scholarly journals Towards deciphering the structure of long homozygous stretches in cattle genome

2021 ◽  
Author(s):  
Michael Smaragdov
Keyword(s):  
Normal Distribution ◽  
Relative Position ◽  
Software Tool ◽  
Cattle Genome ◽  
Runs Of Homozygosity ◽  
Heterozygous Snps ◽  
Significant Bias ◽  
Specific Objective ◽  
The Mean ◽  
Inbreeding Level

p-to-day there is no as universally accepted software tool and threshold parameters to identify runs of homozygosity ( ROH ). The relative position of POH segments in the cattle genome has not been studied extensively. Specific objective of this study was to evaluate the effect of allowed missing and heterozygous SNPs in ROH on their number, on the estimate of inbreeding level, and on structure of ROH segments in the cattle genome. In this study 371 Holsteinized cows from six herds were genotyped with BovineSNP50 array. To identify ROH, the consecutive and sliding runs were carried out with detectRUNS and Plink tools. Neither effect was shown for missing SNPs genotype calls. Allowing even one heterozygous SNP resulted in significant bias of ROH data.  Furthermore, the sliding runs identified less ROH than consecutive runs. The mean coefficient of inbreeding across herds was 0.111 ± 0.003 and 0.104 ± 0.003 based on consecutive and sliding runs respectively. It was shown how, using the heterozygous SNPs in ROH, may be possible to derive a distribution of ROH segments in the cow genome. We suggested it was similar to normal distribution. Furthermore, frequency of ROH in the chromosomes did not depend on their length. Of 29 chromosomes, the most abundant with ROH were BTA 14, BTA 7, and BTA 18. The result of this study confirmed more accurately identification of ROH with consecutive runs, uneven their distribution in the cattle genome, significant bias of the data due to allowing heterozygous SNPs in ROH.

Multi-Center Calibration of the Second Reference Material for Thromboplastin, Rabbit, Plain, Coded CRM 149R

1991 ◽  
Vol 65 (03) ◽  
pp. 263-267 ◽  
Author(s):  
A M H P van den Besselaar ◽  
R M Bertina
Keyword(s):  
Reference Material ◽  
Standard Error ◽  
Standard Errors ◽  
Sensitivity Index ◽  
Long Term Stability ◽  
Significant Bias ◽  
The Mean ◽  
The Relationship ◽  
International Sensitivity Index

SummaryIn a collaborative trial of eleven laboratories which was performed mainly within the framework of the European Community Bureau of Reference (BCR), a second reference material for thromboplastin, rabbit, plain, was calibrated against its predecessor RBT/79. This second reference material (coded CRM 149R) has a mean International Sensitivity Index (ISI) of 1.343 with a standard error of the mean of 0.035. The standard error of the ISI was determined by combination of the standard errors of the ISI of RBT/79 and the slope of the calibration line in this trial.The BCR reference material for thromboplastin, human, plain (coded BCT/099) was also included in this trial for assessment of the long-term stability of the relationship with RBT/79. The results indicated that this relationship has not changed over a period of 8 years. The interlaboratory variation of the slope of the relationship between CRM 149R and RBT/79 was significantly lower than the variation of the slope of the relationship between BCT/099 and RBT/79. In addition to the manual technique, a semi-automatic coagulometer according to Schnitger & Gross was used to determine prothrombin times with CRM 149R. The mean ISI of CRM 149R was not affected by replacement of the manual technique by this particular coagulometer.Two lyophilized plasmas were included in this trial. The mean slope of relationship between RBT/79 and CRM 149R based on the two lyophilized plasmas was the same as the corresponding slope based on fresh plasmas. Tlowever, the mean slope of relationship between RBT/79 and BCT/099 based on the two lyophilized plasmas was 4.9% higher than the mean slope based on fresh plasmas. Thus, the use of these lyophilized plasmas induced a small but significant bias in the slope of relationship between these thromboplastins of different species.

Limit tolerances for sums of measurement errors

2018 ◽  
Vol 934 (4) ◽  
pp. 59-62
Author(s):  
V.I. Salnikov
Keyword(s):  
Normal Distribution ◽  
Mean Square Error ◽  
Gaussian Distribution ◽  
Measurement Errors ◽  
Theory And Practice ◽  
Mean Square ◽  
The Mean ◽  
Limiting Values ◽  
Limiting Value

The question of calculating the limiting values of residuals in geodesic constructions is considered in the case when the limiting value for measurement errors is assumed equal to 3m, ie ∆рred = 3m, where m is the mean square error of the measurement. Larger errors are rejected. At present, the limiting value for the residual is calculated by the formula 3m√n, where n is the number of measurements. The article draws attention to two contradictions between theory and practice arising from the use of this formula. First, the formula is derived from the classical law of the normal Gaussian distribution, and it is applied to the truncated law of the normal distribution. And, secondly, as shown in [1], when ∆рred = 2m, the sums of errors naturally take the value equal to ?pred, after which the number of errors in the sum starts anew. This article establishes its validity for ∆рred = 3m. A table of comparative values of the tolerances valid and recommended for more stringent ones is given. The article gives a graph of applied and recommended tolerances for ∆рred = 3m.

scholarly journals Ethnic variation in medial orbital wall anatomy and its implications for decompression surgery

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Minhui Amy Chan ◽  
Farah Ibrahim ◽  
Arjunan Kumaran ◽  
Kailing Yong ◽  
Anita Sook Yee Chan ◽  
...  
Keyword(s):  
Relative Position ◽  
Ethmoid Sinus ◽  
Decompression Surgery ◽  
Ethnic Variation ◽  
Sinus Wall ◽  
Orbital Wall ◽  
Mean Width ◽  
Significant Difference ◽  
The Mean ◽  
Medial Orbital Wall

Abstract Background To describe the inter-ethnic variation in medial orbital wall anatomy between Chinese, Malay, Indian and Caucasian subjects. Methods Single-centre, retrospective, Computed Tomography (CT)-based observational study. 20 subjects of each ethnicity, were matched for gender and laterality. We excluded subjects younger than 16 years and those with orbital pathology. OsiriX version 8.5.1 (Pixmeo., Switzerland) and DICOM image viewing software CARESTREAM Vue PACS (Carestream Health Inc., USA) were used to measure the ethmoidal sinus length, width and volume, medial orbital wall and floor angle and the relative position of the posterior ethmoid sinus to the posterior maxillary wall. Statistical analyses were performed using Statistical Package for Social Sciences version 25.0 (IBM, USA). Results There were 12 males (60 %) in each group, with no significant difference in age (p = 0.334–0.994). The mean ethmoid sinus length in Chinese, Malay, Indian and Caucasian subjects, using the Chinese as reference, were 37.2, 36.9, 38.0 and 37.4mm, the mean width was 11.6, 10.5, 11.4 and 10.0mm (p = 0.020) and the mean ethmoid sinus volume were 3362, 3652, 3349 and 3898mm3 respectively. The mean medial orbital wall and floor angle was 135.0, 131.4, 131.0 and 136.8 degrees and the mean relative position of posterior ethmoid sinus to posterior maxillary wall were − 2.0, -0.2, -1.5 and 1.6mm (p = 0.003) respectively. Conclusions No inter-ethnic variation was found in decompressible ethmoid sinus volume. Caucasians had their posterior maxillary sinus wall anterior to their posterior ethmoidal walls unlike the Chinese, Malay and Indians. Awareness of ethnic variation is essential for safe orbital decompression.

The Mean of the Inverse of a Punctured Normal Distribution and Its Application

2004 ◽  
Vol 46 (4) ◽  
pp. 420-429 ◽  
Author(s):  
C. D. Lai ◽  
G. R. Wood ◽  
C. G. Qiao
Keyword(s):  
Normal Distribution ◽  
The Mean

scholarly journals Tamaño óptimo de la muestra

2017 ◽  
Vol 5 (9) ◽  
Author(s):  
M. H. Badii ◽  
J. Castillo ◽  
A. Guillen
Keyword(s):  
Sample Size ◽  
Normal Distribution ◽  
Key Words ◽  
Sample Size Estimation ◽  
Size Estimation ◽  
Bias Estimation ◽  
Population Variance ◽  
Population Proportion ◽  
Estimation Process ◽  
The Mean

Key words: Bias, estimation, population, sampleAbstract. The basics of sample size estimation process are described. Assuming the normal distribution, the procedures for estimation of sample size for the mean; with and without knowledge of the population variance, and population proportion are noted. Sample size for more than one population feature is also given.Palabras clave: Estimación, muestra, población, sesgoResumen. Se describen los fundamentos del proceso de la estimación del tamaño óptimo de la muestra. Suponiendo una distribución normal para una población, se notan los procedimientos de la estimación del tamaño óptimo de la muestra para la media muestral con y sin el conocimiento de la varianza poblacional. Se presenta el tamaño óptimo de la muestra con más de una característica poblacional.

scholarly journals Teaching International Students to Analyze Textual-Discursive Categories

2021 ◽  
Vol 10 (4) ◽  
pp. 34
Author(s):  
Ivanna Fetsko ◽  
Ilona Novak ◽  
Liubov Terletska ◽  
Oksana Soshko ◽  
Oksana Lytvynko
Keyword(s):  
Discourse Analysis ◽  
International Students ◽  
Qualitative Data ◽  
Software Tool ◽  
The Political ◽  
Mean Values ◽  
Stepwise Approach ◽  
Observation Report ◽  
The Mean ◽  
Observation Method

The purpose of the study is to identify how the course that covers the components of the ten-stepwise approach to discourse analysis of political texts helps international students study the political meanings in Ukraine. The study used the structured observation method to collect rather quantitative than qualitative data and observers’ reports on the sampled students’ performance in the in-class and out-of-class assignments. It also used discourse analysis awareness test, observation report checklist, and assessment checklist to yield the quantitative data. The course that is based on the ten-stepwise approach to discourse analysis of political texts proved to raise the students’ overall awareness of analysis of textual-discursive categories and fosters their skills of both discourse analysis and technical skills to use the NVivo 12 software tool. The results of the Discourse Analysis Awareness Test showed that the sampled students’ awareness of discourse analysis was generally good. The mean values varied between 0.643 and0.857, which corresponded to 65-85 grades ECTS. The analysis of the observation reports showed that the five most frequent words used in the corpus of the observation reports of seven experts were as follows: students, contributed, equally, succeeded, managed. All of them evoke a positive idea and feeling and reveal success in meeting goals. The quotes yielded from the reports implied that the course sessions were engaging, challenging, and fruitful in terms of learning how to analyze textual-discursive categories found in political texts. The descriptive statistics drawn from the observation checklist and presented by course topic showed that the observers’ mean values improved throughout the course sessions that meant that the students progressed in the discourse analysis.

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