scholarly journals Time-Specific Associations of Wearable, Sensor-Based Cardiovascular and Behavioral Readouts with Disease Phenotypes in the Outpatient Setting of the Chronic Renal Insufficiency Cohort (CRIC)

2022 ◽  
Author(s):  
Nicholas F Lahens ◽  
Mahboob Rahman ◽  
Jordana B Cohen ◽  
Debbie L Cohen ◽  
Jing Chen ◽  
...  
Keyword(s):  
Renal Insufficiency ◽  
Chronic Renal Insufficiency ◽  
Nervous Activity ◽  
Outpatient Setting ◽  
Fluctuation Analysis ◽  
Diabetic Patients ◽  
Clinical Environments ◽  
Time Specific ◽  
Detrended Fluctuation

Patients with chronic kidney disease (CKD) are at risk of developing cardiovascular disease. To facilitate out-of-clinic evaluation, we piloted wearable device-based analysis of heart rate variability and behavioral readouts in patients with CKD participating in the Chronic Renal Insufficiency Cohort and (n=49) controls. Time-specific partitioning of HRV readouts indicate higher parasympathetic nervous activity during the night (mean RR at night 14.4+/-1.9 ms versus 12.8+/-2.1 ms during active hours; n=47, ANOVA q=0.001). The alpha2 long-term fluctuations in the detrended fluctuation analysis, a parameter predictive of cardiovascular mortality, significantly differentiated between diabetic and non-diabetic patients (prominent at night with 0.58+/-0.2 versus 0.45+/-0.12, respectively, adj. p=0.004). Both diabetic and nondiabetic CKD patients showed loss of rhythmic organization compared to controls, with diabetic CKD patients exhibiting deconsolidation of peak phases between their activity and SDNN (standard deviation of interbeat intervals) rhythms (mean phase difference CKD 8.3h, CKD/T2DM 4h, controls 6.8h). This work provides a roadmap toward deriving actionable clinical insights from the data collected by wearable devices outside of highly controlled clinical environments.

scholarly journals Shen-Zhi-Ling Oral Liquid Improves Behavioral and Psychological Symptoms of Dementia in Alzheimer’s Disease

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Weidong Pan ◽  
Qiudong Wang ◽  
Shin Kwak ◽  
Yu Song ◽  
Baofeng Qin ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Rating Scale ◽  
Psychological Symptoms ◽  
Fluctuation Analysis ◽  
Double Blind ◽  
Oral Liquid ◽  
Detrended Fluctuation ◽  
Behavioral And Psychological Symptoms

We evaluated the effects of the traditional Chinese medicine (TCM) Shen-Zhi-Ling oral liquid (SZL) on the behavioral and psychological symptoms of dementia (BPSD) in patients with Alzheimer’s disease (AD). Among 98 patients with AD and BPSD enrolled (mean age, 57.2 ± 8.9 years old), 91 (M = 55,F = 36; mean age, 57.2 ± 9.7 years old) completed the study. Patients took either SZL (n=45) or placebo granules (n=46) in a double-blind manner for 20 weeks while maintaining other anticognitive medications unchanged. Changes in BPSD between week 0, week 10, week 20, and week 25 were assessed using the behavioral pathology in Alzheimer’s disease (BEHAVE-AD) rating scale and the neuropsychiatric inventory (NPI), detrended fluctuation analysis (DFA) represented by diurnal activity (DA), evening activity (EA), and nocturnal activity (NA) according to actigraphic recordings. SZL but not placebo oral liquid delayed the development of BPSD significantly according to the changes in some of the clinical scores and the EA and NA parameters of DFA at week 20 compared with week 0. No side effects were observed in laboratory tests. The results indicate that SZL might delay the development of BPSD in AD patients and thus is a potentially suitable drug for long-term use.

Chronic renal insufficiency in a boy with cystic renal lymphangiectasia: morphological findings and long-term follow-up

2007 ◽  
Vol 68 (12) ◽  
pp. 416-421 ◽  
Author(s):  
S. Ueda ◽  
H. Yanagida ◽  
K. Sugimoto ◽  
S. Fujita ◽  
K. Yagi ◽  
...  
Keyword(s):  
Renal Insufficiency ◽  
Chronic Renal Insufficiency ◽  
Morphological Findings ◽  
Long Term Follow Up

Scaling behavior of earthquakes’ inter-events time series

Open Physics ◽  
2009 ◽  
Vol 7 (3) ◽  
Author(s):  
Shahriar Shadkhoo ◽  
Fakhteh Ghanbarnejad ◽  
Gholam Jafari ◽  
Mohammad Tabar
Keyword(s):  
Time Series ◽  
Time Scales ◽  
Hurst Exponent ◽  
Detrended Fluctuation Analysis ◽  
Fluctuation Analysis ◽  
Data Set ◽  
Scaling Properties ◽  
Independent Events ◽  
Detrended Fluctuation

AbstractIn this paper, we investigate the statistical and scaling properties of the California earthquakes’ inter-events over a period of the recent 40 years. To detect long-term correlations behavior, we apply detrended fluctuation analysis (DFA), which can systematically detect and overcome nonstationarities in the data set at all time scales. We calculate for various earthquakes with magnitudes larger than a given M. The results indicate that the Hurst exponent decreases with increasing M; characterized by a Hurst exponent, which is given by, H = 0:34 + 1:53/M, indicating that for events with very large magnitudes M, the Hurst exponent decreases to 0:50, which is for independent events.

scholarly journals Trends and Persistence of Dry–Wet Conditions in Northeast Brazil

Atmosphere ◽  
2020 ◽  
Vol 11 (10) ◽  
pp. 1134
Author(s):  
Antonio Samuel Alves da Silva ◽  
Moacyr Cunha Filho ◽  
Rômulo Simões Cezar Menezes ◽  
Tatijana Stosic ◽  
Borko Stosic
Keyword(s):  
Time Scales ◽  
Water Resource Management ◽  
Standardized Precipitation Index ◽  
Kendall Test ◽  
Spatially Explicit ◽  
Fluctuation Analysis ◽  
Short Term ◽  
Agricultural Planning ◽  
Detrended Fluctuation

We analyze trend and persistence in Standardized Precipitation Index (SPI) time series derived from monthly rainfall data at 133 gauging stations in Pernambuco state, Brazil, using a suite of complementary methods to address the spatially explicit tendencies, and persistence. SPI was calculated for 1-, 3-, 6-, and 12-month time scales from 1950 to 2012. We use Mann–Kendall test and Sen’s slope to determine sign and magnitude of the trend, and detrended fluctuation analysis (DFA) method to quantify long-term correlations. For all time scales significant negative trends are obtained in the Sertão (deep inland) region, while significant positive trends are found in the Agreste (intermediate inland), and Zona da Mata (coastal) regions. The values of DFA exponents show different scaling behavior for different time scales. For short-term conditions described by SPI-1 the DFA exponent is close to 0.5 indicating weak persistency and low predictability, while for medium-term conditions (SPI-3 and SPI-6) DFA exponents are greater than 0.5 and increase with time scale indicating stronger persistency and higher predictability. For SPI-12 that describes long-term precipitation patterns, the values of DFA exponents for inland regions are around 1, indicating strong persistency, while in the shoreline the value of the DFA exponent is between 1.0 and 1.5, indicating anti-persistent fractional Brownian motion. These results should be useful for agricultural planning and water resource management in the region.

LONG-TERM TREATMENT WITH ORAL TORSEMIDE AND ITS EFFECT ON BODY WEIGHT AND FLUID BALANCE IN PATIENTS WITH CHRONIC RENAL INSUFFICIENCY

1996 ◽  
Vol 3 (11) ◽  
pp. 743-749
Author(s):  
Andrew Whelton ◽  
William B. Smith ◽  
J. David Wallin ◽  
Lawrence J. Hak ◽  
Barry McLean ◽  
...  
Keyword(s):  
Body Weight ◽  
Renal Insufficiency ◽  
Fluid Balance ◽  
Chronic Renal Insufficiency ◽  
Term Treatment ◽  
Long Term Treatment

Survival and Long-Term Cardiovascular Outcomes after Carotid Endarterectomy in Patients with Chronic Renal Insufficiency

2015 ◽  
Vol 29 (1) ◽  
pp. 15-21 ◽  
Author(s):  
Efthymios D. Avgerinos ◽  
Catherine Go ◽  
Jennifer Ling ◽  
Michel S. Makaroun ◽  
Rabih A. Chaer
Keyword(s):  
Renal Insufficiency ◽  
Carotid Endarterectomy ◽  
Chronic Renal Insufficiency ◽  
Cardiovascular Outcomes
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