scholarly journals Extending and using anatomical vocabularies in the Stimulating Peripheral Activity to Relieve Conditions (SPARC) project

2021 ◽  
Author(s):  
Monique C Surles-Zeigler ◽  
Troy Sincomb ◽  
Thomas H Gillespie ◽  
Bernard de Bono ◽  
Jacqueline Bresnahan ◽  
...  
Keyword(s):  
Experimental Data ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Autonomic Nervous ◽  
Expert Review ◽  
Bioelectronic Medicine ◽  
Comprehensive Knowledge ◽  
Set Up ◽  
Term Management

The Stimulating Peripheral Activity to Relieve Conditions (SPARC) program is a US National Institutes of Health-funded effort to improve our understanding of the neural circuitry of the autonomic nervous system in support of bioelectronic medicine. As part of this effort, the SPARC project is generating multi-species, multimodal data, models, simulations, and anatomical maps supported by a comprehensive knowledge base of autonomic circuitry. To facilitate the organization of and integration across multi-faceted SPARC data and models, SPARC is implementing the FAIR data principles to ensure that all SPARC products are findable, accessible, interoperable, and reusable. We are therefore annotating and describing all products with a common FAIR vocabulary. The SPARC Vocabulary is built from a set of community ontologies covering major domains relevant to SPARC, including anatomy, physiology, experimental techniques, and molecules. The SPARC Vocabulary is incorporated into tools researchers use to segment and annotate their data, facilitating the application of these ontologies for annotation of research data. However, since investigators perform deep annotations on experimental data, not all terms and relationships are available in community ontologies. We therefore implemented a term management and vocabulary extension pipeline where SPARC researchers may extend the SPARC Vocabulary using InterLex, an online vocabulary management system. To ensure the quality of contributed terms, we have set up a curated term request and review pipeline specifically for anatomical terms involving expert review. Accepted terms are added to the SPARC Vocabulary and, when appropriate, contributed back to community ontologies to enhance autonomic nervous system coverage. Here, we provide an overview of the SPARC Vocabulary, the infrastructure and process for implementing the term management and review pipeline. In an analysis of > 300 anatomical contributed terms, the majority represented composite terms that necessitated combining terms within and across existing ontologies. Although these terms are not good candidates for community ontologies, they can be linked to structures contained within these ontologies. We conclude that the term request pipeline serves as a useful adjunct to community ontologies for annotating experimental data and increases the FAIRness of SPARC data.

scholarly journals Sentra PM (a Medical Food) and Trazodone in the Management of Sleep Disorders

2012 ◽  
Vol 4 ◽  
pp. JCNSD.S9381
Author(s):  
William E. Shell Md ◽  
Lawrence A. May Md ◽  
Debora H. Bullias Bs, Cra, Crc ◽  
Stephanie L. Pavlik Cra ◽  
David S. Silver Md
Keyword(s):  
Nervous System ◽  
Autonomic Nervous System ◽  
Sleep Disorders ◽  
Sleep Latency ◽  
Quality Of Sleep ◽  
Autonomic Nervous System Activity ◽  
Medical Food ◽  
Autonomic Nervous ◽  
Nervous System Activity

Sleep disorders are a common and poorly treated disease state. This double blind, four arm placebo-controlled, randomized trial compared (1) low dose trazodone, (2) Sentra PM, a neurotransmitter based medical food, (3) the joint administration of trazodone and the medical food Sentra PM and (4) placebo. There were 111 subjects studied in 12 independent sites. Subjects underwent baseline screening, informed consent and an initial sleep questionnaire. After 14 days subjects underwent a second evaluation by questionnaire. At baseline and Day 14 the subjects underwent 24 hour ECG recordings that were analyzed in the frequency domain of heart rate variability. The specific high frequency parasympathetic autonomic nervous system activity was analyzed. The primary endpoints were sleep latency and parasympathetic autonomic nervous system improvement in sleeping hours. The results showed improvement in sleep latency for the Sentra PM and combination of Sentra PM and trazodone (−41 and −56 minutes P < 0.001). There was an improvement in quality of sleep for the amino acid formulation Sentra PM and the combination (3.86 and 6.48 Likert units on a 10 point scale P < 0.001). There was an activation of circadian activity percent at night in the medical food and combination groups while there was no change in parasympathetic activity in either the placebo or trazodone group. These data indicate that Sentra PM can improve the quality of sleep, the response to trazodone as a sleep medication and parasympathetic autonomic nervous system activity.

scholarly journals Сlinical features of changes in the microcirculation system among children with allergic rhinitis, depending on the severity of dysfunction of the autonomic nervous system

2021 ◽  
Vol 23 (1) ◽  
pp. 169-172
Author(s):  
N. S. Tataurschikova ◽  
P. V. Berezhansky
Keyword(s):  
Quality Of Life ◽  
Allergic Rhinitis ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Adaptive Systems ◽  
Allergic Diseases ◽  
The Body ◽  
Individual Treatment ◽  
Autonomic Nervous

In recent years, there has been an increase in the prevalence of allergic diseases in children. Allergic rhinitis (AR) ranks first among other allergic diseases in terms of prevalence and impact on the health and quality of life patients. In various countries of the world, according to various sources, from 10 to 40% of the population suffers. Allergic rhinitis is a serious medical, social and economic problem. In addition, allergic rhinitis, especially with multiple sensitization and insufficiently controlled course, is an independent risk factor for recurrence of respiratory infections and the development of bronchial asthma, and also significantly reduces the quality of life patients.AR is a multifactorial disease in the development of which many factors play a role. The basis of the pathological process in AR is IgE--dependent mucosal inflammation, which is realized under the influence of specific and nonspecific mechanisms and has a Th2 character. The tissues and organs involved in the process determine the formation of complex mechanisms of interaction between the immune, microcirculatory and autonomic nervous systems.The inflammatory process in AR is characterized by a number of features, for example, the presence of minimal persistent inflammation and the priming effect, which in turn is a predisposing factor for the clinical onset and progression of AR. Microcirculatory mechanisms are of great pathogenetic significance in the development of allergic inflammation, including in AR.Depending on the leading pathognomonic trait, it is now customary to distinguish individual phenotypes and endotypes of AR.The phenotype covers the clinically significant properties of AR, but does not reveal the detailed mechanisms of its development, on the basis of which a personalized algorithm for prevention, treatment and prognosis can be created.And the autonomic nervous system is responsible for setting links between the body, ambient and internal environment through the regulation of metabolism, functioning of organs and tissues based on changes in this environment; it also provides the integration of all organs into a single whole acting as one of the main body’s adaptive systems.Since the autonomic nervous system governs the body and homeostasis uniting separate pathogenetic links of disease progression and sets the basis for structural and functional unity. In light of this, the failure of neuroregulatory mechanisms takes the lead among the causes of systemic changes in the microvasculature, which, in turn, reflects general pathogenetic processes in the body. The regulatory mechanism is implemented through nerves and reflexes by different neurohumoral factors, their nature has been studied under experimental conditions and is beyond doubt to date.The study of the main indicators of microcirculation and the autonomic nervous system among children with allergic rhinitis in various combinations with concomitant pathology will highlight new AR phenotypes and select an individual treatment and rehabilitation plan for these children.

scholarly journals Features of autonomic regulation in cholelithiasis before and after cholecystectomy

2018 ◽  
pp. 60-64
Author(s):  
A. D. Bagmet ◽  
A. P. Ruban ◽  
V. N. Egorov ◽  
T. V. Tayutina
Keyword(s):  
Quality Of Life ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Mathematical Analysis ◽  
Sympathetic Activity ◽  
Heart Rhythm ◽  
Autonomic Regulation ◽  
Autonomic Nervous ◽  
Before And After

It is appropriate and necessary to examine the functional state of the autonomic nervous system and the quality of life in patients with cholelithiasis using the mathematical analysis of the heart rhythm at the present-day level. Materials and methods: 136 patients (115 women and 21 men) were examined, of which 70 patients after cholecystectomy with cholelithiasis and 66 patients with cholelithiasis. Fractional chromatic minute-type duodenal intubation with an analysis of the biochemical and microscopic composition of the bile was used to assess the biliary system condition. The examination of the autonomic nervous system was carried out by determining the heart rhythm using the cardiointervalography method with further mathematical analysis of the structure and variational pulsometry. Changes in the autonomic status in patients with cholelithiasis before and after cholecystectomy differ in general patterns: adaptive possibilities decrease and sympathetic activity of the autonomic regulation increases. An increase in the lithogenicity of bile, which positively correlates with the level of sympathicotonia, is characteristic for patients with cholelithiasis before and after cholecystectomy. The autonomic regulation in patients with cholelithiasis after cholecystectomy improves, however, the high bile lithogenicity persists. 

Diagnosing Autonomic Nervous System Disorders - Existing Guidelines and Future Perspectives

2011 ◽  
Vol 6 (1) ◽  
pp. 52 ◽  
Author(s):  
Heinz Lahrmann ◽  
Isabel Rocha ◽  
Walter Struhal ◽  
Roland D Thijs ◽  
Max Hilz ◽  
...  
Keyword(s):  
Nervous System ◽  
Autonomic Nervous System ◽  
Severe Adverse Effect ◽  
Current Standard ◽  
Autonomic Nervous ◽  
Sympathetic Function ◽  
Important Means ◽  
Autonomic Nervous System Disorders ◽  
Bedside Tests

Primary and secondary autonomic nervous system (ANS) disorders often have a severe adverse effect on the quality of life of patients. Diagnostics for ANS disorders are under represented, despite their common occurrence. Precise history taking is of key importance for ANS evaluation: it may help to rule out differential diagnoses and provide important clues to the underlying ANS disorder. In fact, in conjunction with additional bedside tests, it can achieve a clear diagnosis. The analysis of heart rate variability and the results of the standardised tests that make up the Ewing battery are important means of evaluating the parasympathetic and sympathetic nervous system. In addition, sudomotor testing can be used to evaluate cholinergic sympathetic function, and the spontaneous baroreceptor reflex can be assessed using new computerised techniques. These tests provide valuable information on cardiovascular autonomic control. This paper presents a structured review of current standard techniques for diagnosing ANS disorders.

scholarly journals Acute phase of depression treatment - current research and its perspectives on Jessenius Faculty of Medicine

2016 ◽  
Vol 63 (1) ◽  
pp. 25-28
Author(s):  
M. Oppa ◽  
T. Kulhan ◽  
G. Nosáľová ◽  
I. Ondrejka
Keyword(s):  
Quality Of Life ◽  
Nervous System ◽  
Depressive Symptoms ◽  
Autonomic Nervous System ◽  
Acute Phase ◽  
Depression Treatment ◽  
New Work ◽  
Efficacy And Safety ◽  
Autonomic Nervous

Abstract In the previous research at Jessenius Faculty of Medicine in Martin has been studied depression and its treatment from the aspects of the quality of life and functioning of the patients, as well as comparing the efficacy and safety of venlafaxine versus venlafaxine and olanzapine treatment. Last years have been studied the parameters of the autonomic nervous system in the context of depression. Our new work will build on these findings, during the exploration of efficacy and safety of a novel antidepressant vortioxetine in monotherapy and in combination with olanzapine. Since combination of vortixetine and olanzapine is not yet understood, it is unknown whether the effect of the treatment of depressive symptoms and associated problems will be stronger and faster compared to vortioxetine monotherapy.

scholarly journals Autonomic Nervous System Dysfunction Is Associated With Re-hospitalization in Pediatric Septic Shock Survivors

2022 ◽  
Vol 9 ◽  
Author(s):  
Colleen M. Badke ◽  
Lindsey Swigart ◽  
Michael S. Carroll ◽  
Debra E. Weese-Mayer ◽  
L. Nelson Sanchez-Pinto
Keyword(s):  
Quality Of Life ◽  
Heart Rate ◽  
Septic Shock ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Sensitivity Analyses ◽  
Autonomic Nervous System Dysfunction ◽  
Targeted Interventions ◽  
Autonomic Nervous

Objective: Re-hospitalization after sepsis can lead to impaired quality of life. Predictors of re-hospitalization could help identify sepsis survivors who may benefit from targeted interventions. Our goal was to determine whether low heart rate variability (HRV), a measure of autonomic nervous system dysfunction, is associated with re-hospitalization in pediatric septic shock survivors.Materials and Methods: This was a retrospective, observational cohort study of patients admitted between 6/2012 and 10/2020 at a single institution. Patients admitted to the pediatric intensive care unit with septic shock who had continuous heart rate data available from the bedside monitors and survived their hospitalization were included. HRV was measured using age-normalized z-scores of the integer HRV (HRVi), which is the standard deviation of the heart rate sampled every 1 s over 5 consecutive minutes. The 24-h median HRVi was assessed on two different days: the last 24 h of PICU admission (“last HRVi”) and the 24-h period with the lowest median HRVi (“lowest HRVi”). The change between the lowest and last HRVi was termed “delta HRVi.” The primary outcome was re-hospitalization within 1 year of discharge, including both emergency department encounters and hospital readmission, with sensitivity analyses at 30 and 90 days. Kruskal-Wallis, logistic regression, and Poisson regression evaluated the association between HRVi and re-hospitalizations and adjusted for potential confounders.Results: Of the 463 patients who met inclusion criteria, 306 (66%) were re-hospitalized, including 270 readmissions (58%). The last HRVi was significantly lower among re-hospitalized patients compared to those who were not (p = 0.02). There was no difference in the lowest HRVi, but patients who were re-hospitalized showed a smaller recovery in their delta HRVi compared to those who were not re-hospitalized (p = 0.02). This association remained significant after adjusting for potential confounders. In the sensitivity analysis, a smaller recovery in delta HRVi was consistently associated with a higher likelihood of re-hospitalization.Conclusion: In pediatric septic shock survivors, a smaller recovery in HRV during the index admission is significantly associated with re-hospitalization. This continuous physiologic measure could potentially be used as a predictor of patients at risk for re-hospitalization and lower health-related quality of life.

Effects of Far Infrared Acupoint Stimulation on Autonomic Activity and Quality of Life in Hemodialysis Patients

2009 ◽  
Vol 37 (02) ◽  
pp. 215-226 ◽  
Author(s):  
Ling-Hwa Su ◽  
Kwan-Dun Wu ◽  
Li-Shan Lee ◽  
Harrison Wang ◽  
Chi-Feng Liu
Keyword(s):  
Quality Of Life ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Far Infrared ◽  
Hemodialysis Patients ◽  
Autonomic Nervous ◽  
Stage Renal Disease ◽  
The Impact ◽  
Regular Hemodialysis

Patients receiving regular hemodialysis sessions have been known to suffer from fatigue and depression. This experiment was designed to determine the effects of far infrared ray (FIR) stimulation on acupoints of patients suffering from renal failure who are receiving regular hemodialysis. Patients receiving long-term and regular hemodialysis who volunteered for this procedure were randomly selected to undergo either FIR or heat pad (HP) therapy to determine the impact of FIR treatment on these patients. Both the activities of the autonomic nervous system and changes in quality of life were measured before and after treatment to determine the effectiveness of the FIR treatment. Results from this study show that FIR therapy decreases both stress and fatigue levels of these patients. It also stimulates autonomic nervous system (ANS) activity in patients who are diagnosed with end-stage renal disease (ESRD) and are receiving regular hemodialysis (HD). Therefore, benefits of FIR stimulation on these patients are clearly demonstrated in this preliminary study.

scholarly journals Diagnosing Autonomic Nervous System Disorders—Existing Guidelines and Future Perspectives

US Neurology ◽  
2011 ◽  
Vol 07 (01) ◽  
pp. 55 ◽  
Author(s):  
Heinz Lahrmann ◽  
Isabel Rocha ◽  
Walter Struhal ◽  
Roland D Thijs ◽  
Max Hilz ◽  
...  
Keyword(s):  
Nervous System ◽  
Autonomic Nervous System ◽  
Severe Adverse Effect ◽  
Current Standard ◽  
Autonomic Nervous ◽  
Sympathetic Function ◽  
Important Means ◽  
Autonomic Nervous System Disorders ◽  
Bedside Tests

Primary and secondary autonomic nervous system (ANS) disorders often have a severe adverse effect on the quality of life of patients. Diagnostics for ANS disorders are under represented, despite their common occurrence. Precise history taking is of key importance for ANS evaluation: it may help to rule out differential diagnoses and provide important clues to the underlying ANS disorder. In fact, in conjunction with additional bedside tests, it can achieve a clear diagnosis. The analysis of heart rate variability and the results of the standardized tests that make up the Ewing battery are important means of evaluating the parasympathetic and sympathetic nervous system. In addition, sudomotor testing can be used to evaluate cholinergic sympathetic function, and the spontaneous baroreceptor reflex can be assessed using new computerized techniques. These tests provide valuable information on cardiovascular autonomic control. This paper presents a structured review of current standard techniques for diagnosing ANS disorders.

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