“Clinical, Radiological and Therapeutic Characteristics of Patients with COVID-19 in Saudi Arabia”

AbstractBACKGROUNDCoronavirus disease 2019 (COVID-19) is a rapidly spreading global pandemic. The clinical characteristics of COVID-19 has been reported; however, there are limited researches that investigated the clinical characteristics of COVID-19 in the Middle East. The aim of this study is to investigate the clinical, radiological and therapeutic characteristics of patients diagnosed with COVID19 in Saudi Arabia.METHODSThis study is a retrospective single-centre case series study. We extracted data for patients who were admitted to the Al-Noor Specialist hospital with a PCR confirmed SARS-COV-2 between 12th and 31st of March 2020. Descriptive statistics were used to describe patients’ characteristics. Continuous data were reported as mean ± SD. Chi-squared test/Fisher test were used as appropriate to compare proportions for categorical variables.RESULTSA total of 150 patients were hospitalised for COVID-19 during the study period. The mean age was 46.1 years (SD: 15.3 years). Around 61.0% (n= 90) were males and six patients (3.9%) reported working in the healthcare sector. The most common comorbidities were hypertension (28.8%, n= 42) and diabetes mellitus (26.0%, n= 38). The majority of the patients, 64.4% (n = 96) had a recent contact history with a COVID patient. Regarding the severity of the hospitalised patients, 105 patients (70.0%) were mild, 29 (19.3%) were moderate, and 16 patients (10.7%) were severe or required ICU care. From the 105 mild patients, around 31.3% (n= 47) were asymptomatic.CONCLUSIONThis case series provides clinical, radiological and therapeutic characteristics of hospitalised patients with confirmed COVID-19 in Saudi Arabia.

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Maternal and Perinatal Outcomes in Women with Eclampsia by Mode of delivery at Riley Mother Baby Hospital: A longitudinal case-series study

10.21203/rs.3.rs-61697/v1 ◽

2020 ◽

Author(s):

Philippe Amubuomombe Poli ◽

Koech MMED Irene ◽

Richard Mogeni ◽

Ann Mwangi ◽

Andrew Cheruiyot ◽

...

Keyword(s):

Mode Of Delivery ◽

Case Series ◽

Perinatal Outcomes ◽

Adverse Outcomes ◽

Sub Saharan Africa ◽

Categorical Variables ◽

Chi Square ◽

Case Series Study ◽

Chi Square Test ◽

Series Study

Abstract Background Eclampsia, considered a serious complication of preeclampsia, remains a life-threatening condition among pregnant women. It accounts for 12% of maternal deaths and 16–31% of perinatal deaths worldwide. Most deaths from eclampsia occurred in resource-limited settings of sub-Saharan Africa. This study was performed to determine the optimum mode of delivery, as well as factors associated with the mode of delivery, in women admitted with eclampsia at Riley Mother and Baby Hospital. Methods This was a hospital-based longitudinal case-series study conducted at the largest and busiest obstetric unit of the tertiary hospital of western Kenya. Maternal and perinatal variables, such as age, parity, medications, initiation of labour, mode of delivery, admission to the intensive care unit, admission to the newborn care unit, organ injuries, and mortality, were analysed using the Statistical Package for the Social Sciences software version 20.0. Quantitative data were described using frequencies and percentages. The significance of the obtained results was judged at the 5% level. The chi-square test was used for categorical variables, and Fisher’s exact test or the Monte Carlo correction was used for correction of the chi-square test when more than 20% of the cells had an expected count of less than 5. Results During the study period, 53 patients diagnosed with eclampsia were treated and followed up to 6 weeks postpartum. There was zero maternal mortality; however, perinatal mortality was reported in 9.4%. Parity was statistically associated with an increased odds of adverse perinatal outcomes (p = 0.004, OR = 9.1, 95% CI = 2.0-40.8) and caesarean delivery (p = 0.020, OR = 4.7, 95% CI = 1.3–17.1). In addition, the induction of labour decreased the risk of adverse outcomes (p = 0.232, OR = 0.3, 95% CI = 0.1-2.0). Conclusion There is no benefit of emergency caesarean section for women with eclampsia. Instead, it increases the risk of perinatal adverse outcomes, including the risk of admission to the newborn unit and perinatal death.

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The clinical characteristics of melanoma with BRAF V600R mutation: a case series study

Melanoma Research ◽

10.1097/cmr.0000000000000630 ◽

2020 ◽

Vol 30 (1) ◽

pp. 107-112 ◽

Cited By ~ 2

Author(s):

Karen A. Malkhasyan ◽

Sydney L. Rooney ◽

Anthony N. Snow ◽

Brian L. Swick ◽

Mohammed M. Milhem ◽

...

Keyword(s):

Clinical Characteristics ◽

Case Series ◽

Case Series Study ◽

Series Study

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Adverse drug reactions in SARS-CoV-2 hospitalised patients: a case-series with a focus on drug–drug interactions

Internal and Emergency Medicine ◽

10.1007/s11739-020-02586-8 ◽

2020 ◽

Author(s):

Giada Crescioli ◽

Valentina Brilli ◽

Cecilia Lanzi ◽

Andrea Burgalassi ◽

Alessandra Ieri ◽

...

Keyword(s):

Adverse Drug Reactions ◽

Case Series ◽

University Hospital ◽

Drug Reactions ◽

Case Evaluation ◽

Hospitalised Patients ◽

Number Of Patients ◽

Case Series Study ◽

Caucasian Patients ◽

Series Study

AbstractDue to the need of early and emergency effective treatments for COVID-19, less attention may have been paid to their safety during the global emergency. In addition, characteristics of drug–drug interaction (DDI)-related adverse drug reactions (ADRs) in COVID-19 patients have not yet been studied in depth. The aim of the present case-series study is to describe clinical and pharmacological characteristics of SARS-CoV-2 hospitalised patients, focusing on ADRs, particularly those related to DDIs. We evaluated all reports of COVID-19 medication-related ADRs collected within the COVID-19 Units of Careggi University Hospital, Florence (Italy), between January 1st and 31st May 2020. Information regarding COVID-19 medications, patients’ demographic and clinical characteristics, concomitant drugs, ADRs description and outcome, were collected. Each case was evaluated for the causality assessment and to identify the presence of DDIs. During the study period, 23 Caucasian patients (56.5% males, mean age 76.1 years) experienced one or more ADRs. The majority of them were exposed to polypharmacy and 17.4% presented comorbidities. ADRs were referred to cardiovascular, psychiatric and gastrointestinal disorders. The most frequently reported preferred term was QT prolongation (mean QT interval 496.1 ms). ADRs improved or resolved completely in 60.8% of cases. For all patients, a case-by-case evaluation revealed the presence of one or more DDIs, especially those related to pharmacokinetic interactions. Despite the small number of patients, our evidence underline the clinical burden of DDIs in SARS-CoV-2 hospitalised patients and the risk of unexpected and uncommon psychiatric ADRs.

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Childhood strokes in China describing clinical characteristics, risk factors and performance indicators: a case-series study

Stroke and Vascular Neurology ◽

10.1136/svn-2021-001062 ◽

2021 ◽

pp. svn-2021-001062

Author(s):

Yaxian Deng ◽

Gaifen Liu ◽

Guitao Zhang ◽

Juanyu Xu ◽

Chunmei Yao ◽

...

Keyword(s):

Risk Factors ◽

Clinical Characteristics ◽

Age At Onset ◽

Case Series ◽

Haemorrhagic Stroke ◽

Epidemiological Studies ◽

Neurological Deficits ◽

Retrospective Case ◽

Case Series Study ◽

Series Study

AimTo investigate clinical characteristics, risk factors (RFs), neurologic deficits and medical care provided in children who had a stroke in China.MethodsWe conducted a retrospective case-series study using the medical records of children aged 1 month to 18 years with arterial ischaemic stroke (AIS) or haemorrhagic stroke (HS) (with the entry codes I60, I61, I62, I63 (ICD-10)), who were admitted to different hospitals in Beijing, between January 2018 and December 2018. We obtained the following information from the charts: demographic characteristics, clinical presentations, RFs for paediatric stroke, laboratory examination, neuroimaging records and neurologic sequelae.ResultsWe identified 312 first admissions for stroke (172 AIS and 140 HS). The mean age at onset was 8.6±3.9 years for patients who had an AIS and 8 (5–13) years for patients who had an HS. There were more males than females in both groups (AIS: 59.88% vs 40.12%; HS: 52.14% vs 47.86%). A known aetiology was identified in 92.44% and 86.43% of patients who had an AIS and HS, respectively. The leading cause of AIS was cerebrovascular diseases including moyamoya (68.6%), while that for HS was arteriovenous malformation (51.43%). The most common initial clinical presentation was hemiplegia (86.05%) in patients who had an AIS and headache (67.86%) in patients who had an HS. The use of healthcare, including acute treatment (antithrombotic in 17.44%, anticoagulant in 5.23%) and secondary prevention (antithrombotic in 6.39%, anticoagulant in 1.16%), varied and was significantly lower among patients who had an AIS. The most common complications were epilepsy (22.09%) and pneumonia (4.65%) in patients who had an AIS and epilepsy (17.14%) and hydrocephalus (12.14%) in patients who had an HS. Neurological deficits occurred in 62.8% of patients who had an AIS and 72.86% of patients who had an HS.ConclusionCerebral arteriopathy was a major RF for both AIS and HS in children living in China. Large epidemiological studies are required to identify RFs to prevent stroke as well as appropriate interventions.

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Management of palatal myoclonic tinnitus based on clinical characteristics: a large case series study

Acta Oto-Laryngologica ◽

10.1080/00016489.2020.1749724 ◽

2020 ◽

Vol 140 (7) ◽

pp. 553-557

Author(s):

Jung Mee Park ◽

Woo Jin Kim ◽

Jae Sang Han ◽

So Young Park ◽

Shi Nae Park

Keyword(s):

Clinical Characteristics ◽

Case Series ◽

Case Series Study ◽

Large Case Series ◽

Series Study ◽

Large Case

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Clinical characteristics and overuse patterns of medication overuse headache: Retrospective case-series study

Clinical Neurology and Neurosurgery ◽

10.1016/j.clineuro.2017.10.029 ◽

2017 ◽

Vol 163 ◽

pp. 124-127 ◽

Cited By ~ 3

Author(s):

Karolis Kluonaitis ◽

Elena Petrauskiene ◽

Kristina Ryliskiene

Keyword(s):

Clinical Characteristics ◽

Medication Overuse ◽

Medication Overuse Headache ◽

Case Series ◽

Retrospective Case ◽

Retrospective Case Series ◽

Case Series Study ◽

Series Study

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Non-small-cell lung cancer (NSCLC) harboring driver mutation (EGFR mutation or ALK translocations) with clinical characteristics and management in a real-life setting: a retrospective observational multicenter case series study

Ortadoğu Tıp Dergisi ◽

10.21601/ortadogutipdergisi.343275 ◽

2018 ◽

Vol 10 (3) ◽

pp. 361-367

Author(s):

Ali Murat Sedef ◽

Züleyha Çalıkuşu ◽

Yasemin Bakkal Temi ◽

Serkan Gökçay ◽

Hüseyin Mertsoylu ◽

...

Keyword(s):

Lung Cancer ◽

Clinical Characteristics ◽

Egfr Mutation ◽

Real Life ◽

Case Series ◽

Small Cell ◽

Small Cell Lung ◽

Real Life Setting ◽

Case Series Study ◽

Series Study

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Clinical outcomes in post-epikeratophakic eyes after removal of epikeratoplasty lenticule

BMC Ophthalmology ◽

10.1186/s12886-021-02109-9 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Young-ho Jung ◽

Mee Kum Kim

Keyword(s):

Epithelial Cell ◽

Clinical Characteristics ◽

Case Series ◽

Average Difference ◽

Retrospective Case ◽

Refractive Power ◽

Case Series Study ◽

Aphakic Eyes ◽

The Mean ◽

Series Study

Abstract Background Assessment of the optical outcome and adverse events in post-epikeratopathic eyes after removal of the epikeratoplasty lenticule (EKPL). Methods This was a retrospective case-series study of patients who underwent EKPL removal between 2002 and 2020. Ten eyes were included in the analysis. We compared the clinical characteristics of the patients before surgery, 6 months after surgery, before lenticular removal, and after removal, and reported optical or ocular surface complications. Results We removed EKPL due to the lenticular opacity in five eyes (50%), intraocular lens (IOL) insertion (n = 4, 40%) after cataract surgery (n = 3) or in aphakic eyes (n = 1), and lenticule-induced irregular astigmatism in one eye (10%). After EKPL removal, the mean refractive power of the cornea (Km) revealed a tendency to increase. Out of nine cases, six cases showed corneal steepening and three cases revealed corneal flattening. When the keratometric readings of pre-epikeratoplasty and post-lenticular removal were compared within the same case, the average difference was 5.1 D ± 4.0 (n = 8). Complications were observed in 3 of 10 cases (excessive corneal flatness, ectatic change, and abnormal epithelial cell ingrowth) after removal. Conclusions The surgeon should expect the corneal refractive power to steepen or flatten in some cases with abnormal astigmatism and irregularity. Epikeratophakic eyes may exhibit serious ectatic changes, and abnormal epithelial cell ingrowth after removal of epikeratophakic lenticules.

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