scholarly journals Maternal cytokine response after SARS-CoV-2 infection during pregnancy

2022 ◽  
Author(s):  
Frederieke A.J. Gigase ◽  
Nina M. Molenaar ◽  
Roy D. Missall ◽  
Anna-Sophie Rommel ◽  
Whitney Lieb ◽  
...  
Keyword(s):  
Pregnancy Outcomes ◽  
Case Control Study ◽  
Normal Values ◽  
Case Control ◽  
Igg Antibody ◽  
Blood Samples ◽  
Cytokine Levels ◽  
Race Ethnicity ◽  
Adverse Pregnancy ◽  
Control Study

Objective: Dysregulation of the immune system during pregnancy is associated with adverse pregnancy outcomes. Recent studies report cytokine changes during the acute phase of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We examine whether there is a lasting association between SARS-CoV-2 infection during pregnancy and peripheral blood cytokine levels. Study design: We conducted a case-control study at the Mount Sinai health system in NYC including 100 SARS-CoV-2 IgG antibody positive people matched to 100 SARS-CoV-2 IgG antibody negative people on age, race/ethnicity, parity, and insurance status. Blood samples were collected at a median gestational age of 34 weeks. Levels of 14 cytokines were measured. Results: Individual cytokine levels and cytokine cluster Eigenvalues did not differ significantly between groups, indicating no persisting maternal cytokine changes after SARS-CoV-2 infection during pregnancy. Conclusion: Our findings suggest that the acute inflammatory response after SARS-CoV-2 infection may be restored to normal values during pregnancy.

Pregnancy Outcomes in Women Affected by Fetal Alpha-thalassemia: A Case Control Study

2021 ◽  
Author(s):  
Jiangheng Li ◽  
Jingli Yan ◽  
Yongquan Huang ◽  
Jinlu Wei ◽  
Bingyan Xie ◽  
...  
Keyword(s):  
Pregnancy Outcomes ◽  
Dna Analysis ◽  
Case Control Study ◽  
Case Control ◽  
Child Health Service ◽  
Apgar Scores ◽  
Thalassemia Trait ◽  
Adverse Pregnancy ◽  
Control Study ◽  
Hbh Disease

Abstract To evaluate the possible associations between fetal α-thalassemia and risk of adverse pregnancy outcomes using a provincial woman-child health service information database in China. This was a case control study (N=438,747) in which we compared all singleton pregnancies of women with or without the α-thalassemia trait from May 2016 to May 2020, and where women with the trait were further allocated to a normal fetal group, a group of fetuses with the α-thalassemia trait, and a fetal group with hemoglobin H (HbH) disease according to the results of fetal DNA analysis. With thalassemic women whose fetuses were normal as the reference, fetuses in the HbH disease group showed a higher increase in the odds of Apgar scores being <7 at 1 minute (adjusted odds ratio [aOR], 2.79; 1.03–7.59) and 5 minutes (aOR, 4.56; 1.07–19.40). With non-thalassemic women as the reference, these trends were more obvious (aOR, 4.83; 2.55–9.16; aOR, 6.24; 2.75–14.18, respectively); whereas the normal fetal group was more likely to be diagnosed with postpartum hemorrhage (aOR, 1.66; 1.10–2.50). In addition, fetal HbH disease and gestational age were two independent factors influencing low Apgar scores, and their combination reflected medium accuracy in Apgar predictions.

scholarly journals Pregnancy outcomes in women affected by fetal alpha-thalassemia: a case control study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jiangheng Li ◽  
Jingli Yan ◽  
Yongquan Huang ◽  
Jinlu Wei ◽  
Bingyan Xie ◽  
...  
Keyword(s):  
Pregnancy Outcomes ◽  
Dna Analysis ◽  
Case Control Study ◽  
Case Control ◽  
Child Health Service ◽  
Apgar Scores ◽  
Thalassemia Trait ◽  
Adverse Pregnancy ◽  
Control Study ◽  
Hbh Disease

AbstractTo evaluate the possible associations between fetal α-thalassemia and risk of adverse pregnancy outcomes using a provincial woman-child health service information database in China. This was a case control study (N = 438,747) in which we compared all singleton pregnancies of women with or without the α-thalassemia trait from May 2016 to May 2020, and where women with the trait were further allocated to a normal fetal group, a group of fetuses with the α-thalassemia trait, and a fetal group with hemoglobin H (HbH) disease according to the results of fetal DNA analysis. With thalassemic women whose fetuses were normal as the reference, fetuses in the HbH disease group showed a higher increase in the odds of Apgar scores being < 7 at 1 min (adjusted odds ratio [aOR], 2.79; 1.03–7.59) and 5 min (aOR, 4.56; 1.07–19.40). With non-thalassemic women as the reference, these trends were more obvious (aOR, 4.83; 2.55–9.16; aOR, 6.24; 2.75–14.18, respectively); whereas the normal fetal group was more likely to be diagnosed with postpartum hemorrhage (aOR, 1.66; 1.10–2.50). In addition, fetal HbH disease and gestational age were two independent factors influencing low Apgar scores, and their combination reflected medium accuracy in Apgar predictions.

scholarly journals Is severe OHSS associated with adverse pregnancy outcomes? Evidence from a case–control study

2014 ◽  
Vol 29 (2) ◽  
pp. 216-221 ◽  
Author(s):  
Jigal Haas ◽  
Micha Baum ◽  
Katya Meridor ◽  
Anat Hershko-Klement ◽  
Shai Elizur ◽  
...  
Keyword(s):  
Pregnancy Outcomes ◽  
Case Control Study ◽  
Case Control ◽  
Adverse Pregnancy Outcomes ◽  
Adverse Pregnancy ◽  
Control Study ◽  
Severe Ohss
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