scholarly journals Ferritin nanoparticle based SARS-CoV-2 RBD vaccine induces persistent antibody response and long-term memory in mice

2020 ◽  
Author(s):  
Wenjun Wang ◽  
Baoying Huang ◽  
Yanping Zhu ◽  
Wenjie Tan ◽  
Mingzhao Zhu
Keyword(s):  
Antibody Response ◽  
Memory B Cells ◽  
Long Term Memory ◽  
Recall Response ◽  
Term Memory ◽  
Vaccine Candidates ◽  
Memory Response ◽  
Post Immunization ◽  
Antibody Persistence

ABSTRACTSince the outbreak of COVID-19, over 200 vaccine candidates have been documented and some of them have advanced to clinical trials with encouraging results. However, the antibody persistence over 3 months post immunization and the long-term memory have been rarely reported. Here, we report that a ferritin nanoparticle based SARS-CoV-2 RBD vaccine induced in mice an efficient antibody response which lasts for at least 7 months post immunization. Significantly higher number of memory B cells were maintained and a significantly higher level of recall response was induced upon antigen challenge. Thus, we believe our current study provide the first information about the long-term antibody persistence and memory response of a COVID-19 vaccine. This information would be also timely useful for the development and evaluation of other vaccines.

Protein profile of scorpion venom from Hottentotta rugiscutis and its immunogenic potential in inducing long term memory response

Toxicon ◽  
2021 ◽  
Author(s):  
Kambaiah Nagaraj Santhosh ◽  
Dattatreya Pavana ◽  
Balakrishna Rao Shruthi ◽  
Nayaka Boramuthi Thippeswamy
Keyword(s):  
Protein Profile ◽  
Scorpion Venom ◽  
Long Term Memory ◽  
Term Memory ◽  
Memory Response

Complement and natural antibody are required in the long-term memory response to influenza virus

Vaccine ◽  
2008 ◽  
Vol 26 ◽  
pp. I86-I93 ◽  
Author(s):  
Santiago Fernandez Gonzalez ◽  
Jerome Priyantha Jayasekera ◽  
Michael C. Carroll
Keyword(s):  
Influenza Virus ◽  
Natural Antibody ◽  
Long Term Memory ◽  
Term Memory ◽  
Memory Response

The role of complement and natural antibody in the long-term memory response to influenza virus

2008 ◽  
Vol 45 (16) ◽  
pp. 4142
Author(s):  
Santiago F. Gonzalez ◽  
Jerome Jayasekera ◽  
Michael Carroll
Keyword(s):  
Influenza Virus ◽  
Natural Antibody ◽  
Long Term Memory ◽  
Term Memory ◽  
Memory Response

Some Relevant Factors in the Transfer of Material from Short-Term to Long-Term Memory

1967 ◽  
Vol 19 (4) ◽  
pp. 300-308 ◽  
Author(s):  
Ronal L. Cohen ◽  
Bo S. Johansson
Keyword(s):  
Short Term Memory ◽  
Long Term Memory ◽  
Short Term ◽  
Recall Response ◽  
Term Memory ◽  
Rehearsal Strategy ◽  
Improved Performance ◽  
The Relationship ◽  
Relevant Factors

The relationship between short-term memory (STM) and long-term memory (LTM) for digits was investigated by means of a Hebb-type experiment, viz. a presentation of a series of nine-digit numbers, in which a certain number recurs at intervals. Improvement in performance, with regard to the critical, or recurring, number was found when the rehearsal grouping was three-three-and-three, but was absent when there were no opportunities for rehearsal or when the rehearsal strategy was grouping five-and-four or searching for systematic numbers. However, if an overt recall response was given on each occasion the recurring number was presented, improved performance was found even with rehearsal strategy five-and-four. The conclusion was drawn that rehearsal is the main transferring mechanism from STM to LTM, with the occurrence of an over recall response as a subsidiary factor.

scholarly journals Long-term Memory Response After a Single Intramuscular Rabies Booster Vaccination 10–24 Years After Primary Immunization

2021 ◽  
Author(s):  
Cornelis A De Pijper ◽  
Annefleur C Langedijk ◽  
Sanne Terryn ◽  
Steven Van Gucht ◽  
Martin P Grobusch ◽  
...  
Keyword(s):  
Booster Vaccination ◽  
Long Term Memory ◽  
Published Data ◽  
Primary Immunization ◽  
Term Memory ◽  
Booster Immunization ◽  
Memory Response ◽  
Antibody Titers ◽  
Exposure Prophylaxis

Abstract Background Published data regarding long-lasting immunological rabies memory after pre-exposure prophylaxis (PrEP) are scarce. We tested the hypothesis that rabies booster immunization elicits rapid anamnestic responses. Methods For this observational study, we included participants who had received PrEP 10–24 years before inclusion. We measured rabies antibody titers before, and on days 3, 7, and 14 after a single intramuscular booster. Results All 28 participants responded adequately regardless of route of administration or 2-dose vs 3-dose PrEP regimen. Conclusion Rabies immunological memory is reactivated within 7 days after a single intramuscular booster immunization, even when administered 10–24 years after PrEP.

Identifying long-term memory B-cells in vaccinated children despite waning antibody levels specific for Bordetella pertussis proteins

Vaccine ◽  
2011 ◽  
Vol 29 (7) ◽  
pp. 1431-1437 ◽  
Author(s):  
Lotte H. Hendrikx ◽  
Kemal Öztürk ◽  
Lia G.H. de Rond ◽  
Reinier H. Veenhoven ◽  
Elisabeth A.M. Sanders ◽  
...  
Keyword(s):  
B Cells ◽  
Bordetella Pertussis ◽  
Memory B Cells ◽  
Long Term Memory ◽  
Term Memory ◽  
Antibody Levels

scholarly journals Long-Term Immunological Memory Induced by Recombinant Oral Salmonella Vaccine Vectors

2000 ◽  
Vol 68 (7) ◽  
pp. 4370-4373 ◽  
Author(s):  
James J. Kohler ◽  
Latha Pathangey ◽  
Adnan Hasona ◽  
Ann Progulske-Fox ◽  
Thomas A. Brown
Keyword(s):  
Immune Responses ◽  
Long Term Memory ◽  
Primary Immunization ◽  
Recall Response ◽  
Term Memory ◽  
Hemagglutinin Gene ◽  
Serovar Typhimurium ◽  
Residual Response ◽  
Vaginal Wash

ABSTRACT We have previously shown that Salmonella entericaserovar Typhimurium expressing the hagB hemagglutinin gene from Porphyromonas gingivalis can induce primary and recall immune responses in serum and secretions in mice; however, the longevity of memory induced by oral Salmonella carriers has not been adequately demonstrated. In this study, we examined the capacity of mice to mount a recall response 52 weeks after primary immunization. Recall responses were seen in serum immunoglobulin G (IgG) and IgA following boosting at week 52, and in most cases, they were equal to or greater than the primary responses. Significant mucosal IgA recall responses in saliva and vaginal wash were also detected following boosting at week 52. In addition, there was a considerable residual response in secretions at week 51, prior to boosting. These results indicate that oral Salmonellavectors can induce long-term memory to recombinant HagB and are particularly effective at inducing long-lasting mucosal responses as well as at inducing the capacity for mucosal recall responses.

scholarly journals Ferritin nanoparticle-based SARS-CoV-2 RBD vaccine induces a persistent antibody response and long-term memory in mice

2021 ◽  
Vol 18 (3) ◽  
pp. 749-751
Author(s):  
Wenjun Wang ◽  
Baoying Huang ◽  
Yanping Zhu ◽  
Wenjie Tan ◽  
Mingzhao Zhu
Keyword(s):  
Antibody Response ◽  
Long Term Memory ◽  
Term Memory

Conceptual short-term memory (CSTM) supports core claims of Christiansen and Chater

2016 ◽  
Vol 39 ◽  
Author(s):  
Mary C. Potter
Keyword(s):  
Working Memory ◽  
Rapid Serial Visual Presentation ◽  
Language Comprehension ◽  
Short Term Memory ◽  
Visual Presentation ◽  
Long Term Memory ◽  
Short Term ◽  
Term Memory ◽  
Use Of Knowledge

AbstractRapid serial visual presentation (RSVP) of words or pictured scenes provides evidence for a large-capacity conceptual short-term memory (CSTM) that momentarily provides rich associated material from long-term memory, permitting rapid chunking (Potter 1993; 2009; 2012). In perception of scenes as well as language comprehension, we make use of knowledge that briefly exceeds the supposed limits of working memory.

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