scholarly journals Investigating the genetic regulation of the expression of 63 lipid metabolism genes in the pig skeletal muscle

2017 ◽  
Author(s):  
Rayner González-Prendes ◽  
Raquel Quintanilla ◽  
Marcel Amills
Keyword(s):  
Lipid Metabolism ◽  
Genetic Regulation ◽  
Gluteus Medius ◽  
Acid Activation ◽  
Nucleotide Polymorphisms ◽  
Microarray Gene Expression ◽  
Fatty Acid Activation ◽  
Lipoprotein Uptake ◽  
Lipid Metabolism Genes

AbstractDespite their potential involvement in the determination of fatness phenotypes, a comprehensive and systematic view about the genetic regulation of lipid metabolism genes is still lacking in pigs. Herewith, we have used a dataset of 104 pigs, with available genotypes for 62,163 single nucleotide polymorphisms and microarray gene expression measurements in the gluteus medius muscle, to investigate the genetic regulation of 63 genes with crucial roles in the uptake, transport, synthesis and catabolism of lipids. By performing an eQTL scan with the GEMMA software, we have detected 12 cis- and 18 trans-eQTL modulating the expression of 19 loci. Genes regulated by eQTL had a variety of functions such as the β-oxidation of fatty acids, lipid biosynthesis and lipolysis, fatty acid activation and desaturation, lipoprotein uptake, apolipoprotein assembly and cholesterol trafficking. These data provide a first picture about the genetic regulation of loci involved in porcine lipid metabolism.

scholarly journals Polymorphisms in Genes of Lipid Metabolism Are Associated with Type 2 Diabetes Mellitus and Periodontitis, as Comorbidities, and with the Subjects’ Periodontal, Glycemic, and Lipid Profiles

2021 ◽  
Vol 2021 ◽  
pp. 1-21
Author(s):  
Ingra G. Nicchio ◽  
Thamiris Cirelli ◽  
Rafael Nepomuceno ◽  
Marco A. R. Hidalgo ◽  
Carlos Rossa ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Lipid Metabolism ◽  
Lipid Profiles ◽  
Gene Marker ◽  
Nucleotide Polymorphisms ◽  
Glucose And Lipid Metabolism ◽  
Lipid Metabolism Genes

Background. Type 2 diabetes mellitus (T2DM) and periodontitis (P) commonly occur as comorbidities, but the commonalities in the genetic makeup of affected individuals is largely unknown. Since dyslipidemia is a frequent condition in these individuals, we investigate the association of genomic variations in genes involved in lipid metabolism with periodontal, glycemic, lipid profiles, and the association with periodontitis and T2DM (as comorbidities). Methods. Based on clinical periodontal examination and biochemical evaluation, 893 subjects were divided into T2DM+P (T2DM subjects also affected by periodontitis, n = 205 ), periodontitis ( n = 345 ), and healthy ( n = 343 ). Fourteen single-nucleotide polymorphisms (SNPs) were investigated: LDLR gene (rs5925 and rs688), APOB (rs676210, rs1042031, and rs693), ABCC8 (rs6544718 and 6544713), LPL (rs28524, rs3735964, and rs1370225), HNF1A (rs2650000), APOE (rs429358 and rs7412), and HNF4A (rs1800961). Multiple linear and logistic regressions (adjusted for covariates) were made for all populations and stratified by sex and smoking habits. Results. Individuals carrying APOB-rs1042031-CT (mainly women and never smokers) had a lower risk of developing periodontitis and T2DM (T2DM+P); altogether, this genotype was related with healthier glycemic, lipid, and periodontal parameters. Significant disease-phenotype associations with gene-sex interaction were also found for carriers of APOB-rs1676210-AG, HNF4A-rs1800961-CT, ABCC8-rs6544718-CT, LPL-rs13702-CC, and LPL-rs285-CT. Conclusions. Polymorphisms in lipid metabolism genes are associated with susceptibility to T2DM-periodontitis comorbidities, demonstrating gene-sex interaction. The APOB-rs1042031 was the most relevant gene marker related to glucose and lipid metabolism profiles, as well as with obesity and periodontitis.

scholarly journals Investigating the genetic regulation of the expression of 63 lipid metabolism genes in the pig skeletal muscle

2017 ◽  
Vol 48 (5) ◽  
pp. 606-610 ◽  
Author(s):  
R. González-Prendes ◽  
R. Quintanilla ◽  
M. Amills
Keyword(s):  
Skeletal Muscle ◽  
Lipid Metabolism ◽  
Genetic Regulation ◽  
Lipid Metabolism Genes

scholarly journals The Interaction between Pesticide Use and Genetic Variants Involved in Lipid Metabolism on Prostate Cancer Risk

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Gabriella Andreotti ◽  
Stella Koutros ◽  
Sonja I. Berndt ◽  
Kathryn Hughes Barry ◽  
Lifang Hou ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Lipid Metabolism ◽  
Cancer Risk ◽  
Pesticide Exposure ◽  
Prostate Cancer Risk ◽  
Health Study ◽  
Nucleotide Polymorphisms ◽  
High Exposure ◽  
Prostate Carcinogenesis ◽  
Lipid Metabolism Genes

Background. Lipid metabolism processes have been implicated in prostate carcinogenesis. Since several pesticides are lipophilic or are metabolized via lipid-related mechanisms, they may interact with variants of genes in the lipid metabolism pathway.Methods. In a nested case-control study of 776 cases and 1444 controls from the Agricultural Health Study (AHS), a prospective cohort study of pesticide applicators, we examined the interactions between 39 pesticides (none, low, and high exposure) and 220 single nucleotide polymorphisms (SNPs) in 59 genes. The false discovery rate (FDR) was used to account for multiple comparisons.Results. We found 17 interactions that displayed a significant monotonic increase in prostate cancer risk with pesticide exposure in one genotype and no significant association in the other genotype. The most noteworthy association was forALOXE3rs3027208 and terbufos, such that men carrying the T allele who were low users had an OR of 1.86 (95% CI = 1.16–2.99) and high users an OR of 2.00 (95% CI = 1.28–3.15) compared to those with no use of terbufos, while men carrying the CC genotype did not exhibit a significant association.Conclusion. Genetic variation in lipid metabolism genes may modify pesticide associations with prostate cancer; however our results require replication.

Development of a simple method for the determination of single nucleotide polymorphisms

2010 ◽  
Vol 34 (8) ◽  
pp. S75-S75
Author(s):  
Weifeng Zhu ◽  
Zhuoqi Liu ◽  
Daya Luo ◽  
Xinyao Wu ◽  
Fusheng Wan
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Nucleotide Polymorphisms ◽  
Simple Method ◽  
Single Nucleotide

scholarly journals Dysregulated liver lipid metabolism and innate immunity associated with hepatic steatosis in neonatal BBdp rats and NOD mice

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
D. Serrano ◽  
J. A. Crookshank ◽  
B. S. Morgan ◽  
R. W. Mueller ◽  
M.-F. Paré ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Lipid Metabolism ◽  
Hepatic Steatosis ◽  
Liver Lipid ◽  
Nod Mice ◽  
Gene Signature ◽  
Enhanced Expression ◽  
Liver Lipid Metabolism ◽  
Hepatic Innate Immunity ◽  
Lipid Metabolism Genes

Abstract In a previous study we reported that prediabetic rats have a unique gene signature that was apparent even in neonates. Several of the changes we observed, including enhanced expression of pro-inflammatory genes and dysregulated UPR and metabolism genes were first observed in the liver followed by the pancreas. In the present study we investigated further early changes in hepatic innate immunity and metabolism in two models of type 1 diabetes (T1D), the BBdp rat and NOD mouse. There was a striking increase in lipid deposits in liver, particularly in neonatal BBdp rats, with a less striking but significant increase in neonatal NOD mice in association with dysregulated expression of lipid metabolism genes. This was associated with a decreased number of extramedullary hematopoietic clusters as well as CD68+ macrophages in the liver of both models. In addition, PPARɣ and phosphorylated AMPKα protein were decreased in neonatal BBdp rats. BBdp rats displayed decreased expression of antimicrobial genes in neonates and decreased M2 genes at 30 days. This suggests hepatic steatosis could be a common early feature in development of T1D that impacts metabolic homeostasis and tolerogenic phenotype in the prediabetic liver.

Fatty Acid Activation and Temperature Perturbation of Rat Brain Microsomal Phospholipase D

1982 ◽  
Vol 39 (2) ◽  
pp. 299-305 ◽  
Author(s):  
Robert Chalifour ◽  
Julian N. Kanfer
Keyword(s):  
Fatty Acid ◽  
Rat Brain ◽  
Phospholipase D ◽  
Temperature Perturbation ◽  
Acid Activation ◽  
Fatty Acid Activation

scholarly journals Fatty acid activation in carcinogenesis and cancer development: Essential roles of long‑chain acyl‑CoA synthetases (Review)

2018 ◽  
Author(s):  
Yue Tang ◽  
Jing Zhou ◽  
Shing Hooi ◽  
Yue‑Ming Jiang ◽  
Guo‑Dong Lu
Keyword(s):  
Fatty Acid ◽  
Cancer Development ◽  
Acid Activation ◽  
Chain Acyl ◽  
Fatty Acid Activation ◽  
Long Chain

scholarly journals Effect of BCHE single nucleotide polymorphisms on lipid metabolism markers in women

2017 ◽  
Vol 40 (2) ◽  
pp. 408-414 ◽  
Author(s):  
Jéssica de Oliveira ◽  
Luciane Viater Tureck ◽  
Willian dos Santos ◽  
Louise Farah Saliba ◽  
Caroline Schovanz Schenknecht ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Single Nucleotide Polymorphisms ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide

scholarly journals Mechanistic Studies of Fatty Acid Activation by CYP152 Peroxygenases Reveal Unexpected Desaturase Activity

ACS Catalysis ◽  
2018 ◽  
Vol 9 (1) ◽  
pp. 565-577 ◽  
Author(s):  
Mathias Pickl ◽  
Sara Kurakin ◽  
Fabián G. Cantú Reinhard ◽  
Philipp Schmid ◽  
Alexander Pöcheim ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Desaturase Activity ◽  
Acid Activation ◽  
Mechanistic Studies ◽  
Fatty Acid Activation
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