scholarly journals Probabilistic atlas of the lateral parabrachial nucleus, medial parabrachial nucleus, vestibular nuclei complex and medullary viscero-sensory-motor nuclei complex in living humans from 7 Tesla MRI

2019 ◽  
Author(s):  
Kavita Singh ◽  
Iole Indovina ◽  
Jean C. Augustinack ◽  
Kimberly Nestor ◽  
María G. García-Gomar ◽  
...  
Keyword(s):  
Vestibular Nuclei ◽  
3 Tesla ◽  
7 Tesla ◽  
Parabrachial Nucleus ◽  
Single Subject ◽  
Probabilistic Atlas ◽  
Lateral Parabrachial Nucleus ◽  
Sensory Motor ◽  
7 Tesla Mri ◽  
Motor Nuclei

AbstractThe lateral parabrachial nucleus, medial parabrachial nucleus, vestibular nuclei complex and medullary viscero-sensory-motor nuclei complex (the latter including among others the solitary nucleus, vagus nerve nucleus, and hypoglossal nucleus) are anatomically and functionally connected brainstem gray-matter structures that convey signals across multiple modalities between the brain and the spinal cord to regulate vital bodily functions. It is remarkably difficult to precisely extrapolate the location of these nuclei from ex vivo atlases to conventional 3 Tesla in vivo images; thus, a probabilistic brainstem atlas in stereotaxic neuroimaging space in living humans is needed. We delineated these nuclei using single-subject high contrast 1.1 mm isotropic resolution 7 Tesla MRI images. After precise coregistration of nuclei labels to stereotaxic space, we generated a probabilistic atlas of their anatomical locations. Finally, we validated the nuclei labels in the atlas by assessing their inter-rater agreement, consistency across subjects and volumes. We also performed a preliminary comparison of their location and microstructural properties to histologic sections of a postmortem human brainstem specimen. In future, the resulting probabilistic atlas of these brainstem nuclei in stereotaxic space may assist researchers and clinicians in evaluating autonomic, vestibular and viscero-sensory-motor nuclei structure, function and connectivity in living humans using conventional 3 Tesla MRI scanners.

scholarly journals Clinical value of (dedicated) 3 Tesla and 7 Tesla MRI for cT1 glottic carcinoma: A feasibility study

2019 ◽  
Vol 4 (1) ◽  
pp. 95-101
Author(s):  
Sylvia L. van Egmond ◽  
Bernard M.D. Vonck ◽  
Johanna J. Bluemink ◽  
Frank A. Pameijer ◽  
Jan Willem Dankbaar ◽  
...  
Keyword(s):  
Feasibility Study ◽  
3 Tesla ◽  
7 Tesla ◽  
Glottic Carcinoma ◽  
Clinical Value ◽  
7 Tesla Mri

3 Tesla and 7 Tesla MRI of multiple sclerosis cortical lesions

2010 ◽  
Vol 32 (4) ◽  
pp. 971-977 ◽  
Author(s):  
Emma C. Tallantyre ◽  
Paul S. Morgan ◽  
Jennifer E. Dixon ◽  
Ali Al-Radaideh ◽  
Matthew J. Brookes ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
3 Tesla ◽  
7 Tesla ◽  
Cortical Lesions ◽  
7 Tesla Mri

1,5 Tesla versus 3 Tesla versus 7 Tesla MRT des Abdomen - eine Feldstärkenvergleichsstudie

2013 ◽  
Vol 185 (S 01) ◽  
Author(s):  
L Umutlu ◽  
S Maderwald ◽  
A Fischer ◽  
M Forsting ◽  
M Ladd ◽  
...  
Keyword(s):  
3 Tesla ◽  
7 Tesla

scholarly journals A probabilistic atlas of the human ventral tegmental area (VTA) based on 7 Tesla MRI data

2021 ◽  
Vol 226 (4) ◽  
pp. 1155-1167 ◽  
Author(s):  
Anne C. Trutti ◽  
Laura Fontanesi ◽  
Martijn J. Mulder ◽  
Pierre-Louis Bazin ◽  
Bernhard Hommel ◽  
...  
Keyword(s):  
Ventral Tegmental Area ◽  
Region Of Interest ◽  
Reward Processing ◽  
7 Tesla ◽  
Subcortical Structures ◽  
7 Tesla Mri ◽  
Subcortical Nuclei ◽  
Ventral Tegmental ◽  
The Brain

AbstractFunctional magnetic resonance imaging (fMRI) BOLD signal is commonly localized by using neuroanatomical atlases, which can also serve for region of interest analyses. Yet, the available MRI atlases have serious limitations when it comes to imaging subcortical structures: only 7% of the 455 subcortical nuclei are captured by current atlases. This highlights the general difficulty in mapping smaller nuclei deep in the brain, which can be addressed using ultra-high field 7 Tesla (T) MRI. The ventral tegmental area (VTA) is a subcortical structure that plays a pivotal role in reward processing, learning and memory. Despite the significant interest in this nucleus in cognitive neuroscience, there are currently no available, anatomically precise VTA atlases derived from 7 T MRI data that cover the full region of the VTA. Here, we first provide a protocol for multimodal VTA imaging and delineation. We then provide a data description of a probabilistic VTA atlas based on in vivo 7 T MRI data.

7 Tesla MRI

2021 ◽  
Vol 29 (1) ◽  
pp. i
Author(s):  
Meng Law
Keyword(s):  
7 Tesla ◽  
7 Tesla Mri

scholarly journals Vestibular Effects of a 7 Tesla MRI Examination Compared to 1.5 T and 0 T in Healthy Volunteers

PLoS ONE ◽  
2014 ◽  
Vol 9 (3) ◽  
pp. e92104 ◽  
Author(s):  
Jens M. Theysohn ◽  
Oliver Kraff ◽  
Kristina Eilers ◽  
Dorian Andrade ◽  
Marcus Gerwig ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
7 Tesla ◽  
Mri Examination ◽  
7 Tesla Mri

scholarly journals GLP-1 Receptor Stimulation of the Lateral Parabrachial Nucleus Reduces Food Intake: Neuroanatomical, Electrophysiological, and Behavioral Evidence

Endocrinology ◽  
2014 ◽  
Vol 155 (11) ◽  
pp. 4356-4367 ◽  
Author(s):  
Jennifer E. Richard ◽  
Imre Farkas ◽  
Fredrik Anesten ◽  
Rozita H. Anderberg ◽  
Suzanne L. Dickson ◽  
...  
Keyword(s):  
Feeding Behavior ◽  
Fluorescent Protein ◽  
Yellow Fluorescent Protein ◽  
Parabrachial Nucleus ◽  
Lateral Parabrachial Nucleus ◽  
Electrophysiological Studies ◽  
Glucagon Like Peptide 1 ◽  
Behavioral Evidence ◽  
Stimulation Of

Abstract The parabrachial nucleus (PBN) is a key nucleus for the regulation of feeding behavior. Inhibitory inputs from the hypothalamus to the PBN play a crucial role in the normal maintenance of feeding behavior, because their loss leads to starvation. Viscerosensory stimuli result in neuronal activation of the PBN. However, the origin and neurochemical identity of the excitatory neuronal input to the PBN remain largely unexplored. Here, we hypothesize that hindbrain glucagon-like peptide 1 (GLP-1) neurons provide excitatory inputs to the PBN, activation of which may lead to a reduction in feeding behavior. Our data, obtained from mice expressing the yellow fluorescent protein in GLP-1-producing neurons, revealed that hindbrain GLP-1-producing neurons project to the lateral PBN (lPBN). Stimulation of lPBN GLP-1 receptors (GLP-1Rs) reduced the intake of chow and palatable food and decreased body weight in rats. It also activated lPBN neurons, reflected by an increase in the number of c-Fos-positive cells in this region. Further support for an excitatory role of GLP-1 in the PBN is provided by electrophysiological studies showing a remarkable increase in firing of lPBN neurons after Exendin-4 application. We show that within the PBN, GLP-1R activation increased gene expression of 2 energy balance regulating peptides, calcitonin gene-related peptide (CGRP) and IL-6. Moreover, nearly 70% of the lPBN GLP-1 fibers innervated lPBN CGRP neurons. Direct intra-lPBN CGRP application resulted in anorexia. Collectively, our molecular, anatomical, electrophysiological, pharmacological, and behavioral data provide evidence for a functional role of the GLP-1R for feeding control in the PBN.

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