scholarly journals Applying SCA for high-accuracy cortical auditory ERPs in children

2020 ◽  
Author(s):  
S.E.P. Bruzzone ◽  
N. T. Haumann ◽  
M. Kliuchko ◽  
P. Vuust ◽  
E. Brattico
Keyword(s):  
Event Related Potentials ◽  
Component Analysis ◽  
High Accuracy ◽  
Clinical Settings ◽  
List Type ◽  
Spike Density ◽  
Individual Level ◽  
Related Potentials ◽  
Auditory Erps ◽  
The Individual

AbstractOverlapping neurophysiological signals are the main obstacle preventing from using cortical event-related potentials (ERPs) in clinical settings. Children ERPs are particularly affected by this problem, as their cerebral cortex is still maturing. To overcome this problem, we applied a new version of Spike-density Component Analysis (SCA), an analysis method recently introduced, to isolate with high accuracy the neural components of auditory ERP responses (AEPs) in 8-year-old children. Electroencephalography was used with 33 children to record AEPs to auditory stimuli varying in spectrotemporal features. Three different analysis approaches were adopted: the standard ERP analysis procedure, SCA with template-match (SCA-TM), and SCA with half-split average consistency (SCA-HSAC). SCA-HSAC most successfully allowed the extraction of AEPs for each child, revealing that the most consistent components were P1 and N2. An immature N1 component was also detected.Superior accuracy in isolating neural components at the individual level even in children was demonstrated for SCA-HSAC over other SCA approaches. Reliable methods of extraction of neurophysiological signals at the individual level are crucial for the application of cortical AEPs for routine diagnostic exams in clinical settings both in children and adults.HighlightsSpike-density component analysis (SCA) was validated on children ERPsSCA extracted overlapping neural components from auditory ERPs (AEPs)Child AEPs were modelled at the individual level

scholarly journals Recollection is more than retrieving context or source memory: evidence from ERPs of Recognition and Source Memory combinations

2020 ◽  
Author(s):  
Richard J. Addante ◽  
Alana Muller ◽  
Lindsey A. Sirianni
Keyword(s):  
Source Memory ◽  
Response Times ◽  
Event Related Potentials ◽  
Individual Variability ◽  
List Type ◽  
Opposite Pattern ◽  
Physiological Characterization ◽  
Related Potentials ◽  
The Individual

AbstractThe goal of this study was to investigate a relatively unstudied memory condition for paradoxical combinations of item + source memory confidence responses, which challenged the conventional views of the memory processes supporting item and source memory judgments. We studied instances in which people provided accurate source memory judgments (conventionally ascribed as representing recollection) after having first produced low- confidence item recognition hits for the same items (conventionally thought to reflect familiarity-based processing). This paradoxical combination does not fit traditional accounts of being recollection (because it had low-confidence recognition) nor accounts of familiarity (since it had accurate source memory), and event-related potentials (ERPs) were used to adjudicate which processes support these kinds of memories. ERP results were unlike the conventional ERP effects of memory, lacking both an FN400 and the parietal old-new effect (LPC), and instead exhibited a significant negative-going ERP effect occurring later in time (800-1200ms) in central-parietal sites. Behavioral measures of response times revealed a crossover interaction: low confident recognition hits were slower during recognition but faster during source memory when compared to the opposite pattern seen for instances of high confident hits. Results provide a comprehensive characterization of the individual variability of the FN400 and LPC effects of memory, while adding the behavioral and physiological characterization of a late negative-going ERP effect for accurate source memory without recollection. Conclusions indicated that episodic context could be retrieved independently from recollection, while suggesting a role for a process of context familiarity that is independent from item-familiarity.HighlightsRecollection is often defined as remembering the source or context of informationPrior work used ERPs to identify times when source memory did not have recollectionCurrent work replicated ERPs with added response times and measures of varianceRecollection was not evident in certain source memories, which had a negative ERPRecollection is independent of context and is more than just remembering sourcesGraphical Abstract

scholarly journals A New Perspective on Individual Reliability beyond Group Effects for Event-related Potentials: A Multisensory Investigation and Computational Modeling

2021 ◽  
Author(s):  
Zhenxing Hu ◽  
Zhiguo Zhang ◽  
Zhen Liang ◽  
Li Zhang ◽  
Linling Li ◽  
...  
Keyword(s):  
Comprehensive Evaluation ◽  
Event Related Potentials ◽  
Group Level ◽  
Individual Level ◽  
Latency Jitter ◽  
Related Potentials ◽  
New Perspective ◽  
The Individual ◽  
Test Retest Reliability ◽  
Group Effects

AbstractThe dominant approach in investigating the individual reliability for event-related potentials (ERPs) is to extract peak-related features at electrodes showing the strongest group effects. Such a peak-based approach implicitly assumes ERP components showing a stronger group effect are also more reliable, but this assumption has not been substantially validated and few studies have investigated the reliability of ERPs beyond peaks. In this study, we performed a rigorous evaluation of the test-retest reliability of ERPs collected in a multisensory and cognitive experiment from 82 healthy adolescents, each having two sessions. By comparing group effects and individual reliability, we found that a stronger group-level response in ERPs did not guarantee a higher reliability. Further, by simulating ERPs with a computational model, we found that the consistency between group-level ERP responses and individual reliability was modulated by inter-subject latency jitter and inter-trial variability. The current findings suggest that the conventional peak-based approach may underestimate the individual reliability in ERPs. Hence, a comprehensive evaluation of the reliability of ERP measurements should be considered in individual-level neurophysiological trait evaluation and psychiatric disorder diagnosis.

Scalp-Recorded Auditory P300 Event-Related Potentials in New-Onset Untreated Temporal Lobe Epilepsy

2007 ◽  
Vol 38 (3) ◽  
pp. 168-171 ◽  
Author(s):  
Wuttichai V. Chayasirisobhon ◽  
Sirichai Chayasirisobhon ◽  
Sue Nwe Tin ◽  
Ngoc Leu ◽  
Keo Tehrani ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Hippocampal Sclerosis ◽  
Event Related Potentials ◽  
Auditory Event ◽  
Auditory P300 ◽  
Related Potentials ◽  
Auditory Erps ◽  
Auditory Event Related Potentials ◽  
New Onset

We studied scalp-recorded auditory event-related potentials (ERPs) of 30 untreated patients with new-onset temporal lobe epilepsy and 30 age-and sex-matched normal controls. This study was designed to eliminate the effects of intractability of seizures and chronic use of antiepileptic drugs on P300 auditory ERPs. There were no statistically significant differences in both latency and amplitude of P300 between the two groups. Similar methods were also used to analyze component latencies and amplitudes of ERPs of 9 patients who had hippocampal sclerosis with comparison to control subjects. There were no statistically significant differences between these two groups as well. Our study evidently does not support temporal lobe sources of P300 scalp-recorded auditory ERPs. We also conclude that the scalp-recorded auditory ERPs procedure is not a useful tool to evaluate temporal lobe epilepsy.

scholarly journals Auditory attention alterations in migraine: a behavioral and MEG/EEG study

2019 ◽  
Author(s):  
Rémy Masson ◽  
Yohana Lévêque ◽  
Geneviève Demarquay ◽  
Hesham ElShafei ◽  
Lesly Fornoni ◽  
...  
Keyword(s):  
Event Related Potentials ◽  
Orienting Response ◽  
List Type ◽  
Top Down ◽  
Attention Task ◽  
Bottom Up ◽  
Attentional Processes ◽  
Related Potentials ◽  
The Right ◽  
Task Irrelevant

AbstractObjectivesTo evaluate alterations of top-down and/or bottom-up attention in migraine and their cortical underpinnings.Methods19 migraineurs between attacks and 19 matched control participants performed a task evaluating jointly top-down and bottom-up attention, using visually-cued target sounds and unexpected task-irrelevant distracting sounds. Behavioral responses and MEG/EEG were recorded. Event-related potentials and fields (ERPs/ERFs) were processed and source reconstruction was applied to ERFs.ResultsAt the behavioral level, neither top-down nor bottom-up attentional processes appeared to be altered in migraine. However, migraineurs presented heightened evoked responses following distracting sounds (orienting component of the N1 and Re-Orienting Negativity, RON) and following target sounds (orienting component of the N1), concomitant to an increased recruitment of the right temporo-parietal junction. They also displayed an increased effect of the cue informational value on target processing resulting in the elicitation of a negative difference (Nd).ConclusionsMigraineurs appear to display increased bottom-up orienting response to all incoming sounds, and an enhanced recruitment of top-down attention.SignificanceThe interictal state in migraine is characterized by an exacerbation of the orienting response to attended and unattended sounds. These attentional alterations might participate to the peculiar vulnerability of the migraine brain to all incoming stimuli.HighlightsMigraineurs performed as well as healthy participants in an attention task.However, EEG markers of both bottom-up and top-down attention are increased.Migraine is also associated with a facilitated recruitment of the right temporo-parietal junction.

scholarly journals On Optimal Allocation of Treatment/Condition Variance in Principal Component Analysis

2018 ◽  
Vol 7 (4) ◽  
pp. 50
Author(s):  
André Beauducel ◽  
Norbert Hilger
Keyword(s):  
Principal Component Analysis ◽  
Treatment Condition ◽  
Optimal Allocation ◽  
Principal Component ◽  
Event Related Potentials ◽  
Component Analysis ◽  
Necessary Condition ◽  
Condition Effect ◽  
Loading Patterns ◽  
Related Potentials

The allocation of a (treatment) condition-effect on the wrong principal component (misallocation of variance) in principal component analysis (PCA) has been addressed in research on event-related potentials of the electroencephalogram. However, the correct allocation of condition-effects on PCA components might be relevant in several domains of research. The present paper investigates whether different loading patterns at each condition-level are a basis for an optimal allocation of between-condition variance on principal components. It turns out that a similar loading shape at each condition-level is a necessary condition for an optimal allocation of between-condition variance, whereas a similar loading magnitude is not necessary.

Event-Related Potentials

2017 ◽  
Author(s):  
Marco Congendo ◽  
Fernando H. Lopes da Silva
Keyword(s):  
Principal Component ◽  
Event Related Potentials ◽  
Component Analysis ◽  
Statistical Testing ◽  
Time Averaging ◽  
Common Spatial Pattern ◽  
Topographic Analysis ◽  
Temporal Filtering ◽  
Related Potentials ◽  
Spatio Temporal

Event-related potentials (ERPs) can be elicited by a variety of stimuli and events in diverse conditions. This chapter covers the methodology of analyzing and quantifying ERPs in general. Basic models (additive, phase modulation and resetting, potential asymmetry) that account for the generation of ERPs are discussed. The principles and requirements of ensemble time averaging are presented, along with several univariate and multivariate methods that have been proposed to improve the averaging procedure: wavelet decomposition and denoising, spatial, temporal and spatio-temporal filtering. We emphasize basic concepts of principal component analysis, common spatial pattern, and blind source separation, including independent component analysis. We cover practical questions related to the averaging procedure: overlapping ERPs, correcting inter-sweep latency and amplitude variability, alternative averaging methods (e.g., median), and estimation of ERP onset. Some specific aspects of ERP analysis in the frequency domain are surveyed, along with topographic analysis, statistical testing, and classification methods.

Late Positive Event-Related Potentials after Commissural Section in Humans

1990 ◽  
Vol 2 (3) ◽  
pp. 258-271 ◽  
Author(s):  
Marta Kutas ◽  
Steven A. Hillyard ◽  
Bruce T. Volpe ◽  
Michael S. Gazzaniga
Keyword(s):  
Corpus Callosum ◽  
Left Hemisphere ◽  
Visual Fields ◽  
Event Related Potentials ◽  
Auditory Oddball ◽  
Oddball Task ◽  
Related Potentials ◽  
The Individual ◽  
The Right ◽  
Auditory Oddball Task

The lateral distribution of the P300 component of the event-related brain potential (ERP) was studied in five epileptic patients whose corpus callosum had been surgically sectioned and in seven neurologically intact controls. The P300 was elicited in an auditory “oddball” task using high- and low-pitched tones and in a visual oddball task in which target words were presented either to the left or right visual fields, or to both fields simultaneously. Commissurotomy altered the normal pattern of bilaterally symmetrical P300 waves over the left and right hemispheres, but in a different manner for auditory and visual stimuli. The auditory P3 to binaural tones was larger in amplitude over the right than the left hemisphere for the patients. In the visual task, the laterality of the P300 varied with the visual field of the target presentation. Left field targets elicited much larger P300 amplitudes over the right than the left hemisphere, as did bilateral targets. In contrast, right field targets triggered P300 waves of about the same amplitude over the two hemispheres. The overall amplitude of the P300 to simultaneous bilateral targets was less than the sum of the individual P300 amplitudes produced in response to the unilateral right and left field targets. These shifts in P300 laterality argue against the view that the P300 is an index of diffuse arousal or activation that is triggered in both hemispheres simultaneously irrespective of which hemisphere processes the target information. The results further demonstrate that the P300 does not depend for its production on interhemispheric comparisons of information mediated by the corpus callosum, as suggested recently by Knight et al. (1989).

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