scholarly journals MicroRNAs provide the first evidence of genetic link between diapause and aging in vertebrates

2015 ◽  
Author(s):  
Luca Dolfi ◽  
Mario Baumgart ◽  
Marco Groth ◽  
Matthias Platzer ◽  
Alessandro Cellerino
Keyword(s):  
Embryonic Development ◽  
Mirna Expression ◽  
Genetic Networks ◽  
Early Embryonic Development ◽  
Mirna Regulation ◽  
Annual Species ◽  
Genetic Link ◽  
Annual Killifish ◽  
Nothobranchius Furzeri ◽  
Genetic Mechanisms

Diapause and aging are controlled by overlapping genetic mechanisms in C.elegans and these include microRNAs (miRNAs). Here, we investigated miRNA regulation in embryos of annual killifish that naturally undergo diapause to overcome desiccation of their habitats. We compared miRNA expression in diapausing and non-diapausing embryos in three independent lineages of killifish. We identified 13 miRNAs with similar regulation in all three lineages. One of these is miR-430, which is known as key regulator of early embryonic development in fish. We further tested whether this regulation overlaps with the aging-dependent regulation of miRNAs in one annual species: Nothobranchius furzeri. We found that miR-101a and miR-18a are regulated in the same direction during diapause and aging. These results provide the first evidence that overlapping genetic networks control diapause and aging in vertebrates and suggest that diapause mimics aging to some extent

Cytological observations on fertilization and early embryonic development in sea cucumber Apostichopus japonicus

2012 ◽  
Vol 36 (2) ◽  
pp. 272 ◽  
Author(s):  
Jie TAN ◽  
Hui-ling SUN ◽  
Fei GAO ◽  
Jing-ping YAN ◽  
Ying-hui DONG ◽  
...  
Keyword(s):  
Embryonic Development ◽  
Sea Cucumber ◽  
Apostichopus Japonicus ◽  
Early Embryonic Development

Studies on the early embryonic development of artificially-bred Siberian sturgeon(Acipenser baeri)

2010 ◽  
Vol 34 (5) ◽  
pp. 777-785 ◽  
Author(s):  
Wei SONG ◽  
Jia-kun SONG ◽  
Chun-xin FAN ◽  
Tao ZHANG ◽  
Bin WANG
Keyword(s):  
Embryonic Development ◽  
Siberian Sturgeon ◽  
Early Embryonic Development ◽  
Acipenser Baeri

scholarly journals Unfolded protein response triggers differential apoptotic mechanisms in ovaries and early embryos exposed to maternal type 1 diabetes

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Aslı Okan ◽  
Necdet Demir ◽  
Berna Sozen
Keyword(s):  
Embryonic Development ◽  
Er Stress ◽  
Unfolded Protein Response ◽  
Molecular Mechanisms ◽  
Early Embryonic Development ◽  
Unfolded Protein ◽  
Caspase 12 ◽  
Early Embryos ◽  
Protein Response

AbstractDiabetes mellitus (DM) has profound effects on the female mammalian reproductive system, and early embryonic development, reducing female reproductive outcomes and inducing developmental programming in utero. However, the underlying cellular and molecular mechanisms remain poorly defined. Accumulating evidence implicates endoplasmic reticulum (ER)-stress with maternal DM associated pathophysiology. Yet the direct pathologies and causal events leading to ovarian dysfunction and altered early embryonic development have not been determined. Here, using an in vivo mouse model of Type 1 DM and in vitro hyperglycaemia-exposure, we demonstrate the activation of ER-stress within adult ovarian tissue and pre-implantation embryos. In diabetic ovaries, we show that the unfolded protein response (UPR) triggers an apoptotic cascade by the co-activation of Caspase 12 and Cleaved Caspase 3 transducers. Whereas DM-exposed early embryos display differential ER-associated responses; by activating Chop in within embryonic precursors and Caspase 12 within placental precursors. Our results offer new insights for understanding the pathological effects of DM on mammalian ovarian function and early embryo development, providing new evidence of its mechanistic link with ER-stress in mice.

scholarly journals Role of miRNAs in Normal Endometrium and in Endometrial Disorders: Comprehensive Review

2021 ◽  
Vol 10 (16) ◽  
pp. 3457
Author(s):  
Kamila Kolanska ◽  
Sofiane Bendifallah ◽  
Geoffroy Canlorbe ◽  
Arsène Mekinian ◽  
Cyril Touboul ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Mirna Expression ◽  
Expression Patterns ◽  
Mirna Regulation ◽  
Rigorous Analysis ◽  
Sexual Hormones ◽  
Physiological Mechanisms ◽  
Normal Endometrium ◽  
Gynecological Disorders

The molecular responses to hormonal stimuli in the endometrium are modulated at the transcriptional and post-transcriptional stages. Any imbalance in cellular and molecular endometrial homeostasis may lead to gynecological disorders. MicroRNAs (miRNAs) are involved in a wide variety of physiological mechanisms and their expression patterns in the endometrium are currently attracting a lot of interest. miRNA regulation could be hormone dependent. Conversely, miRNAs could regulate the action of sexual hormones. Modifications to miRNA expression in pathological situations could either be a cause or a result of the existing pathology. The complexity of miRNA actions and the diversity of signaling pathways controlled by numerous miRNAs require rigorous analysis and findings need to be interpreted with caution. Alteration of miRNA expression in women with endometriosis has been reported. Thus, a potential diagnostic test supported by a specific miRNA signature could contribute to early diagnosis and a change in the therapeutic paradigm. Similarly, specific miRNA profile signatures are expected for RIF and endometrial cancer, with direct implications for associated therapies for RIF and adjuvant therapies for endometrial cancer. Advances in targeted therapies based on the regulation of miRNA expression are under evaluation.

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