scholarly journals Indexing Cerebrovascular Health Using Near-infrared Spectroscopy

2021 ◽  
Author(s):  
Rashid Afkhami ◽  
Frederick Rohan Walker ◽  
Saadallah Ramadan ◽  
Rachel Wong ◽  
Sarah Johnson
Keyword(s):  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Augmentation Index ◽  
New Technology ◽  
Early Results ◽  
Cerebrovascular Health ◽  
Magnetic Resonance Imaging Mri ◽  
Tracking Device ◽  
Relationship Of

Near-infrared spectroscopy (NiRS) is a relatively new technology of brain imaging with its potential in the assessment of cerebrovascular health only recently discovered. Encouraging early results suggest that NiRS can be used as an inexpensive and portable cerebrovascular health tracking device using a recently proposed pulse relaxation function (PReFx). In this paper, we propose a new NiRS timing index, TI-NiRS, of cerebrovascular health. TI-NiRS is a novel use of the NiRS technology. TI-NiRS is motivated by the previously proved relationship of the timing of the reflected wave with vascular resistance and compliance in the context of pressure waveforms. We correlated both TI-NiRS and PReFx against age, a non-exercise cardiorespiratory fitness (CRF) index, and two existing indices of cerebrovascular health, namely Transcranial Doppler (TCD) augmentation index, AI-TCD, and magnetic resonance imaging (MRI) blood flow pulsatility index, PI-MRI. The TI-NiRS correlations with Age, CRF, PI-MRI and AI-TCD all are significant, i.e., r = 0.53 (p = 0.002), r = 0.44 (p = 0.011), r = 0.45 (p = 0.012) and r = 0.46 (p = 0.010), respectively. PReFx, however, did not have significant correlations with any of the vascular health factors. The proposed timing index is a reliable indicator of cerebrovascular aging factors in the NiRS waveform.

scholarly journals Indexing cerebrovascular health using near-infrared spectroscopy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Rashid Afkhami ◽  
Frederick R. Walker ◽  
Saadallah Ramadan ◽  
Rachel Wong ◽  
Sarah J. Johnson
Keyword(s):  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Augmentation Index ◽  
New Technology ◽  
Early Results ◽  
Cerebrovascular Health ◽  
Magnetic Resonance Imaging Mri ◽  
Tracking Device ◽  
Relationship Of

AbstractNear-infrared spectroscopy (NiRS) is a relatively new technology of brain imaging with its potential in the assessment of cerebrovascular health only recently discovered. Encouraging early results suggest that NiRS can be used as an inexpensive and portable cerebrovascular health tracking device using a recently proposed pulse relaxation function (PReFx). In this paper, we propose a new NiRS timing index, $$\text {TI}_{\rm NiRS}$$ TI NiRS , of cerebrovascular health. $$\text {TI}_{\rm NiRS}$$ TI NiRS is a novel use of the NiRS technology. $$\text {TI}_{\rm NiRS}$$ TI NiRS is motivated by the previously proved relationship of the timing of the reflected wave with vascular resistance and compliance in the context of pressure waveforms. We correlated both $$\text {TI}_{\rm NiRS}$$ TI NiRS and PReFx against age, a non-exercise cardiorespiratory fitness (CRF) index, and two existing indices of cerebrovascular health, namely transcranial Doppler (TCD) augmentation index, $$\text {AI}_{\rm TCD}$$ AI TCD , and magnetic resonance imaging (MRI) blood flow pulsatility index, $$\text {PI}_{\rm MRI}$$ PI MRI . The $$\text {TI}_{\rm NiRS}$$ TI NiRS correlations with Age, CRF, $$\text {PI}_{\rm MRI}$$ PI MRI and $$\text {AI}_{\rm TCD}$$ AI TCD all are significant, i.e., $$r=0.53$$ r = 0.53 ($$p=0.002$$ p = 0.002 ), $$r=-0.44$$ r = - 0.44 ($$p=0.011$$ p = 0.011 ), $$r=0.45$$ r = 0.45 ($$p=0.012$$ p = 0.012 ) and $$r=0.46$$ r = 0.46 ($$p=0.010$$ p = 0.010 ), respectively. PReFx, however, did not have significant correlations with any of the vascular health factors. The proposed timing index is a reliable indicator of cerebrovascular aging factors in the NiRS waveform.

scholarly journals The mapping of cortical activation by near-infrared spectroscopy might be a biomarker related to the severity of fibromyalgia’s symptoms

2021 ◽  
Author(s):  
Daniela Gabiatti Donadel ◽  
Maxciel Zortea ◽  
Iraci Lucena da Silva Torres ◽  
Felipe Fregni ◽  
Wolnei Caumo
Keyword(s):  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Roc Analysis ◽  
Near Infrared ◽  
Clinical Symptoms ◽  
Cortical Activation ◽  
Functional Near Infrared Spectroscopy ◽  
The Right ◽  
Relationship Of ◽  
The Relationship

Abstract We compared the activation pattern at the motor cortex (MC and prefrontal cortex (PFC) based on the delta value (Δ) of oxy-hemoglobin (HbO) by functional near-infrared spectroscopy (fNIRS). We examined the relationship of the ΔHbO based on the peaks at 5°C and 25°C by right-hand immersion in water in 22 fibromyalgia and 19 controls. Fibromyalgia showed a shorter peak latency for HbO at the left MC. In contrast, at the left MC, their HbO increased 117.64% compared to 92.85% in the controls. A receiver operator characteristics (ROC) analysis showed the ΔHbO cutoffs equal to –0.175 at the left and –0.205 at the right PFC offer sensitivity and specificity of at least 80% in screening fibromyalgia compared to controls. In fibromyalgia, a ROC analysis showed that these cutoff points could discriminate those with higher disability due to pain and more severe central sensitization symptoms (CSS). The ROC with the best discriminatory profile was to the CSS score with the ΔHbO at the left PFC (AUC = 0.82, CI 95% = 0.61–100). These results indicate that cortical activation based on the ΔHbO at the PFC might be a sensitive marker to identify those fibromyalgia patients with more severe clinical symptoms.

Role of Near-Infrared Spectroscopy in Monitoring the Clinical Course of Asphyxiated Neonates Treated with Hypothermia

2021 ◽  
Author(s):  
Marwa Mohamed Farag ◽  
Ahmed Abd El-Halim Abd El-Raziq Khedr ◽  
MennattAllah Hassan Attia ◽  
Hesham Abd EL-Rahim Ghazal
Keyword(s):  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Neonatal Intensive Care ◽  
Near Infrared ◽  
Clinical Course ◽  
Birth Asphyxia ◽  
Maternity Hospital ◽  
Key Points ◽  
Near Term ◽  
Magnetic Resonance Imaging Mri

Objective Hypoxic-ischemic encephalopathy (HIE) affects millions of newborns annually, especially in low-resource settings. Real-time monitoring of hypoxic-ischemic brain damage is urgently needed for assessment of severity and management of neonates with birth asphyxia. Aim of the work is monitoring of near-infrared spectroscopy (NIRS)-measured cerebral regional oxygen saturation (cRSO2) and cerebral fractional tissue oxygen extraction (FTOE) in neonates after birth asphyxia in relation to their clinical course. Study Design Forty asphyxiated-term and near-term neonates with mild to severe HIE admitted at neonatal intensive care unit of Alexandria University Maternity Hospital from March to October 2019, received therapeutic hypothermia (TH) and had continuous NIRS monitoring of cRSO2 for 72 hours. Infants were categorized into HIE with seizing and nonseizing groups, and abnormal and normal magnetic resonance imaging (MRI) groups. Results Clinical seizures (CS) occurred in 15 (37.5%) of HIE neonates and 13.3% of them died (n = 2). In the current study, significantly higher cRSO2 and lower FTOE values were found in the seizing infants as compared with nonseizing group (p < 0.001). NIRS-measured day 2-cRSO2 and day 1-FTOE were associated with CS in newborns with HIE and day 1-cRSO2 and FTOE were associated with abnormal MRI at 1 month of age. cRSO2 values were found to correlate positively with initial Thompson score especially in days 1 and 2. Further, neonates with CS were more likely to have MRI abnormalities at follow-up. Conclusion NIRS measures may highlight differences between asphyxiated neonates who develop CS or later MRI abnormalities and those who do not. Key Points

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