were proven by either computerized tomography imaging or needle aspiration. One of the patients was treated with intravenous antibiotics and corticosteroid. The other 2 patients underwent needle aspiration for confirmation of diagnosis and subsequent incision and drainage. All patients were treated successfully with complete resolution. Bilateral PTA should always be considered when there is presence of bilateral peritonsillar swelling with non-deviated uvula and trismus. Despite surgical drainage being the most common management, the option of medical therapy alone may be sufficient. To the best of our knowledge, this is the first case of bilateral PTA reported being treated successfully with medical therapy.</p>

scholarly journals An invasive infection with an unusual spaB-possessing Erysipelothrix rhusiopathiae in a human

2020 ◽  
Vol 69 (10) ◽  
pp. 1249-1252
Author(s):  
Yudai Taguchi ◽  
Kazumasa Shiraiwa ◽  
Yohsuke Ogawa ◽  
Tomoki Oi ◽  
Shigeo Nakamura ◽  
...  
Keyword(s):  
Type Species ◽  
Protective Antigen ◽  
Gene Organization ◽  
Invasive Infection ◽  
Erysipelothrix Rhusiopathiae ◽  
Pcr Assay ◽  
Spa Typing ◽  
Sequence Element ◽  
Content Type ◽  
Link Type

Erysipelothrix rhusiopathiae is a zoonotic pathogen that causes erysipelas in a variety of animals. In humans, in contrast to the cutaneous form called erysipeloid, which is an occupational disease and common in individuals who handle raw meat and fish, invasive systemic infections are unusual. E. rhusiopathiae expresses an immunogenic surface protein, Spa (surface protective antigen), which is involved in virulence. Among the antigenically different Spa proteins (SpaA, B and C), which are mostly associated with serovars, SpaA is by far the most prevalent in E. rhusiopathiae isolates from diseased animals. However, the Spa type has not been examined for human isolates, and it is unknown whether SpaB- or SpaC-possessing isolates can cause disease in humans. A Gram-positive, rod-shaped bacterium isolated from a case of human pyogenic spondylitis was analysed. The bacterium was identified as E. rhusiopathiae by a routine biochemical test and MS, and ultimately confirmed by an E. rhusiopathiae -specific PCR assay. Spa typing by sequencing revealed the SpaB type, and the serovar of the strain was identified as untypeable by a conventional agar gel precipitation test, but determined to be serovar 6 by a serotyping PCR assay. Sequence analysis of the serovar-defining chromosomal region revealed that the isolate displayed the same gene organization as the serovar 6 reference strain, but the region was disrupted by an insertion sequence element, suggesting that the isolate originated from a serovar 6 strain. These results highlight that unusual, spaB-possessing E. rhusiopathiae strains can potentially pose serious risks to humans.

scholarly journals Streptococcus lutetiensis neonatal meningitis with empyema

2021 ◽  
Vol 3 (9) ◽  
Author(s):  
Allen T. Yu ◽  
Kate Shapiro ◽  
Christy A. Beneri ◽  
Lisa S. Wilks-Gallo
Keyword(s):  
United States ◽  
Neonatal Sepsis ◽  
Type Species ◽  
The United States ◽  
Neonatal Meningitis ◽  
Content Type ◽  
Link Type ◽  
First Case

Streptococcus lutetiensis has been known to cause sepsis in adults, but only one case regarding neonatal sepsis has been reported internationally, with no sequelae. We report the first case of neonatal bacteremia and meningitis with empyema caused by S. lutetiensis in the United States.

scholarly journals Bacterial gastroenteritis caused by the putative zoonotic pathogen Campylobacter lanienae: First reported case in Germany

2021 ◽  
Author(s):  
Juliane Fornefett ◽  
Anne Busch ◽  
Sandra Döpping ◽  
Helmut Hotzel ◽  
Dagmar Rimek
Keyword(s):  
Type Species ◽  
Campylobacter Coli ◽  
Pathogenic Potential ◽  
Content Type ◽  
Link Type ◽  
First Case ◽  
Strain Collection ◽  
Causative Agents ◽  
Bacterial Gastroenteritis ◽  
Abattoir Workers

Foodborne campylobacteriosis is the most common cause of human bacterial enteritis in Germany. Campylobacter jejuni and Campylobacter coli are the main causative agents for enteric disease, but a number of other species are involved, including rare ones. These rare Campylobacter spp. are emerging zoonotic pathogens in humans due to increasing international movement of supplies, livestock and people. Campylobacter lanienae was first isolated from healthy abattoir workers in Switzerland and at first its pathogenic potential for humans was considered to be low. Recently, the first case of Campylobacter lanienae -associated human enteritis was reported in Canada. Here, we describe a case of mild Campylobacter lanienae -associated enteritis with subsequent asymptomatic excretion in a butcher. The isolate is available at the TLV strain collection (no. TP00333/18). This first reported case of human Campylobacter lanienae campylobacteriosis in Germany demonstrates the agent’s likely zoonotic pathogenicity.

scholarly journals Empedobacter brevisBacteremia in a Patient Infected with HIV: Case Report and Review of Literature

2015 ◽  
Vol 2015 ◽  
pp. 1-3 ◽  
Author(s):  
Syed Bokhari ◽  
Naeem Abbas ◽  
Manisha Singh ◽  
Richard B. Cindrich ◽  
Cosmina Zeana
Keyword(s):  
Leukocyte Count ◽  
Total Leukocyte Count ◽  
Review Of Literature ◽  
Emerging Pathogen ◽  
First Case ◽  
Intravenous Antibiotics ◽  
Immunodeficiency Virus ◽  
Chief Complaints ◽  
Health Care Associated Infections ◽  
Gastrointestinal Colonization

Clinical disease caused byEmpedobacter brevis(E. brevis) is very rare. We report the first case ofE. brevisbacteremia in a patient with HIV and review the current literature. A 69-year-old man with human immunodeficiency virus (HIV) and CD4 count of 319 presented with chief complaints of black tarry stools, nausea and vomiting for 2 days. Physical exam was significant for abdominal pain on palpation with no rebound or guarding. His total leukocyte count was 32,000 cells/μL with 82% neutrophils and 9% bands. Emergent colonoscopy and endoscopic esophagogastroduodenoscopy showed esophageal candidiasis, a nonbleeding gastric ulcer, and diverticulosis. Blood cultures drawn on days 1, 2, and 3 of hospitalization grewE. brevis. Patient improved with intravenous antibiotics. This case is unusual, raising the possibility of gastrointestinal colonization as a source of the patient’s bacteremia. In conclusion,E. brevisis an emerging pathogen that can cause serious health care associated infections.

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