scholarly journals A COMPREHENSIVE GUIDE TO MEGA-PRESS FOR GABA MEASUREMENT

2021 ◽  
Author(s):  
Aimie L Peek ◽  
Trudy J Rebbeck ◽  
Andrew M Leaver ◽  
Nicolaas Puts ◽  
Sheryl Foster ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Working Party ◽  
Quality Data ◽  
Resonance Spectroscopy ◽  
High Quality ◽  
High Quality Data ◽  
Quality Reporting ◽  
Study Protocols ◽  
The Central Nervous System

Background: The aim of this guideline is to provide a series of evidence-based recommendations that allow those new to the field of MEGA-PRESS to produce high-quality data for the measurement of GABA levels using edited magnetic resonance spectroscopy with the MEGA-PRESS sequence at 3T. GABA is the main inhibitory neurotransmitter of the central nervous system and has been increasingly studied due to its relevance in many clinical disorders of the central nervous system. MEGA-PRESS is the most widely used method for quantification of GABA at 3T, but is technically challenging and operates at a low signal-to-noise ratio. Therefore, the acquisition of high-quality MRS data relies on avoiding numerous pitfalls and observing important caveats. Methods: The guideline was developed by a working party that consisted of experts in MRS and experts in guideline development and implementation, together with key stakeholders. Strictly following a translational framework, we first identified evidence using a systematically conducted scoping literature review, then synthesised and graded the quality of evidence that formed recommendations. These recommendations were then sent to a panel of 21 world leaders in MRS for feedback and approval using a modified-Delphi process across two rounds. Results: The final guideline consists of 23 recommendations across six domains essential for GABA MRS acquisition (Parameters, Practicalities, Data acquisition, Confounders, Quality/reporting, Post-processing). Overall, 78% of recommendations were formed from high-quality evidence, and 91% received agreement from over 80% of the expert panel. Conclusion: These 23 expert-reviewed recommendations and accompanying extended documentation form a readily usable guideline to allow those new to the field of MEGA-PRESS to design appropriate MEGA-PRESS study protocols and generate high-quality data.

scholarly journals Merosin-positive congenital muscular dystrophy: neuroimaging findings

2007 ◽  
Vol 65 (1) ◽  
pp. 167-169
Author(s):  
André Palma da Cunha Matta ◽  
Márcia de Castro Diniz Gonsalves
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Autosomal Recessive ◽  
Congenital Muscular Dystrophy ◽  
Metabolic Changes ◽  
Resonance Spectroscopy ◽  
Muscle Dystrophy ◽  
Metabolic Disturbances ◽  
The Central Nervous System ◽  
The Brain

Congenital muscle dystrophy (CMD) is a heterogeneous group of autosomal recessive myopathies. It is known that CMD may affect the central nervous system (CNS). Some authors have shown that merosin-negative CMD patients may have encephalic metabolic disturbances. In order to study metabolic changes within the brain, the authors performed a magnetic resonance spectroscopy (MRS) study in a 1-year-old girl with merosin-positive CMD (MP-CMD). MRS of brain demonstrated that NAA/Cr ratio was decreased (1.52), while Cho/Cr ratio was increased (1.78). These findings suggest that metabolic changes in CNS can also be found in patients with MP-CMD.

Primary granulomatous angiitis of the central nervous system: findings of magnetic resonance spectroscopy and fractional anisotropy in diffusion tensor imaging prior to surgery

2007 ◽  
Vol 107 (4) ◽  
pp. 873-877 ◽  
Author(s):  
Takaaki Beppu ◽  
Takashi Inoue ◽  
Hideaki Nishimoto ◽  
Shinichi Nakamura ◽  
Yoichi Nakazato ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Fractional Anisotropy ◽  
Mr Spectroscopy ◽  
Diffusion Tensor ◽  
Resonance Spectroscopy ◽  
Granulomatous Angiitis ◽  
The Central Nervous System

✓Primary granulomatous angiitis of the central nervous system (CNS) is extremely rare. Its preoperative diagnosis is difficult as the condition displays nonspecific features on routine neuroimaging investigations. In this paper, the authors report findings of magnetic resonance (MR) spectroscopy and fractional anisotropy (FA) with diffusion tensor MR imaging in a case of granulomatous angiitis of the CNS. A 30-year-old man presented with morning headaches and grand mal seizures. An MR image revealed a mass resembling glioblastoma in the right temporal lobe. Magnetic resonance spectroscopy showed a high choline/creatine (Cho/Cr) ratio indicative of a malignant neoplasm, accompanied by a slight elevation of glutamate and glutamine. The FA value was very low, which is inconsistent with malignant glioma. The mass was totally removed surgically. Histologically, the peripheral lesion of the mass consisted of a rough accumulation of fat granule cells, infiltration of inflammatory cells, and distribution of capillary vessels. Some vessels within the lesion were replaced by granulomas. The histological diagnosis was granulomatous angiitis of the CNS. The MIB-1–positive rate of the granuloma was approximately 5%. Both MR spectroscopy and FA were unable to accurately diagnose granulomatous angiitis of the CNS prior to surgery; however, elevated Cho/Cr and glutamate and glutamine shown by MR spectroscopy may indicate the moderate proliferation potential of the granuloma and the inflammatory process, respectively, in this condition. Although the low FA value in the present case enabled the authors to rule out a diagnosis of glioblastoma, FA values in inflammatory lesions require careful interpretation.

scholarly journals Novel method using DW-MRI and ADC images to guide stereotactic biopsy for the diagnosis small primary angiitis of the central nervous system: A case report

2021 ◽  
Author(s):  
Xu Su ◽  
Liang Han ◽  
Mengxing Li ◽  
Zhengming Wang ◽  
Jiadui Gao ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Magnetic Resonance ◽  
Stereotactic Biopsy ◽  
Diffusion Tensor ◽  
Resonance Spectroscopy ◽  
Enhanced Mri ◽  
Diffusion Weighted ◽  
Primary Angiitis ◽  
The Central Nervous System

Abstract Objective To determine the role of diffusion-weighted magnetic resonance imaging (DW-MRI) and apparent diffusion coefficient (ADC) imaging to guide stereotactic biopsy for the diagnosis of intracranial angiitis. Case presentation In a 28-year-old woman who had experienced inactive headache and right limbs numbness for 4 days, preoperative magnetic resonance (MR) scanning, enhanced scanning, diffusion tensor imaging, magnetic resonance spectroscopy, diffusion-weighted imaging (DWI), and ADC image scanning were performed. Stereotactic biopsy was performed in one target where the area of edema detected with MR FLAIR, and two targets where the area shown as a high-value and a lower-value area in the DWI/ ADC image. Pathological examinations together with computed tomographic and enhanced MRI scans were conducted after surgery. A preoperative enhanced MRI scan showed a uniform low-intensity lesion in the patient’s left centrum semiovale, with a volume of 3.1 cm3. The DWI and ADC images showed uneven high-intensity signals and different ADC values in the lesion area, respectively. During surgery, tissues around the lesion and the lesion center were sampled at the three selected targets. The postoperative pathological diagnosis was primary angiitis of the central nervous system, and the patient was given anti-inflammatory medication and hormone therapy. The 3-year follow-up confirmed that the patient had recovered well, with a Glasgow Outcome Scale score of 5.Conclusion DW-MRI and ADC images can be reliably used to determine the location of small intracranial lesions, and guide stereotactic biopsy to facilitate the diagnosis of primary vasculitis of the central nervous system.

On the discovery of the elements 110-112 (IUPAC Technical Report)

2001 ◽  
Vol 73 (6) ◽  
pp. 959-967 ◽  
Author(s):  
P. J. Karol ◽  
H. Nakahara ◽  
B. W. Petley ◽  
E. Vogt
Keyword(s):  
Working Group ◽  
Research Collaboration ◽  
Relevant Literature ◽  
Working Party ◽  
Quality Data ◽  
High Quality ◽  
High Quality Data ◽  
Technical Report

The IUPAC/IUPAP joint working party on the priority of claims to the discovery of elements 110, 111, and 112 has reviewed the relevant literature pertaining to the several claims. In accordance with the criteria for the discovery of elements, previously established by the 1992 IUPAC/IUPAP Transfermium Working Group, it was determined that the claim by the Hofmann et al. research collaboration for the discovery of element 110 at GSI has fulfilled those criteria. For elements 111 and 112, the collaboration of Hofmann et al. produced high-quality data with plausible interpretations, but confirmation by further results is needed to assign priority of discovery for these elements. The working party was not convinced that claims of other collaborations have satisfied the discovery criteria.

On the Claims for Discovery of Elements 110, 111, 112, 114, 116, and 118 (IUPAC Technical Report)

2003 ◽  
Vol 75 (10) ◽  
pp. 1601-1611 ◽  
Author(s):  
P. J. Karol ◽  
H. Nakahara ◽  
B. W. Petley ◽  
E. Vogt
Keyword(s):  
Working Group ◽  
Research Collaboration ◽  
Relevant Literature ◽  
Working Party ◽  
Quality Data ◽  
High Quality ◽  
High Quality Data ◽  
Technical Report

The IUPAC/IUPAP Joint Working Party on the priority of claims to the discovery of new elements has reviewed the relevant literature pertaining to several claims. In accordance with the criteria for the discovery of elements, previously established by the 1992 IUPAC/IUPAP Transfermium Working Group, and reinforced by the 1999 IUPAC/IUPAP Joint Working Party, it was determined that the claim by the Hofmann et al. research collaboration for the discovery of element 111 at Gesellschaft für Schwerionenforschung (GSI) has fulfilled those criteria. For elements 112, 114, and 116, the collaborations of Hofmann et al. and of Oganessian et al. produced high-quality data with plausible interpretations. However, confirmation by further results is needed to assign priority of discovery for these elements. The working party was not persuaded that other collaborations have satisfied the discovery criteria.

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