scholarly journals Analysis of commonly expressed genes between first trimester fetal heart and placenta cell types in the context of congenital heart disease

2022 ◽  
Author(s):  
Rebecca Wilson ◽  
Victor Yuan ◽  
Jennifer Alexander Courtney ◽  
Alyssa Tipler ◽  
James Cnota ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Endothelial Cells ◽  
Heart Disease ◽  
Congenital Heart ◽  
Fetal Heart ◽  
Reduction Process ◽  
Cell Types ◽  
First Trimester ◽  
Cellular Respiration ◽  
Oxidation Reduction

Congenital heart disease (CHD) is often associated with fetal growth abnormalities. During the first trimester of pregnancy, the heart and placenta develop concurrently, and share key developmental pathways. Hence, it is hypothesized that defective morphogenesis of either organ is synergistically linked. However, many studies determined to understand the mechanisms behind CHD overlook the contribution of the placenta. In this study, we aimed to identify commonly expressed genes between first trimester heart and placenta cells using two publicly available single cell sequencing databases. Using a systematic computational approach, we identified 328 commonly expressed genes between heart and placenta endothelial cells and enrichment in pathways including Vasculature Development (GO:0001944, FDR 2.90E-30), and Angiogenesis (GO:0001525, FDR 1.18E-27). We also found, in comparison with fetal heart endothelial cells, 197 commonly expressed genes with placenta extravillous trophoblasts, 128 with cytotrophoblasts and 80 with syncytiotrophoblasts, and included genes such as FLT1, GATA2, ENG and CDH5. Finally, comparison of first trimester cardiomyocytes and placenta cytotrophoblasts revealed 53 commonly expressed genes and enrichment in biological processes integral to cellular function including Cellular Respiration (GO:0045333; FDR 5.05E-08), Ion Transport (GO:0006811; FDR 2.08E-02), and Oxidation-Reduction Process (GO:0055114; FDR 1.58E-07). Overall, our results identify specific genes and cellular pathways common between first trimester fetal heart and placenta cells which if disrupted may concurrently contribute to the developmental perturbations resulting in CHD.

scholarly journals Ultrasound Patterns in the First Trimester Diagnosis of Congenital Heart Disease

2021 ◽  
Vol 10 (15) ◽  
pp. 3206
Author(s):  
Catalin G. Herghelegiu ◽  
Anca Maria Panaitescu ◽  
Simona Duta ◽  
Ana Maria Vayna ◽  
Anca Marina Ciobanu ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Fetal Heart ◽  
Color Doppler ◽  
First Trimester ◽  
American Institute ◽  
Color Doppler Flow ◽  
First Trimester Of Pregnancy ◽  
And Child Health

Congenital heart disease (CHD) is the most common birth defect, with a reported prevalence of 5–12 per 1000 live births. Very recently, the American Institute of Ultrasound in Medicine published a guideline recommending the use of the four-chamber and the three-vessel and trachea views to screen for CHD in the first trimester of pregnancy. Our aim is to present abnormal image patterns that are seen in the four-chamber, three-vessel, and trachea views of the fetal heart in the first trimester and to describe their association with specific CHD types. We used a total of 29 cases of CHD from the archives of Filantropia Hospital and the Maternal and Child Health Institute (INSMC) fetal medicine units. We selected cases with a clear and well-documented diagnosis of the CHD type. We identified a series of repeating color doppler flow patterns seen in the four-chamber, three-vessel, and trachea views of the studied cases. Our observations could be developed into a diagnosis algorithm to orientate the examiner to the most likely type of CHD in individual cases.

Generalized Bone Changes and Thrombocytopenic Purpura in Association with Intrauterine Rubella

PEDIATRICS ◽  
1965 ◽  
Vol 36 (2) ◽  
pp. 264-268
Author(s):  
AARON R. RAUSEN ◽  
ROBERT D. LONDON ◽  
ABRAHAM MIZRAHI ◽  
LOUIS Z. COOPER
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Rubella Virus ◽  
Congenital Heart ◽  
Newborn Infants ◽  
First Trimester ◽  
Long Bones ◽  
Thrombocytopenic Purpura ◽  
Bone Changes ◽  
First Trimester Of Pregnancy

Two newborn infants are presented whose mothers had rubella in the first trimester of pregnancy. Both infants were born with thrombocytopenic purpura and suggestive evidence of a hemolytic disorder. The second infant had congenital heart disease as well. Roentgenographic changes in the metaphyseal ends of several long bones, observed in the first infant at 3 days of age, regressed completely by 2 months of age. The second infant had roentgenographic evidence of metaphyseal changes of a lesser degree, limited to the distal ends of the femora. These changes were no longer present at 6 weeks of age. Both infants were shown to be harboring an interfering agent with the characteristics of the rubella virus.

Screening for congenital heart disease with the four-chamber view of the fetal heart

1992 ◽  
Vol 167 (4) ◽  
pp. 1000-1003 ◽  
Author(s):  
Patrizia Vergani ◽  
Silvana Mariani ◽  
Alessandro Ghidini ◽  
Riccardo Schiavina ◽  
Maria Cavallone ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Fetal Heart ◽  
Chamber View

scholarly journals Magnetic resonance imaging in the normal fetal heart and in congenital heart disease

2012 ◽  
Vol 39 (3) ◽  
pp. 322-329 ◽  
Author(s):  
C. Votino ◽  
J. Jani ◽  
N. Damry ◽  
H. Dessy ◽  
X. Kang ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Congenital Heart Disease ◽  
Heart Disease ◽  
Magnetic Resonance ◽  
Congenital Heart ◽  
Fetal Heart ◽  
Resonance Imaging

scholarly journals 2076927 Is the Brain-Sparing Effect Described in Fetuses With Congenital Heart Disease Evident in the First Trimester?

2015 ◽  
Vol 41 (4) ◽  
pp. S52
Author(s):  
Reem Abu-Rustum ◽  
M. Fouad Ziade ◽  
Assaad Kesrouani ◽  
Sameer Abu-Rustum ◽  
Linda Daou
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
First Trimester ◽  
Sparing Effect ◽  
The Brain

scholarly journals First trimester fetal heart evaluation. A pictorial essay

2020 ◽  
Author(s):  
Ioana Cristina Rotar ◽  
Daniel Mureșan ◽  
Claudiu Mărginean ◽  
Claudiu Mărginean ◽  
Dominic Gabriel Iliescu ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Cardiac Disease ◽  
Congenital Heart ◽  
Fetal Heart ◽  
First Trimester ◽  
Second Trimester ◽  
Doppler Examination ◽  
Examination Protocol ◽  
Evaluation Protocol ◽  
Pictorial Essay

Classically fetal heart evaluation is mandatory in the second trimester of pregnancy. Recent data suggest that the diagnosis of congenital heart disease is feasible in the first trimester (FT) of pregnancy, especially for trained examiners. In this pictorial essay we aim to illustrate in detail the particularity of the FT heart evaluation: the specific ultrasound techniques including practical tips for the basic and extended first trimester fetal heart evaluation protocol. The diagnosis is possible by the use of a variety of ultrasound techniques (B mode, CFM, Bidirectional Doppler, STIC, TUI) using the transabdominal/transvaginal probes. An abnormal FT heart scan requires second trimester reassessment. Unfortunately, not all cardiac disease can be potentially diagnosed in the first trimester. Based on their own experience the authors recommend that heart examination in the FT should be attempted in all fetuses, even in low risk pregnancies, using at least the basic Doppler examination protocol.

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