scholarly journals A crowdsourced analysis to identifyab initiomolecular signatures predictive of susceptibility to viral infection

2018 ◽  
Author(s):  
Slim Fourati ◽  
Aarthi Talla ◽  
Mehrad Mahmoudian ◽  
Joshua G. Burkhart ◽  
Riku Klén ◽  
...  
Keyword(s):  
Gene Expression ◽  
Healthy Subjects ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Respiratory Viruses ◽  
Community Based ◽  
Blood Gene Expression ◽  
Predictors Of Response ◽  
Peripheral Blood Gene Expression ◽  
Physiologic Responses

AbstractRespiratory viruses are highly infectious; however, the variation of individuals’ physiologic responses to viral exposure is poorly understood. Most studies examining molecular predictors of response focus on late stage predictors, typically near the time of peak symptoms. To determine whether pre- or early post-exposure factors could predict response, we conducted a community-based analysis to identify predictors of resilience or susceptibility to several respiratory viruses (H1N1, H3N2, Rhinovirus, and RSV) using peripheral blood gene expression profiles collected from healthy subjects prior to viral exposure, as well as up to 24 hours following exposure. This analysis revealed that it is possible to construct models predictive of symptoms using profiles even prior to viral exposure. Analysis of predictive gene features revealed little overlap among models; however, in aggregate, these genes were enriched for common pathways. Heme Metabolism, the most significantly enriched pathway, was associated with higher risk of developing symptoms following viral exposure.

scholarly journals Peripheral blood gene expression profiles in COPD subjects

2011 ◽  
Vol 1 (1) ◽  
pp. 12 ◽  
Author(s):  
Soumyaroop Bhattacharya ◽  
Shivraj Tyagi ◽  
Sorachai Srisuma ◽  
Dawn L DeMeo ◽  
Steven D Shapiro ◽  
...  
Keyword(s):  
Gene Expression ◽  
Peripheral Blood ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Blood Gene Expression ◽  
Peripheral Blood Gene Expression

scholarly journals Diagnosis of Partial Body Radiation Exposure in Mice Using Peripheral Blood Gene Expression Profiles

PLoS ONE ◽  
2010 ◽  
Vol 5 (7) ◽  
pp. e11535 ◽  
Author(s):  
Sarah K. Meadows ◽  
Holly K. Dressman ◽  
Pamela Daher ◽  
Heather Himburg ◽  
J. Lauren Russell ◽  
...  
Keyword(s):  
Gene Expression ◽  
Radiation Exposure ◽  
Peripheral Blood ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Blood Gene Expression ◽  
Peripheral Blood Gene Expression ◽  
Partial Body

scholarly journals Subtype-specific peripheral blood gene expression profiles in recent-onset juvenile idiopathic arthritis

2009 ◽  
Vol 60 (7) ◽  
pp. 2102-2112 ◽  
Author(s):  
Michael G. Barnes ◽  
Alexei A. Grom ◽  
Susan D. Thompson ◽  
Thomas A. Griffin ◽  
Paul Pavlidis ◽  
...  
Keyword(s):  
Gene Expression ◽  
Juvenile Idiopathic Arthritis ◽  
Peripheral Blood ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Blood Gene Expression ◽  
Recent Onset ◽  
Peripheral Blood Gene Expression

scholarly journals Current Tolerance-Associated Peripheral Blood Gene Expression Profiles After Liver Transplantation Are Influenced by Immunosuppressive Drugs and Prior Cytomegalovirus Infection

2022 ◽  
Vol 12 ◽  
Author(s):  
Aafke A. Duizendstra ◽  
Michelle V. van der Grift ◽  
Patrick P. Boor ◽  
Lisanne Noordam ◽  
Robert J. de Knegt ◽  
...  
Keyword(s):  
Gene Expression ◽  
Peripheral Blood ◽  
Cytomegalovirus Infection ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Immunosuppressive Drugs ◽  
Differentially Expressed ◽  
Blood Gene Expression ◽  
Operational Tolerance ◽  
Peripheral Blood Gene Expression

Spontaneous operational tolerance to the allograft develops in a proportion of liver transplant (LTx) recipients weaned off immunosuppressive drugs (IS). Several previous studies have investigated whether peripheral blood gene expression profiles could identify operational tolerance in LTx recipients. However, the reported gene expression profiles differed greatly amongst studies, which could be caused by inadequate matching of clinical parameters of study groups. Therefore, the purpose of this study was to validate differentially expressed immune system related genes described in previous studies that identified tolerant LTx recipients after IS weaning. Blood was collected of tolerant LTx recipients (TOL), a control group of LTx recipients with regular IS regimen (CTRL), a group of LTx recipients with minimal IS regimen (MIN) and healthy controls (HC), and groups were matched on age, sex, primary disease, time after LTx, and cytomegalovirus serostatus after LTx. Quantitative Polymerase Chain Reaction was used to determine expression of twenty selected genes and transcript variants in PBMCs. Several genes were differentially expressed between TOL and CTRL groups, but none of the selected genes were differentially expressed between HC and TOL. Principal component analysis revealed an IS drug dosage effect on the expression profile of these genes. These data suggest that use of IS profoundly affects gene expression in peripheral blood, and that these genes are not associated with operational tolerance. In addition, expression levels of SLAMF7 and NKG7 were affected by prior cytomegalovirus infection in LTx recipients. In conclusion, we found confounding effects of IS regimen and prior cytomegalovirus infection, on peripheral blood expression of several selected genes that were described as tolerance-associated genes by previous studies.

scholarly journals Expression Profiling of Transcriptome and Its Associated Disease Risk in Yang Deficiency Constitution of Healthy Subjects

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Ruoxi Yu ◽  
Yin Yang ◽  
Yuanyuan Han ◽  
Pengwei Hou ◽  
Yingshuai Li ◽  
...  
Keyword(s):  
Gene Expression ◽  
Healthy Subjects ◽  
Mononuclear Cells ◽  
Clinical Medicine ◽  
Disease Risk ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Molecular Evidence ◽  
Chinese Han ◽  
Peripheral Blood Mononuclear

Objectives. Differences among healthy subjects and associated disease risks are of substantial interest in clinical medicine. According to the theory of “constitution-disease correlation” in traditional Chinese medicine, we try to find out if there is any connection between intolerance of cold in Yang deficiency constitution and molecular evidence and if there is any gene expression basis in specific disorders. Methods. Peripheral blood mononuclear cells were collected from Chinese Han individuals with Yang deficiency constitution (n=20) and balanced constitution (n=8) (aged 18–28) and global gene expression profiles were determined between them using the Affymetrix HG-U133 Plus 2.0 array. Results. The results showed that when the fold change was ≥1.2 and q ≤ 0.05, 909 genes were upregulated in the Yang deficiency constitution, while 1189 genes were downregulated. According to our research differential genes found in Yang deficiency constitution were usually related to lower immunity, metabolic disorders, and cancer tendency. Conclusion. Gene expression disturbance exists in Yang deficiency constitution, which corresponds to the concept of constitution and gene classification. It also suggests people with Yang deficiency constitution are susceptible to autoimmune diseases, enteritis, arthritis, metabolism disorders, and cancer, which provides molecular evidence for the theory of “constitution-disease correlation.”

Sign in / Sign up

Export Citation Format

Share Document