Evolutionary coupling range varies widely among enzymes
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AbstractRecent studies proposed that active sites induce long-range evolutionary constraints in enzymes. However, the prevalence of such long-range evolutionary coupling is unknown and its relationship to the underlying physical coupling is unclear. Here I show that evolutionary coupling is not universally long range, but that range varies widely among enzymes, from 2Å to 20Å, influencing from 10% to 87% of protein sites. Moreover, evolutionary coupling range is not determined by physical coupling, which is short-range for all enzymes, but by selection pressure. The reason for this is that increasing selection pressure turns small physical couplings into large evolutionary couplings.
1977 ◽
Vol 38
(C7)
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pp. C7-202-C7-206
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ANDERSON LOCALIZATION FOR A MULTIDIMENSIONAL MODEL INCLUDING LONG RANGE POTENTIALS AND DISPLACEMENTS
2002 ◽
Vol 14
(03)
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pp. 273-302
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1965 ◽
Vol 138
(5A)
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pp. A1384-A1389
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Keyword(s):
1999 ◽
Vol 6
(3)
◽
pp. 773-775
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1962 ◽
Vol 52
(5)
◽
pp. 1007-1016
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