scholarly journals Presence of causative mutations affecting prolificacy in the Noire du Velay and Mouton Vendéen sheep breeds

2018 ◽  
Author(s):  
L. Chantepie ◽  
L. Bodin ◽  
J. Sarry ◽  
F. Woloszyn ◽  
J. Ruesche ◽  
...  

AbstractFor many decades, prolificacy has been selected in meat sheep breeds as a polygenic trait but with limited genetic gain. However, the discovery of major genes affecting prolificacy has changed the way of selection for some ovine breeds implementing gene-assisted selection as in the French Lacaune and Grivette meat breeds, or in the Spanish Rasa Aragonesa breed. Based on statistical analysis of litter size parameters from 34 French meat sheep populations, we suspected the segregation of a mutation in a major gene affecting prolificacy in the Noire du Velay and in the Mouton Vendéen breeds exhibiting a very high variability of the litter size. After the genotyping of mutations known to be present in French sheep breeds, we discovered the segregation of the FecLL mutation at the B4GALNT2 locus and the FecXGr mutation at the BMP15 locus in Noire du Velay and Mouton Vendéen, respectively. The frequency of ewes carrying FecLL in the Noire du Velay population was estimated at 21.2% and the Mouton Vendéen ewes carrying FecXGr at 10.3%. The estimated mutated allele effect of FecLL and FecXGron litter size at +0.4 and +0.3 lamb per lambing in Noire du Velay and Mouton Vendéen, respectively. Due to the fairly high frequency and the rather strong effect of the FecLL and FecXGr prolific alleles, specific management programmes including genotyping should be implemented for a breeding objective of prolificacy adapted to each of these breeds.

2008 ◽  
Vol 40 (6) ◽  
pp. 663
Author(s):  
Isabelle Palhiere ◽  
Mickaël Brochard ◽  
Katayoun Moazami-Goudarzi ◽  
Denis Laloë ◽  
Yves Amigues ◽  
...  

1997 ◽  
Vol 65 (2) ◽  
pp. 209-215
Author(s):  
I. Ap Dewi ◽  
J. B. Owen ◽  
R. F. E. Axford ◽  
M. T. Beigi-Nassiri

AbstractPrevious reports have suggested the presence of a major gene influencing prolificacy in the Cambridge sheep breed. To estimate the effect of such a gene, high and low prolificacy groups were established in a Cambridge sheep flock between lambing years 1990 and 1993. In 1990-1991 ovulation rate (OR) was used as the basis for allocating ewes into groups but for 1992-1993 litter size was used also as a secondary selection criterion. In 1990 and 1991 small groups (each with one ram) of extreme phenotype were formed. In 1992 and 1993, six high and six low groups were formed using all available ewes, increasing the number of observations but with less selection pressure for high and low prolificacy. Results from the groups were interpreted on the basis of a major gene with additive effect resulting in three distinct genotypes (CC, Cc and cc). It was assumed, because of the selection method adopted, that CC ewes were exclusively in the high groups, heterozygotes (Cc) were distributed between the high and low groups and that cc ewes were exclusively in the low groups. In 1990-1991 there was a difference in OR of 4·0 between ewes allocated to the high and low groups. In 1992-1993 the difference was 1·9. Litter size differences between groups averaged 0·73. Whilst the high group progeny had higher OR, the differences between groups were less than differences observed between groups based on selected dam records, possibly a reflexion of the young age at which progeny records were collected. Differences between the high and low groups suggest a gene effect for adult ewes of approximately 2·0, with expected OR, above a basal level of 2·0, of 4·0 and 6·0 for heterozygous and homozygous carriers respectively. The effect of the gene in young ewes (predominantly 1 to 2 years) was approximately 0·8.


2008 ◽  
Vol 40 (6) ◽  
pp. 663-680 ◽  
Author(s):  
Isabelle Palhiere ◽  
Mickaeël BRochard ◽  
Katayoun MOAZAMI-Goudarzi ◽  
Denis Laloeë ◽  
Yves Amigues ◽  
...  

2002 ◽  
Vol 80 (10) ◽  
pp. 2566 ◽  
Author(s):  
J. Estany ◽  
D. Villalba ◽  
M. Tor ◽  
D. Cubiló ◽  
J. L. Noguera

1977 ◽  
Author(s):  
D. V. Campbell ◽  
William Kennebeck ◽  
A. Zanella ◽  
Paul Sexton

Animals ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 571
Author(s):  
Fengyan Wang ◽  
Mingxing Chu ◽  
Linxiang Pan ◽  
Xiangyu Wang ◽  
Xiaoyun He ◽  
...  

Litter size is one of the most important economic traits in sheep. GDF9 and BMPR1B are major genes affecting the litter size of sheep. In this study, the whole coding region of GDF9 was sequenced and all the SNPs (single nucleotide polymorphisms) were determined in Luzhong mutton ewes. The FecB mutation was genotyped using the Sequenom MassARRAY®SNP assay technology. Then, the association analyses between polymorphic loci of GDF9 gene, FecB, and litter size were performed using a general linear model procedure. The results showed that eight SNPs were detected in GDF9 of Luzhong mutton sheep, including one novel mutation (g.41769606 T > G). The g.41768501A > G, g.41768485 G > A in GDF9 and FecB were significantly associated with litter size in Luzhong mutton ewes. The g.41768485 G > A is a missense mutation in the mature GDF9 protein region and is predicted to affect the tertiary structure of the protein. The results preliminarily demonstrated that GDF9 was a major gene affecting the fecundity of Luzhong mutton sheep and the two loci g.41768501A > G and g.41768485 G > A may be potential genetic markers for improving litter size.


2021 ◽  
pp. 1-16
Author(s):  
Xu Hu ◽  
Bin Lin ◽  
Ping Wang ◽  
Hongguang Lyu ◽  
Tie-Shan Li

Abstract The very high frequency data exchange system (VDES) is promising in promoting electronic navigation (E-navigation) and improving navigation safety. The multiple access control (MAC) protocol is crucial to the transmission performance of VDES. The self-organising time division multiple access (SOTDMA) protocol, as the only access mode given by current recommendations, leads to a high rate of transmission collisions in the traditional automatic identification system (AIS), especially with heavy traffic loads. This paper proposes a novel feedback based time division multiple access (FBTDMA) protocol to address the problems caused by SOTDMA, such that collision of transmissions can be avoided in information transmission among vessels. Simulation results demonstrate that the proposed FBTDMA outperforms the traditional SOTDMA in terms of channel utilisation and throughput, and significantly reduces the transmission collision rate. The study is expected to provide insights into VDES standardisation and E-navigation modernisation.


Materials ◽  
2021 ◽  
Vol 14 (12) ◽  
pp. 3360
Author(s):  
Yakir Dahan ◽  
Eldad Holdengreber ◽  
Elichai Glassner ◽  
Oz Sorkin ◽  
Shmuel E. Schacham ◽  
...  

A new measurement technique of electrical parameters of superconducting thin films at the Very High Frequency (VHF) range is described, based on resonators with microstrip (MS) structures. The design of an optimal resonator was achieved, based on a thorough theoretical analysis, which is required for derivation of the exact configuration of the MS. A theoretical model is presented, from which an expression for the attenuation of a MS line can be derived. Accordingly, simulations were performed, and an optimal resonator for the VHF range was designed and implemented. Production constraints of YBa2Cu3O7 (YBCO) limited the diameter of the sapphire substrate to 3″. Therefore, a meander configuration was formed to fit the long λ/4 MS line on the wafer. By measuring the complex input reflection coefficients of a λ/4 resonator, we extracted the quality factor, which is mainly affected by the dielectric and conductor attenuations. The experimental results are well fitted by the theoretical model. The dielectric attenuation was calculated using the quasi-static analysis of the MS line. An identical copper resonator was produced and measured to compare the properties of the YBCO resonator in reference to the copper one. A quality factor of ~6·105 was calculated for the YBCO resonator, three orders of magnitude larger than that of the copper resonator. The attenuation per unit length of the YBCO layer was smaller by more than five orders of magnitude than that of the copper.


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