Infection with cytomegalovirus in patients with inflammatory bowel disease: prevalence, clinical significance and outcome

Despite frequent use of immunosuppressive drugs in patients with inflammatory bowel disease (IBD) and reports of cytomegalovirus (CMV) infection following post-transplant immunosuppression, data on the frequency and clinical significance of CMV in patients with IBD are scant. Sixty-three patients with IBD (61 ulcerative colitis and two Crohn's disease) were evaluated for CMV using serology (IgM antibody, μ-capture ELISA), PCR for CMV DNA in colonic biopsy and histological assessment of haematoxylin and eosin-stained colonic biopsy. Positive result in any test was considered as CMV infection. Various parameters associated with CMV infection were analysed using univariate and multivariate analysis. Ten of 63 (15.8 %) patients (age 36.0 ± 11.2 years, 31 female) were infected with CMV (DNA alone in four, IgM antibody alone in two and both in four, inclusion body in one). Patients with CMV infection were more often female (8/10 vs 23/53, P < 0.05), had pancolitis (10/10 vs 33/53, P < 0.05), histological activity (9/10 vs 17/53, P < 0.005) and used azathioprine (5/10 vs 7/53, P = 0.04; Fisher exact test for all). On multivariate analysis, female gender, pancolitis and histological activity were the independent factors associated with infection. Patients with CMV infection more often required surgical treatment for IBD (4/10 vs 4/53, P = 0.01) and had fatal outcome (3/10 vs 0/53, P = 0.003). CMV infection in patients with IBD may be common and is associated with poor outcome. PCR of rectal biopsy was the most sensitive method of detection followed by IgM antibody for diagnosis.

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P702 Clinical significance of cytomegalovirus (CMV) infection in inflammatory bowel disease

Journal of Crohn s and Colitis ◽

10.1016/s1873-9946(13)60723-0 ◽

2013 ◽

Vol 7 ◽

pp. S292

Author(s):

G. Inserra ◽

M. Mendolaro ◽

S. Siringo ◽

G. Scalia ◽

L. Samperi ◽

...

Keyword(s):

Inflammatory Bowel Disease ◽

Clinical Significance ◽

Bowel Disease ◽

Cmv Infection ◽

Inflammatory Bowel

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P.01.13 CLINICAL SIGNIFICANCE OF CYTOMEGALOVIRUS (CMV) INFECTION IN INFLAMMATORY BOWEL DISEASE

Digestive and Liver Disease ◽

10.1016/s1590-8658(13)60258-3 ◽

2013 ◽

Vol 45 ◽

pp. S93-S94

Author(s):

G. Inserra ◽

M. Mendolaro ◽

G. Scalia ◽

S. Siringo ◽

L. Samperi ◽

...

Keyword(s):

Inflammatory Bowel Disease ◽

Clinical Significance ◽

Bowel Disease ◽

Cmv Infection ◽

Inflammatory Bowel

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Risk factors for developing high-output ileostomy in CRC patients: a retrospective study

BMC Surgery ◽

10.1186/s12893-021-01288-y ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Dongxiao Bai ◽

Lei Li ◽

Zhiling Shen ◽

Tianchen Huang ◽

Qingbing Wang ◽

...

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

Inflammatory Bowel Disease ◽

Multivariate Analysis ◽

Anastomotic Leakage ◽

Bowel Disease ◽

Total Colectomy ◽

Abdominal Infection ◽

Inflammatory Bowel ◽

High Output

Abstract Background Anastomotic leakage is one of the most serious postoperative complications of rectal cancer. Prophylactic ileostomy has been widely used to reduce the risk and severity of complications of anastomotic leakage. However, prophylactic ileostomy itself has some complications, and ileostomy high output syndrome (HOS) is one of them. This study was performed to explore the risk factors of HOS in ileostomy. Methods A total of 114 patients with HOS were screened out from 494 eligible ileostomy patients in the last 5 years. The relationship between HOS and the clinicopathological data was analyzed using the Chi-square test and Fisher’s exact probability. Multivariate analysis was performed by logistic regression. Results The incidence of HOS was 23.07% in this study. Dehydration was the most common symptom of HOS (37.7%). There was no clear correlation between HOS occurrence with sex, age, gross typing, histological grade, tumor location, lymph node metastasis, and TNM stage (p > 0.05). The incidence of HOS was 14/18 in inflammatory bowel disease patients, 18/28 in diabetes mellitus patients, and 23/72 in neoadjuvant chemoradiotherapy patients, 13/17 in total colectomy and abdominal infection patients. Multivariate analysis showed that they are risk factors for HOS (p < 0.05). Conclusion HOS occurred occasionally but rarely studied and lacks attention. Inflammatory bowel disease, diabetes mellitus, neoadjuvant radiotherapy chemotherapy, total colectomy and abdominal infection are the risk factors for HOS.

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Clinical significance of soluble immunoglobulins A and G and their coated bacteria in feces of patients with inflammatory bowel disease

Journal of Translational Medicine ◽

10.1186/s12967-018-1723-0 ◽

2018 ◽

Vol 16 (1) ◽

Cited By ~ 11

Author(s):

Ritian Lin ◽

Hongwei Chen ◽

Weigang Shu ◽

Mingming Sun ◽

Leilei Fang ◽

...

Keyword(s):

Inflammatory Bowel Disease ◽

Clinical Significance ◽

Bowel Disease ◽

Inflammatory Bowel

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CLINICAL SIGNIFICANCE OF PSOAS MUSCLE COMPOSITION IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE

Gastroenterology ◽

10.1053/j.gastro.2021.01.059 ◽

2021 ◽

Vol 160 (3) ◽

pp. S11-S12

Author(s):

Bixuan Lin ◽

Poonam Beniwal-Patel

Keyword(s):

Inflammatory Bowel Disease ◽

Clinical Significance ◽

Bowel Disease ◽

Psoas Muscle ◽

Muscle Composition ◽

Inflammatory Bowel

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P154 Sinusitis Prompts Evaluation for Co-existing or Subsequent inflammatory bowel disease

Journal of Crohn s and Colitis ◽

10.1093/ecco-jcc/jjz203.283 ◽

2020 ◽

Vol 14 (Supplement_1) ◽

pp. S214-S215

Author(s):

V Rai ◽

C Traboulsi ◽

G Gulotta ◽

D Rubin

Keyword(s):

Inflammatory Bowel Disease ◽

Multivariate Analysis ◽

Bowel Disease ◽

Categorical Variables ◽

Continuous Variables ◽

White Race ◽

Black Race ◽

Female Sex ◽

Co Morbidity ◽

Inflammatory Bowel

Abstract Background The relationship between sinusitis and inflammatory bowel disease (IBD) has not yet been established. Though the two are characterised by dysfunction of the epithelial barrier, there lacks evidence on the relative contributions of infection or inflammation to this co-morbidity in IBD patients. Previous analyses from our group identified an increased prevalence of sinusitis among patients with IBD, predictive factors of developing sinusitis in IBD, and differences in stratifying patients with IBD and sinusitis (IBD+S) based on order in which these conditions were diagnosed. We now report on the factors associated with the development of IBD in patients with sinusitis. Methods This is a retrospective study at our tertiary IBD center. We utilised our institution’s electronic medical record data warehouse of 2.4 million patients to identify those with diagnostic codes for both sinusitis (J32) and IBD (K50.90 and K51.90). Patients with a confirmed diagnosis of IBD and/or sinusitis between 1/2000–5/2019 and age ≥18 years were included. Demographic and disease-related information were collected. Categorical variables were analysed using Fisher’s exact test and continuous variables were analysed using Wilcoxon rank-sum test. Results Of 14,366 patients with IBD, 386 (2.69%) patients have IBD+S. Of the 386 IBD+S patients, 118 patients (30.6%) were diagnosed with sinusitis before IBD. These 118 IBD+S patients were included in univariate and multivariate analysis with 14,753 non-IBD patients with sinusitis. The average age at IBD diagnosis among all IBD patients was 37.32 ± 18.79 years, and the average age at sinusitis diagnosis for sinusitis patients was 40.93 ± 21.42 years. On multivariate analysis, age of sinusitis diagnosis >40 years old (OR 1.52, 95% CI 1.04–2.28), black race (OR 2.82, 95% CI 1.29–7.43), white race (OR 4.33, 95% CI 2.02–11.23), and female sex (OR 1.52, 95% CI 1.03–2.28) were significant predictors of IBD in sinusitis patients (Table 1A). In comparison, multivariate analysis showed that black race (OR 8.09, 95% CI 4.91–14.26), white race (OR 3.35, 95% CI 2.08–5.80), female sex (OR 1.51, 95% CI 1.22–1.87), and bowel obstruction (OR 2.00, 95% CI 1.53–2.58) were significantly associated with sinusitis in IBD patients (Table 1B). Conclusion Sinusitis patients diagnosed older than 40 years old have 1.5 greater odds of subsequent IBD, suggesting that a diagnosis of sinusitis should prompt consideration of co-existing or subsequent IBD risk. Female sex and race are shared factors in the risk of sinusitis in IBD patients and risk of IBD in sinusitis patients.

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P004 Correlation Between Histological Activity and Use of Anti-TNF in Patients With Inflammatory Bowel Disease in a Mexican Tertiary Hospital Centre

The American Journal of Gastroenterology ◽

10.14309/01.ajg.0000612984.90569.bc ◽

2019 ◽

Vol 114 (1) ◽

pp. S1-S2

Author(s):

Dassaev Aleman Abitia ◽

Goméz Jesús López ◽

Trujillo de la Fuente Korely ◽

Christian Navarro Gerrard ◽

Hernandez Jhonatan Aguilar ◽

...

Keyword(s):

Inflammatory Bowel Disease ◽

Bowel Disease ◽

Tertiary Hospital ◽

Inflammatory Bowel ◽

Histological Activity

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Clinical Significance of C-Reactive Protein Levels in Predicting Responsiveness to Iron Therapy in Patients with Inflammatory Bowel Disease and Iron Deficiency Anemia

Digestive Diseases and Sciences ◽

10.1007/s10620-014-3460-4 ◽

2014 ◽

Vol 60 (5) ◽

pp. 1375-1381 ◽

Cited By ~ 14

Author(s):

Tariq Iqbal ◽

Jürgen Stein ◽

Naveen Sharma ◽

Stefanie Kulnigg-Dabsch ◽

Senthil Vel ◽

...

Keyword(s):

Inflammatory Bowel Disease ◽

Iron Deficiency ◽

Clinical Significance ◽

Iron Deficiency Anemia ◽

Bowel Disease ◽

Deficiency Anemia ◽

C Reactive Protein ◽

Protein Levels ◽

Reactive Protein ◽

Inflammatory Bowel

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Prevalence of Joint Hypermobility and Patterns of Articular Manifestations in Patients with Inflammatory Bowel Disease

Gastroenterology Research and Practice ◽

10.1155/2009/924138 ◽

2009 ◽

Vol 2009 ◽

pp. 1-5 ◽

Cited By ~ 19

Author(s):

P. Vounotrypidis ◽

E. Efremidou ◽

P. Zezos ◽

M. Pitiakoudis ◽

E. Maltezos ◽

...

Keyword(s):

Inflammatory Bowel Disease ◽

Bowel Disease ◽

Study Groups ◽

Joint Hypermobility ◽

Fisher Exact Test ◽

Hypermobility Syndrome ◽

Exact Test ◽

Significant Difference ◽

Healthy Control ◽

Inflammatory Bowel

Objective. The objective is the investigation of Joint Hypermobility (JH) and the Hypermobility Syndrome (HMS) in patients with inflammatory bowel disease (IBD).Methods. We examined 83 patients with IBD and 67 healthy individuals for the presence of JH. Patients were excluded if they were under 18 or over 50 years of age and if they had other conditions which affect joint mobility. Thex2and the Fisher exact test were used appropriately between study groups. Odds ratios (ORs) for the risk of JH and HMS in IBD groups were calculated.Results. A total of 150 individuals (83 IBD patients and 67 healthy controls) participated in the study. 69 IBD patients, 41 with Crohn's Disease (CD) and 28 with ulcerative colitis (UC), were finally eligible. JH was detected in 29 CD patients (70.7%), in 10 UC patients (35.7%), and in 17 healthy control subjects (25.4%). Significant difference was detected on JH in CD patients as compared to UC patients (P=.0063) and controls (P<.0001). The estimated OR for JH was 7.108 (95% CI: 2.98–16.95) in CD and 1.634 (95% CI: 0.63–4.22) in UC patients. HMS was detected in 5 (12.2%) CD and in 1 (3.57%) UC patients. The OR for HMS in CD was 3.75 (95% CI: 0.41–34.007), while 7 (17.1%) CD patients had overlapping symptoms for both HMS and early spondylarthropathy.Conclusions. JH and the HMS are common in CD patients, thus articular manifestations should be carefully interpreted. This implies an involvement of collagen varieties in the pathogenesis of IBD.

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