scholarly journals Comparing a new device to measure lung volumes with three traditional methods in individuals with different lung conditions

2021 ◽  
Author(s):  
Jacob Zac ◽  
Salomon Zac ◽  
Rogelio Pérez-Padilla ◽  
Arantxa Remigio-Luna ◽  
Nicolas Guzmán-Boulloud ◽  
...  
Keyword(s):  
Lung Diseases ◽  
Correlation Coefficients ◽  
Random Order ◽  
Ct Scanning ◽  
Mean Difference ◽  
Chest Roentgenogram ◽  
Lung Volumes ◽  
Obstructive Lung Diseases ◽  
New Device ◽  
New Instrument

AbstractBackgroundLung volumes can be measured by body plethysmography (BP), by inert gas dilution during a single-breath or multiple breaths and by radiographic methods based on chest roentgenogram or CT scanning. Our objective was to analyze the concordance between several methods including a new instrument in a variety of pulmonary conditions.MethodsWe recruited four groups of adult volunteers at the COPD and Tobacco Clinic of a respiratory referral hospital: patients with lung bullae, with obstructive lung diseases, with restrictive lung diseases and healthy controls; all subjects underwent lung volume measurements according to ATS/ERS standards in random order with each method and then CT scanning. Differences among groups were estimated by Kruskal-Wallis tests. Concordance correlation coefficients (CCC) and Bland-Altman plots were performed.ResultsSixty-two patients were studied including 15 with lung bullae, 14 with obstructive lung diseases, 12 with restrictive lung disease and 21 healthy subjects. Highest concordance was obtained between BP and CT scanning (CCC 0.95, mean difference −0.35 L) and the lowest, with TLC-DLCOsb (CCC 0.65, difference - 1.05 L). TLC measured by BP had a moderate concordance with Minibox (CCC=0.91, mean difference −0.19 L). Minibox, on the other hand had the lowest intratest repeatibility (2.7%) of all tested methods.ConclusionsLung volumes measured by BP and CT had a substantial concordance in the scenario of varied pulmonary conditions including lung bullae, restrictive and obstructive diseases. The new minibox device, had low intratest variability, and was easy to perform, with a reasonable concordance with BP.

scholarly journals Corneal Pachymetry measured with Pentacam and CorvisST in Normal and Keratoconic Eyes

2013 ◽  
Vol 2 (3) ◽  
pp. 104-107
Author(s):  
Jose M González-Méijome ◽  
Daniela Lopes-Ferreira ◽  
Laura Rico-del-Viejo ◽  
Patrícia Neves ◽  
Helena Ferreira ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Correlation Coefficients ◽  
Random Order ◽  
Healthy Population ◽  
Healthy Group ◽  
New Instrument ◽  
Biomechanical Response ◽  
The Difference ◽  
Highly Correlated

ABSTRACT Purpose To evaluate the agreement of pachymetry data provided by a new instrument to measure intraocular pressure (IOP) and the corneal biomechanical response with the values provided by Pentacam in healthy and keratoconic eyes. Methods Fifty-four right eyes from 54 healthy patients (32 females, 22 males) and 82 eyes from 43 keratoconus patients (20 females, 23 males) were included in the study. All patients were evaluated with Pentacam and CorvisST (Oculus, Wetzlar, Germany) in random order in the same session. CorvisCCT was compared to Pentacam pachymetry in at the corneal center (PentacamCCT) and at the thinnest point (PentacamMinCT). Results Average pachymetry provided by CorvisST was 534 ± 34 microns in the healthy population and 476 ± 56 microns in the population with keratoconus. Pachymetric values obtained with Pentacam were highly correlated between them as well as with the Corvis value in both groups, but the correlation coefficients were higher in the healthy group. Conclusion Corvis pachymetry can be used interchangeably with Pentacam thinnest point pachymetry in healthy corneas. However, in keratoconic corneas, the difference between both parameters will be higher as the disease progresses and increases the difference between Pentacam pachymetry at cornea center and at the thinnest point. How to cite this article González-Méijome JM, Lopes-Ferreira D, Rico-del-Viejo L, Neves P, Ferreira H, Salgado-Borges J. Corneal Pachymetry measured with Pentacam and CorvisST in Normal and Keratoconic Eyes. Int J Kerat Ect Cor Dis 2013;2(3):104-107.

scholarly journals Phenotypes of Obstructive Lung Diseases in Elderly: A Real-Life Study in a Non-Clinical Setting

2020 ◽  
Author(s):  
João Gaspar-Marques ◽  
Iolanda Caires ◽  
Teresa Palmeiro ◽  
Paula Leiria Pinto ◽  
Maria-Jesus Chasqueira ◽  
...  
Keyword(s):  
Phase I ◽  
Phase Ii ◽  
Lung Diseases ◽  
Phase Iii ◽  
Airflow Limitation ◽  
Lung Volumes ◽  
Obstructive Lung Diseases ◽  
Medical Visits ◽  
Tnf Α ◽  
Group 3

Abstract Background: This study aimed to characterize the clinical, functional, inflammatory and immunological features of the main obstructive lung diseases (OLD) in elderly. Methods: We included subjects aged ≥ 65 years. In Phase I, participants answered standardized questionnaires, performed spirometry, fractional exhaled nitric oxide, an atopy assessment and blood analysis. In Phase II, patients with COPD or asthma criteria and a control group were invited to undergo a more detailed evaluation that included the determination of IL-1-β, IL-5, IL-6, IL-13, TNF-α and periostin. In Phase III was assessed the frequency of non-scheduled medical visits due to respiratory exacerbations, hospitalization and mortality. Results: Phase I included 286 participants. The median age was 85.8 (P27-P75: 81.0 - 90.2) years and 69% were females: 27.3% had chronic obstructive pulmonary disease (COPD) without asthma (Group 1), 2.8% asthma without COPD (Group 2) and 5.2% presented asthma and COPD traits (Group 3). The remaining participants (64.7%), without asthma or COPD, were classified as Group 4. At this stage, Group 3 was more atopic and presented a lower post-bronchodilator FEV 1 and FEV 1 /FVC. In Phase II, that included 82 participants, Group 3 presented the higher median values of TNF-α (p-value: 0.072) and higher lung volumes (p=0.001). No statistically differences were found for other cytokines among groups. In Phase III, Group 3 patients needed more non-scheduled visits. Conclusions: In our study patients with asthma and COPD traits presented more severe airflow limitation, higher values of TNF-α, higher lung volumes and more non-scheduled medical visits.

Therapeutic effect of nebulized hypertonic saline for muco-obstructive lung diseases: a systematic review and meta-analysis with trial sequential analysis

2020 ◽  
pp. jim-2020-001479
Author(s):  
Yin Zhang ◽  
Anchao Song ◽  
Jingyue Liu ◽  
Jihong Dai ◽  
Jilei Lin
Keyword(s):  
Hypertonic Saline ◽  
Therapeutic Effect ◽  
Lung Diseases ◽  
Sequential Analysis ◽  
Mean Difference ◽  
Trial Sequential Analysis ◽  
Controlled Trials ◽  
Cochrane Central Register ◽  
Obstructive Lung Diseases ◽  
Randomized Controlled

Overproduction of mucus and impaired clearance play important roles in the pathogenesis of muco-obstructive lung diseases (MOLDs). This study aims to evaluate the therapeutic effect and safety of nebulized hypertonic saline (HS) on MOLDs. Five electronic databases including PubMed, Excerpt Medica Database (EMBASE), Cochrane Central Register of Controlled Trials, ClinicalTrials.gov and International Standard Randomized Controlled Trial Number Register were searched until June 2019. Randomized controlled trials or randomized controlled crossover trials which investigated the therapeutic effect of HS versus non-HS for MOLDs were included. Twenty-one studies met the eligibility criteria. For cystic fibrosis (CF), although the forced expiratory volume in the first second and forced vital capacity did not improve significantly (mean difference (MD) −0.48, 95% CI −3.72 to 2.76), (MD 1.85, 95% CI −4.31 to 8.01), respectively), the clearance capability of lung and quality of life (QOL) improved significantly in the HS group ((standard mean difference 0.44, 95% CI 0.02 to 0.87), (MD −0.64, 95% CI −)1.14, to 0.13), respectively). However, the results of trial sequential analysis showed the evidence needed more researches to support. The effect of nebulized HS on non-CF bronchiectasis, chronic obstructive pulmonary disease, and primary ciliary dyskinesia also need more evidence to conclude, since current studies are limited and results are inconsistent. Most adverse events of nebulized HS were mild and transient. In summary, the current available evidence suggests that nebulized HS may increase the QOL in CF, but there was no significant improvement in lung function. However, it is not possible to draw firm conclusions for other MOLDs due to limited data.

scholarly journals Measuring Lung Volumes in an Office With a New Device Body-Box Free

CHEST Journal ◽  
2021 ◽  
Vol 159 (6) ◽  
pp. 2143-2144
Author(s):  
Rogelio Pérez-Padilla ◽  
Laura Gochicoa-Rangel ◽  
Ireri Thirión-Romero
Keyword(s):  
Lung Volumes ◽  
New Device

scholarly journals Poor Cognitive Function Is Associated with Obstructive Lung Diseases in Taiwanese Adults

2021 ◽  
Vol 18 (5) ◽  
pp. 2344
Author(s):  
Sun-Wung Hsieh ◽  
Da-Wei Wu ◽  
Chih-Wen Wang ◽  
Szu-Chia Chen ◽  
Chih-Hsing Hung ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Lung Function ◽  
Lung Diseases ◽  
Mmse Score ◽  
Multivariable Analysis ◽  
Forced Expiratory Volume ◽  
Normal Lung ◽  
Obstructive Lung Diseases ◽  
Normal Lung Function ◽  
Function Group

Previous studies have reported an association between the impairment of cognitive performance and lung diseases. However, whether obstructive or restrictive lung diseases have an impact on cognitive function is still inconclusive. We aimed to investigate the association between cognitive function and obstructive or restrictive lung diseases in Taiwanese adults using the Mini-Mental State Examination (MMSE). In this study, we used data from the Taiwan Biobank. Cognitive function was evaluated using the MMSE. Spirometry measurements of forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) were obtained to assess lung function. Participants were classified into three groups according to lung function, namely, normal, restrictive, and obstructive lung function. In total, 683 patients enrolled, of whom 357 participants had normal lung function (52.3%), 95 had restrictive lung function (13.9%), and 231 had obstructive lung function (33.8%). Compared to the normal lung function group, the obstructive lung function group was associated with a higher percentage of cognitive impairment (MMSE < 24). In multivariable analysis, a low MMSE score was significantly associated with low FVC, low FEV1, and low FEV1/FVC. Furthermore, a low MMSE score was significantly associated with low FEV1 in the participants with FEV1/FVC < 70%, whereas MMSE was not significantly associated with FVC in the participants with FEV1/FVC ≥ 70%. Our results showed that a low MMSE score was associated with low FEV1, low FVC and low FEV1/FVC. Furthermore, a low MMSE score was associated with obstructive lung diseases but not with restrictive lung diseases.

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