scholarly journals Streptococcus lutetiensis neonatal meningitis with empyema

2021 ◽  
Vol 3 (9) ◽  
Author(s):  
Allen T. Yu ◽  
Kate Shapiro ◽  
Christy A. Beneri ◽  
Lisa S. Wilks-Gallo
Keyword(s):  
United States ◽  
Neonatal Sepsis ◽  
Type Species ◽  
The United States ◽  
Neonatal Meningitis ◽  
Content Type ◽  
Link Type ◽  
First Case

Streptococcus lutetiensis has been known to cause sepsis in adults, but only one case regarding neonatal sepsis has been reported internationally, with no sequelae. We report the first case of neonatal bacteremia and meningitis with empyema caused by S. lutetiensis in the United States.

scholarly journals Mycobacterium talmoniae, a Potential Pulmonary Pathogen Isolated from Multiple Patients with Bronchiectasis in the United States, Including the First Case of Clinical Disease in a Patient with Cystic Fibrosis

2018 ◽  
Vol 57 (2) ◽  
Author(s):  
Ravikiran Vasireddy ◽  
Sruthi Vasireddy ◽  
Barbara A. Brown-Elliott ◽  
Alexander L. Greninger ◽  
Rebecca M. Davidson ◽  
...  
Keyword(s):  
United States ◽  
Cystic Fibrosis ◽  
16S Rrna ◽  
Type Strain ◽  
Gene Sequencing ◽  
The United States ◽  
Average Nucleotide Identity ◽  
Content Type ◽  
First Case ◽  
Multiple Patients

ABSTRACTWe characterize three respiratory isolates of the recently described speciesMycobacterium talmoniaerecovered in Texas, Louisiana, and Massachusetts, including the first case of disease in a patient with underlying cystic fibrosis. The three isolates had a 100% match toM. talmoniaeNE-TNMC-100812Tby complete 16S rRNA,rpoBregion V, andhsp65 gene sequencing. Core genomic comparisons between one isolate and the type strain revealed an average nucleotide identity of 99.8%. The isolates were susceptible to clarithromycin, amikacin, and rifabutin, while resistance was observed for tetracyclines, ciprofloxacin, and linezolid.M. talmoniaeshould be added to the list of potential pulmonary pathogens, including in the setting of cystic fibrosis.

scholarly journals d-Serine induces distinct transcriptomes in diverse Escherichia coli pathotypes

Microbiology ◽  
2021 ◽  
Vol 167 (10) ◽  
Author(s):  
James P. R. Connolly ◽  
Natasha C. A. Turner ◽  
Jennifer C. Hallam ◽  
Patricia T. Rimbi ◽  
Tom Flett ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Type Species ◽  
Pathogenic Bacteria ◽  
Neonatal Meningitis ◽  
Published Data ◽  
Toxic Metabolite ◽  
Transcriptional Responses ◽  
Content Type ◽  
E Coli ◽  
Link Type

Appropriate interpretation of environmental signals facilitates niche specificity in pathogenic bacteria. However, the responses of niche-specific pathogens to common host signals are poorly understood. d-Serine (d-ser) is a toxic metabolite present in highly variable concentrations at different colonization sites within the human host that we previously found is capable of inducing changes in gene expression. In this study, we made the striking observation that the global transcriptional response of three Escherichia coli pathotypes – enterohaemorrhagic E. coli (EHEC), uropathogenic E. coli (UPEC) and neonatal meningitis-associated E. coli (NMEC) – to d-ser was highly distinct. In fact, we identified no single differentially expressed gene common to all three strains. We observed the induction of ribosome-associated genes in extraintestinal pathogens UPEC and NMEC only, and the induction of purine metabolism genes in gut-restricted EHEC, and UPEC indicating distinct transcriptional responses to a common signal. UPEC and NMEC encode dsdCXA – a genetic locus required for detoxification and hence normal growth in the presence of d-ser. Specific transcriptional responses were induced in strains accumulating d-ser (WT EHEC and UPEC/NMEC mutants lacking the d-ser-responsive transcriptional activator DsdC), corroborating the notion that d-ser is an unfavourable metabolite if not metabolized. Importantly, many of the UPEC-associated transcriptome alterations correlate with published data on the urinary transcriptome, supporting the hypothesis that d-ser sensing forms a key part of urinary niche adaptation in this pathotype. Collectively, our results demonstrate distinct pleiotropic responses to a common metabolite in diverse E. coli pathotypes, with important implications for niche selectivity.

scholarly journals Carbapenemase-Producing Enterobacteriaceae in Swine Production in the United States: Impact and Opportunities

2016 ◽  
Vol 61 (2) ◽  
Author(s):  
Timothy J. Johnson
Keyword(s):  
United States ◽  
The United States ◽  
Swine Production ◽  
Content Type ◽  
Link Type

ABSTRACT The discovery of carbapenemase-producing Enterobacteriaceae in U.S. swine production is troubling and underscores a tumultuous period where the outlook on the battle against superbugs is bleak. However, all is not lost. This commentary highlights both the good and the bad that can come from such findings, including those of a recent study published by Mollenkopf et al. (Antimicrob Agents Chemother 61:e012198-16, 2017, https://doi.org/doi:10.1128/AAC.01298-16 ).

scholarly journals Laboratory Investigation of the First Case of Botulism Caused by Clostridium butyricum Type E Toxin in the United States

2015 ◽  
Vol 53 (10) ◽  
pp. 3363-3365 ◽  
Author(s):  
Janet K. Dykes ◽  
Carolina Lúquez ◽  
Brian H. Raphael ◽  
Loretta McCroskey ◽  
Susan E. Maslanka
Keyword(s):  
United States ◽  
Laboratory Investigation ◽  
The United States ◽  
Clostridium Butyricum ◽  
Content Type ◽  
First Case ◽  
Microbiological Examination

We report here the laboratory investigation of the first known case of botulism in the United States caused byClostridium butyricumtype E. This investigation demonstrates the importance of extensive microbiological examination of specimens, which resulted in the isolation of this organism.

scholarly journals Sneathia amnii bacteraemia and chorioamnionitis leading to second trimester abortion: a case report

2021 ◽  
Vol 3 (12) ◽  
Author(s):  
Lien Gruwier ◽  
Aaron Sprenkels ◽  
Sofie Hulsbosch ◽  
Anne Vankeerberghen ◽  
Reinoud Cartuyvels
Keyword(s):  
Type Species ◽  
Culture Broth ◽  
Second Trimester ◽  
Trimester Abortion ◽  
Content Type ◽  
Link Type ◽  
First Case ◽  
Gene Sequence Analysis ◽  
The Usa ◽  
Septic Abortion

Background. Sneathia amnii (formerly designated as Leptotrichia amnionii ) was first described in 2002 in the USA. Members of the genus Sneathia can be part of the normal flora of the genitourinary tract, but have been implicated in invasive (mostly gynaecological) infections. Case presentation. To the best of our knowledge, here we present the first case of S. amnii infection in Belgium, in a young woman presenting with fever leading to second trimester septic abortion. Conclusions. Despite its pathogenicity, S. amnii remains an underrated cause of infections due to inherent difficulties with conventional laboratory methods. By extracting the bacterial DNA directly from the blood culture broth and performing a 16S ribosomal RNA gene sequence analysis we succeeded in identifying S. amnii as the most probable cause of the septic abortion in our patient.

scholarly journals First case report of post-operative infection due to Francisella tularensis after cardiac surgery

2019 ◽  
Vol 1 (8) ◽  
Author(s):  
Arif Maqsood Ali ◽  
Muhammad Noor ul Amin ◽  
Shazia Arif
Keyword(s):  
Cardiac Surgery ◽  
Case Report ◽  
Francisella Tularensis ◽  
Type Species ◽  
Detection Methods ◽  
Culture Bottle ◽  
Content Type ◽  
Chest Infection ◽  
Link Type ◽  
First Case

Background. Francisella tularensis is a rare zoonotic bacterium that spreads sporadically by various routes, including infected arthropod bites, ingestion of contaminated water and inhalation of contaminated dust. However, its occurrence in postoperative chest infection has never been reported. Pathogen isolation, serology and molecular detection methods are commonly used for the diagnosis of tularaemia. Case presentation. We present the first case report of the isolation of F. tularensis from a patient with a chest infection (a boy in his teens) following cardiac surgery for closure of a ventral septal defect. It was isolated on blood and chocolate agar on the third day after the subculture of drain fluid collected in a blood culture bottle incubated in Bact T/Alert 3-D (bioMerieux, France). The organism was identified as F. tularensis by Vitek GN ID Cards (Vitek 2 Compact, bioMerieux, France). The patient made a smooth recovery with antibiotic therapy. Conclusion. F. tularensis can cause post-operative infection, especially in patients with a rural background.

Intracranial sparganosis: an uncommon infection

1984 ◽  
Vol 60 (6) ◽  
pp. 1282-1286 ◽  
Author(s):  
Karl Anders ◽  
Kevin Foley ◽  
W. Eugene Stern ◽  
W. Jann Brown
Keyword(s):  
United States ◽  
Lower Extremity ◽  
Parietal Lobe ◽  
The United States ◽  
Pathological Features ◽  
Content Type ◽  
First Case ◽  
The Right ◽  
Clinical And Pathological Features ◽  
Fine Print

✓ The first case of intracranial sparganosis to be reported from the United States is presented. The patient, a 27-year-old woman, complained of focal seizures involving the right lower extremity. A left parietal parasagittal craniotomy was performed, and a granuloma containing a sparganum was excised from the parietal lobe. The clinical and pathological features of sparganosis are reviewed. Only five cases of intracranial sparganosis have previously been described.

scholarly journals Bacterial gastroenteritis caused by the putative zoonotic pathogen Campylobacter lanienae: First reported case in Germany

2021 ◽  
Author(s):  
Juliane Fornefett ◽  
Anne Busch ◽  
Sandra Döpping ◽  
Helmut Hotzel ◽  
Dagmar Rimek
Keyword(s):  
Type Species ◽  
Campylobacter Coli ◽  
Pathogenic Potential ◽  
Content Type ◽  
Link Type ◽  
First Case ◽  
Strain Collection ◽  
Causative Agents ◽  
Bacterial Gastroenteritis ◽  
Abattoir Workers

Foodborne campylobacteriosis is the most common cause of human bacterial enteritis in Germany. Campylobacter jejuni and Campylobacter coli are the main causative agents for enteric disease, but a number of other species are involved, including rare ones. These rare Campylobacter spp. are emerging zoonotic pathogens in humans due to increasing international movement of supplies, livestock and people. Campylobacter lanienae was first isolated from healthy abattoir workers in Switzerland and at first its pathogenic potential for humans was considered to be low. Recently, the first case of Campylobacter lanienae -associated human enteritis was reported in Canada. Here, we describe a case of mild Campylobacter lanienae -associated enteritis with subsequent asymptomatic excretion in a butcher. The isolate is available at the TLV strain collection (no. TP00333/18). This first reported case of human Campylobacter lanienae campylobacteriosis in Germany demonstrates the agent’s likely zoonotic pathogenicity.

scholarly journals Vibrio metoecus sp. nov., a close relative of Vibrio cholerae isolated from coastal brackish ponds and clinical specimens

2014 ◽  
Vol 64 (Pt_9) ◽  
pp. 3208-3214 ◽  
Author(s):  
Paul C. Kirchberger ◽  
Maryann Turnsek ◽  
Dana E. Hunt ◽  
Bradd J. Haley ◽  
Rita R. Colwell ◽  
...  
Keyword(s):  
Vibrio Cholerae ◽  
Type Species ◽  
The United States ◽  
Nucleotide Identity ◽  
Close Relative ◽  
Average Nucleotide Identity ◽  
Content Type ◽  
The Past ◽  
Link Type ◽  
Close Resemblance

A Gram-staining-negative, curved-rod-shaped bacterium with close resemblance to Vibrio cholerae , the aetiological agent of cholera, was isolated over the course of several years from coastal brackish water (17 strains) and from clinical cases (two strains) in the United States. 16S rRNA gene identity with V. cholerae exceeded 98 % yet an average nucleotide identity based on genome data of around 86 % and multi locus sequence analysis of six housekeeping genes (mdh, adk, gyrB, recA, pgi and rpoB) clearly delineated these isolates as a distinct genotypic cluster within the V. cholerae – V. mimicus clade. Most standard identification techniques do not differentiate this cluster of isolates from V. cholerae . Only amplification of the ompW gene using V. cholerae -specific primers and a negative Voges–Proskauer test showed a difference between the two clusters. Additionally, all isolated strains differed phenotypically from V. cholerae in their ability to utilize N-acetyl-d-galactosamine and d-glucuronic acid as sole carbon sources. Furthermore, they were generally unable to infect the slime mould Dictyostelium discoideum, a widespread ability in V. cholerae . Based on these clear phenotypic differences that are not necessarily apparent in standard tests as well as average nucleotide identity and phylogeny of protein-coding genes, we propose the existence of a novel species, Vibrio metoecus sp. nov. with the type strain OP3HT ( = LMG 27764T = CIP 110643T). Due to its close resemblance to V. cholerae and the increasing number of strains isolated over the past several years, we suggest that V. metoecus sp. nov. is a relatively common species of the genus Vibrio , isolates of which have been identified as atypical isolates of V. cholerae in the past. Its isolation from clinical samples also indicates that strains of this species, like V. cholerae , are opportunistic pathogens.

scholarly journals Mycobacterium mucogenicum meningitis due to external ventricular drain

2020 ◽  
Vol 2 (11) ◽  
Author(s):  
Salwa Moiz ◽  
Omar Rahman ◽  
Mark Morcos ◽  
Asma Siddiqui ◽  
Usman Bin Hameed
Keyword(s):  
Type Species ◽  
Obstructive Hydrocephalus ◽  
External Ventricular Drain ◽  
Response To Therapy ◽  
Case Presentation ◽  
Content Type ◽  
Link Type ◽  
First Case ◽  
Neurological Exam ◽  
Mycobacterium Mucogenicum

Introduction. Mycobacterium mucogenicum is a rare non-tuberculous organism associated with catheter-related infections when pathogenic in humans. We present the first case of an external ventricular drain (EVD)-associated M. mucogenicum meningitis. Case presentation. A 55-year-old woman had EVD placement for obstructive hydrocephalus following traumatic subarachnoid haemorrhage. Cerebrospinal fluid (CSF) was obtained 5 days later for fever and neurological changes. M. mucogenicum was ultimately isolated from the CSF and the patient was placed on appropriate antibiotics. Her management included replacement of the EVD and a prolonged course of anti-mycobacterial antibiotics. CSF findings showed her response to therapy and neurological exam improved after 6 weeks. Conclusion. M. mucogenicum infections are very rare and existing reports indicate that it may be a device- or catheter-related pathogen. This microorganism has not been previously associated with an EVD. Ours may be the first documented report of EVD-related M. mucogenicum infection.

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