The Pbs2 MAP kinase kinase is essential for the oxidative-stress response in the fungal pathogen Candida albicans

Microbiology ◽  
2005 ◽  
Vol 151 (4) ◽  
pp. 1033-1049 ◽  
Author(s):  
David M. Arana ◽  
César Nombela ◽  
Rebeca Alonso-Monge ◽  
Jesús Pla
Keyword(s):  
Oxidative Stress ◽  
Candida Albicans ◽  
Stress Response ◽  
Map Kinase ◽  
Fungal Pathogen ◽  
Oxidative Stress Response ◽  
Map Kinase Kinase

scholarly journals The MAP kinase MpkA controls cell wall integrity, oxidative stress response, gliotoxin production and iron adaptation in Aspergillus fumigatus

2011 ◽  
Vol 82 (1) ◽  
pp. 39-53 ◽  
Author(s):  
Radhika Jain ◽  
Vito Valiante ◽  
Nicole Remme ◽  
Teresa Docimo ◽  
Thorsten Heinekamp ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Wall ◽  
Stress Response ◽  
Aspergillus Fumigatus ◽  
Map Kinase ◽  
Oxidative Stress Response ◽  
Cell Wall Integrity

scholarly journals Trehalose accumulation induced during the oxidative stress response is independent of TPS1 mRNA levels in Candida albicans

2003 ◽  
Vol 6 (2) ◽  
pp. 121-125 ◽  
Author(s):  
�scar Zaragoza ◽  
Pilar Gonz�lez-P�rraga ◽  
Yolanda Pedre�o ◽  
Francisco J. Alvarez-Peral ◽  
Juan-Carlos Arg�elles
Keyword(s):  
Oxidative Stress ◽  
Candida Albicans ◽  
Stress Response ◽  
Oxidative Stress Response ◽  
Mrna Levels ◽  
Trehalose Accumulation

scholarly journals High Resistance to Oxidative Stress in the Fungal Pathogen Candida glabrata Is Mediated by a Single Catalase, Cta1p, and Is Controlled by the Transcription Factors Yap1p, Skn7p, Msn2p, and Msn4p

2008 ◽  
Vol 7 (5) ◽  
pp. 814-825 ◽  
Author(s):  
Mayra Cuéllar-Cruz ◽  
Marcela Briones-Martin-del-Campo ◽  
Israel Cañas-Villamar ◽  
Javier Montalvo-Arredondo ◽  
Lina Riego-Ruiz ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Saccharomyces Cerevisiae ◽  
Candida Albicans ◽  
Transcription Factors ◽  
Adaptive Response ◽  
Fungal Pathogen ◽  
Candida Glabrata ◽  
Systemic Infection ◽  
Oxidative Stress Response

ABSTRACT We characterized the oxidative stress response of Candida glabrata to better understand the virulence of this fungal pathogen. C. glabrata could withstand higher concentrations of H2O2 than Saccharomyces cerevisiae and even Candida albicans. Stationary-phase cells were extremely resistant to oxidative stress, and this resistance was dependent on the concerted roles of stress-related transcription factors Yap1p, Skn7p, and Msn4p. We showed that growing cells of C. glabrata were able to adapt to high levels of H2O2 and that this adaptive response was dependent on Yap1p and Skn7p and partially on the general stress transcription factors Msn2p and Msn4p. C. glabrata has a single catalase gene, CTA1, which was absolutely required for resistance to H2O2 in vitro. However, in a mouse model of systemic infection, a strain lacking CTA1 showed no effect on virulence.

Roles of Cch1 and Mid1 in Morphogenesis, Oxidative Stress Response and Virulence in Candida albicans

2012 ◽  
Vol 174 (5-6) ◽  
pp. 359-369 ◽  
Author(s):  
Qilin Yu ◽  
Hui Wang ◽  
Xinxin Cheng ◽  
Ning Xu ◽  
Xiaohui Ding ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Candida Albicans ◽  
Stress Response ◽  
Oxidative Stress Response

scholarly journals Deletion of the fungus specific protein phosphatase Z1 exaggerates the oxidative stress response in Candida albicans

BMC Genomics ◽  
2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Krisztina Szabó ◽  
Ágnes Jakab ◽  
Szilárd Póliska ◽  
Katalin Petrényi ◽  
Katalin Kovács ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Candida Albicans ◽  
Stress Response ◽  
Protein Phosphatase ◽  
Transcript Level ◽  
Opportunistic Pathogen ◽  
Sublethal Concentration ◽  
Specific Protein ◽  
Oxidative Stress Response ◽  
Short Term Treatment

Abstract Background Candida albicans is an opportunistic pathogen which is responsible for widespread nosocomial infections. It encompasses a fungus specific serine/threonine protein phosphatase gene, CaPPZ1 that is involved in cation transport, cell wall integrity, oxidative stress response, morphological transition, and virulence according to the phenotypes of the cappz1 deletion mutant. Results We demonstrated that a short-term treatment with a sublethal concentration of tert-butyl hydroperoxide suppressed the growth of the fungal cells without affecting their viability, both in the cappz1 mutant and in the genetically matching QMY23 control strains. To reveal the gene expression changes behind the above observations we carried out a global transcriptome analysis. We used a pilot DNA microarray hybridization together with extensive RNA sequencing, and confirmed our results by quantitative RT-PCR. Novel functions of the CaPpz1 enzyme and oxidative stress mechanisms have been unraveled. The numbers of genes affected as well as the amplitudes of the transcript level changes indicated that the deletion of the phosphatase sensitized the response of C. albicans to oxidative stress conditions in important physiological functions like membrane transport, cell surface interactions, oxidation-reduction processes, translation and RNA metabolism. Conclusions We conclude that in the wild type C. albicans CaPPZ1 has a protective role against oxidative damage. We suggest that the specific inhibition of this phosphatase combined with mild oxidative treatment could be a feasible approach to topical antifungal therapy.

The oxidative stress response of the opportunistic fungal pathogen Candida glabrata

2014 ◽  
Vol 31 (1) ◽  
pp. 67-71 ◽  
Author(s):  
Marcela Briones-Martin-Del-Campo ◽  
Emmanuel Orta-Zavalza ◽  
Jacqueline Juarez-Cepeda ◽  
Guadalupe Gutierrez-Escobedo ◽  
Israel Cañas-Villamar ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Stress Response ◽  
Fungal Pathogen ◽  
Candida Glabrata ◽  
Oxidative Stress Response ◽  
Opportunistic Fungal Pathogen

scholarly journals The Iron-Dependent Regulation of the Candida albicans Oxidative Stress Response by the CCAAT-Binding Factor

PLoS ONE ◽  
2017 ◽  
Vol 12 (1) ◽  
pp. e0170649 ◽  
Author(s):  
Ananya Chakravarti ◽  
Kyle Camp ◽  
David S. McNabb ◽  
Inés Pinto
Keyword(s):  
Oxidative Stress ◽  
Candida Albicans ◽  
Stress Response ◽  
Oxidative Stress Response ◽  
Binding Factor
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