scholarly journals Assessing Knowledge, Attitudes, and Practices towards Causal Directed Acyclic Graphs among Epidemiologists and Medical Researchers: a qualitative research project

Author(s):  
Ruby Barnard-Mayers ◽  
Ellen Childs ◽  
Laura Corlin ◽  
Ellen Caniglia ◽  
Matthew P Fox ◽  
...  

AbstractBackgroundEstimating the strength of causal effects is an important component of epidemiologic research, and causal graphs provide a key tool for optimizing the validity of these effect estimates. Although a large literature exists on the mathematical theory underlying the use of causal graphs, including directed acyclic graphs, to assess and describe causal assumptions, and translate these assumptions into appropriate statistical analysis plans, less literature exists to aid applied researchers in understanding how best to develop and use causal graphs in their research projects.ObjectiveWe sought to understand this gap by surveying practicing epidemiologists and medical researchers on their knowledge, level of interest, attitudes, and practices towards the use of causal graphs in applied epidemiology and health research.MethodsWe conducted an anonymous survey of self-identified epidemiology and health researchers via Twitter and via the Society of Epidemiologic Research membership listserv. The survey was conducted using Qualtrics and asked a series of multiple choice and open-ended questions about causal graphs.ResultsIn total, 439 responses were collected. Overall, 62% reported being comfortable with using causal graphs, and 60% reported using them ‘sometimes’, ‘often’, or ‘always’ in their research. About 70% of respondents had received formal training on causal graphs (typically causal directed acyclic graphs). Having received any training appeared to improve comprehension of the underlying assumptions of causal graphs. Forty percent of respondents who did not use causal graphs reported lack of knowledge as a barrier. Of the participants who did not use DAGs, 39% expressed that trainings, either in-person or online, would be useful resources to help them use causal graphs more often in their research.ConclusionCausal graphs are of interest to epidemiologists and medical researchers, but there are several barriers to their uptake. Additional training and clearer guidance are needed. In addition, methodological developments regarding visualization of effect measure modification and interaction on causal graphs is needed.

Author(s):  
Michael Webster-Clark ◽  
Alexander Breskin

Abstract Directed acyclic graphs (DAGs) have had a major impact on the field of epidemiology by providing straightforward graphical rules for determining when estimates are expected to lack causally interpretable internal validity. Much less attention has been paid, however, to what DAGs can tell researchers about effect measure modification and external validity. In this work, we describe 2 rules based on DAGs related to effect measure modification. Rule 1 states that if a variable, $P$, is conditionally independent of an outcome, $Y$, within levels of a treatment, $X$, then $P$ is not an effect measure modifier for the effect of $X$ on $Y$ on any scale. Rule 2 states that if $P$ is not conditionally independent of $Y$ within levels of $X$, and there are open causal paths from $X$ to $Y$ within levels of $P$, then $P$ is an effect measure modifier for the effect of $X$ on $Y$ on at least 1 scale (given no exact cancelation of associations). We then show how Rule 1 can be used to identify sufficient adjustment sets to generalize nested trials studying the effect of $X$ on $Y$ to the total source population or to those who did not participate in the trial.


2021 ◽  
Author(s):  
Ruby Barnard-Mayers ◽  
Hiba Kouser ◽  
Jamie A. Cohen ◽  
Katherine Tassiopoulos ◽  
Ellen C. Caniglia ◽  
...  

Background: Developing a causal graph is an important step in etiologic research planning and can be used to highlight data flaws and irreparable bias and confounding. Recent findings have suggested that the human papillomavirus (HPV) vaccine is less effective in protection against HPV associated disease in a population of girls living with HIV. Development: In order to understand the relationship between HIV status and HPV vaccine effectiveness, it is important to outline the key assumptions of the causal mechanisms before designing a study to investigate the effect of the HPV vaccine in girls living with HIV infection. Application: We present a causal graph to describe our assumptions and proposed approach to explore this relationship. We hope to obtain feedback on our assumptions prior to data analysis and exemplify the process for designing an etiologic study.Conclusion: The approach we lay out in this paper may be useful for other researchers who have an interest in using causal graphs to describe and assess assumptions in their own research prior to undergoing data collection and/or analysis.


Author(s):  
Balaji D. More ◽  
Anju B. More ◽  
Harshad Sutar

Background: The knowledge, attitudes and practices of scientific authorship vary across different regions. We conducted this study to understand this variation among medical researchers in India.Methods: An anonymous web-based researcher-survey invited all faculty, researchers and PhD students at Pacific institute of Medical sciences, Udaipur, India. The study design and the questionnaire were approved by the institutional ethics committee.  Basic information on study was given to obtain consent for participation. The 30 questions on authorship experience and related issues were based on the statements in International Committee of Medical Journal Editors (ICMJE) and other national and international recommendations on authorship. Participants reported their authorship experiences and answered multiple choice questionnaires.Results: The response rate was 36.36% among the participants, who were post-graduate with up to 10 years of research experience. About 62.5% had not been appropriately acknowledged as authors at some point during their career. Contributors (authorship) and ethical peer review is perceived as the key principle of research integrity. Though, single authorship was regarded as more significant, interdisciplinary management of diseases increases number of co-authors. A platform to challenge authorship, declaration of contribution in authorship and shared responsibility of co-authors in case of fraudulent publication was majority opinion.Conclusions: Almost 50 of the participant medical researchers had knowledge of formal authorship requirements. Majority agreed with the criteria would help in decreasing the authorship dispute in the medical research. There is need for awareness and continuous education on these criteria.


2020 ◽  
Vol 69 (4) ◽  
Author(s):  
Ligia B. da Silva ◽  
Mariana Gabriel ◽  
Márcia M. Marques ◽  
Fernanda C. Carrer ◽  
Flávia Gonçalves ◽  
...  

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