Self-reported word-finding complaints are associated with cerebrospinal fluid beta-amyloid and atrophy in cognitively normal older adults

Background and Objectives: Self-reported language complaints, and more specifically word-finding difficulties, are among the most frequent cognitive complaints in cognitively normal older adults (CN). The clinical significance of elevated self-reported word-finding complaints in CN is still a matter of debate. The present study aims at characterizing word-finding complaints in CN, establish their sociodemographic and psychological correlates, determine if they are predictive of lower levels of cerebrospinal fluid Aβ levels and finally, investigate if they are associated with brain atrophy in regions associated with naming impairments. Methods: In this observational case-control study, 239 CN from the Alzheimer Disease Neuroimaging Initiative (ADNI) database were selected. All participants completed the self-reported version of the Everyday Cognition (ECog) questionnaire, as well as a lumbar puncture for Aβ and a MRI. Results: Word-finding complaints were rated equally severe as a few other memory items and significantly more severe compared to all the other cognitive complaints. Ecog-Lang1 (Forgetting the names of objects) was not related to any demographic (age, sex, years of education) or psychological variable (depression-related symptoms, anxiety-related symptoms), while Ecog-Lang3 (Finding the right words to use in a conversation) was significantly negatively associated with years of education and positively associated with depression-related symptoms. Ecog-Lang1 severity significantly predicted CSF Aβ levels in CN, and this result remained significant even when controlling for all demographic and psychological variables as well as general level of cognitive complaint. Individuals with high Ecog-Lang1 complaints showed atrophy in the left fusiform gyrus and the left rolandic operculum in comparison to CN with no or low Ecog-Lang1 complaints. Discussion: Overall, our results support the fact that word-finding complaints are significant in CN and should be taken seriously. They have the potential to identify CN at risk of AD and support the need to include other cognitive domains in the investigation of subjective cognitive decline.

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Cerebrospinal fluid amyloid levels are associated with delayed memory retention in cognitively normal biomarker-negative older adults

Neurobiology of Aging ◽

10.1016/j.neurobiolaging.2019.08.010 ◽

2019 ◽

Vol 84 ◽

pp. 90-97 ◽

Cited By ~ 2

Author(s):

Lok-Kin Yeung ◽

Christiane Hale ◽

Briana S. Last ◽

Howard Andrews ◽

Richard P. Sloan ◽

...

Keyword(s):

Older Adults ◽

Cerebrospinal Fluid ◽

Memory Retention ◽

Cognitively Normal

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Subjective Cognitive Complaints, Personality and Brain Amyloid-beta in Cognitively Normal Older Adults

American Journal of Geriatric Psychiatry ◽

10.1016/j.jagp.2015.01.008 ◽

2015 ◽

Vol 23 (9) ◽

pp. 985-993 ◽

Cited By ~ 69

Author(s):

Beth E. Snitz ◽

Lisa A. Weissfeld ◽

Ann D. Cohen ◽

Oscar L. Lopez ◽

Robert D. Nebes ◽

...

Keyword(s):

Older Adults ◽

Amyloid Beta ◽

Cognitive Complaints ◽

Cognitively Normal ◽

Subjective Cognitive Complaints

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COVID-19 - RELATED COGNITIVE IMPAIRMENT IN PATIENTS FOLLOWED AT A REFERRAL CENTER IN SÃO PAULO, BRAZIL

10.5327/1980-5764.rpda071 ◽

2021 ◽

Author(s):

Flávia Dahy ◽

Aline Matos ◽

Thais Romano ◽

Rosa Maria Marcusso ◽

Tatiane Assone ◽

...

Keyword(s):

Cognitive Impairment ◽

Cognitive Decline ◽

Central Nervous System Involvement ◽

P Value ◽

Cognitive Complaints ◽

Cognitively Normal ◽

Normal Individuals ◽

Cognitive Complaint ◽

The Mean ◽

Impaired Attention

Background: Central nervous system involvement associated with Coronavirus Disease 2019 (COVID-19) has been reported, including cognitive impairment, even in patients with mild COVID-19. processes. Objective: To assess cognitive decline related to the SARS-CoV-2 infection in patients with neurological disease after COVID-19. Methods: Longitudinal prospective study developed to compare the cognitive performance of patients after COVID-19 based on cognitive complaints. The Addenbrooke´s Cognitive ExaminationRevised (ACE-R), a 100-point test, was applied for investigation, with cut-off score for cognitively normal individuals ≥ 78. Results: Fifty patients were evaluated, 33 women (66%). Thirty-six patients with cognitive complaint (72%), this being the only symptom in 18 (50%), more frequent in women (5:1). Among all patients, the mean score of ACE-R was 80.8 (SD 11) and median of 84. In patients with cognitive complaints, mean of 80.37 (SD 12.2) and median of 84. For the other patients, mean of 81.86 (SD 7.65) and median of 82.5 (p value = 0.9869). Cognitive decline was confirmed in 10/35 (28.57%) of patients with cognitive complaint, and in 4/14 (28.57%) of other patients (exacto de Fisher = 0.8809). Regarding the ACE-R subanalyses, impaired attention and orientation were observed in both groups. Conclusion: Cognitive complaint was not a predictor of cognitive decline, but impairment in attention and orientation were observed in the entire sample.

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Relationship between cerebrospinal fluid biomarkers of Alzheimer's disease and cognition in cognitively normal older adults

Neuropsychologia ◽

10.1016/j.neuropsychologia.2015.09.024 ◽

2015 ◽

Vol 78 ◽

pp. 63-72 ◽

Cited By ~ 22

Author(s):

Corinne Pettigrew ◽

Anja Soldan ◽

Abhay Moghekar ◽

Mei-Cheng Wang ◽

Alden L. Gross ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Older Adults ◽

Alzheimer's Disease ◽

Cerebrospinal Fluid ◽

Cognitively Normal ◽

Cerebrospinal Fluid Biomarkers

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“Senior Moments” or More? Diagnostic Evaluation of Cognitive Complaints in Older Adults and the Role of Cerebrospinal Fluid Biomarkers

The Journal of Applied Laboratory Medicine ◽

10.1373/jalm.2019.029546 ◽

2019 ◽

Vol 5 (1) ◽

pp. 219-224 ◽

Cited By ~ 1

Author(s):

Steven E Arnold

Keyword(s):

Older Adults ◽

Cerebrospinal Fluid ◽

Diagnostic Evaluation ◽

Cognitive Complaints ◽

Cerebrospinal Fluid Biomarkers

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Influence of early maladaptive schemas, depression, and anxiety on the intensity of self-reported cognitive complaint in older adults with subjective cognitive decline

International Psychogeriatrics ◽

10.1017/s1041610217001119 ◽

2017 ◽

Vol 29 (10) ◽

pp. 1657-1667 ◽

Cited By ~ 8

Author(s):

Caroline Tandetnik ◽

Thierry Hergueta ◽

Philippe Bonnet ◽

Bruno Dubois ◽

Catherine Bungener

Keyword(s):

Older Adults ◽

Cognitive Decline ◽

Short Form ◽

Structured Interview ◽

Early Maladaptive Schemas ◽

Subjective Cognitive Decline ◽

Depression And Anxiety ◽

Maladaptive Schemas ◽

Cognitive Complaint ◽

And Performance

AbstractBackground:Subjective cognitive decline (SCD) designates a self-reported cognitive decline despite preserved cognitive abilities. This study aims to explore, in older adults with SCD, the association between intensity of self-reported cognitive complaint and psychological factors including Young's early maladaptive schemas (EMSs) (i.e. enduring cognitive structures giving rise to beliefs about oneself and the world), as well as depression and anxiety.Methods:Seventy-six subjects (69.22 years ± 6.1) with intact cognitive functioning were recruited through an advertisement offering free participation in an intervention on SCD. After undergoing a neuropsychological examination (including global cognition (MMSE) and episodic memory (FCSRT)) and a semi-structured interview to assess depressive symptoms (MADRS), they completed a set of online self-reported questionnaires on SCD (McNair questionnaire), Young's EMSs (YSQ-short form), depression (HADS-D), and anxiety (HADS-A and trait-STAI-Y).Results:The McNair score did not correlate with the neuropsychological scores. Instead, it was highly (r > 0.400; p < 0.005) correlated with trait anxiety and three EMSs belonging to the “Impaired autonomy and performance” domain: Dependence/incompetence, Failure to achieve and Vulnerability to harm or illness. Our final regression model comprising depression, anxiety, and these three EMSs as predictors (while controlling for age, gender, and objective cognition) accounted for 38.5% of the observed variance in SCD intensity.Conclusions:The level of cognitive complaint is significantly associated with Young's EMSs in the category of “Impaired autonomy and performance”. We assume that SCD may primarily be driven by profound long-term inner beliefs about oneself that do not specifically refer to self-perceived memory abilities.

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Associations of Sleep Characteristics with Cerebrospinal Fluid sTREM2 in Cognitively Normal Older Adults: the CABLE Study

Neurotoxicity Research ◽

10.1007/s12640-021-00383-5 ◽

2021 ◽

Author(s):

He-Ying Hu ◽

Ling-Zhi Ma ◽

Hao Hu ◽

Yan-Lin Bi ◽

Ya-Hui Ma ◽

...

Keyword(s):

Older Adults ◽

Cerebrospinal Fluid ◽

Cognitively Normal

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Gait Kinematic and Kinetic Characteristics of Older Adults With Mild Cognitive Impairment and Subjective Cognitive Decline: A Cross-Sectional Study

Frontiers in Aging Neuroscience ◽

10.3389/fnagi.2021.664558 ◽

2021 ◽

Vol 13 ◽

Author(s):

Qian Zhong ◽

Nawab Ali ◽

Yaxin Gao ◽

Han Wu ◽

Xixi Wu ◽

...

Keyword(s):

Older Adults ◽

Cross Sectional Study ◽

Heel Strike ◽

Subjective Cognitive Decline ◽

Cross Sectional ◽

Gait Kinematics ◽

Level Walking ◽

The Right ◽

Post Hoc ◽

Strike Angle

BackgroundOlder adults with mild cognitive impairment (MCI) have slower gait speed and poor gait performance under dual-task conditions. However, gait kinematic and kinetic characteristics in older adults with MCI or subjective cognitive decline (SCD) remain unknown. This study was designed to explore the difference in gait kinematics and kinetics during level walking among older people with MCI, SCD, and normal cognition (NC).MethodsThis cross-sectional study recruited 181 participants from July to December 2019; only 82 met the inclusion criteria and consented to participate and only 79 completed gait analysis. Kinematic and kinetic data were obtained using three-dimensional motion capture system during level walking, and joint movements of the lower limbs in the sagittal plane were analyzed by Visual 3D software. Differences in gait kinematics and kinetics among the groups were analyzed using multivariate analysis of covariance (MANCOVA) with Bonferroni post-hoc analysis. After adjusting for multiple comparisons, the significance level was p < 0.002 for MANCOVA and p < 0.0008 for post-hoc analysis.ResultsTwenty-two participants were MCI [mean ± standard deviation (SD) age, 71.23 ± 6.65 years], 33 were SCD (age, 72.73 ± 5.25 years), and 24 were NC (age, 71.96 ± 5.30 years). MANCOVA adjusted for age, gender, body mass index (BMI), gait speed, years of education, diabetes mellitus, and Geriatric Depression Scale (GDS) revealed a significant multivariate effect of group in knee peak extension angle (F = 8.77, p < 0.0001) and knee heel strike angle (F = 8.07, p = 0.001) on the right side. Post-hoc comparisons with Bonferroni correction showed a significant increase of 5.91° in knee peak extension angle (p < 0.0001) and a noticeable decrease of 6.21°in knee heel strike angle (p = 0.001) in MCI compared with NC on the right side. However, no significant intergroup difference was found in gait kinetics, including dorsiflexion, plantar flexion, knee flexion, knee extension, hip flexion, and hip extension(p > 0.002).ConclusionAn increase of right knee peak extension angle and a decrease of right knee heel strike angle during level walking were found among older adults with MCI compared to those with NC.

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