scholarly journals The role of the metabolic profile in mediating the relationship between body mass index and left ventricular mass in adolescents: analysis of a prospective cohort study

2020 ◽  
Author(s):  
Alice R Carter ◽  
Diana L. Santos Ferreira ◽  
Amy E Taylor ◽  
Deborah A Lawlor ◽  
George Davey Smith ◽  
...  
Keyword(s):  
Risk Factors ◽  
Body Mass Index ◽  
Left Ventricular Mass ◽  
Body Mass ◽  
Metabolic Profile ◽  
Left Ventricular ◽  
Resonance Spectroscopy ◽  
Metabolic Traits ◽  
Ventricular Mass

AbstractBackgroundWe aimed to quantify the role of the plasma metabolic profile in explaining the effect of adiposity on cardiac structure.MethodsBody mass index (BMI) was measured at age 11 in the Avon Longitudinal Study of Parents and Children. Left ventricular mass indexed to height2.7 (LVMI), was assessed by echocardiography at age 17. The metabolic profile was quantified via nuclear magnetic resonance spectroscopy at age 15.Multivariable confounder (maternal age, parity, highest qualification, maternal smoking, pre-pregnancy BMI, pre-pregnancy height, household social class and adolescent birthweight, adolescent smoking, fruit and vegetable consumption, physical activity) -adjusted linear regression estimated the association of BMI with LVMI and mediation by metabolic traits. We considered 156 metabolomic traits individually, jointly as principal components (PCs) explaining 95% of the variance in the NMR platform, and assessed whether the PCs for the metabolic traits added to the proportion of the association explained by established cardiovascular risk factors (systolic and diastolic blood pressure, insulin, triglycerides, low density lipoprotein, and glucose).ResultsA 1kg/m2 higher BMI was associated with a 0.70 g/m2.7 (0.53, 0.88) and 0.66 g/m2.7 (0.53, 0.79) higher LVMI in males (N=437) and females (N=536), respectively. Established risk factors explained 3% (95% CI: 2% to 5%) of this association in males, increasing to 10% (95% CI: 8%, 13%) when including metabolic PCs. In females, the standard risk factors explained 3% (95% CI: 2%, 5%) of the association, and did not increase when including the metabolic PCs.ConclusionThe addition of the NMR measured metabolic traits appear to mediate more of the effect of BMI on LVMI than the established risk factors alone in adolescent males, but not females.

scholarly journals Role of the Metabolic Profile in Mediating the Relationship Between Body Mass Index and Left Ventricular Mass in Adolescents: Analysis of a Prospective Cohort Study

2020 ◽  
Vol 9 (20) ◽  
Author(s):  
Alice R. Carter ◽  
Diana L. Santos Ferreira ◽  
Amy E. Taylor ◽  
Deborah A. Lawlor ◽  
George Davey Smith ◽  
...  
Keyword(s):  
Risk Factors ◽  
Body Mass Index ◽  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Principal Components ◽  
Metabolic Profile ◽  
Left Ventricular ◽  
Metabolic Traits ◽  
Nuclear Magnetic

Background We aimed to quantify the role of the plasma metabolic profile in explaining the effect of adiposity on cardiac structure. Methods and Results Body mass index (BMI) was measured at age 11 in the Avon Longitudinal Study of Parents and Children. Left ventricular mass indexed to height 2.7 (LVMI) was assessed by echocardiography at age 17. The metabolic profile was quantified via 1 H‐nuclear magnetic resonance spectroscopy at age 15. Multivariable confounder (maternal age, parity, highest qualification, maternal smoking, prepregnancy BMI, prepregnancy height, household social class, adolescent birthweight, adolescent smoking, fruit and vegetable consumption, and physical activity)–adjusted linear regression estimated the association of BMI with LVMI and mediation by metabolic traits. We considered 156 metabolomic traits individually and jointly as principal components explaining 95% of the variance in the nuclear magnetic resonance platform and assessed whether the principal components for the metabolic traits added to the proportion of the association explained by putative cardiovascular risk factors (systolic and diastolic blood pressures, insulin, triglycerides, low‐density lipoprotein cholesterol, and glucose). A 1 kg/m 2 higher BMI was associated with a 0.70 g/m 2.7 (95% CI, 0.53–0.88 g/m 2.7 ) and 0.66 g/m 2.7 (95% CI, 0.53–0.79 g/m 2.7 ) higher LVMI in males (n=437) and females (n=536), respectively. Putative risk factors explained 3% (95% CI, 2%–5%) of this association in males, increasing to 10% (95% CI, 8%–13%) when including metabolic principal components. In females, the standard risk factors explained 3% (95% CI, 2%–5%) of the association and did not increase when including the metabolic principal components. Conclusions The addition of the nuclear magnetic resonance‐measured metabolic traits appears to mediate more of the association of BMI on LVMI than the putative risk factors alone in adolescent males, but not females.

Left ventricular mass by echocardiographic measures in children and adolescents

2012 ◽  
Vol 23 (5) ◽  
pp. 727-737 ◽  
Author(s):  
Sudhir K. Mehta
Keyword(s):  
Body Mass Index ◽  
Children And Adolescents ◽  
Surface Area ◽  
Left Ventricular Mass ◽  
Body Surface Area ◽  
Body Mass ◽  
Body Surface ◽  
Left Ventricular ◽  
Ventricular Mass ◽  
Cardiovascular Morbidity And Mortality

AbstractBackgroundRecent evidence in adults suggests that left ventricular mass measured as left ventricular mass/height1.7 predicts cardiovascular morbidity and mortality better than the two widely used indices, left ventricular mass/body surface area and left ventricular mass/height2.7. Standards of left ventricular mass/height1.7 have not been reported in children, for whom, owing to lack of significant cardiovascular morbidity and mortality, body mass index has traditionally been used as a potential cardiovascular risk factor.MethodsIn this retrospective study, 692 clinically normal children aged 1 day to 18 years underwent detailed echocardiographic assessment to assess whether any of the left ventricular mass indices – left ventricular mass/height1.7, left ventricular mass/body surface area, and left ventricular mass/height2.7 – are associated with obesity as measured by body mass index. Correlations, t-tests, and linear regressions were used for statistical testing.ResultsLeft ventricular mass/height1.7 was better correlated (R2 = 0.36) with body mass index than left ventricular mass/body surface area (R2 = 0.179) and left ventricular mass/height2.7 (R2 = 0.006), although all three dependent variables show a significant correlation (p < 0.035). In addition, a higher percentage of obese patients were noted to have elevated left ventricular mass as measured by left ventricular mass/height1.7 than by the other two methods.ConclusionsLeft ventricular mass/height1.7 is a reliable indicator of obesity-associated left ventricular hypertrophy. Left ventricular mass/height1.7 can be used conveniently during transitions from youth to adults for long-term follow-up. These findings support the importance of including left ventricular mass/height1.7 in future studies of cardiovascular risks and preventive strategies in children and adolescents.

scholarly journals Adiponectin correlates with body mass index and to a lesser extent with left ventricular mass in dialysis patients

2018 ◽  
Vol 25 (4) ◽  
pp. 501-511 ◽  
Author(s):  
Afrim Poniku ◽  
Gani Bajraktari ◽  
Shpend Elezi ◽  
Pranvera Ibrahimi ◽  
Michael Y. Henein
Keyword(s):  
Body Mass Index ◽  
Left Ventricular Mass ◽  
Body Mass ◽  
Left Ventricular ◽  
Dialysis Patients ◽  
Ventricular Mass

Relationship of Left Ventricular Mass to Insulin Sensitivity and Body Mass Index in Healthy Individuals

2006 ◽  
Vol 61 (4) ◽  
pp. 398-406 ◽  
Author(s):  
Haksun EBINÇ ◽  
Fatma Ayerden EBINÇ ◽  
Zübeyde Nur ÖZKURT ◽  
Tolga DOGRU ◽  
Murat YILMAZ
Keyword(s):  
Body Mass Index ◽  
Insulin Sensitivity ◽  
Left Ventricular Mass ◽  
Body Mass ◽  
Left Ventricular ◽  
Healthy Individuals ◽  
Ventricular Mass ◽  
Relationship Of

scholarly journals Effect of haemodynamic and metabolic predictors on echocardiographic left ventricular mass in non-diabetic hypertensive patients

1970 ◽  
Vol 8 (2) ◽  
pp. 173-178
Author(s):  
N Gupta ◽  
P Karki ◽  
S Sharma ◽  
N Shrestha ◽  
P Acharya
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Stroke Volume ◽  
Left Ventricular Mass ◽  
Body Mass ◽  
Left Ventricular ◽  
Metabolic Factors ◽  
Hypertensive Patients ◽  
Ventricular Mass ◽  
Lv Mass

Background: Left ventricular hypertrophy is a forerunner of coronary heart disease, congestive cardiac failure, stroke and may also lead to sudden death. Estimation of left ventricular mass by echocardiography offers prognostic information better than the evaluation of traditional cardiovascular risk factors. Objective: The aim of this study was to determine the relative contributions of haemodynamic and metabolic factors affecting left ventricular mass in non-diabetic patients with essential hypertension. Material and methods: 100 non-diabetic hypertensive patients were taken. The association between age, gender, smoking, alcohol, height, weight, heart rate, clinic blood pressure, fasting blood glucose, lipid profile, haemoglobin, body mass index and stroke volume with LV mass was studied. Left ventricular mass was measured by using standard M-mode echocardiography measurement obtained by way of standard recommended by the American Society of Echocardiography. Results: Left ventricular mass was analyzed as a continuous variable. In males body mass index (r=.35, p<.004) and stroke volume(r=-.26, p<.039) were significantly correlated with LV mass. In females body weight was significantly related to left ventricular mass(r=.36, p<.02). The independent association between significant factors and left ventricular mass was assessed by stepwise multivariate logistic regression. Body mass index and systolic blood pressure came as independent determinants of left ventricular mass in all patients. A maximum of 13% of left ventricular mass variability could be explained by these two factors. Conclusion: In untreated patients with hypertension patient's body mass index and systolic blood pressure are independent predictors of left ventricular mass after adjustment for other haemodynamic and metabolic factors. They explain a maximum of 13% of left ventricular mass variability. More knowledge is needed about factors that may alter cardiac morphology in the evolution of hypertensive patients. Key words: Echocardiography; Haemodynamic; Metabolic Factors; Left Ventricular Mass; Non-diabetic; Hypertensive DOI: 10.3126/kumj.v8i2.3553 Kathmandu University Medical Journal (2010), Vol. 8, No. 2, Issue 30, 173-178

scholarly journals Changes in Left Ventricular Mass and Geometry in the Older Adults: Role of Body Mass and Central Obesity

2019 ◽  
Vol 32 (10) ◽  
pp. 1318-1325 ◽  
Author(s):  
Tetz C. Lee ◽  
Zhezhen Jin ◽  
Shunichi Homma ◽  
Koki Nakanishi ◽  
Mitchell S.V. Elkind ◽  
...  
Keyword(s):  
Older Adults ◽  
Left Ventricular Mass ◽  
Body Mass ◽  
Central Obesity ◽  
Left Ventricular ◽  
Ventricular Mass

scholarly journals Anger Types: Heritability and Relation to Blood Pressure, Body Mass Index, and Left Ventricular Mass

2008 ◽  
Vol 10 (9) ◽  
pp. 700-706 ◽  
Author(s):  
Lillian Gleiberman ◽  
Tiffany A. Greenwood ◽  
Amy Luke ◽  
Maria C. Delgado ◽  
Alan B. Weder
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Left Ventricular Mass ◽  
Body Mass ◽  
Left Ventricular ◽  
Ventricular Mass
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