Profile qualitative variables on the dynamics of weight loss programs in dogs

Obesity is the most common nutritional disorder in dogs and it is associated with many comorbidities. Some obesity risk factors have already been established, however, the evaluation of the effect of different individual variables on weight loss induced by calorie restriction, although very important, is still poorly explored. The weight loss protocol can be updated and improved by more precise and adjusted equations throughout the weight loss program in the clinical routine practice. Therefore, the objective of this study was to analyze weight loss program dynamics in groups according to reproductive status, age, body size, and breed, as well as to define more accurately the amount of calories per target metabolic weight throughout the program. Data of 1,053 cases, presented between 2012 and 2019 at the Veterinary Hospital of the School of Veterinary Medicine and Animal Science of the University of São Paulo (FMVZ-USP) were retrospectively analyzed. A total of 77 obese dogs (body condition scores 8/9 or 9/9) of different ages, breeds, sizes, and reproductive status were selected. These dogs did not have any concomitant illnesses and successfully completed the weight loss program. Statistical analysis was performed and values of p≤0.05 were considered significant. The proposed weight loss program was based on an energy restriction protocol where daily energy intake (in kcal) was estimated as 70 kcal × target weight0.75. The target weight (TW) was defined as 80% of the animal’s current weight. The average calorie intake for weight loss (calories x target weight0.75) was lower for spayed females (62.36), differing from intact males (66.14) and neutered males (65.41), while intact females (63.66) showed intermediate values without differing between groups (p = 0.015). There were no differences between weight loss calories according to age (p = 0.473) or body size (p = 0.084), allowing the use of the same mathematical equation for intact and neutered dogs; for dogs older than 1 year and of different body sizes. Regarding the breed, the average calorie intake was lower (p = 0.002) in mixed breed dogs (61.54xTW0.75) when compared to obesity-prone purebred dogs (64.17xTW0.75) and other purebreds (65.27xTW0.75). It was concluded that spayed females and mixed breed dogs have greater difficulty in losing weight, that is, they need fewer calories per metabolic body weight for the weight loss program to succeed. A more accurate equation for energy requirement for weight loss can improve chances of success, therefore improving compliance and helping clinical management of obesity in dogs.

Bodies and Minds: Heavier Weight Targets Are De-Mentalized as Lacking in Mental Agency

Five experiments investigate the hypothesis that heavier weight individuals are denied mental agency (i.e., higher order cognitive and intentional capacities), but not experience (e.g., emotional and sensory capacities), relative to average weight individuals. Across studies, we find that as targets increase in weight, they are denied mental agency; however, target weight has no reliable influence on ascriptions of experience (Studies 1a–2b). Furthermore, the de-mentalization of heavier weight targets was associated with both disgust and beliefs about targets’ physical agency (Study 3). Finally, de-mentalization affected role assignments. Heavier weight targets were rated as helpful for roles requiring experiential but not mentally agentic faculties (Study 4). Heavier weight targets were also less likely than chance to be categorized into a career when it was described as requiring mental agency (versus experience; Study 5). These findings suggest novel insights into past work on weight stigma, wherein discrimination often occurs in domains requiring mental agency.

Striking the Balance: GLP-1/Glucagon Co-Agonism as a Treatment Strategy for Obesity

Obesity and Type 2 diabetes represent global health challenges, and there is an unmet need for long-lasting and effective pharmacotherapies. Although long-acting glucagon-like peptide-1 (GLP-1) analogues are now in routine use for diabetes and are now being utilised for obesity per se, the need for ever better treatments has driven the development of co-agonists, with the theoretical advantages of improved efficacy by targeting multiple pathways and reduced adverse effects. In this review, we highlight the past and present progress in our understanding and development of treatments based on GLP-1/glucagon co-agonism. We also reflect on the divergent effects of varying the GLP-1:glucagon activity and ratio in the context of pre-clinical and human clinical trial findings. In particular, the multiple metabolic actions of glucagon highlight the importance of understanding the contributions of individual hormone action to inform the safe, effective and tailored use of GLP-1/glucagon co-agonists to target weight loss and metabolic disease in the future.

Homeostasis Disrupted and Restored—A Fresh Look at the Mechanism and Treatment of Obesity During COVID-19

The prevalence of obesity in the United States approaches half of the adult population. The COVID-19 pandemic endangers the health of obese individuals. In addition, the metabolic syndrome poses a challenge to the health of obese adults. Bariatric surgery and diet restore metabolic homeostasis in obese individuals; however, it is still unclear which strategy is most effective. For example, intermittent fasting improves insulin sensitivity and diet alone decreases visceral adipose tissue at a disproportionately high rate compared to weight loss. Bariatric surgery causes rapid remission of type 2 diabetes and increases incretins for long-term remission of insulin resistance before meaningful weight loss has occurred. Malabsorptive surgeries have provided insight into the mechanism of altering metabolic parameters, but strong evidence to determine the duration of their effects is yet to be established. When determining the best method of weight loss, metabolic parameters, target weight loss, and risk-benefit analysis must be considered carefully. In this review, we address the pros and cons for the optimal way to restore metabolic homeostasis.

Mean Convergence of Entire Interpolations in Weighted Space

We investigate the convergence of entire Lagrange interpolations and of Hermite interpolations of exponential type $$\tau $$ τ , as $$\tau \rightarrow \infty $$ τ → ∞ , in weighted $$L^p$$ L p -spaces on the real line. The weights are reciprocals of entire functions that depend on $$\tau $$ τ and may be viewed as smoothed versions of a target weight w. The convergence statements are obtained from weighted Marcinkiewicz inequalities for entire functions. We apply our main results to deal with power weights.

Patient perspectives of target weight management and ultrafiltration in haemodialysis: a multi-center survey

Background Decisions around planned ultrafiltration volumes are the only part of the haemodialysis prescription decided upon at every session. Removing too much fluid or too little is associated with both acute symptoms and long-term outcomes. The degree to which patients engage with or influence decision-making is not clear. We explored patient perspectives of prescribing ultrafiltration volumes, their understanding of the process and engagement with it. Methods A questionnaire developed for this study was administered to 1077 patients across 10 UK Renal Units. Factor analysis reduced the dataset into factors representing common themes. Relationships between survey results and factors were investigated using regression models. ANCOVA was used to explore differences between Renal Units. Results Patients generally felt in control of their fluid management and that they were given the final say on planned ultrafiltration volumes. Around half of the respondents reported they take an active role in their treatment. However, respondents were largely unable to relate signs and symptoms to fluid management practice and a third said they would not report common signs and symptoms to clinicians. A fifth of patients reported not to know how ultrafiltration volumes were calculated. Patients responded positively to questions relating to healthcare staff, though with significant variation between units, highlighting differences in perception of care. Conclusions Despite a lack of formal acknowledgement in fluid management protocols, patients have significant involvement in decisions regarding fluid removal during dialysis. Furthermore, substantial gaps remain in patient knowledge and engagement. Formalizing the role of patients in these decisions, including patient education, may improve prescription and achievement of target weights.

Rapid amelioration of anorexia nervosa in a male adolescent during metreleptin treatment including recovery from hypogonadotropic hypogonadism

With this case report we support our medical hypothesis that metreleptin treatment ameliorates starvation related emotional, cognitive and behavioral symptomatology of anorexia nervosa (AN) and show for the first time strong effects in a male patient with AN. A 15.9 year old adolescent with severe AN of eight-month duration was treated off-label with metreleptin. Hyperactivity was assessed with accelerometry. Visual analogue scales (VAS), validated self- and clinician rating scales and lab results tracked changes from baseline to end of the 24-day dosing period and a five-month follow-up. Substantial improvements of mood and eating disorder related cognitions and hyperactivity set in after two days of treatment. During dosing, sub-physiological testosterone and TT3 levels normalized; clinically libido reemerged. Weight did not increase substantially during the dosing period. During follow-up target weight was attained; mood did not deteriorate; hyperactivity ceased. The results substantiate the strong effects seen in female cases and underscore the need for a double-blind placebo-controlled trial to confirm the observed strong, multiple and rapid onset beneficial effects of metreleptin in AN.

Impact of deferred grazing on profitability of a hill country farm in north-western Waikato

Deferred grazing is a common management practice in which pastures are rested from grazing between mid-spring and the end of summer/early autumn. It has been used to rejuvenate pastures and better manage the spring pasture surplus although its impact on farm profitability is unknown. FARMAX was used to explore the impact of deferred grazing on profitability on a north-western Waikato beef and sheep hill country farm based on experimental data and likely management responses. The Base Scenario modelled farm profitability assuming spring surplus in a typical year. When 15% of the farm was deferred and it was assumed that the increased grazing pressure on the rest of the farm led to greater control of the spring feed surplus and improved pasture quality, there was an increase in ewe performance and the number lambs sold at target weight. Per head and total farm gross margins increased by 8%. Results demonstrate how the use of deferred grazing as a pasture management tool to increase resilience can also enhance livestock performance and profitability at the whole-farm level.

Growth Performance of Short Scrotum and Castrated Hair Sheep Lambs on Pasture During Different Seasons

Castrated lambs tend to grow slower compared to intact males. Rendering lambs short scrotum offers an opportunity to achieve comparable growth to an intact lamb while allowing them to be co-grazed with ewe lambs. Here we evaluated lamb growth in a mixed flock of castrated (CA), short-scrotum (SS) and female (FE) Barbados Blackbelly and St. Croix hair sheep lambs. Lambs were born in December (n = 30) and April (n = 45) from the same ewe flock mated to different sires each season. Ram lambs were either rendered short scrotum or completely castrated using elastrator bands at weaning, and all lambs transitioned in dry lot for 2 mo before return to pasture. Lambs co-grazed in a rotational pasture system and were moved based on visual assessment of forage availability and were provided bermudagrass hay when forage availability was limited. Lambs were supplemented with soy hull at 3% BW to ensure diet continuity between forage environments. Ewe lambs were grown to target weights of 35 kg and males to 40 kg. Data were analyzed for sex class, breed, and season as main effects. Pasture ADG was higher (P < 0.001) in SS (132 g/d) than in CA (102 g/d) and FE (96 g/d) lambs. Age at target weight tended to be earlier (P < 0.1) in SS (261 d) than CA (291 d). December-born lambs had higher pen ADG (236 vs. 135 g/d; P< 0.001) than April-born lambs, but had similar pasture ADG (102 vs. 108 g/d). In contrast, St. Croix lambs had similar pre-pasture growth to Blackbelly lambs, but higher pasture ADG (118 vs. 94 g/d; P < 0.001) and reached target weight 40 d earlier (P < 0.001). Data indicate that the forage environment allowed differences in growth potential derived from sex type and breed to be expressed, but that soy hull supplementation likely masked seasonal differences associated with forage quality.