scholarly journals Dorsal anterior cingulate cortex intrinsic functional connectivity linked to electrocortical measures of error-monitoring

2020 ◽  
Author(s):  
Hayley Gilbertson ◽  
Lin Fang ◽  
Jeremy A. Andrzejewski ◽  
Joshua M. Carlson
Keyword(s):  
Functional Connectivity ◽  
Anterior Cingulate Cortex ◽  
Flanker Task ◽  
Monitoring Network ◽  
Cingulate Cortex ◽  
Event Related Potential ◽  
Anterior Cingulate ◽  
Functional Coupling ◽  
Error Monitoring ◽  
Dorsal Anterior Cingulate Cortex

AbstractThe error-related negativity (ERN) is a response-locked event-related potential, occurring approximately 50 ms following an erroneous response at frontocentral electrode sites. Source localization and functional magnetic resonance imaging (fMRI) research indicate that the ERN is likely generated by activity in the dorsal anterior cingulate cortex (dACC). The dACC is thought to be a part of a broader network of brain regions that collectively comprise an error-monitoring network. However, little is known about how intrinsic connectivity within the dACC-based error-monitoring network contributes to variability in ERN amplitude. The purpose of this study was to assess the relationship between dACC functional connectivity and ERN amplitude. In a sample of 53 highly trait-anxious individuals, the ERN was elicited in a flanker task and functional connectivity was assessed in a 10-minute resting-state fMRI scan. Results suggest that the strength of dACC seeded functional connectivity with the supplementary motor area is correlated with the ΔERN (i.e., incorrect – correct responses) amplitude such that greater ΔERN amplitude was accompanied by greater functional coupling between these regions. In addition to the dACC, exploratory analyses found that functional connectivity in the caudate, cerebellum, and a number of regions in the error-monitoring network were linked to variability in ΔERN amplitude. In sum, ERN amplitude appears to be related to the strength of functional connectivity between error-monitoring and motor control regions of the brain.

scholarly journals Altered resting-state dorsal anterior cingulate cortex functional connectivity in patients with post-traumatic stress disorder

2018 ◽  
Vol 53 (1) ◽  
pp. 68-79 ◽  
Author(s):  
Hui Juan Chen ◽  
Li Zhang ◽  
Jun Ke ◽  
Rongfeng Qi ◽  
Qiang Xu ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Anterior Cingulate Cortex ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Stress Disorder ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Post Traumatic Stress ◽  
Dorsal Anterior Cingulate Cortex ◽  
Post Traumatic

Objective: The brain functional alterations at regional and network levels in post-traumatic stress disorder patients are still unclear. This study explored brain functional alterations at regional and network levels in post-traumatic stress disorder patients with resting-state functional magnetic resonance imaging and evaluated the relationship between brain function and clinical indices in post-traumatic stress disorder. Methods: Amplitude of low-frequency fluctuation and seed-based functional connectivity analyses were conducted among typhoon survivors with ( n = 27) and without post-traumatic stress disorder ( n = 33) and healthy controls ( n = 30) to assess the spontaneous brain activity and network-level brain function. Pearson correlation analyses were performed to examine the association of brain function with clinical symptom and social support. Results: Both the post-traumatic stress disorder group and the trauma-exposed control group showed decreased amplitude of low-frequency fluctuation in the dorsal anterior cingulate cortex relative to the healthy control group. The post-traumatic stress disorder group showed increased dorsal anterior cingulate cortex functional connectivity with the right paracentral lobule and bilateral precentral gyrus/postcentral gyrus relative to both control groups. Both traumatized groups exhibited decreased dorsal anterior cingulate cortex functional connectivity with the right hippocampus and left cerebellum relative to the healthy control group. More decreased dorsal anterior cingulate cortex functional connectivity with the right hippocampus was found in the post-traumatic stress disorder group. The Checklist-Civilian Version score positively correlated with functional connectivity between the dorsal anterior cingulate cortex and the right paracentral lobule as well as between the dorsal anterior cingulate cortex and the right precentral gyrus/postcentral gyrus. The social support was associated with functional connectivity between the dorsal anterior cingulate cortex and the bilateral precentral gyrus/postcentral gyrus as well as the dorsal anterior cingulate cortex and the left middle frontal gyrus. Conclusion: Trauma exposure may result in aberrant local and network-level functional connectivity in individuals with or without post-traumatic stress disorder. Altered amplitude of low-frequency fluctuation in the dorsal anterior cingulate cortex may be a predisposing risk factor for post-traumatic stress disorder development following trauma exposure. More prominent decreased dorsal anterior cingulate cortex functional connectivity with the right hippocampus might be specific in the post-traumatic stress disorder group. Improvement of social support might possibly be significant for post-traumatic stress disorder patients.

scholarly journals The impacts of actual and perceived nicotine administration on insula functional connectivity with the anterior cingulate cortex and nucleus accumbens

2019 ◽  
Vol 33 (12) ◽  
pp. 1600-1609 ◽  
Author(s):  
Robin N Perry ◽  
Hera E Schlagintweit ◽  
Christine Darredeau ◽  
Carl Helmick ◽  
Aaron J Newman ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Functional Connectivity ◽  
Anterior Cingulate Cortex ◽  
Resting State ◽  
Cingulate Cortex ◽  
Anterior Insula ◽  
Anterior Cingulate ◽  
Resting State Functional Connectivity ◽  
Dorsal Anterior Cingulate Cortex ◽  
Nicotine Administration

Background: Changes in resting state functional connectivity between the insula and dorsal anterior cingulate cortex as well as between the insula and nucleus accumbens have been linked to nicotine withdrawal and/or administration. However, because many of nicotine’s effects in humans appear to depend, at least in part, on the belief that nicotine has been administered, the relative contribution of nicotine’s pharmacological actions to such effects requires clarification. Aims: The purpose of this study was to examine the impacts of perceived and actual nicotine administration on neural responses. Methods: Twenty-six smokers were randomly assigned to receive either a nicotine inhaler (4 mg deliverable) or a nicotine-free inhaler across two sessions. Inhaler content instructions (told nicotine vs told nicotine-free) differed across sessions. Resting state functional connectivity between sub-regions of the insula and the dorsal anterior cingulate cortex and nucleus accumbens was measured using magnetic resonance imaging before and after inhaler administration. Results: Both actual and perceived nicotine administration independently altered resting state functional connectivity between the anterior insula and the dorsal anterior cingulate cortex, with actual administration being associated with decreased resting state functional connectivity, and perceived administration with increased resting state functional connectivity. Actual nicotine administration also contralaterally reduced resting state functional connectivity between the anterior insula and nucleus accumbens, while reductions in resting state functional connectivity between the mid-insula and right nucleus accumbens were observed when nicotine was administered unexpectedly. Changes in resting state functional connectivity associated with actual or perceived nicotine administration were unrelated to changes in subjective withdrawal and craving. Changes in withdrawal and craving were however independently associated with resting state functional connectivity between the nucleus accumbens and insula. Conclusions: Our findings highlight the importance of considering non-pharmacological factors when examining drug mechanisms of action.

scholarly journals Anterior cingulate cortex differently modulates fronto-parietal functional connectivity between resting-state and working memory tasks

2019 ◽  
Author(s):  
Xin Di ◽  
Heming Zhang ◽  
Bharat B Biswal
Keyword(s):  
Working Memory ◽  
Functional Connectivity ◽  
Anterior Cingulate Cortex ◽  
Resting State ◽  
Cingulate Cortex ◽  
Task Demands ◽  
Anterior Cingulate ◽  
Functional Coupling ◽  
The Right ◽  
State 1

AbstractThe brain fronto-parietal regions and the functional communications between them are critical in supporting working memory and other executive functions. The functional connectivity between fronto-parietal regions are modulated by working memory loads, and are shown to be modulated by a third brain region in resting-state. However, it is largely unknown that whether the third-region modulations remain the same during working memory tasks or were largely modulated by task demands. In the current study, we collected functional MRI (fMRI) data when the subjects were performing n-back tasks and in resting-state. We first used a block-designed localizer to define the fronto-parietal regions that showed higher activations in the 2-back than the 1-back condition. Next, we performed physiophysiological interaction (PPI) analysis using left and right middle frontal gyrus (MFG) and superior parietal lobule (SPL) regions, respectively, in three continuous-designed runs of resting-state, 1-back, and 2-back conditions. No regions showed consistent modulatory interactions with the seed pairs in the three conditions. Instead, the anterior cingulate cortex (ACC) showed different modulatory interactions with the right MFG and SPL among the three conditions. While increased activity of the ACC was associated with decreased functional coupling between the right MFG and SPL in resting-state, it was associated with increased functional coupling in the 2-back condition. The observed task modulations support the functional significance of the modulations of the ACC on fronto-parietal connectivity.

scholarly journals Inflexible Functional Connectivity of the Dorsal Anterior Cingulate Cortex in Adolescent Major Depressive Disorder

2017 ◽  
Vol 42 (12) ◽  
pp. 2434-2445 ◽  
Author(s):  
Tiffany C Ho ◽  
Matthew D Sacchet ◽  
Colm G Connolly ◽  
Daniel S Margulies ◽  
Olga Tymofiyeva ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Functional Connectivity ◽  
Depressive Disorder ◽  
Anterior Cingulate Cortex ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Dorsal Anterior Cingulate Cortex ◽  
Major Depressive

scholarly journals Sulcal Pattern Variability and Dorsal Anterior Cingulate Cortex Functional Connectivity Across Adult Age

2020 ◽  
Vol 10 (6) ◽  
pp. 267-278 ◽  
Author(s):  
Davide Fedeli ◽  
Nicola Del Maschio ◽  
Camilla Caprioglio ◽  
Simone Sulpizio ◽  
Jubin Abutalebi
Keyword(s):  
Functional Connectivity ◽  
Anterior Cingulate Cortex ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Dorsal Anterior Cingulate Cortex ◽  
Adult Age ◽  
Pattern Variability ◽  
Sulcal Pattern

scholarly journals Developing Functional Network Connectivity of the Dorsal Anterior Cingulate Cortex Mediates Externalizing Psychopathology in Adolescents with Child Neglect

2021 ◽  
Author(s):  
Sarita Silveira ◽  
Simone Boney ◽  
Susan F. Tapert ◽  
Jyoti Mishra
Keyword(s):  
Functional Connectivity ◽  
Anterior Cingulate Cortex ◽  
Child Neglect ◽  
Childhood Adversity ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Dorsal Anterior Cingulate Cortex ◽  
Functional Brain ◽  
Externalizing Psychopathology ◽  
Increased Risk

AbstractChildhood adversity in form of child abuse and neglect is associated with elevated risk for psychopathologies. We investigated whether development of functional brain networks important for executive function (EF) could serve as potential mediators of this association. We analyzed data of 475 adolescents, a subsample of the multisite longitudinal NCANDA (National Consortium on Alcohol and Neurodevelopment in Adolescence) cohort with completed measures of childhood trauma, resting-state functional brain connectivity data, and internalizing/externalizing psychopathological syndrome data at baseline and follow-up years 1-4. Using parallel process latent growth models, we found that childhood adversity was associated with increased risk for externalizing/internalizing behaviors. We specifically investigated whether functional connectivity of the dorsal anterior cingulate cortex (dACC) to brain regions within the cingulo-opercular (CO) network, a well-known EF network that underlies control of attention and self-regulation, mediates the association between adversity and psychopathological behaviors. We found that childhood adversity, specifically neglect was negatively associated with functional connectivity of the dACC within the CO network, and that this connectivity mediated the association between child neglect and externalizing behaviors. Our study advances a mechanistic understanding of how childhood adversity may impact the development of psychopathology, highlighting the relevance of dACC functional networks particularly for externalizing psychopathology.

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